The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
phot1 and phot2 mediate blue light regulation of stomatal opening
Abstract
The stomatal pores of higher plants allow for gaseous exchange into and out of leaves. Situated in the epidermis, they are surrounded by a pair of guard cells which control their opening in response to many environmental stimuli, including blue light. Opening of the pores is mediated by K(+) accumulation in guard cells through a K(+) channel and driven by an inside-negative electrical potential. Blue light causes phosphorylation and activation of the plasma membrane H(+)-ATPase that creates this potential. Thus far, no blue light receptor mediating stomatal opening has been identified, although the carotenoid, zeaxanthin, has been proposed. Arabidopsis mutants deficient in specific blue-light-mediated responses have identified four blue light receptors, cryptochrome 1 (cry1), cryptochrome 2 (cry2), phot1 and phot2. Here we show that in a double mutant of phot1 and phot2 stomata do not respond to blue light although single mutants are phenotypically normal. These results demonstrate that phot1 and phot2 act redundantly as blue light receptors mediating stomatal opening.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Stomatal opening is regulated by the functional redundancy of PHOT1 and PHOT2”
From The action of enhancing weak light capture via phototropic growth and chloroplast movement in plants (2022) · cites this paper as Kinoshita et al., 2001
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
Ahmad, M., & Cashmore, A. R. (1993) · Nature · doi:10.1038/366162a0 · Cited by 1,279
G UARD C ELL S IGNAL T RANSDUCTION
Schroeder, J. I., Allen, G. J., Hugouvieux, V., Kwak, J. M., & Waner, D. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.627 · Cited by 1,154
Niyogi, K., Grossman, A. R., & Björkman, O. (1998) · The Plant Cell · doi:10.1105/tpc.10.7.1121 · Cited by 970
Sakai, T., Kagawa, T., Kasahara, M., Swartz, T. E., Christie, J. M., Briggs, W. R., Wada, M., & Okada, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101137598 · Cited by 715
Self-citationArabidopsis NPH1: A Protein Kinase with a Putative Redox-Sensing Domain
Huala, E., Oeller, P. W., Emmanuel Liscum, A., Han, I., Larsen, E., & Briggs, W. R. (1997) · Science · doi:10.1126/science.278.5346.2120 · Cited by 706
Merlot, S., Gosti, F., Guerrier, D., Vavasseur, A., & Giraudat, J. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.00965.x · Cited by 682
Arabidopsis NPL1: A Phototropin Homolog Controlling the Chloroplast High-Light Avoidance Response
Kagawa, T., Sakai, T., Suetsugu, N., Oikawa, K., Ishiguro, S., Kato, T., Tabata, S., Okada, K., & Wada, M. (2001) · Science · doi:10.1126/science.291.5511.2138 · Cited by 651
Self-citationChristie, J. M., Salomon, M., Nozue, K., Wada, M., & Briggs, W. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8779 · Cited by 576
Self-citation
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of stomata in sensing and driving environmental change
Hetherington, A. M., & Woodward, F. I. (2003) · Nature · doi:10.1038/nature01843 · Cited by 2,468
“Only when both receptor genes in the phot1 , phot2 double mutant are disrupted do the stomata fail to respond to blue ligh”
BackgroundROS and redox signalling in the response of plants to abiotic stress
Suzuki, N., Koussevitzky, S., Mittler, R., & Miller, G. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2011.02336.x · Cited by 1,700
Light Signal Transduction in Higher Plants
Chen, M., Chory, J., & Fankhauser, C. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092259 · Cited by 1,002
“Blue light–driven stomatal opening is also a phototropin-mediated response (98).”
BackgroundPhototropin Blue-Light Receptors
Christie, J. M. (2007) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.58.032806.103951 · Cited by 937
“This response is controlled redundantly by phot1 and phot2, which unlike the situation for phototropism contribute equally to stomatal opening by acting across the same light intensity range (88).”
BackgroundLight Regulation of Stomatal Movement
Shimazaki, K., Doi, M., Assmann, S. M., & Kinoshita, T. (2007) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105434 · Cited by 924
“However, further confirmation is needed because the stomatal aperture responses reported for the npq1 mutant could not be reproduced in leaves, epidermes, or guard cell protoplasts (29, 72, 180).”
BackgroundSelf-citationLight-Regulated Plant Growth and Development
Kami, C., Lorrain, S., Hornitschek, P., & Fankhauser, C. (2010) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)91002-8 · Cited by 927
“This response primarily depends on phot1 and phot2 with cry1 and cry2 playing a more limited role (Kinoshita et al., 2001; Mao et al., 2005).”
