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Ferroptosis: process and function
Open accessAbstract
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. It can be induced by experimental compounds (e.g., erastin, Ras-selective lethal small molecule 3, and buthionine sulfoximine) or clinical drugs (e.g., sulfasalazine, sorafenib, and artesunate) in cancer cells and certain normal cells (e.g., kidney tubule cells, neurons, fibroblasts, and T cells). Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter is involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism and can be pharmacologically inhibited by iron chelators (e.g., deferoxamine and desferrioxamine mesylate) and lipid peroxidation inhibitors (e.g., ferrostatin, liproxstatin, and zileuton). Glutathione peroxidase 4, heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 (especially acetylation-defective mutant p53) act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. In this review, we summarize the regulation mechanisms and signaling pathways of ferroptosis and discuss the role of ferroptosis in disease.
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“Ferroptosis is a form of RCD initiated by specific perturbations of the intracellular microenvironment, notably severe lipid peroxidation, which relies on ROS generation and iron availability [533–536].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [535]
In the citing paper
“It is morphologically and mechanistically distinct from apoptotic, necroptotic, and autophagic cell death (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Moreover, ferroptosis can be blocked with iron chelators but not with inhibitors of apoptosis and necroptosis (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Ferroptosis is an iron-dependent oxidative form of cell death associated with increased lipid peroxidation (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Ferroptosis is characterized by the accumulation of iron and malondialdehyde (MDA), and peroxidation of lipids; depletion of glutathione (GSH); and alteration in mitochondrial morphology, including decreased number of or diminished mitochondrial cristae and ruptured outer mitochondrial membranes (Dixon et al., 2012;Xie et al., 2016).”
From MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure (2022) · cites this paper as Xie et al., 2016
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1 retracted
Chen, L., Li, X., LIU, L., Yu, B., Xue, Y., & Liu, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.3712 · Cited by 286
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 1,011
Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome
Zheng, Y., Huang, Y., Xu, Y., Sang, L., Liu, X., & Li, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01369-2 · Cited by 80
Kudarha, R. R., Dhas, N. L., & Mutalik, S. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215330 · Cited by 75
Deng, Y., Chu, X., Li, Q., Zhu, G., Hu, J. Y., Sun, J., Zeng, H., Huang, J., & Ge, G. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155458 · Cited by 79
Self-citationNanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities
Hajipour, M. J., Mehrani, M., Abbasi, S. H., Amin, A., Kassaian, S. E., Garbern, J. C., Caracciolo, G., Zanganeh, S., Chitsazan, M., Aghaverdi, H., et al. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00323 · Cited by 77
Zhang, L., Huang, Y., Ling, J., Zhuo, W., Yu, Z., Luo, Y., & Zhu, Y. (2018) · Future Oncology · doi:10.2217/fon-2017-0540 · Cited by 76
Wiczew, D., Szulc, N., & Tarek, M. (2021) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2021.107869 · Cited by 75
Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma
Xiao, R., Wang, S., Guo, J., Liu, S., Ding, A., Wang, G., Li, W., Zhang, Y., Bian, X., Zhao, S., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17171 · Cited by 75
Role of oxidative stress in the pathogenesis of COPD
Nucera, F., MUMBY, S., Paudel, K. R., Dharwal, V., Stefano, A. D., Casolaro, V., HANSBRO, P. M., Adcock, I. M., & Caramori, G. (2022) · Minerva Medica · doi:10.23736/s0026-4806.22.07972-1 · Cited by 75
Ocansey, D. K. W., Yuan, J., Wei, Z., Mao, F., & Zhang, Z. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5256 · Cited by 74
TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
Kim, T. W., Koo, S. Y., Rießland, M., Chaudhry, F. F., Kolisnyk, B., Cho, H., Russo, M. V., Saurat, N. G., Mehta, S., Garippa, R. J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.030 · Cited by 81
Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury
Park, S. J., Cho, S. S., Kim, K. M., Yang, J. H., Kim, J., Jeong, E. H., Yang, J. W., Han, C. Y., Ku, S., Cho, I. J., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114665 · Cited by 75
Gao, X., Guo, N., Xu, H., Pan, T., Lei, H., Yan, A., Mi, Y., & Xu, L. (2019) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000825 · Cited by 76
Functions and Implications of Autophagy in Colon Cancer
Devenport, S. N., & Shah, Y. M. (2019) · Cells · doi:10.3390/cells8111349 · Cited by 76
The circadian clock protects against ferroptosis-induced sterile inflammation
Liu, Y., Wang, Y., Liu, J., Kang, R., & Tang, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.142 · Cited by 74
Self-citationLi, Z., Wu, X., Wang, W., Gai, C., Zhang, W., Li, W., & Ding, D. (2021) · Nanoscale Research Letters · doi:10.1186/s11671-021-03497-z · Cited by 74
Hong, Z., Tang, P., Liu, B., Ran, C., Yuan, C. G., Zhang, Y., Lü, Y., Duan, X., Yang, Y., & Wu, H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57164 · Cited by 74
The role of iron homeostasis and iron-mediated ROS in cancer.
