Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Cited by (1,032)

Items 101–200 of 1,032

  1. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    Xiaoling Xu, Kay‐Uwe Wagner, Denise M. Larson, Zoë Weaver Ohler, Cuiling Li, Thomas Ried, Lothar G. Hennighausen, Anthony J. Wynshaw-Boris, Chu‐Xia Deng · 1999 · Nature Genetics
  2. Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
    Chène, Patrick · 2003 · Nature Reviews Cancer
  3. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.
    Ted A. Weinert, Gretchen L. Kiser, Leland H. Hartwell · 1994 · Genes & Development
  4. Mediation of c-Myc-Induced Apoptosis by p53
    Heiko Hermeking, Dirk Eick · 1994 · Science
  5. Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
    Bengt Fadeel, Sten Orrenius · 2005 · Journal of Internal Medicine
  6. A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53
    Dae‐Sik Lim, Paul Hasty · 1996 · Molecular and Cellular Biology
  7. Mapping of the p53 and mdm-2 Interaction Domains
    Jiandong Chen, Vincent Maréchal, Arnold J. Levine · 1993 · Molecular and Cellular Biology
  8. Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically
    Miranda Thomas, Ann Kalita, Sylvie Labrecque, David Pim, Lawrence Banks, Greg Matlashewski · 1999 · Molecular and Cellular Biology
  9. Urothelial tumorigenesis: a tale of divergent pathways
    Xue‐Ru Wu · 2005 · Nature reviews. Cancer
  10. Twenty years of p53 research: structural and functional aspects of the p53 protein
    Pierre May, Evelyne May · 1999 · Oncogene
  11. Human prostate cancer risk factors
    David G. Bostwick, HARRY B. BURKE, Daniel Djakiew, Susan Y. Euling, Shuk‐Mei Ho, Joseph Richard Landolph, HOWARD I. MORRISON, Babasaheb R. Sonawane, Tiffany Shifflett, David J. Waters et al. · 2004 · Cancer
  12. The mighty mouse: genetically engineered mouse models in cancer drug development
    Norman E. Sharpless, Ronald Anthony DePinho · 2006 · Nature Reviews Drug Discovery
  13. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    Li, Zhe, Cai, Xiaoqiang, Cai, Chen-Leng, Wang, Jiapeng, Zhang, Wenyong, Petersen, Bruce E., Yang, Feng-Chun, Xu, Mingjiang · 2011 · Blood
  14. Smad3 Mutant Mice Develop Metastatic Colorectal Cancer
    Yuan Zhu, James A. Richardson, Luis F. Parada, Jonathan M. Graff · 1998 · Cell
  15. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    Andreas Strasser · 1994 · Cell
  16. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.
    Scott W. Lowe, H. Earl Ruley · 1993 · Genes & Development
  17. Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    Chaoying Yin, Charles Michael Knudson, Stanley J. Korsmeyer, Terry Van Dyke · 1997 · Nature
  18. Apoptosis: Molecular Regulation of Cell Death
    Annette J. Hale, Christopher A. Smith, Leslie C. Sutherland, Victoria E. A. Stoneman, Vanessa L. Longthorne, Aedín C. Culhane, Gwyn T. Williams · 1996 · European Journal of Biochemistry
  19. Central role of p53 in the suntan response and pathologic hyperpigmentation
    Cui, Rutao, Widlund, Hans R., Feige, Erez, Lin, Jennifer Y., Wilensky, Dara L., Igras, Viven E., D'Orazio, John, Fung, Claire Y., Schanbacher, Carl F., Granter, Scott R. et al. · 2007 · Cell
  20. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)