BackgroundPhotoreceptor Signaling Networks in Plant Responses to Shade
Casal, J. J. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120221 · Cited by 865
Phototropins 1 and 2: versatile plant blue-light receptors
Briggs, W. R., & Christie, J. M. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02245-8 · Cited by 785
FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis
Imaizumi, T., Tran, H. G., Swartz, T. E., Briggs, W. R., & Kay, S. A. (2003) · Nature · doi:10.1038/nature02090 · Cited by 593
Chloroplast avoidance movement reduces photodamage in plants
Kasahara, M., Kagawa, T., Oikawa, K., Suetsugu, N., Miyao, M., & Wada, M. (2002) · Nature · doi:10.1038/nature01213 · Cited by 581
“Furthermore, the efficiency of gas exchange for photosynthesis under high light does not seem to differ either, because there is no difference in stomatal opening patterns between wild-type, phot1-5 and phot2-1 plant”
BackgroundSelf-citationCominelli, E., Galbiati, M., Vavasseur, A., Conti, L., Sala, T., Vuylsteke, M., Leonhardt, N., Dellaporta, S. L., & Tonelli, C. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.048 · Cited by 575
“Total RNA samples were extracted at indicated time intervals, expressed in hours (h), and the tryptophan synthase1-b subunit (TSB1) gene was used as a control. array analysis of blue-light regulation of Arabidopsis transcription-factor expression, in wild-type and phot1phot2 mutant seedlings, indicates that the blue-l…”
BackgroundIn the light of stomatal opening: new insights into ‘the Watergate’
Roelfsema, M. R. G., & Hedrich, R. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01460.x · Cited by 545
“For this pathway, both the receptors and the downstream responses have been identified (Kinoshita & Shimazaki, 1999; Kinoshita et al., 2001) and fit the changes in transport activity measured directly on single guard cells (Roelfsema et al.”
BackgroundIn Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning
Greco, M., Chiappetta, A. A. C., Bruno, L., & Bitonti, M. B. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err313 · Cited by 555
Plasma Membrane H + -ATPase Regulation in the Center of Plant Physiology
Falhof, J., Pedersen, J. T., Fuglsang, A. T., & Palmgren, M. B. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.11.002 · Cited by 533
“These data are in accordance with a model proposed by Kinoshita and Hayashi (2011) in which the target of blue light-induced signaling is thought to be an unidentified protein kinase that phosphorylates Thr-947 in the PM H+-ATPase.”
BackgroundResultUlm, R., Baumann, A., Oravecz, A., Máté, Z., Ádám, É., Oakeley, E. J., Schäfer, E., & Nagy, F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308044100 · Cited by 501
Hedrich, R. (2012) · Physiological Reviews · doi:10.1152/physrev.00038.2011 · Cited by 498
“Upon BL stimulation, BL receptor kinases phototropin 1 and 2 trigger phosphorylation of the H -ATPase (169, 170).”
BackgroundCarbonic anhydrases are upstream regulators of CO2-controlled stomatal movements in guard cells
Hu, H., Boisson‐Dernier, A., Israelsson‐Nordström, M., Böhmer, M., Xue, S., Ries, A., Godoski, J., Kuhn, J. M., & Schroeder, J. I. (2009) · Nature Cell Biology · doi:10.1038/ncb2009 · Cited by 459
Huché‐Thélier, L., Crespel, L., Gourrierec, J. L., Morel, P., Sakr, S., & Leduc, N. (2015) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2015.06.009 · Cited by 484
Liu, L., Zhang, Y.-C., Li, Q.-H., Sang, Y., Mao, J., Lian, H., Wang, L., & Yang, H. (2008) · The Plant Cell · doi:10.1105/tpc.107.057281 · Cited by 419
“, 1998), and together with the blue light photoreceptor phototropins, mediate blue light regulation of stomatal opening (Kinoshita et al., 2001; Mao et al., 2005).”
BackgroundCellular and Subcellular Localization of Phototropin 1
Sakamoto, K., & Briggs, W. R. (2002) · The Plant Cell · doi:10.1105/tpc.003293 · Cited by 405
“The strongest signals detected in the leaf epidermis arose from the guard cells (Figures 4A and 4C), which is not surprising given the recent evidence that phot1 serves as one of the photoreceptors for blue light–activated stomatal opening (Kinoshita et al., 2002).”
BackgroundGreen light: a signal to slow down or stop
Folta, K. M., & Maruhnich, S. A. (2007) · Journal of Experimental Botany · doi:10.1093/jxb/erm130 · Cited by 399
Influence of environmental factors on stomatal development
Casson, S. A., & Gray, J. E. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2007.02351.x · Cited by 396
“A number of stomatal response mutants exist that could be used to evaluate this (Kinoshita et al., 2001; Cominelli et al., 2005; Hashimoto et al., 2006; Xie et al., 2006, Young et al., 2006).”