Ying, J., Lu, Z.-B., Fu, L., Tong, Y., Wang, Z., Li, W., & Mou, X. (2021) · PubMed · Cited by 85
Hwang, J., Park, J.-H., Park, B., Kim, H., Kim, J.-J., Sim, W., Mishchenko, N. P., Fedoreyev, S. A., Васильева, Е. А., Ban, K., et al. (2021) · Antioxidants · doi:10.3390/antiox10101624 · Cited by 75
Novel Insights on Lipid Metabolism Alterations in Drug Resistance in Cancer
Yang, R., Yi, M., & Xiang, B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.875318 · Cited by 80
Zhao, S., Huang, M., Yan, L., Zhang, H., Shi, C., Liu, J., Shousong, Z., Liu, H., & Wang, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8287227 · Cited by 74
The Potential Value of Targeting Ferroptosis in Early Brain Injury After Acute CNS Disease
Chen, J., Wang, Y., Wu, J., Yang, J., Li, M., & Chen, Q. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00110 · Cited by 75
Ferroptosis‐inducing agents enhance TRAIL‐induced apoptosis through upregulation of death receptor 5
Lee, Y., Lee, D., Jeong, S. Y., Park, S. H., Oh, S. C., Park, Y. S., Yu, J., Choudry, H. A., Bartlett, D. L., & Lee, Y. J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27456 · Cited by 72
Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella)
Yang, M., Lu, Z., Li, F., Shi, F., Zhan, F., Zhao, L., Li, Y., Li, J., Lin, L., & Qin, Z. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.09.036 · Cited by 72
Hu, M., Zhang, Y., Ma, S., Li, J., Wang, X., Liang, M., Sferruzzi-Perri, A. N., Wu, X., Ma, H., Brännström, M., et al. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab067 · Cited by 77
He, J., Ding, H., Li, H., Pan, Z., & Chen, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.770857 · Cited by 73
Modes of Brain Cell Death Following Intracerebral Hemorrhage
Zhang, Y., Khan, S., Liu, Y., Zhang, R., Li, H., Wu, G., Tang, Z., Xue, M., & Yong, V. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.799753 · Cited by 71
Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics
Huang, J., Zhang, J., Ma, J., Ma, J., Liu, J., Wang, F., & Tang, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9678625 · Cited by 75
Self-citationExposure to low-dose cadmium induces testicular ferroptosis
Xiong, L., Zhou, B., Young, J. L., Wintergerst, K. A., & Cai, L. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113373 · Cited by 73
Li, Y., Wen, Y., Liu, X., Zhuang, L., Lin, B., Deng, C., Yu, Z., Zhu, Y., Zhao, L., Su, W., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02621-9 · Cited by 74
Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis
Yang, W., & Chi, J. (2019) · Molecular & Cellular Oncology · doi:10.1080/23723556.2019.1699375 · Cited by 72
Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy
Li, L., Qiu, C., Hou, M., Wang, X., Huang, C., Zou, J., Liu, T., & Qu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.665945 · Cited by 74
Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer
Chen, J., Qin, C., Zhou, Y., Chen, Y., Mao, M., & Yang, J. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13314 · Cited by 72
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis
Ni, H., Ruan, G., Sun, C., Yang, X., Miao, Z., Li, J., Chen, Y., Qin, H., Liu, Y., Zheng, L., et al. (2022) · Environmental Toxicology · doi:10.1002/tox.23388 · Cited by 72
Fang, J., Kong, B., Shuai, W., Xiao, Z., Dai, C., Qin, T., Gong, Y., Zhu, J., Liu, Q., & Huang, H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174622 · Cited by 72
Zhou, A., Fang, T., Chen, K., Xu, Y., Chen, Z., & Ning, X. (2022) · Small · doi:10.1002/smll.202106568 · Cited by 72
