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Ferroptosis: process and function
Open accessAbstract
Ferroptosis is a recently recognized form of regulated cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. It can be induced by experimental compounds (e.g., erastin, Ras-selective lethal small molecule 3, and buthionine sulfoximine) or clinical drugs (e.g., sulfasalazine, sorafenib, and artesunate) in cancer cells and certain normal cells (e.g., kidney tubule cells, neurons, fibroblasts, and T cells). Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter is involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism and can be pharmacologically inhibited by iron chelators (e.g., deferoxamine and desferrioxamine mesylate) and lipid peroxidation inhibitors (e.g., ferrostatin, liproxstatin, and zileuton). Glutathione peroxidase 4, heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 (especially acetylation-defective mutant p53) act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. In this review, we summarize the regulation mechanisms and signaling pathways of ferroptosis and discuss the role of ferroptosis in disease.
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“Moreover, ferroptosis can be blocked with iron chelators but not with inhibitors of apoptosis and necroptosis (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Ferroptosis is a form of RCD initiated by specific perturbations of the intracellular microenvironment, notably severe lipid peroxidation, which relies on ROS generation and iron availability [533–536].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [535]
In the citing paper
“It is morphologically and mechanistically distinct from apoptotic, necroptotic, and autophagic cell death (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Ferroptosis is an iron-dependent oxidative form of cell death associated with increased lipid peroxidation (Xie et al., 2016).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Xie et al., 2016
In the citing paper
“Ferroptosis is characterized by the accumulation of iron and malondialdehyde (MDA), and peroxidation of lipids; depletion of glutathione (GSH); and alteration in mitochondrial morphology, including decreased number of or diminished mitochondrial cristae and ruptured outer mitochondrial membranes (Dixon et al., 2012;Xie et al., 2016).”
From MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure (2022) · cites this paper as Xie et al., 2016
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1 retracted
Chen, L., Li, X., LIU, L., Yu, B., Xue, Y., & Liu, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.3712 · Cited by 286
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Ferroptosis as a p53-mediated activity during tumour suppression
Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069
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Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Self-citationGalluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
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Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171
Mittler, R. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2016.08.002 · Cited by 3,499
Broadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 3,012
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationThe molecular machinery of regulated cell death
Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,675
Self-citationAutophagy promotes ferroptosis by degradation of ferritin
Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2016) · Autophagy · doi:10.1080/15548627.2016.1187366 · Cited by 2,332
Self-citationFerroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Self-citationFerroptosis, a new form of cell death: opportunities and challenges in cancer
Mou, Y., Wang, J., Wu, J., He, D., Zhang, C., Duan, C., & Li, B. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0720-y · Cited by 1,964
Recent Progress in Ferroptosis Inducers for Cancer Therapy
Liang, C., Zhang, X., Yang, M., & Dong, X. (2019) · Advanced Materials · doi:10.1002/adma.201904197 · Cited by 1,578
Copper homeostasis and cuproptosis in health and disease
Chen, L., Min, J., & Wang, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01229-y · Cited by 1,588
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Kraft, V. A. N., Bezjian, C. T., Pfeiffer, S., Ringelstetter, L., Müller, C., Zandkarimi, F., Merl‐Pham, J., Bao, X., Anastasov, N., Kössl, J., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b01063 · Cited by 1,367
ROS homeostasis and metabolism: a dangerous liason in cancer cells
Panieri, E., & Santoro, M. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.105 · Cited by 1,187
Energy-stress-mediated AMPK activation inhibits ferroptosis
Lee, H., Zandkarimi, F., Zhang, Y., Meena, J. K., Kim, J., Zhuang, L., Tyagi, S., Ma, L., Westbrook, T. F., Steinberg, G. R., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0461-8 · Cited by 1,157
Identification of ACSL4 as a biomarker and contributor of ferroptosis
Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071
Self-citationFerroptosis is a type of autophagy-dependent cell death
Zhou, B., Liu, J., Kang, R., Klionsky, D. J., Kroemer, G., & Tang, D. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.03.002 · Cited by 1,094
Self-citationZilka, O., Shah, R., Li, B., Angeli, J. P. F., Grießer, M., Conrad, M., & Pratt, D. A. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00028 · Cited by 1,084
The development of the concept of ferroptosis
Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052
BAP1 links metabolic regulation of ferroptosis to tumour suppression
Zhang, Y., Shi, J., Liu, X., Li, F., Gong, Z., Koppula, P., Sirohi, K., Li, X., Wei, Y., Lee, H., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0178-0 · Cited by 1,043