    1998 · British Journal of Cancer
  21. MDMX: a novel p53‐binding protein with some functional properties of MDM2.
    Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J. et al. · 1996 · The EMBO Journal
  22. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
    Alan F. Wahl, Karen L. Donaldson, Craig Faircnild, Frank Lee, Scott A. Foster, G. William Demers, Denise A. Galloway · 1996 · Nature Medicine
  23. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
    S. Perwez Hussain, Jonathan Schwank, Frank Staib, Xin Wei Wang, Curtis C. Harris · 2007 · Oncogene
  24. MDM2 — master regulator of the p53 tumor suppressor protein
    Momand, Jamil, Wu, Hsiao-Huei, Dasgupta, Gargi · 2000 · Gene
  25. The Cell Cycle: A Review
    Kenneth A. Schafer · 1998 · Veterinary Pathology
  26. GADD45 induction of a G 2 /M cell cycle checkpoint
    Wang, Xin Wei, Zhan, Qimin, Coursen, Jill D., Khan, Mohammed A., Kontny, H. Udo, Yu, Lijia, Hollander, M. Christine, O’Connor, Patrick M., Fornace, Albert J., Harris, Curtis C. · 1999 · Proceedings of the National Academy of Sciences
  27. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
    Renbin Zhao, Kurt Gish, Maureen E. Murphy, Yuxin Yin, Daniel A. Notterman, William H. Hoffman, Ed Tom, David H. Mack, Arnold J. Levine · 2000 · Genes & Development
  28. FOXO3A directs a protective autophagy program in haematopoietic stem cells
    Warr, Matthew R., Binnewies, Mikhail, Flach, Johanna, Reynaud, Damien, Garg, Trit, Malhotra, Ritu, Debnath, Jayanta, Passegué, Emmanuelle · 2013 · Nature
  29. Tumour suppression by p53: a role for the DNA damage response?
    David W. Meek · 2009 · Nature reviews. Cancer
  30. Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma
    Mark John Smyth, Kevin Y. T. Thia, Shayna E.A. Street, Duncan P MacGregor, Dale Ian Godfrey, Joseph A. Trapani · 2000 · The Journal of Experimental Medicine
  31. The SWI/SNF complex — chromatin and cancer
    Charles W.M. Roberts, Stuart H. Orkin · 2004 · Nature reviews. Cancer
  32. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    Jonathan P. Katz, Nathalie Perreault, Bree G. Goldstein, Catherine S. Lee, Patricia Ann Labosky, Vincent W. Yang, Klaus H. Kaestner · 2002 · Development
  33. E1A signaling to p53 involves the p19ARFtumor suppressor
    Elisa de Stanchina, Mila E. McCurrach, Frédérique Zindy, Sheau-Yann Shieh, Gerardo Ferbeyre, Andrew V. Samuelson, Carol L. Prives, Martine F. Roussel, Charles J. Sherr, Scott W. Lowe · 1998 · Genes & Development
  34. The biology of CML blast crisis
    Bruno Calabretta, Danilo Perrotti · 2004 · Blood
  35. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
    Stéphane Berghmans, Ryan D. Murphey, Erno Wienholds, Donna S Neuberg, Jeffery Lorne Kutok, Christopher D.�M. Fletcher, John P. Morris, Ting Xi Liu, Stefan Schulte‐Merker, John P. Kanki et al. · 2005 · Proceedings of the National Academy of Sciences
  36. Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation
    Fong‐Ying Tsai, Stuart H. Orkin · 1997 · Blood
  37. Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
    Martins, Carla P., Brown-Swigart, Lamorna, Evan, Gerard I. · 2006 · Cell
  38. 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
    Jean C. Manson, Alan Richard Clarke, M.L. Hooper, Lorraine Aitchison, Irene McConnell, J. Hope · 1994 · Molecular Neurobiology
  39. A subset of p53-deficient embryos exhibit exencephaly
    Valerie P. Sah, Laura Donatella Attardi, George Mulligan, Bart O. Williams, Roderick Terry Bronson, Tyler Jacks · 1995 · Nature Genetics
  40. Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape
    Max D. Wellenstein, Karin E. de Visser · 2018 · Immunity
  41. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.