BackgroundMechanisms of Stomatal Development
Pillitteri, L. J., & Torii, K. U. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105451 · Cited by 393
“Stomatal opening in response to light is mediated primarily by the blue-light receptors, cryptochromes and phototropins (51, 68).”
BackgroundThe multifaceted roles of FLOWERING LOCUS T in plant development
Pin, P. A., & Nilsson, O. R. (2012) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2012.02558.x · Cited by 384
“Two blue-light receptor kinases, phototropin 1 and 2, play a major role in stomatal opening since the double phot1 phot2 mutant has a closed-stomata phenotype (Kinoshita et al. 2001; Sakamoto & Briggs 2002).”
BackgroundA role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening
Mao, J., Zhang, Y., Sang, Y., Li, Q., & Yang, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501011102 · Cited by 385
Johkan, M., Shoji, K., Goto, F., Hahida, S., & Yoshihara, T. (2011) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2011.08.010 · Cited by 378
Plant photoreceptors: Multi-functional sensory proteins and their signaling networks
Paik, I., & Huq, E. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.03.007 · Cited by 379
“Phototropins also play an essential role in blue light mediated stomatal opening and chloroplast movement in response to light [59,60].”
BackgroundOptimization of CRISPR/Cas9 genome editing to modify abiotic stress responses in plants
Osakabe, Y., Watanabe, T., Sugano, S. S., Ueta, R., Ishihara, R., Shinozaki, K., & Osakabe, K. (2016) · Scientific Reports · doi:10.1038/srep26685 · Cited by 375
Blue Light Receptors and Signal Transduction
Lin, C. (2002) · The Plant Cell · doi:10.1105/tpc.000646 · Cited by 369
“Indeed, the blue light–induced increase of H -ATPase activity was abolished in the phot1phot2 double mutant, presumably because of the lack of phototropin kinases (Kinoshita et al., 2001).”
BackgroundClosing gaps: linking elements that control stomatal movement
Kollist, H., Nuhkat, M., & Roelfsema, M. R. G. (2014) · New Phytologist · doi:10.1111/nph.12832 · Cited by 365
Photoexcited Structure of a Plant Photoreceptor Domain Reveals a Light-Driven Molecular Switch
Crosson, S., & Moffat, K. (2002) · The Plant Cell · doi:10.1105/tpc.010475 · Cited by 350
“, 1998), and control phototropism, light-induced chloroplast movement, and stomatal opening (Huala et al., 1997; Christie et al., 1998; Jarillo et al., 2001; Kagawa et al., 2001; Kinoshita et al., 2001).”
BackgroundMerlot, S., Leonhardt, N., Fenzi, F., Valon, C., Costa, J. M., Piette, L., Vavasseur, A., Genty, B., Boivin, K., Müller, A., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601750 · Cited by 358
“Among environmental signals, light (particularly blue content) is a potent physiological stimulus of stomatal opening, by activating plasma membrane Hþ -ATPases (Kinoshita et al, 2001).”
BackgroundThe Cryptochrome Blue Light Receptors
Yu, X., Liu, H., Klejnot, J., & Lin, C. (2010) · The Arabidopsis Book · doi:10.1199/tab.0135 · Cited by 346
“…various movement responses in plants (Huala et al., 1997; Christie et al., 1998; Christie et al., 1999; Briggs et al., 2001; Kagawa et al., 2001; Kinoshita et al., 2001), and the F-box/ Kelch-repeat proteins ZTL (ZEITLUPE), FKF (FLAVIN-BINDING, KELCH REPEAT, F-BOX 1), and LKP2 (LOV KELCH REPEAT…”
InfluentialEnergization of Transport Processes in Plants. Roles of the Plasma Membrane H+-ATPase
Søndergaard, T. E., Schulz, A., & Palmgren, M. B. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.048231 · Cited by 339
“Blue light is absorbed by PHOT1 and PHOT2, which are blue-light receptors with protein kinase activity (Kinoshita et al., 2001).”
BackgroundWada, M., Kagawa, T., & Sato, Y. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.135023 · Cited by 330
Self-citationHalavaty, A. S., & Moffat, K. (2007) · Biochemistry · doi:10.1021/bi701543e · Cited by 317
Razi, K., & Muneer, S. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1874280 · Cited by 334
“and PHOT2 senses blue light and leads to the efflux of Hþ from cytosol [216].”
