The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Abstract
Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.
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“This enhanced muscle function, restoring the Dmd reading frame and enabling potential treatment for Duchenne muscular dystrophy.”
From A Review of Research on CRISPR/Cas9 Gene Editing Technology in Disease Treatment (2024) · cites this paper as [13]
In the citing paper
“For instance, Tabebordbar [13] used adeno-associated viral vectors to deliver CRISPR/Cas9 into an mdx mouse model, deleting the mutated exon 23.”
From A Review of Research on CRISPR/Cas9 Gene Editing Technology in Disease Treatment (2024) · cites this paper as [13]
In the citing paper
“Tp53 - knockout mice are born at normal Mendelian ratios and lack apparent phenotypic alterations but are prone to develop spontaneous tumours at around 6 months of age 127,128 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [127]
In the citing paper
“Studies have revealed that after inactivation of the TP53 gene (encoding p53) in mice, cells lacking functional p53 cannot respond appropriately to external stimuli, resulting in a high probability of tumors [7].”
From Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials (2022) · cites this paper as [7]
In the citing paper
“Complete loss of Per2 function reduced the average life span of p53− /− mice from 6 months to 4 months”
From Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice (2010) · cites this paper as [60]
Citations
Cites
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p53 tumour suppressor gene
Levine, A. J., Momand, J. A., & Finlay, C. A. (1991) · Nature · doi:10.1038/351453a0 · Cited by 3,785
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Werness, B. A., Levine, A. J., & Howley, P. M. (1990) · Science · doi:10.1126/science.2157286 · Cited by 2,562
T antigen is bound to a host protein in SY40-transformed cells
Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997
Self-citationThe p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
Baker, S. J., Markowitz, S. D., Fearon, E. R., Willson, J. K. V., & Vogelstein, B. (1990) · Science · doi:10.1126/science.2144057 · Cited by 1,742
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
Research works printed but not linked: 10
- Mowat, M., Cheng, A., Kicumca, N., Bernstein, A. & Benchimol, S. Nature 61, 2777–2781 (1985).
- Ben David, Y., Prideaux, V. R., Chow, V., Benchimol, S. & Bernstein, A. Oncogene 3, 179–185 (1988).
- Stürzbecher, H.-W. et al. Oncogene 5, 795–801 (1990).
- Shaulsky, G., Ben-Ze'ev, A. & Rotter, V. Oncogene 5, 1707–1711 (1990).
- Soussi, T., de Fromentel, C. C. & May, P. Oncogene 5, 945–952 (1990).
- Bradley, A. in Tetratocarcinomas and Embryonic Stem Cells: A Practical Approach (ed. Robertson, E. J.) 113–151 (IRL, Oxford, 1987).
- Stutman, O. Fed. Proc. Fed. Am. Soc. exp. Biol. 33, 2028–2032 (1974).
- Yandell, D. W. Proc. Am. Assoc. Cancer Res. 32, 459–460 (1991).
- Sepulveda, A. R. et al. Cancer Res. 49, 6108–6117 (1989).
- Slagle, B. L., Lanford, R. E., Medina, D. & Butel, J. S. Cancer Res. 42, 2155–2162 (1984).