    Chehab, Nabil H., Malikzay, Asra, Stavridi, Elena S., Halazonetis, Thanos D. · 1999 · Proceedings of the National Academy of Sciences
  42. Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2
    Svetlana S. Gorina, Nikola P. Pavletich · 1996 · Science
  43. p53 mutations increase resistance to ionizing radiation.
    J M Lee, Alan Bernstein · 1993 · Proceedings of the National Academy of Sciences
  44. The p53/p63/p73 family of transcription factors: overlapping and distinct functions
    Massimo Levrero, Vincenzo De Laurenzi, Antonio Costanzo, Stefania Sabatini, Ji‐Ming Gong, J. Y. J. Wang, Gerry Melino · 2000 · Journal of Cell Science
  45. Regulation of the p53 Tumor Suppressor Protein
    Moshe Oren · 1999 · Journal of Biological Chemistry
  46. THE UBIQUITIN-CONJUGATION SYSTEM
    Stefan Jentsch · 1992 · Annual Review of Genetics
  47. Orthotopic Metastatic Mouse Models for Anticancer Drug Discovery and Evaluation: a Bridge to the Clinic
    Robert M. Hoffman · 1999 · Investigational New Drugs
  48. A constitutively active epidermal growth factor receptor cooperates with disruption of G 1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    Eric C. Holland, Wendy P. Hively, Ronald Anthony DePinho, Harold E Varmus · 1998 · Genes & Development
  49. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.
    Anita J. Merritt, Christopher S. Potten, Christopher J. Kemp, John A. Hickman, Allan Balmain, David Philip Lane, Peter A. Hall · 1994 · PubMed
  50. The BCL-2 protein family, BH3-mimetics and cancer therapy
    Alex R. D. Delbridge, Andreas Strasser · 2015 · Cell Death and Differentiation
  51. Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
    Tarek Boutros, Éric Chevet, Peter P. Metrakos · 2008 · Pharmacological Reviews
  52. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    Michael J. Difilippantonio, Jie Zhu, Hua Tang Chen, Eric Meffre, Michel C. Nussenzweig, Edward E. Max, Thomas Ried, André Nussenzweig · 2000 · Nature
  53. p53 modulation of TFIIH–associated nucleotide excision repair activity
    Xin Wei Wang, Heidi Yeh, Laurent Schaeffer, Richard Roy, Vincent Moncollin, Jean‐Marc Egly, Z. Wang, Errol C. Friedberg, Michele K. Evans, Bonita G. Taffe et al. · 1995 · Nature Genetics
  54. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    Yuan Zhu, Frantz Guignard, Dawen Zhao, Li Liu, Dennis K. Burns, Ralph P. Mason, Albee Messing, Luis F. Parada · 2005 · Cancer Cell
  55. Horizontal transfer of oncogenes by uptake of apoptotic bodies
    Bergsmedh, Anna, Szeles, Anna, Henriksson, Marie, Bratt, Anders, Folkman, M. Judah, Spetz, Anna-Lena, Holmgren, Lars · 2001 · Proceedings of the National Academy of Sciences
  56. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
    Fiona Murray-Zmijewski, David Philip Lane, Jean‐Christophe Bourdon · 2006 · Cell Death and Differentiation
  57. Invited Review: Theories of aging
    Brian Tate Weinert, Poala S. Timiras · 2003 · Journal of Applied Physiology
  58. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
    Hongbing Zhang, Gregor Cicchetti, Hiroaki Onda, Henry B. Koon, Kirsten Asrican, Natalia Bajraszewski, Francisca Vázquez, Christopher L. Carpenter, David J. Kwiatkowski · 2003 · Journal of Clinical Investigation
  59. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.