BackgroundThe Membrane Transport System of the Guard Cell and Its Integration for Stomatal Dynamics
Jezek, M., & Blatt, M. R. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.01949 · Cited by 329
“…ion pumps of the plasma membrane and tonoplast, including the H+-ATPases and their regulation (Kinoshita and Shimazaki, 1999; Moriau et al., 1999; Kinoshita et al., 2001; Ueno et al., 2005; Merlot et al., 2007), Ca2+-ATPases, and the tonoplast H+pyrophosphatase (H+-PPase; Martinoia et al., 2007;…”
BackgroundOptogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth
Papanatsiou, M., Petersen, J., Henderson, L., Wang, Y., Christie, J. M., & Blatt, M. R. (2019) · Science · doi:10.1126/science.aaw0046 · Cited by 313
Plant Flavoprotein Photoreceptors
Christie, J. M., Blackwood, L., Petersen, J., & Sullivan, S. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcu196 · Cited by 294
“2001), stomatal opening (Kinoshita et al. 2001), leaf positioning and leaf flattening (Sakamoto and Briggs 2002, Inoue et al.”
BackgroundCryptochromes, Phytochromes, and COP1 Regulate Light-Controlled Stomatal Development in Arabidopsis
Kang, C., Lian, H., Wang, F., Huang, J., & Yang, H. (2009) · The Plant Cell · doi:10.1105/tpc.109.069765 · Cited by 300
“Also, cryptochromes andphototropins act together to mediate blue light regulation of stomatal opening (Kinoshita et al., 2001; Mao et al., 2005).”
BackgroundGuard cell photosynthesis and stomatal function
Lawson, T. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02685.x · Cited by 299
“They established that phot1 and phot2 act redundantly as the blue-light receptors in stomatal responses to blue light, as single mutants showed a typical wild-type blue-light response (Kinoshita et al., 2001), which led to phototropins becoming widely accepted as the main blue-light receptor.”
BackgroundResultInfluentialArabidopsis HT1 kinase controls stomatal movements in response to CO2
Hashimoto, M., Negi, J., Young, J. J., Israelsson, M., Schroeder, J. I., & Iba, K. (2006) · Nature Cell Biology · doi:10.1038/ncb1387 · Cited by 294
“Compared with the advanced understanding of light and water stress responses in guard cell”
BackgroundBlue Light Regulation of Stomatal Opening and the Plasma Membrane H+-ATPase
Inoue, S., & Kinoshita, T. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.00166 · Cited by 298
“Phototropins expressed in guard cells act as major blue light receptors for stomatal opening (Kinoshita et al., 2001, 2003; Inoue et al., 2008).”
BackgroundSelf-citationPhototropin LOV domains exhibit distinct roles in regulating photoreceptor function
Christie, J. M., Swartz, T. E., Bogomolni, R. A., & Briggs, W. R. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01415.x · Cited by 286
“Recent genetic studies have also shown that phot1 and phot2 share redundant roles in regulating blue light-induced stomatal opening (Kinoshita et al., 2001).”
BackgroundDriesen, E., den Ende, W. V., Proft, M. D., & Saeys, W. (2020) · Agronomy · doi:10.3390/agronomy10121975 · Cited by 329
“Blue light primarily is perceived by photoreceptors PHOT1 and PHOT2, which activate the guard cell PM H+-ATPase and CBC (CONVERGENCE OF BLUE LIGHT (BL) AND CO2) kinases, inhibiting S-type anion channels [48,56,57].”
BackgroundKasahara, M., Swartz, T. E., Olney, M. A., Onodera, A., Mochizuki, N., Fukuzawa, H., Asamizu, E., Tabata, S., Kajiya‐Kanegae, H., Takano, M., et al. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.002410 · Cited by 288
“…et al., 2001a) have been shown to serve as photoreceptors mediating phototropism (Huala et al., 1997; Christie et al., 1998), blue light-mediated chloroplast movement (Kagawa et al., 2001; Sakai et al., 2001; Jarillo et al., 2001), and blue light-induced stomatal opening (Kinoshita et al., 2002).”
BackgroundA Mechanism for Reorientation of Cortical Microtubule Arrays Driven by Microtubule Severing
Lindeboom, J. J., Nakamura, M., Hibbel, A., Shundyak, K., Gutierrez, R., Ketelaar, T., Emons, A. M. C., Mulder, B. M., Kirik, V., & Ehrhardt, D. W. (2013) · Science · doi:10.1126/science.1245533 · Cited by 289
“The wild type and the cry1-104 cry2-1 (19) and phot1-5 phot2-1 double-mutant lines (48) expressing the YFP-TUA5 marker were in the Columbia (Col0) ecotype.”