Cited by
Sorted by citations
Items 201–300 of 1,032
Gliomagenesis: genetic alterations and mouse models
Holland, E. C. (2001) · Nature Reviews Genetics · doi:10.1038/35052535 · Cited by 461
Metabolic Regulation by p53 Family Members
Berkers, C. R., Maddocks, O. D. K., Cheung, E. C., Mor, I., & Vousden, K. H. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.019 · Cited by 458
Kemp, C. J., Donehower, L. A., Bradley, A., & Balmain, A. (1993) · Cell · doi:10.1016/0092-8674(93)90461-x · Cited by 456
Self-citationAladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., & Wahl, G. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70061-2 · Cited by 453
Venkatachalam, S., Shi, Y., Jones, S. N., Vogel, H. S., Bradley, A., Pinkel, D., & Donehower, L. A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4657 · Cited by 449
Self-citationChang, M. W., Barr, E., Seltzer, J. H., Jiang, Y.-Q., Nabel, G. J., Nabel, E. G., Parmacek, M. S., & Leiden, J. M. (1995) · Science · doi:10.1126/science.7824950 · Cited by 446
p53 regulates a G 2 checkpoint through cyclin B1
Innocente, S. A., Abrahamson, J., Cogswell, J. P., & Lee, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2147 · Cited by 443
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
Jones, N. C., Lynn, M. L., Gaudenz, K., Sakai, D., Aoto, K., Rey, J., Glynn, E. F., Ellington, L. R., Du, C., Dixon, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1725 · Cited by 440
Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1
Andreassen, P. R., Lohez, O. D., Lacroix, F., & Margolis, R. L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1315 · Cited by 440
TAp73 knockout shows genomic instability with infertility and tumor suppressor functionsPreprint
Tomasini, R., Tsuchihara, K., Wilhelm, M., Fujitani, M., Rufini, A., Cheung, C. C., Khan, F., Itie-YouTen, A., Wakeham, A. C., Tsao, M., et al. (2008) · Genes & Development · doi:10.1101/gad.1695308 · Cited by 440
Distinct requirements for Ras oncogenesis in human versus mouse cellsPreprint
Hamad, N. M., Elconin, J. H., Karnoub, A. E., Bai, W., Rich, J. N., Abraham, R. T., Der, C. J., & Counter, C. M. (2002) · Genes & Development · doi:10.17615/zkd7-3774 · Cited by 439
Rouault, J.-P., Falette, N., Guéhenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-482 · Cited by 434
Development and Selection of T Cells: Facts and Puzzles
Kisielow, P., & von Boehmer, H. (1995) · Advances in immunology · doi:10.1016/s0065-2776(08)60620-3 · Cited by 433
An Attempt to Prevent Senescence: A Mitochondrial Approach
Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
Bredemeyer, A. L., Sharma, G. G., Huang, C., Helmink, B. A., Walker, L. M., Khor, K. C., Nuskey, B., Sullivan, K. E., Pandita, T. K., Bassing, C. H., et al. (2006) · Nature · doi:10.1038/nature04866 · Cited by 435
p53: 25 years after its discovery
Hofseth, L. J., Hussain, S. P., & Harris, C. C. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.009 · Cited by 428
Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish
Amsterdam, A., Sadler, K. C., Lai, K., Farrington, S. M., Bronson, R. T., Lees, J. A., & Hopkins, N. H. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020139 · Cited by 427
Mitotic chromosomal instability and cancer: mouse modelling of the human disease
Schvartzman, J. M., Sotillo, R., & Benezra, R. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2781 · Cited by 427
The transcriptional targets of p53 in apoptosis control
Yu, J., & Zhang, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.189 · Cited by 427
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.
MEURS, E. F., GALABRU, J., Barber, G. N., Katze, M. G., & Hovanessian, A. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.232 · Cited by 427
p53-Dependent apoptosis pathways
Shen, Y., & White, E. (2001) · Advances in cancer research · doi:10.1016/s0065-230x(01)82002-9 · Cited by 424
Zhu, C., Mills, K. D., Ferguson, D. O., Lee, C., Manis, J., Fleming, J., Gao, Y., Morton, C. C., & Alt, F. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00770-5 · Cited by 421
p53 suppresses the self-renewal of adult neural stem cells
Meletis, K., Wirta, V., Hede, S., Nistér, M., Lundeberg, J., & Frisén, J. (2005) · Development · doi:10.1242/dev.02208 · Cited by 422
Bulavin, D. V., Dudgeon, C., Nannenga, B., Timofeev, O. N., Donehower, L. A., Anderson, C. W., Appella, E., & Fornace, A. J. (2004) · Nature Genetics · doi:10.1038/ng1317 · Cited by 419
Self-citationThe PTEN, Mdm2, p53 tumor suppressor–oncoprotein network
Mayo, L. D., & Donner, D. B. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02166-7 · Cited by 419
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis
Levine, A. J., Perry, M. E., Chang, A., Silver, A., Dittmer, D. P., Wu, M. C., & Welsh, D. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.76 · Cited by 418
Cheon, D., & Oršulić, S. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.154244 · Cited by 413
Two faces of p53: aging and tumor suppression
Rodier, F., Campisi, J., & Bhaumik, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm744 · Cited by 413
A comparison of the biological activities of wild‐type and mutant p53
Zambetti, G. P., & Levine, A. J. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.10.8344485 · Cited by 410
Sequence-specific transcriptional activation is essential for growth suppression by p53.
