The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit
Open accessAbstract
Coupling between bone formation and bone resorption refers to the process within basic multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts from precursors, and their bone-forming activity, which needs to be sufficient to replace the bone lost. There are many sources of activities that contribute to coupling at remodeling sites, including growth factors released from the matrix, soluble and membrane products of osteoclasts and their precursors, signals from osteocytes and from immune cells and signaling taking place within the osteoblast lineage. Coupling is therefore a process that involves the interaction of a wide range of cell types and control mechanisms. As bone remodeling occurs at many sites asynchronously throughout the skeleton, locally generated activities comprise very important control mechanisms. In this review, we explore the potential roles of a number of these factors, including sphingosine-1-phosphate, semaphorins, ephrins, interleukin-6 (IL-6) family cytokines and marrow-derived factors. Their interactions achieve the essential tight control of coupling within individual remodeling units that is required for control of skeletal mass.
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Cites
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Cited by
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
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Coupling of bone resorption and formation by RANKL reverse signalling
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Osteoclasts: more than ‘bone eaters’
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Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Sims, N. A., & Martin, T. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034425 · Cited by 286
Self-citation
Metadata
- Authors
- Sims, N. A., & Martin, T. J.
- Venue
- BoneKEy Reports
- Publisher
- Portico
- Published
- 2014-01-08
- Volume
- 3
- Pages
- 481-481
- ISSN
- 2047-6396 (ISSN-L)
- OpenAlex
- W2005794914
- Cited by
- 709
- References
- 14
- FWCI
- 27.38
- Type
- journal article
- Language
- en
- Open access
- green
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