BackgroundPhototropins Promote Plant Growth in Response to Blue Light in Low Light Environments
Takemiya, A., Inoue, S.-I., Doi, M., Kinoshita, T., & Shimazaki, K.-I. (2005) · The Plant Cell · doi:10.1105/tpc.104.030049 · Cited by 279
“Plasma membrane Hþ-ATPase was quantified immunologically with polyclonal antibodies as described previously (Kinoshita and Shimazaki, 1999).”
MethodSelf-citationGriebel, T., & Zeier, J. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.119503 · Cited by 279
“Unlike cry1cry2, the phot1phot2 mutant is blocked in the phototropin-dependent chloroplast, stomatal, and phototropic movements and lacks blue-light induction of calcium currents in mesophyll cells (Kinoshita et al., 2001; Sakai et al., 2001; Stoelzle et al., 2003).”
BackgroundFedorov, R., Schlichting, I., Hartmann, E., Domratcheva, T. M., Fuhrmann, M., & Hegemann, P. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75052-8 · Cited by 267
“…membraneassociated proteins that function as primary photoreceptor for phototropic plant movement (Huala et al., 1997; Christie et al., 1998; Christie et al., 1999), chloroplast relocation (Jarillo et al., 2001; Kagawa et al., 2001), and stomatal opening in guard cells (Kinoshita et al., 2001).”
BackgroundLight perception in plant disease defence signalling
Karpiński, S. M., Gabryś, H., Mateo, A., Karpińska, B., & Mullineaux, P. M. (2003) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(03)00061-x · Cited by 264
From seed to seed: the role of photoreceptors in Arabidopsis development
Sullivan, J. A., & Deng, X. W. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00212-4 · Cited by 264
“While phot1 and phot2 single mutants show only small changes in blue light-induced stomatal opening, this response is completely absent in a phot1phot2 double mutant (Kinoshita et al., 2001).”
BackgroundAUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles
Takahashi, F., Yamagata, D., Ishikawa, M., Fukamatsu, Y., Ogura, Y., Kasahara, M., Kiyosue, T., Kikuyama, M., Wada, M., & Kataoka, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707692104 · Cited by 263
Self-citationKiba, T., Henriques, R., Sakakibara, H., & Chua, N. (2007) · The Plant Cell · doi:10.1105/tpc.107.053033 · Cited by 261
“, 1999), phot1 phot2 (Kinoshita et al., 2001), and phyA phyB (Devlin et al.”
BackgroundInfluentialLi, H., Xu, Z., & Tang, C. (2010) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-010-9763-z · Cited by 261
“In addition, blue light was received directly by phototropins and activated a signaling cascade that resulted in fast stomata opening under background red light (Kinoshita et al. 2001; Doi et al. 2004; Shimazaki et al. 2007).”
BackgroundPennisi, G., Blasioli, S., Cellini, A., Maia, L., Crepaldi, A., Braschi, I., Spinelli, F., Nicola, S., Fernández, J. A., Stanghellini, C., et al. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00305 · Cited by 260
Receptor quality control in the endoplasmic reticulum for plant innate immunity
Saijo, Y., Tintor, N., Lu, X., Rauf, P., Pajerowska-Mukhtar, K. M., Häweker, H., Dong, X., Robatzek, S., & Schulze‐Lefert, P. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.263 · Cited by 261
“Anti-FLS2 and AHA2 antibodies were described elsewhere (Kinoshita et al, 2001; Chinchilla et al, 2006).”
BackgroundEvidence for Involvement of Photosynthetic Processes in the Stomatal Response to CO2
Messinger, S. M., Buckley, T. N., & Mott, K. A. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.073676 · Cited by 265
“The receptor for this response has yet to be identified unequivocally, and there is evidence supporting both zeaxanthin (Zeiger and Zhu, 1998; Talbott et al., 2003) and phototropins (Kinoshita et al., 2001; Doi et al., 2004) for this role.”
BackgroundContributions of green light to plant growth and development
Wang, Y., & Folta, K. M. (2013) · American Journal of Botany · doi:10.3732/ajb.1200354 · Cited by 249
Modulation of environmental responses of plants by circadian clocks
Hotta, C. T., GARDNER, M. J., Hubbard, K., BAEK, S. J., Dalchau, N., Suhita, D., Dodd, A. N., & Webb, A. A. R. (2007) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2006.01627.x · Cited by 247
“CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is believed to function in a similar light transduction pathway as DET1.”