Pietenpol, J. A., Tokino, T., Thiagalingam, S., El‐Deiry, W. S., Kinzler, K. W., & Vogelstein, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.1998 · Cited by 409
When cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404
Xu-Monette, Z. Y., Wu, L., Visco, C., Tai, Y. C., Tzankov, A., Liu, W., Montes‐Moreno, S., Dybkær, K., Chiu, A., Orazi, A., et al. (2012) · Blood · doi:10.1182/blood-2012-05-433334 · Cited by 404
Fan, S., El‐Deiry, W. S., Bae, I., Freeman, J., Jondle, D., Bhatia, K. G., Fornace, A. J., MAGRATH, I. T., Kohn, K. W., & O'Connor, P. M. (1994) · PubMed · Cited by 404
Barr, A. R., Cooper, S., Heldt, F. S., Butera, F., Stoy, H., Mansfeld, J., Novák, B., & Bakal, C. (2017) · Nature Communications · doi:10.1038/ncomms14728 · Cited by 403
Pan, H., & Ae, G. (1994) · Genes & Development · doi:10.1101/gad.8.11.1285 · Cited by 400
Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
Bourdon, J., Surget, S., & Khoury, M. P. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s53876 · Cited by 399
Cell cycle checkpoints and their inactivation in human cancer
Molinari, M. (2000) · Cell Proliferation · doi:10.1046/j.1365-2184.2000.00191.x · Cited by 398
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
Garaycoechea, J. I., Crossan, G. P., Langevin, F., Mulderrig, L., Louzada, S., Yang, F., Guilbaud, G., Park, N., Roerink, S. F., Nik‐Zainal, S., et al. (2018) · Nature · doi:10.1038/nature25154 · Cited by 397
PTEN: a new guardian of the genome
Yin, Y., & Shen, W. H. (2008) · Oncogene · doi:10.1038/onc.2008.241 · Cited by 395
p53 modifications: exquisite decorations of the powerful guardian
Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz060 · Cited by 392
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Mao, J.-H., Perez-losada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S., & Balmain, A. (2004) · Nature · doi:10.1038/nature03155 · Cited by 390
Apoptosis in the development and treatment of cancer
Gerl, R. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh283 · Cited by 390
McClatchey, A. I., Saotome, I., Mercer, K. L., Crowley, D. G., Gusella, J. F., Bronson, R. T., & Jacks, T. (1998) · Genes & Development · doi:10.1101/gad.12.8.1121 · Cited by 390
p53 and breast cancer, an update
Lacroix, M., Toillon, R., & Leclercq, G. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01172 · Cited by 390
p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons
Ghatan, S., Larner, S. F., Kinoshita, Y., Hetman, M., Patel, L. S., Xia, Z., Youle, R. J., & Morrison, R. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.335 · Cited by 388
Links between Tumor Suppressors
Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., & Piccolo, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00308-8 · Cited by 386
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Nature · doi:10.1038/nature05077 · Cited by 382
Hemann, M. T., & Lowe, S. W. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401962 · Cited by 380
Schlissel, M. S., Constantinescu, A., Morrow, T., McDonald and Company Baxter, & Peng, A. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2520 · Cited by 380
Hausen, H. Z. (1994) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-78487-3_8 · Cited by 378
Bcl-2 Blocks p53-Dependent Apoptosis
Chiou, S., Rao, L., & White, E. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.4.2556 · Cited by 377
Xu, X., Qiao, W., Linke, S. P., Cao, L., Li, W., Furth, P. A., Harris, C. C., & Deng, C. (2001) · Nature Genetics · doi:10.1038/90108 · Cited by 376
Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice.
Matzuk, M. M., Finegold, M. J., Mather, J. P., KRUMMEN, L. A., Lu, H., & Bradley, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8817 · Cited by 374
Self-citationAtaxia-telangiectasia and cellular responses to DNA damage.
