Cited by 727Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, Joseph El, Hickman, Suzanne E., Thomas, Christian A., Cao, Long, Silverstein, Samuel C., Loike, John D.·1996·Nature

DOI 10.1038/382716a0

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Abstract

A pathological hallmark of Alzheimer's disease is the senile plaque, containing beta-amyloid fibrils, microglia and astrocytes. Beta-amyloid fibrils exert a cytotoxic effect on neurons, and stimulate microglia to produce neurotoxins, such as reactive oxygen species. Mononuclear phagocytes, including microglia, express scavenger receptors that mediate endocytosis of oxidized low-density lipoproteins, and adhesion to glucose-modified extra-cellular matrix proteins. Here we report that class A scavenger receptors mediate adhesion of rodent microglia and human monocytes to beta-amyloid fibril-coated surfaces leading to secretion of reactive oxygen species and cell immobilization. Thus, class A scavenger receptors are potential therapeutic targets in Alzheimer's disease.

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Authors: Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D.
Affiliations: Columbia University (US)
ORCID: Hickman, Suzanne E.
Thomas, Christian A.
Cao, Long
Loike, John D.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1996-08
Volume: 382
Issue: 6593
Pages: 716-719
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/382716a0
OpenAlex: W2045560271
Cited by: 727
References: 21
Citations by year: 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 19 · 2020: 20 · 2019: 15 · 2018: 12 · 2017: 10 · 2016: 18 · 2015: 21 · 2014: 20 · 2013: 22 · 2012: 31
FWCI: 29.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: scavenger receptors, scavenger receptor A, microglia, amyloid-beta fibrils, Alzheimer's disease, amyloid plaques, reactive oxygen species, monocytes, cell immobilization, therapeutic target
MeSH terms: Alzheimer Disease, Amino Acid Sequence, Animals, Cell Adhesion, Cell Line, Cell Movement, Collagen, Humans, Ligands, Membrane Proteins, Molecular Sequence Data, Monocytes, Peptides, Receptors, Immunologic, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Receptors, Lipoprotein, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, Mice, Rats

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