Cited by 4,649Cancer-related Molecular PathwaysDevelopmental Biology and Gene RegulationCell death mechanisms and regulation

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, Lawrence A., Harvey, Michele, Slagle, Betty L., McArthur, Mark J., Montgomery, Charles A., Butel, Janet S., Bradley, Allan·1992·Nature

DOI 10.1038/356215a0

Open this paper in CoChat — free account

Abstract

Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.

Integrity signals

Registry

Crossref · 10.1038/356215a0

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Self-citation
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
Baker, S. J., Markowitz, S. D., Fearon, E. R., Willson, J. K. V., & Vogelstein, B. (1990) · Science · doi:10.1126/science.2144057 · Cited by 1,742
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 10

Mowat, M., Cheng, A., Kicumca, N., Bernstein, A. & Benchimol, S. Nature 61, 2777–2781 (1985).
Ben David, Y., Prideaux, V. R., Chow, V., Benchimol, S. & Bernstein, A. Oncogene 3, 179–185 (1988).
Stürzbecher, H.-W. et al. Oncogene 5, 795–801 (1990).
Shaulsky, G., Ben-Ze'ev, A. & Rotter, V. Oncogene 5, 1707–1711 (1990).
Soussi, T., de Fromentel, C. C. & May, P. Oncogene 5, 945–952 (1990).
Bradley, A. in Tetratocarcinomas and Embryonic Stem Cells: A Practical Approach (ed. Robertson, E. J.) 113–151 (IRL, Oxford, 1987).
Stutman, O. Fed. Proc. Fed. Am. Soc. exp. Biol. 33, 2028–2032 (1974).
Yandell, D. W. Proc. Am. Assoc. Cancer Res. 32, 459–460 (1991).
Sepulveda, A. R. et al. Cancer Res. 49, 6108–6117 (1989).
Slagle, B. L., Lanford, R. E., Medina, D. & Butel, J. S. Cancer Res. 42, 2155–2162 (1984).

