CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

He, Jianglin, Chen, Youzhi, Farzan, Michael, Choe, Hyeryun, Ohagen, Asa, Gartner, Suzanne, Busciglio, Jorge, Yang, Xiaoyu, Hofmann, Wolfgang, Newman, Walter, Mackay, Charles R., Sodroski, Joseph, Gabuzda, Dana·1997·Nature

DOI 10.1038/385645a0

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Berger, E. A., Murphy, P. M., & Farber, J. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.657 · Cited by 2,180
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
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González-Scarano, F., & Baltuch, G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.219 · Cited by 984
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Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919
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Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
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Qing, K., Mah, C., Hansen, J., Zhou, S., Dwarki, V., & Srivastava, A. (1999) · Nature Medicine · doi:10.1038/4758 · Cited by 443
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Meucci, O., Fatatis, A., Simen, A. A., & Miller, R. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090017497 · Cited by 385
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Cosenza;, M. A., Zhao;, M., Si;, Q., & Lee, S. C. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00461.x · Cited by 238
Untitled work
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Boehme, S. A., Lio, F. M., Maciejewski-Lenoir, D., Bacon, K. B., & Conlon, P. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.397 · Cited by 192
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Williams, K., Alvarez, X., & Lackner, A. A. (2001) · Glia · doi:10.1002/glia.1105 · Cited by 190
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Authors: He, J., Chen, Y., Farzan, M., Choe, H., Ohagen, A., Gartner, S., Busciglio, J., Yang, X., Hofmann, W., Newman, W., Mackay, C. R., Sodroski, J., & Gabuzda, D.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-02
Volume: 385
Issue: 6617
Pages: 645-649
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/385645a0
OpenAlex: W1963855922
Cited by: 913
References: 0
FWCI: 28.75
Type: journal article
Language: en
Open access: closed

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