Dissociation of visual, motor and predictive signals in parietal cortex during visual guidance
Abstract
The role of the posterior parietal cortex (PPC) in the visual guidance of movements was studied in monkeys trained to use a joystick to guide a spot to a target. Visual and motor influences were dissociated by transiently occluding the spot and by varying the relationship between the direction of joystick and spot movements. We found a strong segregation of function in PPC during visual guidance. Neurons in area MST were selectively modulated by the direction of visible moving stimuli, whereas neurons in area MIP were selectively modulated by the direction of hand movement. In contrast, the selectivity of cells in the lateral intraparietal area (LIP) did not directly depend on either visual input or motor output, but rather seemed to encode a predictive representation of stimulus movement. These predictive signals may be an important link in visuomotor transformations.
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Previous studies have shown that LIP responses are modulated by many factors, such as attention, expectation, time, motor intention, experienced value, reward, and the prior probability of making an eye movement.
“In addition, previous studies have shown that LIP responses are modulated by many factors, such as attention, expectation, time, motor intention, experienced value, reward, and the prior probability of making an eye movement12,13,39–42.”
From Microstimulation of macaque area LIP affects decision-making in a motion discrimination task (2006) · cites this paper as [39]
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“…of objects that are potential targets of reach movements (Mountcastle et al., 1975; Johnson et al., 1996; Snyder et al., 1997; Batista et al., 1999; Eskandar and Assad, 1999), as well as the outcome of decisions to direct the arm in a particular direction (Snyder et al., 1997; Eskandar and Assad,…”
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- Authors
- Eskandar, E. N., & Assad, J. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Assad, John A.
- Venue
- Nature Neuroscience
- Published
- 1999-01
- Volume
- 2
- Issue
- 1
- Pages
- 88-93
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- DOI
- 10.1038/4594
- OpenAlex
- W2139637968
- Cited by
- 212
- References
- 16
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 11 · 2014: 4 · 2013: 7 · 2012: 8
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Keywords
- posterior parietal cortex, visual guidance of movement, visuomotor transformation, predictive signals, lateral intraparietal area, hand movement, neuronal selectivity, functional segregation
- MeSH terms
- Animals, Behavior, Animal, Eye Movements, Forecasting, Macaca mulatta, Male, Motor Cortex, Neurons, Parietal Lobe, Psychomotor Performance, Visual Cortex, Signal Transduction
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