BackgroundInfluentialPhot-LOV1: Photocycle of a Blue-Light Receptor Domain from the Green Alga Chlamydomonas reinhardtii
Kottke, T., Heberle, J., Hehn, D., Dick, B., & Hegemann, P. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74933-9 · Cited by 246
“Phototropins and homologs, recently renamed Phot proteins (Briggs et al., 2001), comprise a class of blue-light receptors that are involved in phototropic plant movement (Christie et al., 1998, 1999; Huala et al., 1997), chloroplast relocation (Jarillo et al., 2001; Kagawa et al., 2001), and stomatal opening in guard…”
BackgroundRoles of ion channels and transporters in guard cell signal transduction
Pandey, S., Zhang, W., & Assmann, S. M. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.04.008 · Cited by 245
“light signal upstream of the type 1 protein phosphatase came when studies with the double blue light-receptor mutant phot1 phot2 demonstrated essentially no blue light-stimulated stomatal opening in this mutant [12].”
Spatio‐temporally precise activation of engineered receptor tyrosine kinases by light
Grusch, M., Schelch, K., Riedler, R., Reichhart, E., Differ, C., Berger, W., Inglés‐Prieto, Á., & Janovjak, H. (2014) · The EMBO Journal · doi:10.15252/embj.201387695 · Cited by 246
“…domains such as enzymes [for instance, in the flowering plant Arabidopsis thaliana and the green alga Chlamydomonas reinhardtii (Huang et al, 2002; Kinoshita et al, 2001)] or transcriptional regulators [for instance, in the fungus Neurospora crassa and the yellow-green alga Vaucheria frigida…”
BackgroundBuckley, T. N. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.01772 · Cited by 257
“…example, CO2 responses persist in darkness (Heath and Russell, 1954; Messinger et al., 2006), and the existence of a distinct low-fluence and photosynthesis-independent response to blue light was established many years ago (Shimazaki et al., 1986; Kinoshita et al., 2001; Inoue and Kinoshita, 2017).”
BackgroundBlue light-induced autophosphorylation of phototropin is a primary step for signaling
Inoue, S.-I., Kinoshita, T., Matsumoto, M., Nakayama, K. I., Doi, M., & Shimazaki, K.-I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709189105 · Cited by 269
Self-citationThe pH of the Apoplast: Dynamic Factor with Functional Impact Under Stress
Geilfus, C. (2017) · Molecular Plant · doi:10.1016/j.molp.2017.09.018 · Cited by 240
The FOX hunting system: an alternative gain‐of‐function gene hunting technique
Ichikawa, T., Nakazawa, M., Kawashima, M., Iizumi, H., Kuroda, H., Kondou, Y., Tsuhara, Y., Suzuki, K., Ishikawa, A., Seki, M., et al. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2006.02924.x · Cited by 238
Co-ordination of hydraulic and stomatal conductances across light qualities in cucumber leaves
Savvides, A. M., Fanourakis, D., & van Ieperen, W. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err348 · Cited by 232
Responses of ferns to red light are mediated by an unconventional photoreceptor
Kawai, H., Kanegae, T., Christensen, S., Kiyosue, T., Sato, Y., Imaizumi, T., Kadota, A., & Wada, M. (2003) · Nature · doi:10.1038/nature01310 · Cited by 231
Self-citationWang, Y., Noguchi, K., Ono, N., Inoue, S., Terashima, I., & Kinoshita, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305438111 · Cited by 230
“To produce transgenic plants showing enhanced stomatal opening in response to light, we attempted to express three key components of stomatal opening: PHOTOTROPIN 2 (PHOT2), an isoform of the blue light receptor phototropin (13); ARABIDOPSIS H-ATPASE 2 (AHA2), a typical isoform of the plasma membrane H-ATPase (24); an…”
BackgroundSelf-citationBlue Light Induces a Distinct Starch Degradation Pathway in Guard Cells for Stomatal Opening
Horrer, D., Flütsch, S., Pazmiño, D. M., Matthews, J. S. A., Thalmann, M., Nigro, A., Leonhardt, N., Lawson, T., & Santelia, D. (2016) · Current Biology · doi:10.1016/j.cub.2015.12.036 · Cited by 227
“opened to a greater extent in the presence of 10 μM Fc (Figure 4E)[29].”
Phylogenomic Evidence for the Monophyly of Bryophytes and the Reductive Evolution of Stomata
Harris, B. J., Harrison, C. J. O., Hetherington, A. M., & Williams, T. A. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.048 · Cited by 227
Phosphorylation of BLUS1 kinase by phototropins is a primary step in stomatal opening
Takemiya, A., Sugiyama, N., Fujimoto, H., Tsutsumi, T., Yamauchi, S., Hiyama, A., Tada, Y., Christie, J. M., & Shimazaki, K.-I. (2013) · Nature Communications · doi:10.1038/ncomms3094 · Cited by 219
“B1N; N-terminal fragment of BLUS1 (amino acids 1-294), B1C; C-terminal fragment of BLUS1 (294-487), P1N; N-terminal fragment of phot1 (1-619), P1C; C-terminal fragment of phot1 (620-996).”