Wu, X., Qin, K., Iroegbu, C. D., Xiang, K., Peng, J., Guo, J., Yang, J., & Fan, C. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17239 · Cited by 72
Liang, N.-N., Zhao, Y., Guo, Y., Zhang, Z., Gao, L., Yu, D., Xu, D., & Xu, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108687 · Cited by 72
Yu, R., Zhou, Y., Shi, S., Wang, X. B., Huang, S., & Yu, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154182 · Cited by 72
Ferroptosis and Tumor Drug Resistance: Current Status and Major Challenges
Nie, Z., Chen, M., Gao, Y., Huang, D., Cao, H., Peng, Y., Guo, N., Wang, F., & Zhang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.879317 · Cited by 83
Wang, Y., Shen, Z., Zhao, S., Huang, D., Wang, X., Wu, Y., Pei, C., Shi, S., Jia, N., He, Y., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113615 · Cited by 72
Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer
Liu, X., Zhang, Y., Wu, X., Xu, F., Ma, H., Wu, M., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.909821 · Cited by 78
A novel view of ferritin in cancer
Pandya, B., & Connor, J. R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188917 · Cited by 72
Qi, Z., Liu, R., Ju, H.-N., Huang, M., Li, Z., Li, W., & Wang, Y. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82287 · Cited by 74
Liao, J., Wei, M.-Z., Wang, J., Zeng, J.-S., Liu, D., Du, Q., Ge, J.-W., & Mei, Z.-G. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.115465 · Cited by 73
Ruan, Y., Zhuang, H., Zeng, X., Lin, L., Wang, X., Xue, P., Xu, S., Chen, Q., Yan, S., & Huang, W. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302537 · Cited by 73
Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS
Li, X., Lin, Y., Cheng, X.-Y., Yao, G., Yao, J., Hu, S., Zhu, Q., Wang, Y., Ding, Y., Lu, Y., et al. (2024) · Human Reproduction Open · doi:10.1093/hropen/hoae013 · Cited by 72
Low tumor glutathione level as a sensitivity marker for glutamate‑cysteine ligase inhibitors
Nishizawa, S., Araki, H., Ishikawa, Y., Kitazawa, S., Hata, A., Soga, T., & Hara, T. (2018) · Oncology Letters · doi:10.3892/ol.2018.8447 · Cited by 70
Li, X., Si, W., Li, Z., Tian, Y., Liu, X., Ye, S., Huang, Z., Ji, Y., Zhao, C., Hao, X., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4894 · Cited by 71
Chen, Z., Tian, H., Yao, D.-M., Zhang, Y., Feng, Z., & Yang, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738477 · Cited by 71
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Yang, J., Xu, J., Zhang, B., Tan, Z., Meng, Q., Hua, J., Liu, J., Wang, W., Shi, S., Yu, X., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010944 · Cited by 69
Zhang, X., Wu, S., Guo, C., Guo, K., Hu, Z., Peng, J., Zhang, Z., & Li, J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03483-y · Cited by 71
Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells
Liu, K., Huang, J. X., Liu, J., Klionsky, D. J., Kang, R., & Tang, D. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04974-8 · Cited by 72
Self-citationFerroptosis: A Potential Therapeutic Target in Acute Kidney Injury
Hosohata, K., Harnsirikarn, T., & Chokesuwattanaskul, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126583 · Cited by 73
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Huo, C., Li, G., Hu, Y., & Sun, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214195 · Cited by 76
Chen, Y., Xu, W., Liu, Y., Zhang, J., Yang, Y., Wang, Z.-W., Sun, D., Li, H., Liu, B., & Chen, L.-X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82120 · Cited by 72
Role of mitochondria in the regulation of ferroptosis and disease
Fu, C., Cao, N., Zeng, S., Zhu, W., Fu, X., Liu, W., & Fan, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1301822 · Cited by 71
