The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Abstract
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission. The dopamine transporter is an obligatory target of cocaine and amphetamine, as these psychostimulants have no effect on locomotor activity or dopamine release and uptake in mice lacking the transporter.
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“Mice lacking the DAT gene display markedly increased levels of DA in the mesolimbic system and striatum [373], that results in hyperlocomoter behaviors [373,374] and also deficits in PPI [375,376].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
In the citing paper
“DAT knockout mice show an overall increased level of DA transmission, resulting in increased DA tone, hypermotoric activity, and overall increased movement [373].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [373]
Citations
Cites
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Ehringer, H., & Hornykiewicz, O. (1960) · Journal of Molecular Medicine · doi:10.1007/bf01485901 · Cited by 1,875
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Neurotransmitter Transporters: Recent Progress
Amara, S., & Kuhar, M. J. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.000445 · Cited by 1,088
Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission
Iversen, L. L. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07066.x · Cited by 776
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651
Flagged first, then by citations
Research works printed but not linked: 11
- Barker, E. L., Kimmel, H. L. & Blakely, R. D. Molec. Pharmac. 46, 799–807 (1994).
- Wise, R. A. & Bozarth, M. A. Psychiat. Med. 3, 445–460 (1985).
- Fisher, J. F. & Cho, A. K. J. Pharmac. exp. Ther. 208, 203–209 (1979).
- Eshelman, A. Y., Henningsen, R. A., Neve, K. A. & Janowsky, A. J. Molec. Pharmac. 45, 312–316 (1994).
- Byck, R. & VanDyke, C. NIDA Monogr. 13, 97–118 (1977).
- Chiodo, L. A. Neurochem. Int. 26, 815–845 (1992).
- Raiteri, M., Cerrito, F., Cervoni, A. M. & Levi, G. J. Pharmac. exp. Ther. 208, 195–202 (1979).
- Wall, S. C., Gu, H. & Rudnick, G. Molec. Pharmac. 47, 544–550 (1995).
- Parker, E. M. & Cubeddu, L. X. J. Pharmac. exp. Ther. 237, 179–192 (1986).
- Jacocks, H. M. & Cox, B. M. J. Pharmac. exp. Ther. 262, 356–364 (1992).
- Graham, J. H., Maher, J. R. & Robinson, S. E. J. Pharmac. exp. Ther. 174, 707–717 (1995).
Cited by
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Items 101–114 of 114
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53
Holst, S. C., Müller, T., Valomon, A., Seebauer, B., Berger, W., & Landolt, H.-P. (2017) · Scientific Reports · doi:10.1038/srep45982 · Cited by 45
Mice lacking adenylyl cyclase‐5 cope badly with repeated restraint stress
Kim, K., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22119 · Cited by 42
DIETZ, D., TAPOCIK, J., GAVALCRUZ, M., & KABBAJ, M. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.005 · Cited by 41
Hunn, B. H. M., Vingill, S., Threlfell, S., Alegre-Abarrategui, J., Magdelyns, M., Deltheil, T., Bengoa-Vergniory, N., Oliver, P. L., Cioroch, M., Doig, N. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.029 · Cited by 38
An Open-Label Pilot Study of Risperidone in the Treatment of Methamphetamine Dependence
Meredith, C. W., Jaffe, C., Yanasak, E., Cherrier, M., & Saxon, A. J. (2007) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2007.10399875 · Cited by 37
Catecholamines and opioid peptides increase in plasma in humans during possession trances
Kawai, N., Honda, M., Nakamura, S., Samatra, P., Sukardika, K., Nakatani, Y., Shimojo, N., & Oohashi, T. (2001) · Neuroreport · doi:10.1097/00001756-200111160-00009 · Cited by 35
Differential Regulation of MeCP2 Phosphorylation in the CNS by Dopamine and Serotonin
Hutchinson, A. N., Deng, J. V., Aryal, D. K., Wetsel, W. C., & West, A. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.190 · Cited by 31
Li, J. J., & Lee, S. S. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02563.x · Cited by 28
“…persisted in the extracellular space 100 times longer among mice with DAT inactivated (i.e., homozygotes) compared to mice with partial/full activation of DAT (i.e., heterozygotes and wild-type), suggesting that homozygosity significantly alters neurochemistry and behavior (Giros et al., 1996).”
BackgroundLiu, P.-S., Liaw, C.-T., Lin, M.-K., Shin, S.-H., Kao, L.-S., & Lin, L.-F. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02870-4 · Cited by 21
Kamradt, J. M., Nigg, J. T., Friderici, K. H., & Nikolas, M. A. (2017) · Development and Psychopathology · doi:10.1017/s0954579416000195 · Cited by 19
Gerlach, M., Grünblatt, E., & Lange, K. W. (2013) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-013-0105-y · Cited by 18
Sinzig, J., & Lehmkuhl, G. (2007) · Psychopathology · doi:10.1159/000105531 · Cited by 14
Behavioral effects of SGK1 knockout in VTA and dopamine neurons
Doyle, M. A., Stark, A. R., Fejes-Tóth, G., Náray-Fejes-Tóth, A., & Mazei-Robison, M. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71681-9 · Cited by 9
Metadata
- Authors
- Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Nature
- Published
- 1996-02
- Volume
- 379
- Issue
- 6566
- Pages
- 606-612
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2014793858
- Cited by
- 2,476
- References
- 41
- Citations by year
- 2026: 34 · 2025: 39 · 2024: 32 · 2023: 61 · 2022: 52 · 2021: 62 · 2020: 47 · 2019: 54 · 2018: 62 · 2017: 67 · 2016: 58 · 2015: 74 · 2014: 93 · 2013: 73 · 2012: 97
- FWCI
- 43.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dopamine transporter, hyperlocomotion, cocaine, amphetamine, psychostimulants, dopamine, neurotransmitter levels, locomotor activity, dopamine release, dopamine uptake
- MeSH terms
- Amphetamine, Animals, Carrier Proteins, Cell Line, Cocaine, Dopamine, Dynorphins, Enkephalins, Female, Gene Expression Regulation, Locomotion, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Protein Precursors, Mice, Knockout, Gene Targeting, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice, Rats
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