Cited by 2,526Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, Anders H., Combs, Terry P., Du, Xueliang, Brownlee, Michael, Scherer, Philipp E.·2001·Nature Medicine

DOI 10.1038/90992

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Abstract

Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.

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Authors: Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Scherer, Philipp E.
ORCID: Berg, Anders H.
Scherer, Philipp E.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2001-08
Volume: 7
Issue: 8
Pages: 947-953
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/90992
OpenAlex: W1524321743
Cited by: 2,526
References: 33
Citations by year: 2026: 12 · 2025: 23 · 2024: 38 · 2023: 44 · 2022: 51 · 2021: 54 · 2020: 67 · 2019: 72 · 2018: 62 · 2017: 81 · 2016: 79 · 2015: 84 · 2014: 106 · 2013: 129 · 2012: 133
FWCI: 104.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007491)
National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK 07513-15, R01DK055758, T32DK007513)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: adiponectin, hepatic insulin action, insulin sensitivity, glucose production, hyperglycemia, ob/ob mice, streptozotocin-induced diabetes, adipose tissue, adipokines, glucose metabolism
MeSH terms: Animals, Blood Proteins, Energy Intake, Cell Line, Glucose, Humans, Hypoglycemic Agents, Insulin, Liver, Mice, Inbred C57BL, Proteins, Recombinant Proteins, Thiazoles, Adipocytes, Intercellular Signaling Peptides and Proteins, Thiazolidinediones, Mice, Adiponectin

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The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

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