    Harvey, Michele, McArthur, Mark J., Montgomery, Charles A., Butel, Janet S., Bradley, Allan, Donehower, Lawrence A. · 1993 · Nature Genetics
  60. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
    Andrew J. Wagner, John M. Kokontis, Nissim Hay · 1994 · Genes & Development
  61. CELL CYCLE REGULATION AND APOPTOSIS
    Karen L. King, John Anthony Cidlowski · 1998 · Annual Review of Physiology
  62. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
    Michele Fiscella, Hongliang Zhang, Saijun Fan, Kazuyasu Sakaguchi, Songfa Shen, W. Edward Mercer, George F. Vande Woude, Patrick M. O'Connor, Ettore Appella · 1997 · Proceedings of the National Academy of Sciences
  63. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
    Sean M. Baker, C.Eric Bronner, Lin Zhang, Annemieke W. Plug, Merrilee Robatzek, Gwynedd Warren, Eileen A Elliott, Jian Yu, Terry Ashley, Norman Arnheim et al. · 1995 · Cell
  64. The INK4A/ARF locus and its two gene products.
    Sharpless, Norman E, DePinho, Ronald A · 1999 · Current Opinion in Genetics & Development
  65. Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development
    Eric Keith Rowinsky, Jolene J. Windle, Daniel D. Von Hoff · 1999 · Journal of Clinical Oncology
  66. Li-Fraumeni Syndrome
    David M. Malkin · 2011 · Genes & Cancer
  67. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.
    Carlos Cordon‐Cardo · 1995 · PubMed Central
  68. Coping with stress: multiple ways to activate p53
    Horn, H F, Vousden, K H · 2007 · Oncogene
  69. The Human Papillomavirus E6 protein and its contribution to malignant progression
    Fiamma Mantovani, Lawrence Banks · 2001 · Oncogene
  70. Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
    Sabapathy, Kanaga, Lane, David P. · 2018 · Nature Reviews Clinical Oncology
  71. Genomic instability in Gadd45a-deficient mice
    Mary Christine Hollander, M. Saeed Sheikh, Dmitry V. Bulavin, Karen Lundgren, Laura Augeri-Henmueller, Ronald Shehee, Thomas A. Molinaro, Kate E. Kim, Eva Tolosa, Jonathan D. Ashwell et al. · 1999 · Nature Genetics
  72. Cancer and ageing: rival demons?
    Campisi, Judith · 2003 · Nature Reviews Cancer
  73. p63 and p73: p53 mimics, menaces and more
    Annie Yang, Frank McKeon · 2000 · Nature Reviews Molecular Cell Biology
  74. DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
    Karen M. Frank, Norman E. Sharpless, Yijie Gao, JoAnn Sekiguchi, David O. Ferguson, Chengming Zhu, John P. Manis, James W. Horner, Ronald Anthony DePinho, Frederick W. Alt · 2000 · Molecular Cell
  75. p53 and E2f: partners in life and death
    Polager, Shirley, Ginsberg, Doron · 2009 · Nature Reviews Cancer
  76. The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death
    A Basu · 1998 · Molecular Human Reproduction
  77. Histone H2AX
    Craig H. Bassing, Heikyung Suh, David O. Ferguson, Katrin F. Chua, John P. Manis, Mark Eckersdorff, Megan Gleason, R T Bronson, Charles Lee, Frederick W. Alt · 2003 · Cell
  78. p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
    Byoung-Il Bae, Hong Xu, Shuichi Igarashi, Masahiro Fujimuro, Nishant Agrawal, Yoichi Taya, S. Diane Hayward, Timothy H. Moran, Craig Montell, Christopher A. Ross et al. · 2005 · Neuron
  79. The intestinal epithelial stem cell: the mucosal governor
    Christopher S. Potten, Catherine E. Booth, David Mark Pritchard · 1997 · International Journal of Experimental Pathology
  80. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
    Tanaka, Nobuyuki, Ishihara, Masahiko, Kitagawa, Motoo, Harada, Hisashi, Kimura, Tohru, Matsuyama, Toshifumi, Lamphier, Marc S., Aizawa, Shinichi, Mak, Tak W., Taniguchi, Tadatsugu · 1994 · Cell