Zhao, X., Wang, Z., Wang, L., Jiang, T., Dong, D., & Sun, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107466 · Cited by 76
Zhao, H., Li, X., Yang, L., Zhang, L., Jiang, X., Gao, W., Chen, P., Cheng, Y., Wang, F., & Liu, J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03320-2 · Cited by 69
Sui, M., Xu, D., Zhao, W., Lu, H., Chen, R., Duan, Y., Li, Y., Zhu, Y., Zhang, L., & Zeng, L. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16567 · Cited by 70
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Cheng, L., He, Q., Liu, B., Chen, L., Lv, F., Li, X., Li, Y., Liu, C., Song, Y., & Xing, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05614-5 · Cited by 70
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Self-citationFerroptosis triggers mitochondrial fragmentation via Drp1 activation
Pedrera, L., Clemente, L. P., Dahlhaus, A., Nasudivar, S. L., Tishina, S., González, D. O., Stroh, J., Yapici, F. I., Singh, R. P., Grotehans, N., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-024-07312-2 · Cited by 75
Wei, Y. Y., Chen, T. T., Zhang, D. W., Zhang, Y., Li, F., Ding, Y., Wang, M. Y., Zhang, L., Chen, K. G., & Fei, G. (2025) · Autophagy · doi:10.1080/15548627.2025.2481126 · Cited by 77
Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells
Taylor, W. R., Fedorka, S. R., Gad, I., Shah, R. V., Alqahtani, H. D., Koranne, R., Kuganesan, N., Dlamini, S., Rogers, T., Al-Hamashi, A. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42251-5 · Cited by 71
Arshad, H. M., Alfonso, J. C. L., Franke, R., Michaelis, K., Araujo, L., Habib, A., Zboromyrska, Y., Lücke, E., Strungaru, E., Akmatov, M. K., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2112-z · Cited by 69
Guo, L., Zhang, T., Wang, F., Chen, X., Xu, H., Zhou, C., Chen, M., Yu, F., Wang, S., Yang, D., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15283 · Cited by 67
Chen, C., Huang, Y., Xia, P., Zhang, F., Li, L., Wang, E., Guo, Q., & Ye, Z. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3224 · Cited by 70
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Shimizu, J., Murao, A., Nofi, C. P., Wang, P., & Aziz, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903859 · Cited by 70
Kim, K.-S., Choi, B., Choi, H., Ko, M. J., Kim, D., & Kim, D. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01635-y · Cited by 69
Kim, J. W., Kim, M.-J., Han, T.-H., Lee, J.-Y., Kim, S., Kim, H., Oh, K., Kim, W. K., Han, B., Bae, K., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06070-x · Cited by 76
Sang, M., Luo, R., Bai, Y., Dou, J., Zhang, Z., Liu, F., Feng, F., & Liu, W. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b12469 · Cited by 69
Jiang, T., Chu, J., Chen, H., Cheng, H., Su, J., Wang, X., Cao, Y., Tian, S., & Li, Q. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00824 · Cited by 70
Hong, Y., Lin, M., Ou, D., Huang, Z., & Shen, P. (2021) · BMC Cancer · doi:10.1186/s12885-021-08559-0 · Cited by 68
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Liu, Y., Yang, X., Liu, Y., Jiang, T., Ren, S., Chen, J., Xiong, H., Yuan, M., Li, W., Machens, H., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16597 · Cited by 71
Jin, F., Liu, D., Xu, X., Ji, J., & Du, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s314506 · Cited by 71
Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?
Pasini, A. M. F., Stranieri, C., Girelli, D., Busti, F., & Cominacini, L. (2021) · Antioxidants · doi:10.3390/antiox10111677 · Cited by 72
Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 69
Ferroptosis: a promising target for cancer immunotherapy.