Meyn, M. S. (1995) · PubMed · Cited by 374
Reprogramming of a melanoma genome by nuclear transplantationPreprint
Hochedlinger, K., Blelloch, R. H., Brennan, C., Yamada, Y., Kim, M., Chin, L., & Jaenisch, R. (2004) · Genes & Development · doi:10.1101/gad.1213504 · Cited by 374
Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity
Laurenzi, V. D., Costanzo, A., Barcaroli, D., Terrinoni, A., Falco, M., Annicchiarico‐Petruzzelli, M., Levrero, M., & Melino, G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.9.1763 · Cited by 373
Mouse Tumor Model for Neurofibromatosis Type 1
Vogel, K. S., Klesse, L. J., Velasco-Miguel, S., Meyers, K. A., Rushing, E. J., & Parada, L. F. (1999) · Science · doi:10.1126/science.286.5447.2176 · Cited by 373
Langheinrich, U., Hennen, E., Stott, G. M., & Vacun, G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01319-2 · Cited by 373
Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death
Morrison, R. S., Wenzel, H. J., Kinoshita, Y., Robbins, C. A., Donehower, L. A., & Schwartzkroin, P. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01337.1996 · Cited by 372
Self-citationMolecular Genetics of Acute Lymphoblastic Leukemia
Armstrong, S. A., & Look, A. T. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.047 · Cited by 372
Amati, B. B. (1998) · Frontiers in bioscience · doi:10.2741/a239 · Cited by 370
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
Kemp, C. J., Wheldon, T. E., & Balmain, A. (1994) · Nature Genetics · doi:10.1038/ng0994-66 · Cited by 370
Ren, G., Zhao, X., Wang, Y., Zhang, X., Chen, X., Xu, C., Yuan, Z.-R., Roberts, A. I., Zhang, L., Zheng, H. B., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.013 · Cited by 371
Cooperative tumorigenic effects of germline mutations in Rb and p53
Williams, B. O., Remington, L., Albert, D. M., Mukai, S., Bronson, R. T., & Jacks, T. (1994) · Nature Genetics · doi:10.1038/ng0894-480 · Cited by 370
Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
Inomata, K., Aoto, T., Binh, N. T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.037 · Cited by 368
Deletion of Ku86 causes early onset of senescence in mice
Vogel, H., Lim, D.-S., Karsenty, G., Finegold, M., & Hasty, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10770 · Cited by 368
The role of DNA breaks in genomic instability and tumorigenesis
Mills, K. D., Ferguson, D. O., & Alt, F. W. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00060.x · Cited by 368
Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease
Butel, J. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.405 · Cited by 368
Self-citationCHD5 Is a Tumor Suppressor at Human 1p36
Bagchi, A., Papazoglu, C., Wu, Y., Capurso, D., Brodt, M., Francis, D. B., Bredel, M., Vogel, H. S., & Mills, A. A. (2007) · Cell · doi:10.1016/j.cell.2006.11.052 · Cited by 366
Regulation of cellular senescence by p53
Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365
Ferguson, D. O., Sekiguchi, J., Chang, S. S., Frank, K. M., Gao, Y., DePinho, R. A., & Alt, F. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110152897 · Cited by 361
Li-Fraumeni syndrome – a molecular and clinical review
Varley, J. M., Evans, D. G., & Birch, J. M. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.328 · Cited by 361
Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Pellarin, I., Dall’Acqua, A., Favero, A., Segatto, I., Rossi, V., Crestan, N., Karimbayli, J., Belletti, B., & Baldassarre, G. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02080-z · Cited by 381
p53-independent functions of the p19ARF tumor suppressorPreprint
Weber, J. D., Jeffers, J. R., Rehg, J. E., Randle, D. H., Lozano, G., Roussel, M. F., Sherr, C. J., & Zambetti, G. P. (2000) · Genes & Development · doi:10.1101/gad.827300 · Cited by 361
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
Alexandrova, E. M., Yallowitz, A. R., Li, D., Xu, S., Schulz‐Heddergott, R., Proia, D. A., Lozano, G., Dobbelstein, M., & Moll, U. M. (2015) · Nature · doi:10.1038/nature14430 · Cited by 359
Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis
Lin, Y., Ma, W., & Benchimol, S. (2000) · Nature Genetics · doi:10.1038/79102 · Cited by 359
MacLellan, W. R., & Schneider, M. D. (1997) · Circulation Research · doi:10.1161/01.res.81.2.137 · Cited by 358
Opposing Effects of Ras on p53
Ries, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., & McCormick, F. (2000) · Cell · doi:10.1016/s0092-8674(00)00123-9 · Cited by 357
Jennis, M., Kung, C.-P., Basu, S., Budina-Kolomets, A., Leu, J. I.-J., Khaku, S., Scott, J. P., Cai, K. Q., Campbell, M. R., Porter, D. K., et al. (2016) · Genes & Development · doi:10.1101/gad.275891.115 · Cited by 360
