Cited by 4,649Cancer-related Molecular PathwaysDevelopmental Biology and Gene RegulationCell death mechanisms and regulation

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, Lawrence A., Harvey, Michele, Slagle, Betty L., McArthur, Mark J., Montgomery, Charles A., Butel, Janet S., Bradley, Allan·1992·Nature

DOI 10.1038/356215a0

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Abstract

Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.

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“p53 knockout mice develop tumors with short latency and 100% penetrance [3].”
Background

Authors: Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A.
Affiliations: Baylor College of Medicine (US)
ORCID: Slagle, Betty L.
Butel, Janet S.
Bradley, Allan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1992-03
Volume: 356
Issue: 6366
Pages: 215-221
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/356215a0
OpenAlex: W2126679757
Cited by: 4,649
References: 48
Citations by year: 2026: 16 · 2025: 48 · 2024: 51 · 2023: 74 · 2022: 76 · 2021: 80 · 2020: 86 · 2019: 92 · 2018: 84 · 2017: 96 · 2016: 119 · 2015: 89 · 2014: 121 · 2013: 146 · 2012: 157
FWCI: 82.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, tumor suppressor, spontaneous tumors, carcinogenesis, embryonic development, mouse model, neoplasms
MeSH terms: Alleles, Animals, Base Sequence, Blastocyst, DNA, Exons, Female, Genetic Vectors, Heterozygote, Homozygote, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Mutation, Neoplasms, Experimental, RNA, Messenger, Stem Cells, Blotting, Southern, Polymerase Chain Reaction, Genes, p53, Tumor Suppressor Protein p53, Mice

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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