Sorted by citations

Items 301–400 of 1,032

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
Huang, C. (1999) · Carcinogenesis · doi:10.1093/carcin/20.2.237 · Cited by 337
Essential role of stromally induced hedgehog signaling in B-cell malignancies
Dierks, C., Grbic, J., Zirlik, K., Beigi, R., Englund, N. P., Guo, G.-R., Veelken, H., Engelhardt, M. M., Mertelsmann, R. H., Kelleher, J. F., et al. (2007) · Nature Medicine · doi:10.1038/nm1614 · Cited by 336
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
Amundson, S. A., Bittner, M., Chen, Y., Trent, J. M., Meltzer, P. S., & Fornace, A. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202676 · Cited by 336
The tumore suppressor p53
Donehower, L. A., & Bradley, A. (1993) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(93)90004-v · Cited by 334
Self-citation
p53, cancer and the immune response
Blagih, J., Buck, M. D., & Vousden, K. H. (2020) · Journal of Cell Science · doi:10.1242/jcs.237453 · Cited by 333
Preclinical mouse solid tumour models: status quo, challenges and perspectives
Gengenbacher, N., Singhal, M., & Augustin, H. G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.92 · Cited by 332
The p53 family and programmed cell death
Pietsch, E. C., Sykes, S. M., McMahon, S. B., & Murphy, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.315 · Cited by 331
Hypoxia Links ATR and p53 through Replication Arrest
Hammond, E. M., Denko, N. C., Dorie, M. J., Abraham, R. T., & Giaccia, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1834-1843.2002 · Cited by 330
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Lissy, N. A., Davis, P. K., Irwin, M. S., Kaelin, W. G., & Dowdy, S. F. (2000) · Nature · doi:10.1038/35036608 · Cited by 330
Bax Involvement in p53-Mediated Neuronal Cell Death
Xiang, H., Kinoshita, Y., Knudson, C. M., Korsmeyer, S. J., Schwartzkroin, P. A., & Morrison, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01363.1998 · Cited by 327
Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX
Chen, H. T., Bhandoola, A., Difilippantonio, M. J., Zhu, J., Brown, M. J., Tai, X., Rogakou, E. P., Brotz, T. M., Bonner, W. M., Ried, T., et al. (2000) · Science · doi:10.1126/science.290.5498.1962 · Cited by 326
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Liu, G., Parant, J. M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A. K., Multani, A., Chang, S., & Lozano, G. (2004) · Nature Genetics · doi:10.1038/ng1282 · Cited by 325
The Molecular and Genetic Basis of Neurological Tumours
Zhu, Y. S., & Parada, L. F. (2002) · Nature reviews. Cancer · doi:10.1038/nrc866 · Cited by 325
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons
Pietras, E. M., Lakshminarasimhan, R., Techner, J.-M., Fong, S., Flach, J., Binnewies, M., & Passegué, E. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131043 · Cited by 323
A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency
Cao, L., Xu, X., Bunting, S. F., Liu, J., Wang, R.-H., Cao, L. L., Wu, J. J., Peng, T.-N., Chen, J., Nussenzweig, A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.037 · Cited by 324
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.050 · Cited by 321
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Chen, C., Liu, Y., Rappaport, A., Kitzing, T. M., Schultz, N. D., Zhao, Z., Shroff, A., Dickins, R. A., Vakoc, C. R., Bradner, J. E., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.016 · Cited by 319
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
Bruggeman, S. W. M., Valk-Lingbeek, M. E., van der Stoop, P. P. M., Jacobs, J. J. L., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., et al. (2005) · Genes & Development · doi:10.1101/gad.1299305 · Cited by 315
Mouse models of metastasis: progress and prospects
Gómez-Cuadrado, L., Tracey, N., Ma, R., Qian, B., & Brunton, V. G. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030403 · Cited by 316
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
Gruis, N. A., van der Velden, P. A., Sandkuijl, L. A., Prins, D. E. M., Weaver-Feldhaus, J., Kamb, A., Bergman, W., & Frants, R. R. (1995) · Nature Genetics · doi:10.1038/ng0795-351 · Cited by 312
p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
Kim, N. H., Kim, N.-G., Kim, N.-G., Lee, I., Choi, H.-S., Li, X.-Y., Kang, S. E., Cha, S. Y., Ryu, J. K., Na, J. M., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001744 · Cited by 311
Tumor suppressor p53 and metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy070 · Cited by 313
p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.
Long, X.-Q., Boluyt, M. O., Hipolito, M. L., Lundberg, M. S., Zheng, J. S., O'Neill, L., Cirielli, C., Lakatta, E. G., & Crow, M. T. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119452 · Cited by 311
The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.Preprint
Missero, C., Cunto, F. D., Kiyokawa, H., Koff, A., & Dotto, G. P. (1996) · Genes & Development · doi:10.1101/gad.10.23.3065 · Cited by 311
Manipulating the mammalian genome by homologous recombination
Vásquez, K. M., Marburger, K., Intödy, Z., & Wilson, J. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111009698 · Cited by 310
Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability
Kubbutat, M. H. G., & Vousden, K. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.460 · Cited by 310
p53 Family and Cellular Stress Responses in Cancer
Pflaum, J., Schlosser, S., & ller, M. M. ⁄. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00285 · Cited by 309
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice.Preprint
Baribault, H., Penner, J., Iozzo, R. V., & Wilson-Heiner, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2964 · Cited by 309
Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy
Yue, X., Zhao, Y., Xu, Y., Zheng, M., Feng, Z., & Hu, W. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.03.030 · Cited by 308
Ubiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation
Maki, C. G., & Howley, P. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.355 · Cited by 308
Mouse models for human lung cancerPreprint
Meuwissen, R. L. J., & Berns, A. J. M. (2005) · Genes & Development · doi:10.1101/gad.1284505 · Cited by 307
The p53 family in differentiation and tumorigenesis
Stiewe, T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2072 · Cited by 306
Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice
Crumrine, R. C., Thomas, A. L., & Morgan, P. F. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.119 · Cited by 306
Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.
O'Connor, P. M., Jackman, J., Jondle, D., Bhatia, K. G., MAGRATH, I. T., & Kohn, K. W. (1993) · PubMed · Cited by 306
TP53: an oncogene in disguise
Soussi, T., & Wiman, K. G. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.53 · Cited by 305
P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors
Aloyz, R. S., Bamji, S. X., Pozniak, C. D., Toma, J. G., Atwal, J. K., Kaplan, D. R., & Miller, F. D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1691 · Cited by 305
50 Years of Preclinical Anticancer Drug Screening: Empirical to Target-Driven Approaches
Suggitt, M., & Bibby, M. C. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.971.11.3 · Cited by 304
The p53 network: cellular and systemic DNA damage responses in cancer and aging
Vaddavalli, P. L., & Schumacher, B. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.02.010 · Cited by 304
Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
Danilova, N., Sakamoto, K. M., & Lin, S. (2008) · Blood · doi:10.1182/blood-2008-01-132290 · Cited by 303
The common and distinct target genes of the p53 family transcription factors
Harms, K. L., Nozell, S. E., & Chen, X. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3304-4 · Cited by 303
Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity
Franklin, D. S., Godfrey, V., O’Brien, D. A., Deng, C., & Xiong, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6147-6158.2000 · Cited by 303
Genetic alterations in breast cancer
Bièche, I., & Lidereau, R. (1995) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870140402 · Cited by 303
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
Chipuk, J. E., Maurer, U., Green, D. R., & Schüler, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00272-1 · Cited by 302
The rebel angel: mutant p53 as the driving oncogene in breast cancer
Walerych, D., Napoli, M., Collavin, L., & Sal, G. D. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs232 · Cited by 301
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
Morgan, S. E., & Kastan, M. B. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60095-0 · Cited by 301
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
Lotem, J., & Sachs, L. (1993) · Blood · doi:10.1182/blood.v82.4.1092.1092 · Cited by 301
p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
Dohn, M. R., Zhang, S., & Chen, X. (2001) · Oncogene · doi:10.1038/sj.onc.1204427 · Cited by 300
Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.
Rowan, S., Ludwig, R., Haupt, Y., Bates, S., Lü, X., Oren, M., & Vousden, K. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00418.x · Cited by 300
p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
Valente, L. J., Gray, D. H. D., Michalak, E. M., Hofbauer, J. P., Egle, A., Scott, C. L., Janic, A., & Strasser, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.012 · Cited by 299
Endothelial apoptosis in Braf-deficient mice
Wojnowski, L., Zimmer, A. M., Beck, T. W., Hahn, H., Bernal, R. A., Rapp, U. R., & Zimmer, A. (1997) · Nature Genetics · doi:10.1038/ng0797-293 · Cited by 299
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.Preprint
Howes, K. A., Ransom, N. L., Papermaster, D. S., Lasudry, J., Albert, D. M., & Windle, J. J. (1994) · Genes & Development · doi:10.1101/gad.8.11.1300 · Cited by 299
Role of miR-34c microRNA in the late steps of spermatogenesis
Bouhallier, F., Allioli, N., Lavial, F., Chalmel, F., Perrard, M., Durand, P., Samarut, J., Pain, B., & Rouault, J.-P. (2010) · RNA · doi:10.1261/rna.1963810 · Cited by 298
Gene perturbation and intervention in probabilistic Boolean networks
Shmulevich, I., Dougherty, E. R., & Zhang, W. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.10.1319 · Cited by 298
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
