Fas death receptor signalling: roles of Bid and XIAP

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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

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FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

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Two CD95 (APO‐1/Fas) signaling pathways

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Signalling pathways of the TNF superfamily: a double-edged sword

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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Lethal effect of the anti-Fas antibody in mice

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Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

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IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

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BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

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The inhibitors of apoptosis (IAPs) as cancer targets

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XIAP discriminates between type I and type II FAS-induced apoptosis

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

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MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

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Activation of apoptosis signalling pathways by reactive oxygen species

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

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PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

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Role of Apoptosis in disease

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Mitochondria and cell signalling

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