WT1 proteins: functions in growth and differentiation
Scharnhorst, V., van der Eb, A. J., & Jochemsen, A. G. (2001) · Gene · doi:10.1016/s0378-1119(01)00593-5 · Cited by 355
Inhibition of Cyclooxygenase-2 Gene Expression by p53
Subbaramaiah, K., Altorki, N. K., Chung, W. J., MESTRE, J. R., Sampat, A., & Dannenberg, A. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10911 · Cited by 355
Beck, D. B., Oda, H., Shen, S. S., & Reinberg, D. (2012) · Genes & Development · doi:10.1101/gad.177444.111 · Cited by 355
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
Martín‐Caballero, J., Flores, J. M., Garcı́a, P., & Serrano, M. (2001) · PubMed · Cited by 352
Tumor-Suppressor Functions of the TP53 PathwayPreprint
Aubrey, B. J., Strasser, A., & Kelly, G. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026062 · Cited by 358
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
Mayo, L. D., Dixon, J. E., Durden, D. L., Tonks, N. K., & Donner, D. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108302200 · Cited by 351
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome
Barlow, J. L., Drynan, L. F., Hewett, D. R., Holmes, L. R., Lorenzo-Abalde, S., Lane, A. L., Jolin, H. E., Pannell, R., Middleton, A. J., Wong, S. H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2063 · Cited by 349
mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein
Chen, J., Wu, X., Lin, J., & Levine, A. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2445 · Cited by 348
Koumenis, C., Alarcon, R. M., Hammond, E. M., Sutphin, P. D., Hoffman, W., Murphy, M. E., Derr, J. L., Taya, Y., Lowe, S. W., Kastan, M. B., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1297-1310.2001 · Cited by 348
Osteoblasts are target cells for transformation in c-fos transgenic mice
Grigoriadis, A. E., Schellander, K., Wang, Z., & Wagner, E. F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.685 · Cited by 348
p53 Acetylation: Regulation and Consequences
Reed, S. M., & Quelle, D. E. (2014) · Cancers · doi:10.3390/cancers7010030 · Cited by 344
The p53 tumor suppressor participates in multiple cell cycle checkpoints
Giono, L. E., & Manfredi, J. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20689 · Cited by 342
Selivanova, G., Iotsova, V., Okan, İ., Fritsche, M., Ström, M., Groner, B., Grafström, R. C., & Wiman, K. G. (1997) · Nature Medicine · doi:10.1038/nm0697-632 · Cited by 341
Apoptosis and cancer chemotherapy
Makin, G., & Dive, C. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02124-9 · Cited by 340
Lane, D. P. (1993) · Nature · doi:10.1038/362786a0 · Cited by 340
Gene Disruption of Tissue Transglutaminase
Laurenzi, V. D., & Melino, G. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.148-155.2001 · Cited by 339
Rheinwald, J. G., Hahn, W. C., Ramsey, M. R., Wu, J. Y., Guo, Z., Tsao, H., De Luca, M., Catricalà, C., & O'Toole, K. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5157-5172.2002 · Cited by 338
Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations
Bardeesy, N. M., Falkoff, D., Petruzzi, M. J., Nowak, N. J., Zabel, B., Adam, M., Aguiar, M. C., Grundy, P. E., Shows, T. B., & Pelletier, J. (1994) · Nature Genetics · doi:10.1038/ng0594-91 · Cited by 338
Roberts, C. W. M., Leroux, M. M., Fleming, M. D., & Orkin, S. H. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00185-x · Cited by 338
Westfall, M. D., Mays, D. J., Sniezek, J. C., & Pietenpol, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2264-2276.2003 · Cited by 338
(1999) · PubMed · Cited by 338
Metadata
- Authors
- Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Nature
- Published
- 1992-03
- Volume
- 356
- Issue
- 6366
- Pages
- 215-221
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2126679757
- Cited by
- 4,649
- References
- 48
- Citations by year
- 2026: 16 · 2025: 48 · 2024: 51 · 2023: 74 · 2022: 76 · 2021: 80 · 2020: 86 · 2019: 92 · 2018: 84 · 2017: 96 · 2016: 119 · 2015: 89 · 2014: 121 · 2013: 146 · 2012: 157
- FWCI
- 82.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- p53, tumor suppressor, spontaneous tumors, carcinogenesis, embryonic development, mouse model, neoplasms
- MeSH terms
- Alleles, Animals, Base Sequence, Blastocyst, DNA, Exons, Female, Genetic Vectors, Heterozygote, Homozygote, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Mutation, Neoplasms, Experimental, RNA, Messenger, Stem Cells, Blotting, Southern, Polymerase Chain Reaction, Genes, p53, Tumor Suppressor Protein p53, Mice
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