  81. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting
    Robert D. Cardiff, Miriam R. Anver, Barry A. Gusterson, Lothar G. Hennighausen, Roy A. Jensen, Maria J. Merino, Sabine Rehm, José Russo, Fattaneh A. Tavassoli, Lalage M. Wakefield et al. · 2000 · Oncogene
  82. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
    Lori C. Gowen, B. Lee Johnson, Anne M. Latour, Kathleen K. Sulik, Beverly H. Koller · 1996 · Nature Genetics
  83. p63 regulates proliferation and differentiation of developmentally mature keratinocytes
    Amy B. Truong, Markus Kretz, Todd W. Ridky, Robin A. Kimmel, Paul A. Khavari · 2006 · Genes & Development
  84. Telomeres, stem cells, senescence, and cancer
    Norman E. Sharpless, Ronald Anthony DePinho · 2004 · Journal of Clinical Investigation
  85. p63 and p73: Roles in Development and Tumor Formation
    Ute Martha Moll, Neda Slade · 2004 · Molecular Cancer Research
  86. p53 in growth control and neoplasia
    Tanya M. Gottlieb, Moshe Oren · 1996 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  87. P53, cell cycle control and apoptosis: Implications for cancer
    Michael B. Kastan, Christine E. Canman, Christopher J. Leonard · 1995 · Cancer and Metastasis Reviews
  88. p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment
    Curtis C. Harris · 1993 · Science
  89. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1 -mutated basal-like breast cancer
    Xiaoling Liu, Henne H. Holstege, Hanneke M.L. van der Gulden, Marcelle Treur-Mulder, John Zevenhoven, Arno Velds, Ron M Kerkhoven, Martin H. van Vliet, Lodewyk F.A. Wessels, Johannes L. Peterse et al. · 2007 · Proceedings of the National Academy of Sciences
  90. High-frequency developmental abnormalities in p53-deficient mice
    Jane F Armstrong, M. H. Kaufman, David James Harrison, Alan Richard Clarke · 1995 · Current Biology
  91. Mouse Models of Tumor Development in Neurofibromatosis Type 1
    Karen M. Cichowski, T. Shane Shih, Earlene M. Schmitt, Sabrina Santiago, Karlyne M. Reilly, Margaret E. McLaughlin, Roderick Terry Bronson, Tyler Jacks · 1999 · Science
  92. Down-regulation of bcl-2 by p53 in breast cancer cells.
    Subrata Haldar, Massimo Negrini, Maria Itria Monne, Silvia Sabbioni, Carlo Maria Croce · 1994 · PubMed
  93. The function of PML in p53-dependent apoptosis
    Ailan Guo, Paolo Salomoni, Jianyuan Luo, Alan H. Shih, Sue Zhong, Wei Gu, Pier Paolo Pandolfi · 2000 · Nature Cell Biology
  94. Myc pathways provoking cell suicide and cancer
    Jonas A. Nilsson, John L. Cleveland · 2003 · Oncogene
  95. Mechanisms of sarcoma development
    Lee J. Helman, Paul S. Meltzer · 2003 · Nature reviews. Cancer
  96. Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
    Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas Andreas Lyssiotis et al. · 2012 · Cancer Discovery
  97. p53 Research: The Past Thirty Years and the Next Thirty Years
    David Philip Lane, Arnold J. Levine · 2010 · Cold Spring Harbor Perspectives in Biology
  98. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Toledo, Luis I, Murga, Matilde, Zur, Rafal, Soria, Rebeca, Rodriguez, Antonio, Martinez, Sonia, Oyarzabal, Julen, Pastor, Joaquin, Bischoff, James R, Fernandez-Capetillo, Oscar · 2011 · Nature Structural & Molecular Biology
  99. Apoptosis: mechanisms and clinical implications
    Peter C. A. Kam, N. I. Ferch · 2000 · Anaesthesia
  100. Dissecting p53-dependent apoptosis
    Jerry E. Chipuk, Douglas R. Green · 2006 · Cell Death and Differentiation