Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain
Abstract
▪ Abstract Recently, dozens of mutant mice generated with gene targeting or transgenic technologies have been shown to exhibit a distinct set of impairments in the brain and behavior. In this review, we discuss how studies of mutant mice have helped elucidate the mechanisms that underlie synaptic plasticity and the relationship of these synaptic mechanisms to the activity-dependent phase of neural development and learning and memory. We focus on the recent progress in the analysis of whisker-related pattern formation, elimination of climbing fibers, long-term potentiation, long-term depression, and various learning and memory tasks in mutant mice.
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Previous studies found a correlated impairment in Scc-CA1 LTP and spatial memory.
“These studies found a correlated impairment in Scc-CA1 LTP and spatial memory (but see Conquet et al., 1994).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Chen and Tonegawa, 1997
The only exceptional case, the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results.
“It is important to point out that the only exceptional case, namely that of the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results (Aiba et al., 1994; Conquet et al., 1994; Chen and Tonegawa, 1997).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Chen and Tonegawa, 1997
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- Authors
- Chen, C., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1997-03
- Volume
- 20
- Issue
- 1
- Pages
- 157-184
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2164790343
- Cited by
- 300
- References
- 13
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01 NS32925, R01NS032925)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptic plasticity, learning and memory, mouse mutants, gene targeting, transgenic mice, long-term potentiation, long-term depression
- MeSH terms
- Animals, Brain, Learning, Memory, Molecular Biology, Neuronal Plasticity, Presynaptic Terminals, Mice
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