Cited by 202Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference ‘research perspectives in AF’

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Kirchhof, Paulus, Bax, Jeroen, Blomstrom-Lundquist, Carina, Calkins, Hugh, Camm, A. John, Cappato, Ricardo, Cosio, Francisco, Crijns, Harry +15 more·2009·European Heart Journal

Abstract

Atrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far, we do not have the means to prevent AF or AF-related complications adequately. Therefore, over 70 experts on atrial fibrillation convened for the 2nd AFNET/EHRA consensus conference to suggest directions for research to improve management of AF patients (Supplementary Data). The group defined three main areas in need for research in AF: 1. better understanding of the mechanisms of AF; 2. Improving rhythm control monitoring and management; and 3. comprehensive cardiovascular risk management in AF patients. The group put forward the hypothesis that successful therapy of AF and its associated complications will require comprehensive therapy. This applies e.g. to the “old” debate of “rate versus rhythm control”, since rhythm control is generally added to underlying (continued) rate control therapy, but also to the emerging debate of “antiarrhythmic drugs versus catheter ablation”, of which both may be needed in most patients to maintain sinus rhythm, but also to therapy of conditions that predispose to AF and contribute to cardiovascular complications such as stroke, cognitive decline, heart failure, and acute coronary syndromes. We call for research initiatives aiming at a better understanding of the different causes of AF and its complications, and at development and validation of mechanism-based therapies. The future of AF therapy may require a combination of management of underlying and concomitant conditions, early and comprehensive rhythm control therapy, adequate control of ventricular rate and cardiac function, and continuous therapy to prevent AF-associated complications (e.g. antithrombotic therapy). The reasons for these suggestions are detailed in this paper.

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Authors
Kirchhof, P., Bax, J., Blomstrom-Lundquist, C., Calkins, H., Camm, A. J., Cappato, R., Cosio, F., Crijns, H., Diener, H.-C., Goette, A., Israel, C. W., Kuck, K.-H., Lip, G. Y. H., Nattel, S., Page, R. L., Ravens, U., Schotten, U., Steinbeck, G., Vardas, P., Waldo, A., Wegscheider, K., Willems, S., & Breithardt, G.
Affiliations
  • University of Münster (DE)
  • Leiden University (NL)
  • Uppsala University (SE)
  • Johns Hopkins University (US)
  • St George's, University of London (GB)
  • Policlinico S. Matteo 6 Department of Cardiology , , Pavia ,
  • Hospital Telleras 7 , Madrid ,
  • Maastricht University (NL)
  • University of Duisburg-Essen (DE)
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • Goethe University Frankfurt (DE)
  • General Hospital St Georg 12 Department of Cardiology , , Hamburg ,
  • University of Birmingham (GB)
  • Montreal Heart Institute (CA)
  • University of Washington (US)
  • Technische Universität Dresden (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • University of Crete (GR)
  • Case Western Reserve University (US)
  • Universität Hamburg (DE)
Corresponding author
Kirchhof, Paulus
Venue
European Heart Journal
Published
2009-06-17
Volume
30
Issue
24
Pages
2969-2980
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W1970627024
Cited by
202
References
140
Citations by year
2026: 4 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 16 · 2013: 16 · 2012: 23
FWCI
14.45
Type
journal article
Language
en
Open access
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
Kompetenznetz Vorhofflimmern
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
atrial fibrillation, atrial fibrillation management, rhythm control, rate control, antiarrhythmic drugs, catheter ablation, cardiovascular risk management, stroke prevention, antithrombotic therapy, heart failure, cognitive decline, acute coronary syndrome, mechanism-based therapy, atrial fibrillation mechanisms
MeSH terms
Anti-Arrhythmia Agents, Atrial Fibrillation, Fibrinolytic Agents, Humans, Patient Compliance, Risk Factors, Risk Management, Catheter Ablation, Stroke

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