Self-citationThe Control of Transpiration. Insights from Arabidopsis
Nilson, S. E., & Assmann, S. M. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.093161 · Cited by 225
“Studies that assess impacts of light (Kinoshita et al., 2001; Sothern et al., 2002), CO2 (Hashimoto et al., 2006; Teng et al., 2006; Young et al., 2006), and humidity (Assmann et al., 2000; Yoshida et al., 2002; Xie et al., 2006) on transpiration, while not discussed here, are equally important to…”
BackgroundGuard cells: a dynamic signaling model
Fan, L.-M., Zhao, Z., & Assmann, S. M. (2004) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2004.07.009 · Cited by 226
“The blue-light response is mediated to a great extent by phototropins, with possible contributions from zeaxanthin or phytochrome under specialized conditions [52,53].”
Guard cell metabolism and CO2 sensing
Vavasseur, A., & Raghavendra, A. S. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2004.01276.x · Cited by 222
“Recently the blue light receptor was determined (Kinoshita et al., 2001).”
Sirichandra, C., Wasilewska, A., Vlad, F., Valon, C., & Leung, J. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/ern340 · Cited by 218
“Both are critical for blue-light stimulation of stomatal opening as the double mutant phot1,phot2—but not their respective single mutants—is completely insensitive to blue light (Kinoshita et al., 2001).”
BackgroundPrimary Reactions of the LOV2 Domain of Phototropin, a Plant Blue-Light Photoreceptor
Kennis, J. T. M., Crosson, S., Gauden, M., van Stokkum, I. H. M., Moffat, K., & van Grondelle, R. (2003) · Biochemistry · doi:10.1021/bi034022k · Cited by 221
Ohgishi, M., Saji, K., Okada, K., & Sakai, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305984101 · Cited by 215
Phototropism: Growing towards an Understanding of Plant Movement
Liscum, E., Askinosie, S. K., Leuchtman, D. L., Morrow, J., Willenburg, K. T., & Coats, D. R. (2014) · The Plant Cell · doi:10.1105/tpc.113.119727 · Cited by 215
Inada, S., Ohgishi, M., Mayama, T., Okada, K., & Sakai, T. (2004) · The Plant Cell · doi:10.1105/tpc.019901 · Cited by 215
“Kinoshita et al. (2001) showed that phot1 and phot2 function redundantly in stomatal opening to blue light irradiation.”
MethodInfluentialLight perception and signalling in higher plants
Gyula, P., Schäfer, E., & Nagy, F. (2003) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(03)00082-7 · Cited by 217
“these receptors with different partners — for example, Hþ-ATPase in guard cells [8], ion transporters or channel proteins in other leaf cells [40], and maybe auxin transporters in stem cells — result in different movement responses in different parts of the plant.”
BackgroundDegradation of Phytochrome Interacting Factor 3 in Phytochrome-Mediated Light Signaling
Park, E., Kim, J.-H., Lee, Y. J., Shin, J., Oh, E., Chung, W., Liu, J. R., & Choi, G. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch125 · Cited by 215
Huang, K., & Beck, C. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931459100 · Cited by 210
LOV Domain-Containing F-Box Proteins: Light-Dependent Protein Degradation Modules in Arabidopsis
Ito, S., Song, Y. H., & Imaizumi, T. (2012) · Molecular Plant · doi:10.1093/mp/sss013 · Cited by 212
“…phototropism (Sakai et al., 2001), chloroplast relocation movement (Kagawa et al., 2001; Sakai et al., 2001), light-induced stomatal opening (Kinoshita et al., 2001), cotyledon and leaf expansion (Sakamoto and Briggs, 2002; Takemiya et al., 2005), and hypocotyl growth (Folta and Spalding,…”
BackgroundFLOWERING LOCUS T Regulates Stomatal Opening
Kinoshita, T., Ono, N., Hayashi, Y., Morimoto, S., Nakamura, S., Soda, M., Kato, Y., Ohnishi, M., Nakano, T., Inoue, S., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.025 · Cited by 206
Self-citationMacedo, A. F., Leal-Costa, M. V., Tavares, E. S., Lage, C. L. S., & Esquibel, M. A. (2010) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2010.05.012 · Cited by 207
The signal transducing photoreceptors of plants
Franklin, K. A., Larner, V. S., & Whitelam, G. C. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.051989kf · Cited by 202
“Whereas single (phot1, phot2 ) mutants displayed increased stomatal aperture in response to blue light, the phot1phot2 double mutant remained unresponsive (Kinoshita et al., 2001).”