Almasan, A., Yin, Y., Kelly, R. E., Lee, E. Y., Bradley, A., Li, W., Bertino, J. R., & Wahl, G. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5436 · Cited by 298
Self-citation
Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.
Weiss, M. J., & Orkin, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9623 · Cited by 296
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
Hernando, E., Charytonowicz, E., Dudas, M. E., Menéndez, S., Matushansky, I., Mills, J. E., Socci, N. D., Behrendt, N., Ma, L., Maki, R. G., et al. (2007) · Nature Medicine · doi:10.1038/nm1560 · Cited by 296
The molecular basis for cell cycle delays following ionizing radiation: a review
Maity, A. M., McKenna, W. G., & Muschel, R. J. (1994) · Radiotherapy and Oncology · doi:10.1016/0167-8140(94)90408-1 · Cited by 296
Cancer and aging: a model for the cancer promoting effects of the aging stroma
Krtolica, A., & Campisi, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00053-5 · Cited by 295
Effect of p21WAF1/CIP1 Expression on Tumor Progression in Bladder Cancer
Stein, J. P., Ginsberg, D. A., Grossfeld, G. D., Chatterjee, S. J., Esrig, D., Dickinson, M. G., Groshen, S. G., Taylor, C. R., Jones, P. A., Skinner, D. G., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.14.1072 · Cited by 294
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
Harris, C. C. (1996) · Carcinogenesis · doi:10.1093/carcin/17.6.1187 · Cited by 291
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 299
Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53
Zhai, W., & Comai, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5930-5938.2000 · Cited by 289
Treacher Collins syndrome: etiology, pathogenesis and prevention
Trainor, P. A., Dixon, J., & Dixon, M. J. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.221 · Cited by 289
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286
“Mice were generated by heterozygous breeding of C57BL/6 inbred strains of Bmal1 [50], Cry1;Cry2 [82], Per1;Per2 [52], Per2 [19], Per2;p53 and p53 [60] mice, and 129/C57BL6 hybrid strain of Atm mice [83], and maintained under standard pathogen-free conditions of 2–5 per cage at 21uC–23uC with a humidity of 50%–70%, an…”
MethodSelf-citation
Regulation and Significance of Apoptosis in the Stem Cells of the Gastrointestinal Epithelium
Potten, C. S., Wilson, J. W., & Booth, C. E. (1997) · Stem Cells · doi:10.1002/stem.150082 · Cited by 286
Genetic Dissection of Cardiac Growth Control Pathways
MacLellan, W. R., & Schneider, M. D. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.289 · Cited by 286
Ubiquitin Ligases and the Immune Response
Liu, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104813 · Cited by 286
Brca2 is required for embryonic cellular proliferation in the mouse.Preprint
Suzuki, A., de la Pompa, J. L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A. C., Itié, A., et al. (1997) · Genes & Development · doi:10.1101/gad.11.10.1242 · Cited by 286
Centrosome amplification and the development of cancer
D’Assoro, A. B., Lingle, W. L., & Salisbury, J. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205772 · Cited by 285
Apoptosis and non-apoptotic deaths in cancer development and treatment response
de Bruin, E. C., & Medema, J. P. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.07.001 · Cited by 285
Genetic background alters the spectrum of tumors that develop in p53‐deficient mice
Harvey, M., McArthur, M. J., Montgomery, C. A., Bradley, A., & Donehower, L. A. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.10.8344491 · Cited by 285
Self-citation
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
Guevara, J., Kim, H.-S., Antonova, E. I., & Chan, L. (1999) · Nature Medicine · doi:10.1038/6585 · Cited by 284
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
Cox, L. S., & Lane, D. P. (1995) · BioEssays · doi:10.1002/bies.950170606 · Cited by 284
Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway
Woods, C. M., Zhu, J., McQueney, P. A., Bollag, D. M., & Lazarides, E. (1995) · Molecular Medicine · doi:10.1007/bf03401588 · Cited by 283
H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations
Franco, S., Gostissa, M., Zha, S., Lombard, D. B., Murphy, M. M., Zarrin, A. A., Yan, C., Tepsuporn, S., Morales, J. C., Adams, M. M., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.005 · Cited by 282
To die or not to die: how does p53 decide?
Slee, E. A., O’Connor, D. J., & Lü, X. (2004) · Oncogene · doi:10.1038/sj.onc.1207516 · Cited by 282
p53 mutation heterogeneity in cancer
Soussi, T., & Lozano, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.190 · Cited by 282
NOD-Like Receptors: Master Regulators of Inflammation and Cancer
Saxena, M., & Yeretssian, G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00327 · Cited by 282
Control of the G2/M Transition
Stark, G. R., & Taylor, W. R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:227 · Cited by 282
Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
Wörmann, S. M., Song, L., Ai, J., Diakopoulos, K. N., Kurkowski, M. U., Görgülü, K., Ruess, D. A., Campbell, A. D., Doglioni, C., Jodrell, D. I., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.010 · Cited by 282