Sun, L.-L., Linghu, D.-L., & Hung, M. (2021) · PubMed · Cited by 74
Xiong, G., Huang, D., Lu, L., Luo, X., Wang, Y., Liu, S., Chen, M., Yu, S., Kappen, M., You, C., et al. (2022) · Small Methods · doi:10.1002/smtd.202200379 · Cited by 68
Self-citationATF3 promotes ferroptosis in sorafenib-induced cardiotoxicity by suppressing Slc7a11 expression
Li, Y., Yan, J., Zhao, Q., Zhang, Y., & Zhang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.904314 · Cited by 69
Fu, H., Zhu, L., Mao, L., Zhang, L. H., Zhang, Y., Chang, Y., Liu, X., & Jiang, H. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.161795 · Cited by 68
He, R., Wei, Y., Peng, Z., Yang, J., Zhou, Z., Li, A., Wu, Y., Wang, M., Li, X., Zhao, D., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00605-6 · Cited by 68
Haemin-induced cell death in human monocytic cells is consistent with ferroptosis
Imoto, S., Kono, M., Suzuki, T., Shibuya, Y., Sawamura, T., Mizokoshi, Y., Sawada, H., Ohbuchi, A., & Saigo, K. (2018) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2018.05.028 · Cited by 68
Cell death pathologies: targeting death pathways and the immune system for cancer therapy
Pentimalli, F., Grelli, S., Daniele, N. D., Melino, G., & Amelio, I. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0052-x · Cited by 69
Yang, M., & Lai, C. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00369-w · Cited by 67
Hu, X., Xu, Y. M., Xu, H., Jin, C., Zhang, H., Su, H., Li, Y., Zhou, K., & Ni, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705786 · Cited by 67
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Stančić, A., Saksida, T., Markelic, M. B., Vučetić, M., Grigorov, I., Martinović, V., Gajić, D., Ivanovic, A., Veličković, K., Savic, N., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3873420 · Cited by 69
Jiang, H., Zhang, X., Yang, W.-P., Li, M., Wang, G., & Luo, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869794 · Cited by 67
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Han, X., Zhang, J., Liu, J., Wang, H., Du, F., Zeng, X., & Guo, C. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01785-2 · Cited by 70
Mohan, S., Alhazmi, H. A., Hassani, R., Khuwaja, G., Maheshkumar, V. P., Aldahish, A. A., & Chidambaram, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24786 · Cited by 70
Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches
Cai, K., Jiang, H., Zou, Y., Song, C., Cao, K., Chen, S., Wu, Y., Zhang, Z., Geng, D., Zhang, N., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107281 · Cited by 71
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Xu, H., Wan, S., An, Y., Wu, Q., Xing, Y.-H., Deng, C.-H., Zhang, P., Long, Y., Xu, B.-T., & Jiang, Z. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02168-z · Cited by 72
Chen, J., Yan, L., Zhang, Y., Liu, X., Wei, Y., Zhao, Y., Li, K., Shi, Y., Liu, H., Lai, W., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02911-9 · Cited by 75
Sagasser, J., Ma, B. N., Baecker, D., Salcher, S., Hermann, M., Lamprecht, J., Angerer, S., Obexer, P., Kircher, B., & Gust, R. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00814 · Cited by 68
Non-Apoptotic Cell Death Signaling Pathways in Melanoma
Hartman, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082980 · Cited by 66
Xiong, H., Wang, C., Wang, Z., Lu, H., & Yao, J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.007 · Cited by 66
Zhang, K., Ma, Z., Li, S., Wu, Y., Zhang, J. C., Zhang, W., Zhao, Y., & Han, H. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121502 · Cited by 66
Metadata
- Authors
- Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D.
- Affiliations
- Central South University (CN)
- University of Pittsburgh (US)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Corresponding author
- Kang, R
- Tang, D
- Venue
- Cell Death & Differentiation
- Published
- 2016-01-22
- Volume
- 23
- Issue
- 3
- Pages
- 369-379
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC5072448
- OpenAlex
- W2265062179
- Cited by
- 3,727
- References
- 47
- Citations by year
- 2026: 295 · 2025: 482 · 2024: 644 · 2023: 618 · 2022: 588 · 2021: 470 · 2020: 284 · 2019: 157 · 2018: 94 · 2017: 60 · 2016: 30
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Natural Science Foundation of China (201508020258, R01GM115366, 201400000003, R01CA160417, 31171229, U1132005)
- National Institutes of Health
- National Cancer Institute (R01CA160417)
- National Institute of General Medical Sciences (R01GM115366)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ferroptosis, regulated cell death, lipid peroxidation, reactive oxygen species, iron metabolism, GPX4, NADPH oxidase, p53, NF-E2-related factor 2, mitochondrial membrane damage, mitochondrial voltage-dependent anion channel, endoplasmic reticulum stress, iron chelators, ferroptosis inhibitors, cancer cell death, neurodegenerative diseases, drug-induced liver injury, ischemia-reperfusion injury, T cell immunity
- MeSH terms
- Animals, Humans, Iron, Iron Chelating Agents, Mitochondria, Lipid Peroxidation, Signal Transduction, Cell Death, Reactive Oxygen Species, Oxidative Stress, Endoplasmic Reticulum Stress
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