BackgroundChoi, H. G., Moon, B. Y., & Kang, N. J. (2015) · Scientia Horticulturae · doi:10.1016/j.scienta.2015.03.022 · Cited by 201
Sang, Y., Li, Q., Rubio, V., Zhang, Y., Mao, J., Deng, X., & Yang, H. (2005) · The Plant Cell · doi:10.1105/tpc.104.029645 · Cited by 201
“, 2001) and blue light–induced stomatal opening (Kinoshita et al., 2001), has also been shown to dimerize through its LOV1 domain (Salomon et al.”
BackgroundLi, H., Tang, C., & Xu, Z. (2012) · Scientia Horticulturae · doi:10.1016/j.scienta.2012.10.009 · Cited by 200
Haberer, G., Hindemitt, T., Meyers, B. C., & Mayer, K. (2004) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.046466 · Cited by 202
“In Arabidopsis, partial redundancy and overlapping functionality for duplicated genes (e.g. SHATTERPROOF 1 and 2, AP1/CAULIFLOWER, PHOT1 and 2) have been reported (Ferrandiz et al., 2000; Liljegren et al., 2000; Kinoshita et al., 2001; Pinyopich et al., 2003).”
BackgroundYang, X., Hu, R., Yin, H., Jenkins, J. W., Shu, S., Tang, H., Liu, D., Weighill, D. A., Yim, W. C., Ha, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01491-7 · Cited by 193
Common and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells
Wang, R., Pandey, S., Song, L., Gookin, T. E., Zhao, Z., Albert, R., & Assmann, S. M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-216 · Cited by 196
“CRY1/BLU1 (AT4G08920) encodes the blue light photoreceptor cryptochrome 1 and has been reported to participate in blue light-regulation of stomatal movements [72], while NPH3 functions downstream of the PHOT1/PHOT2 blue light photoreceptors which mediate blue light-specific stomatal opening [73].”
BackgroundZhang, M., Yin, W., Chen, X., Xu, F., Ding, M., Ye, W., Kawai, Y., Toda, Y., Hayashi, Y., Suzuki, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-20964-4 · Cited by 194
Self-citationFolta, K. M., & Childers, K. S. (2008) · HortScience · doi:10.21273/hortsci.43.7.1957 · Cited by 192
Regulation of Transpiration to Improve Crop Water Use
Yoo, C. Y., Pence, H. E., Hasegawa, P. M., & Mickelbart, M. V. (2009) · Critical Reviews in Plant Sciences · doi:10.1080/07352680903173175 · Cited by 190
“PHOTOTROPIN 1 and 2 (PHOT1 and PHOT2) are serine/threonine protein kinases that function as blue-light receptors for stomatal opening (Kinoshita et al., 2001).”
BackgroundHarada, A., Sakai, T., & Okada, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1336802100 · Cited by 185
OnGuard, a Computational Platform for Quantitative Kinetic Modeling of Guard Cell Physiology
Hills, A., Chen, Z., Anna Amtmann, A., Blatt, M. R., & Lew, V. L. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.197244 · Cited by 184
“…or 20% of their outputs in the Open Reference State, consistent with experimental estimates of the known light-stimulated activities of plasma membrane ATPases (Assmann et al., 1985; Shimazaki et al., 1986; Serrano et al., 1988; Goh et al., 1995, 1996; Kinoshita et al., 2001; Chen et al., 2012).”
Background
Metadata
- Authors
- Kinoshita, T., Doi, M., Suetsugu, N., Kagawa, T., Wada, M., & Shimazaki, K.-I.
- Affiliations
- Kyushu University (JP)
- National Institute for Basic Biology (JP)
- Corresponding author
- Shimazaki, Ken-ichiro
- Venue
- Nature
- Published
- 2001-12
- Volume
- 414
- Issue
- 6864
- Pages
- 656-660
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2036131768
- Cited by
- 899
- References
- 31
- Citations by year
- 2026: 24 · 2025: 27 · 2024: 45 · 2023: 31 · 2022: 43 · 2021: 42 · 2020: 40 · 2019: 42 · 2018: 40 · 2017: 33 · 2016: 37 · 2015: 34 · 2014: 43 · 2013: 33 · 2012: 42
- FWCI
- 45.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Keywords
- phot1, phot2, blue light receptor, stomatal opening, guard cells, Arabidopsis thaliana, cryptochrome, plasma membrane H+-ATPase, potassium accumulation, zeaxanthin, phototropism
- MeSH terms
- Cell Membrane, Proton-Translocating ATPases, Light, Mutation, Phosphoproteins, Protein Serine-Threonine Kinases, Arabidopsis, Plant Epidermis, Reverse Transcriptase Polymerase Chain Reaction, Arabidopsis Proteins, Photosynthetic Reaction Center Complex Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