Apoptosis and hepatobiliary disease
Patel, T. C., & Gores, G. J. (1995) · Hepatology · doi:10.1002/hep.1840210635 · Cited by 282
Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress
Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., & Kizaki, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705232200 · Cited by 281
Molecular Pathogenesis of Osteosarcoma
Kansara, M., & Thomas, D. M. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0505 · Cited by 280
Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function
Ludwig, R. L., Bates, S., & Vousden, K. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4952 · Cited by 278
Accumulation of p53 in a Mutant Cell Line Defective in the Ubiquitin Pathway
Chowdary, D., Dermody, J. J., Jha, K. K., & Ozer, H. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1997 · Cited by 277
The nuclear tyrosine kinase c-abl negatively regulates cell growth
Sawyers, C. L., McLaughlin, J., Goga, A., Havlik, M., & Witte, O. N. (1994) · Cell · doi:10.1016/0092-8674(94)90240-2 · Cited by 277
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.Preprint
Donehower, L. A., Godley, L. A., Aldaz, C. M., Pyle, R., Shi, Y. P., Pinkel, D., Gray, J. W., Bradley, A., Medina, D., & VARMUS, H. E. (1995) · Genes & Development · doi:10.1101/gad.9.7.882 · Cited by 277
Self-citation
The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression
Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2004) · The Journal of Medical Investigation · doi:10.2152/jmi.51.146 · Cited by 276
Zebrafish as a Cancer Model
Feitsma, H., & Cuppen, E. P. J. G. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2167 · Cited by 276
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.Preprint
Guidos, C. J., Williams, C. J., Grandal, I., Knowles, G. C., Huang, M. T. F., & Danska, J. S. (1996) · Genes & Development · doi:10.1101/gad.10.16.2038 · Cited by 276
Tumor suppressor p53 and its mutants in cancer metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.12.025 · Cited by 276
Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex
Weber, J. D., Kuo, M.-L., Bothner, B. B., DiGiammarino, E. L., Kriwacki, R. W., Roussel, M. F., & Sherr, C. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2517-2528.2000 · Cited by 275
Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
Komarova, E. A., Chernov, M. V., Franks, R., Wang, K., Armin, G., Zelnick, C. R., Chin, D. M., Bacus, S. S., Stark, G. R., & Gudkov, A. V. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1391 · Cited by 274
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
Bakalkin, G. Y., Yakovleva, T., Selivanova, G., Magnússon, K. P., Székely, L., Владимировна, К. Е., Klein, G., Terenius, L. Y., & Wiman, K. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.413 · Cited by 274
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs
Leonova, K. I., Brodsky, L., Lipchick, B. C., Pal, M., Novototskaya, L. R., Chenchik, A. A., Sen, G. C., Komarova, E. A., & Gudkov, A. V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216922110 · Cited by 273
Apoptosis and melanoma: molecular mechanisms
Hussein, M. R., Haemel, A. K., & Wood, G. S. (2003) · The Journal of Pathology · doi:10.1002/path.1300 · Cited by 272
Caveolae: mining little caves for new cancer targets
Carver, L. A., & Schnitzer, J. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1146 · Cited by 271
Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling
Lengner, C. J., Steinman, H. A., Gagnon, J. A., Smith, T. W., Henderson, J. E., Kream, B. E., Stein, G. S., Lian, J. B., & Jones, S. N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508130 · Cited by 270
Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis
Müller, U. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00021-0 · Cited by 269
Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
Teodoro, J. G., Evans, S. K., & Green, M. R. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0221-2 · Cited by 268

Authors: Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A.
Affiliations: Baylor College of Medicine (US)
ORCID: Slagle, Betty L.
Butel, Janet S.
Bradley, Allan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1992-03
Volume: 356
Issue: 6366
Pages: 215-221
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/356215a0
OpenAlex: W2126679757
Cited by: 4,649
References: 48
Citations by year: 2026: 16 · 2025: 48 · 2024: 51 · 2023: 74 · 2022: 76 · 2021: 80 · 2020: 86 · 2019: 92 · 2018: 84 · 2017: 96 · 2016: 119 · 2015: 89 · 2014: 121 · 2013: 146 · 2012: 157
FWCI: 82.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, tumor suppressor, spontaneous tumors, carcinogenesis, embryonic development, mouse model, neoplasms
MeSH terms: Alleles, Animals, Base Sequence, Blastocyst, DNA, Exons, Female, Genetic Vectors, Heterozygote, Homozygote, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Mutation, Neoplasms, Experimental, RNA, Messenger, Stem Cells, Blotting, Southern, Polymerase Chain Reaction, Genes, p53, Tumor Suppressor Protein p53, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks