Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

Lorenzo, A., & Yankner, B. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12243 · Cited by 1,324

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314

Characterization of ameboid microglia isolated from developing mammalian brain

Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

Krieger, M., & Krieger, J. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.63.1.601 · Cited by 1,169

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

Quinn, M. T., Parthasarathy, S., Fong, L. G., & Steinberg, D. I. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2995 · Cited by 1,138

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4766 · Cited by 806

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

Pike, C. J., Walencewicz‐Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010253.x · Cited by 699

Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor

Fraser, I. P., Hughes, D. A., & Gordon, S. (1993) · Nature · doi:10.1038/364343a0 · Cited by 341

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.5050 · Cited by 330

β-Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes

McDonald, D. R., Bamberger, M. E., Combs, C. K., & Landreth, G. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04451.1998 · Cited by 259

Structural Analysis of Alzheimer's β(1–40) Amyloid: Protofilament Assembly of Tubular Fibrils

Malinchik, S., Inouye, H., Szumowski, K. E., & Kirschner, D. A. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77812-9 · Cited by 253

Microglial Aβ Receptors in Alzheimer’s Disease

Yu, Y., & Ye, R. D. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0101-6 · Cited by 247

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

Mangialasche, F., Polidori, M. C., Monastero, R., Ercolani, S., Camarda, C., Cecchetti, R., & Mecocci, P. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.002 · Cited by 250

Mitotic signaling by β‐amyloid causes neuronal death

Copani, A., Condorelli, F., CARUSO, A., Vancheri, C., Sala, A., Stella, A. M. G., Canonico, P. L., Nicoletti, F., & Sortino, M. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2225 · Cited by 246

Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

ISHIZUKA, K., KIMURA, T., IGATA‐YI, R., KATSURAGI, S., TAKAMATSU, J., & MIYAKAWA, T. (1997) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1997.tb02375.x · Cited by 245

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Clayton, K., Delpech, J. C., Herron, S., Iwahara, N., Ericsson, M., Saito, T., Saido, T. C., Ikezu, S., & Ikezu, T. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00440-9 · Cited by 245

NADPH Oxidase-Derived Reactive Oxygen Species Mediate the Cerebrovascular Dysfunction Induced by the Amyloid β Peptide

Park, L., Anrather, J., Zhou, P., Frys, K., Pitstick, R., Younkin, S., Carlson, G. A., & Iadecola, C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5207-04.2005 · Cited by 244

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 250

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

Mackic, J. B., Stins, M., McComb, J. G., Calero, M., Ghiso, J., Kim, K. S., Yan, S. D., Stern, D., Schmidt, A. M., Frangione, B., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2029 · Cited by 242

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

Nichol, K. E., Poon, W. W., Parachikova, A. I., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-13 · Cited by 250

Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein

Benimetskaya, L., Loike, J. D., Khaled, Z., LoiKe, G., Silverstein, S. C., Cao, L., Khoury, J. E., Cai, T., & Stein, C. A. (1997) · Nature Medicine · doi:10.1038/nm0497-414 · Cited by 240

Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease

Rogers, J., & Lue, L.-F. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00040-7 · Cited by 236

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production

Kim, S. H., Smith, C. J., & Eldik, L. J. V. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00126-x · Cited by 241

β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w

Yao, M., Nguyen, T. V., & Pike, C. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4736-04.2005 · Cited by 233

The Role of Sex and Sex Hormones in Neurodegenerative Diseases

Vegeto, E., Villa, A. M., Torre, S. D., Crippa, V., Rusmini, P., Cristofani, R., Galbiati, M., Maggi, A. C., & Poletti, A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz005 · Cited by 240

Cien Años de Microglía: Milestones in a Century of Microglial Research

Sierra, A., Paolicelli, R. C., & Kettenmann, H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.004 · Cited by 244

Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action

Gasparini, L., Ongini, E., & Wenk, G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02743.x · Cited by 226

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Serrano-Pozo, A., Muzikansky, A., Gómez-Isla, T., Growdon, J. H., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182933788 · Cited by 226

Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?

Kelleher, R. J., & Soiza, R. L. (2013) · Europe PMC (PubMed Central) · Cited by 232

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease

Yankner, B. A., & Lu, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800018200 · Cited by 229

The function of scavenger receptorsexpressed by macrophages and their rolein the regulation of inflammation

Peiser, L., & Gordon, S. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(00)01362-9 · Cited by 232

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Rosenzweig, N., Dvir-Szternfeld, R., Tsitsou-Kampeli, A., Keren‐Shaul, H., Ben-Yehuda, H., Weill-Raynal, P., Cahalon, L., Kertser, A., Baruch, K., Amit, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08352-5 · Cited by 230

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC‐P/collagen type XXV

Hashimoto, T., Wakabayashi, T., Watanabe, A., Kowa, H., Hosoda, R., Nakamura, A., Kanazawa, I., Arai, T., Takio, K., Mann, D. M. A., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1524 · Cited by 223

Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins

Meda, L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00307-4 · Cited by 222

TREM2 and the neuroimmunology of Alzheimer's disease

Hickman, S. E., & El Khoury, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.021 · Cited by 221

TREM2, microglia, and Alzheimer’s disease.

Qin, Q., Teng, Z., Liu, C., Li, Q., Yin, Y., & Tang, Y. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111438 · Cited by 219

Microglial immunophenotype in dementia with Alzheimer’s pathology

CFAS, M., Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A. R., & Boche, D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0601-z · Cited by 219

β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

Giri, R., Shen, Y., Stins, M., Du Yan, S., Schmidt, A. M., Stern, D., Kim, K.-S., Zlokovic, B., & Kalra, V. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1772 · Cited by 218

Immunotherapeutic Approaches to Alzheimer's Disease

Monsonego, A., & Weiner, H. L. (2003) · Science · doi:10.1126/science.1088469 · Cited by 217

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

Frenkel, D., Wilkinson, K., Zhao, L., Hickman, S. E., Means, T. K., Puckett, L., Farfara, D., Kingery, N. D., Weiner, H. L., & El Khoury, J. (2013) · Nature Communications · doi:10.1038/ncomms3030 · Cited by 214

β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway

Giovannini, M. G., Scali, C., Prosperi, C., Bellucci, A., Vannucchi, M. G., Rosi, S., Pepeu, G., & Casamenti, F. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0538 · Cited by 190

Activation of Toll-like Receptor 2 on Microglia Promotes Cell Uptake of Alzheimer Disease-associated Amyloid β Peptide

Chen, K., Iribarren, P., Hu, J., Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M., & Wang, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508125200 · Cited by 214

Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid β-Peptide by Microglial Cells

Chung, H., Brazil, M. I., Soe, T. T., & Maxfield, F. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32301 · Cited by 212

Receptors for oxidized low density lipoprotein

Steinbrecher, U. P. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00127-1 · Cited by 212

Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery

Cohen, R. A., Plane, F., Najibi, S., Huk, I., Maliñski, T., & Garland, C. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4193 · Cited by 210

IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice

Chakrabarty, P., Ceballos-Diaz, C., Beccard, A., Janus, C., Dickson, D., Golde, T. E., & Das, P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903382 · Cited by 206

Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice

Bornemann, K. D., Wiederhold, K., Pauli, C., Ermini, F., Stalder, M., Schnell, L., Sommer, B., Jucker, M., & Staufenbiel, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63945-4 · Cited by 206

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, S. L., Burgess, L. H., Kocsis‐Angle, J., Antal, J. M., Dority, M. D., Embury, P. B., Piotrkowski, A. M., & Brunden, K. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741017.x · Cited by 202

Innate Immunity and Neuroinflammation

Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 207

Standardizing Scavenger Receptor Nomenclature

PrabhuDas, M., Bowdish, D. M. E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J. D., Means, T. K., Moestrup, S. K., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1490003 · Cited by 208

β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide

Wang, Q., Rowan, M. J., & Anwyl, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0233-04.2004 · Cited by 197

β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?

Auld, D. S., Kar, S., & Quirion, R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01144-2 · Cited by 192

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs

Yamada, K., & Nabeshima, T. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00081-4 · Cited by 192

Pleiotropic roles of formyl peptide receptors

Le, Y., Oppenheim, J. J., & Wang, J. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00003-x · Cited by 193

The role of scavenger receptors in pathogen recognition and innate immunity

Mukhopadhyay, S., & Gordon, S. (2004) · Immunobiology · doi:10.1016/j.imbio.2004.02.004 · Cited by 190

Immunological aspects of microglia: relevance to Alzheimer's disease

Benveniste, E. N., Nguyen, V. T., & O'Keefe, G. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00045-6 · Cited by 189

Ligand Specificity of LOX-1, a Novel Endothelial Receptor for Oxidized Low Density Lipoprotein

Moriwaki, H., Kume, N., Sawamura, T., Aoyama, T., Hoshikawa, H., Ochi, H., Nishi, E., Masaki, Τ., & Kita, T. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.10.1541 · Cited by 188

The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis

Martínez, V. G., Moestrup, S. K., Holmskov, U., Mollenhauer, J., & Lozano, F. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004523 · Cited by 192

Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 197

Biology of Aβ Amyloid in Alzheimer's Disease

Wisniewski, T., Ghiso, J., & Frangione, B. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0147 · Cited by 134

Role of Mitochondrial Amyloid-β in Alzheimer's Disease

Chen, J. X., & Yan, S. S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100357 · Cited by 188

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., Shankar, G. M., Costantino, I. M., Carroll, M. C., Mayadas, T. N., et al. (2012) · Glia · doi:10.1002/glia.22331 · Cited by 180

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

Jordán, J., Galindo, M. F., Miller, R. J., Reardon, C. A., Getz, G. S., & LaDu, M. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00195.1998 · Cited by 139

Involvement of Environmental Mercury and Lead in the Etiology of Neurodegenerative Diseases

Monnet‐Tschudi, F., Zurich, M., Boschat, C., Corbaz, A., & Honegger, P. (2006) · Reviews on Environmental Health · doi:10.1515/reveh.2006.21.2.105 · Cited by 176

Stem Cell Transplantation Reveals That Absence of Macrophage CD36 Is Protective Against Atherosclerosis

Febbraio, M., Guy, E. C., & Silverstein, R. L. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000148007.06370.68 · Cited by 176

Toll‐like receptors 2 and 4 mediate Aβ(1–42) activation of the innate immune response in a human monocytic cell line

Udan, M. L. D., Ajit, D., Crouse, N. R., & Nichols, M. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05001.x · Cited by 179

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

Wu, J., Bie, B., Yang, H., Xu, J. J., Brown, D. L., & Naguib, M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.011 · Cited by 180

Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization

Findeis, M. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00034-x · Cited by 175

Mechanisms of microglia accumulation in Alzheimer’s disease: therapeutic implications

Khoury, J. E., & Luster, A. D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.004 · Cited by 171

The Endogenous Estrogen Status Regulates Microglia Reactivity in Animal Models of Neuroinflammation

Vegeto, E., Belcredito, S., Ghisletti, S., Meda, C., Etteri, S., & Maggi, A. C. (2006) · Endocrinology · doi:10.1210/en.2005-1330 · Cited by 178

Glycation—a sweet tempter for neuronal death

Kikuchi, S. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00273-4 · Cited by 169

The sour side of neurodegenerative disorders: the effects of protein glycation

Miranda, H. V., & Outeiro, T. F. (2009) · The Journal of Pathology · doi:10.1002/path.2682 · Cited by 172

Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures

Lue, L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00311-6 · Cited by 169

Microglial Activation in Alzheimer Disease: Association with APOE Genotype

Egensperger, R., Kösel, S., von Eitzen, U., & Graeber, M. B. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00166.x · Cited by 164

Extracellular Matrix Modulates Macrophage Functions Characteristic to Atheroma

Wesley, R. B., Meng, X., Godin, D., & Galis, Z. S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.3.432 · Cited by 166

Estrogen Enhances Uptake of Amyloid β‐Protein by Microglia Derived from the Human Cortex

Li, R., Shen, Y., Yang, L., Lue, L., Finch, C. E., & Rogers, J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751447.x · Cited by 162

Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model

Thanopoulou, K., Fragkouli, A., Stylianopoulou, F., & Georgopoulos, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005888107 · Cited by 161

The physiology of the β‐amyloid precursor protein intracellular domain AICD

Pardossi‐Piquard, R., & Checler, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07475.x · Cited by 159

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 166

Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease

Monsonego, A., Imitola, J., Petrovic, S., Zota, V. E., Nemirovsky, A., Baron, R., Fisher, Y., Owens, T., & Weiner, H. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506209103 · Cited by 165

Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease

Kelley, J., Ozment, T. R., Li, C., Schweitzer, J. B., & Williams, D. L. (2014) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2014010267 · Cited by 160

Expression of Scavenger Receptors in Glial Cells

Alarcón, R., Fuenzalida, C., Santibáñez, M., & Rommy von Bernhardi, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414686200 · Cited by 159

Amyloid-β Induces Chemotaxis and Oxidant Stress by Acting at Formylpeptide Receptor 2, a G Protein-coupled Receptor Expressed in Phagocytes and Brain

Tiffany, H. L., Lavigne, M. C., Cui, Y., Wang, J., Leto, T. L., Gao, J., & Murphy, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101031200 · Cited by 161

Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease

Khoury, J. B. E., Hickman, S., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00036-0 · Cited by 159

The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease

Cacabelos, R., Takeda, M., & Winblad, B. G. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199901)14:1 · Cited by 156

Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

Perini, G., Bianca, V. D., Politi, V., Valle, G. D., Prà, I. D., Rossi, F., & Armato, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011797 · Cited by 155

Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease

von Bernhardi, R., Cornejo, F., Parada, G. E., & Eugenín, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00426 · Cited by 149

Conserved domains of the class A scavenger receptors: evolution and function

Bowdish, D. M. E., & Gordon, S. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00728.x · Cited by 149

Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis

Velázquez, P., Cribbs, D. H., Poulos, T. L., & Tenner, A. J. (1997) · Nature Medicine · doi:10.1038/nm0197-77 · Cited by 147

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.

(1998) · Europe PMC (PubMed Central) · Cited by 146

Inhibition of the electrostatic interaction between β-amyloid peptide and membranes prevents β-amyloid-induced toxicity

Hertel, C., Terzi, E., Hauser, N., Jakob-Røtne, R., Seelig, J., & Kemp, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9412 · Cited by 146

Hepatic and Extrahepatic Scavenger Receptors

Terpstra, V., van Amersfoort, E. S., van Velzen, A. G., Kuiper, J., & van Berkel, T. J. C. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1860 · Cited by 145

Inflammatory aspects of Alzheimer’s disease

Lucena, P. B., & Heneka, M. T. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02790-2 · Cited by 152

Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide

Noda, M., Nakanishi, H., & Akaike, N. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00036-6 · Cited by 144

cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein

Malherbe, P., Richards, J. G., Gaillard, H., Thompson, A., Diener, C., Schuler, A., & Huber, G. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00174-6 · Cited by 143

Microglia and the Immune Pathology of Alzheimer Disease

Giulian, D. (1999) · The American Journal of Human Genetics · doi:10.1086/302477 · Cited by 141

The Neurovascular Unit Dysfunction in Alzheimer’s Disease

Soto-Rojas, L. O., Pacheco‐Herrero, M., Martínez-Gómez, P. A., Campa-Córdoba, B. B., Apátiga-Pérez, R., Villegas-Rojas, M. M., Harrington, C. R., de la Cruz, F., Garcés‐Ramírez, L., & Luna‐Muñoz, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042022 · Cited by 146

Microglia, amyloid and dementia in Alzheimer disease

Arends, Y. M., Duyckaerts, C., Rozemuller, J. M., Eikelenboom, P., & Hauw, J.-J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00094-4 · Cited by 139

CD45 Opposes β-Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase

Tan, J. R., Town, T., Mori, T., Wu, Y., Saxe, M., Crawford, F., & Mullan, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07587.2000 · Cited by 138

Complement Component C1q Modulates the Phagocytosis of Aβ by Microglia

Webster, S. D., Yang, A. J., Margol, L., Garzon-Rodriguez, W., Glabe, C. G., & Tenner, A. J. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7260 · Cited by 138

β Amyloid peptide (Aβ 42 ) is internalized via the G‐protein‐coupled receptor FPRL1 and forms fibrillar aggregates in macrophages 1

YAZAWA, H., YU, Z.-X., TAKEDA, K., LE, Y., GONG, W., FERRANS, V. J., OPPENHEIM, J. J., LI, C. C. H., & WANG, J. M. (2001) · The FASEB Journal · doi:10.1096/fj.01-0251com · Cited by 105

Analysis of Macrophage Scavenger Receptor (SR-A) Expression in Human Aortic Atherosclerotic Lesions

Gough, P. J., Greaves, D. R., Suzuki, H., Häkkinen, T., Hiltunen, M. O., Turunen, M. P., Ylä‐Herttuala, S., Kodama, T., & Gordon, S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.461 · Cited by 136

The role of microglia in human disease: therapeutic tool or target?

Cartier, N., Lewis, C. B., Zhang, R., & Rossi, F. M. V. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1330-y · Cited by 142

Microglia in Alzheimer’s disease: A multifaceted relationship

ElAli, A., & Rivest, S. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.021 · Cited by 134

β‐amyloid inhibition of long‐term potentiation is mediated via tumor necrosis factor

Wang, Q., Wu, J., Rowan, M. J., & Anwyl, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04457.x · Cited by 134

Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention

Zhang, G., Wang, Z., Hu, H., Zhao, M., & Sun, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.749587 · Cited by 137

Microglia and Alzheimer’s disease

Kalaria, R. N. (1999) · Current Opinion in Hematology · doi:10.1097/00062752-199901000-00004 · Cited by 135

Mitochondrial dysfunction and Alzheimer's disease: role of amyloid‐β peptide alcohol dehydrogenase (ABAD)

Yan, S. D., & Stern, D. M. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00427.x · Cited by 136

Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease

Khoury, J. B. E., Hickman, S., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00036-0 · Cited by 159

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64354-4 · Cited by 398

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid

Husemann, J., Loike, J. D., Kodama, T., & Silverstein, S. C. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00239-9 · Cited by 122

Expression of Scavenger Receptors in Glial Cells

Alarcón, R., Fuenzalida, C., Santibáñez, M., & Rommy von Bernhardi, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414686200 · Cited by 159

A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501