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Chen, X., Yu, C., Kang, R., & Tang, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590226 · Cited by 1,001
Self-citationThe Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.055 · Cited by 952
Self-citationPark, E., & Chung, S. W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2064-5 · Cited by 902
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Yang, L., Feng, D., Wang, Z., Zhao, Y., Sun, R., Tian, D., Liu, D., Zhang, F., Ning, S., Yao, J., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0299-4 · Cited by 875
Hambright, W. S., Fonseca, R. S., Chen, L., Na, R., & Ran, Q. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.021 · Cited by 851
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Guo, J., Xu, B.-F., Han, Q., Zhou, H., Xia, Y. F., Gong, C., Dai, X., Li, Z., & Wu, G. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2016.572 · Cited by 796
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Yu, Y., Yan, Y., Niu, F., Wang, Y., Chen, X., Su, G., Liu, Y., Zhao, X., Lü, Q., Liu, P., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00579-w · Cited by 808
Self-citationLoss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
Fang, X., Cai, Z., Wang, H., Han, D., Cheng, Q., Zhang, P., Gao, F., Yu, Y., Song, Z., Wu, Q., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316509 · Cited by 779
Self-citationAMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
Song, X., Zhu, S., Chen, P., Hou, W., Wen, Q., Liu, J., Xie, Y., Liu, J., Klionsky, D. J., Kroemer, G., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.094 · Cited by 757
Self-citationEmerging Strategies of Cancer Therapy Based on Ferroptosis
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Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
Yu, H., Guo, P., Xie, X., Wang, Y., & Chen, G. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13008 · Cited by 720
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Metallothionein‐1G facilitates sorafenib resistance through inhibition of ferroptosis
Sun, X., Niu, X., Chen, R., He, W., Chen, D., Kang, R., & Tang, D. (2016) · Hepatology · doi:10.1002/hep.28574 · Cited by 709
Self-citationThe tumor suppressor protein p53 and the ferroptosis network
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Self-citationEngineering nanomedicine for glutathione depletion-augmented cancer therapy
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Self-citationThe release and activity of HMGB1 in ferroptosis
Wen, Q., Liu, J., Kang, R., Zhou, B., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.090 · Cited by 683
Self-citationThe multifaceted role of ferroptosis in liver disease
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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
Zhou, B., Zhang, J.-Y., Liu, X.-S., Chen, H., Ai, Y.-L., Cheng, K., Sun, R.-Y., Zhou, D., Han, J., & Wu, Q. (2018) · Cell Research · doi:10.1038/s41422-018-0090-y · Cited by 676
Roh, J.-L., Kim, E. H., Jang, H., & Shin, D. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.010 · Cited by 662
Ferroptosis as a novel therapeutic target for cardiovascular disease
Wu, X., Li, Y., Zhang, S., & Zhou, X. (2021) · Theranostics · doi:10.7150/thno.54113 · Cited by 655
Mitochondria regulation in ferroptosis
Wang, H., Liu, C., Zhao, Y., & Gao, G. (2019) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 659
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Wang, Y., Qi, H., Liu, Y., Duan, C., Liu, X., Xia, T., Chen, D., Piao, H., & Liu, H. (2021) · Theranostics · doi:10.7150/thno.56747 · Cited by 657
GPX4 in cell death, autophagy, and disease
Xie, Y., Kang, R., Klionsky, D. J., & Tang, D. (2023) · Autophagy · doi:10.1080/15548627.2023.2218764 · Cited by 682
Self-citationCellular degradation systems in ferroptosis
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Self-citationDai, E., Han, L., Liu, J., Xie, Y., Kroemer, G., Klionsky, D. J., Zeh, H. J., Kang, R., Wang, J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1714209 · Cited by 613
Self-citationVascular smooth muscle cell death, autophagy and senescence in atherosclerosis
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Wang, Y., Quan, F., Cao, Q., Lin, Y., Yue, C., Bi, R., Cui, X., Yang, H., Yang, Y., Birnbaumer, L., et al. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.07.007 · Cited by 604
Cui, Y., Zhang, Y., Zhao, X., Shao, L., Liu, G., Sun, C., Xu, R., & Zhang, Z. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.003 · Cited by 605
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Zhu, S., Zhang, Q., Sun, X., Zeh, H. J., Lotze, M. T., Kang, R., & Tang, D. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1979 · Cited by 576
Self-citationBasit, F., van Oppen, L. M. P. E., Schöckel, L., Bossenbroek, H. M., Vries, S. E. V. E., Hermeling, J. C., Grefte, S., Kopitz, C., Héroult, M., Willems, P. H. G. M., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.133 · Cited by 574
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Self-citationNrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
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Bai, Y., Meng, L., Han, L., Jia, Y., Zhao, Y., Gao, H., Kang, R., Wang, X., Tang, D., & Dai, E. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.039 · Cited by 519
Self-citationOuyang, S., Li, H., Lou, L., Huang, Q., Zhang, Z., Mo, J., Li, M., Lu, J., Zhu, K., Chu, Y., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102317 · Cited by 517
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Self-citationReactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
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Liu, T., Jiang, L., Tavana, O., & Gu, W. J. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3037 · Cited by 498
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Yang, M., Chen, P., Liu, J., Zhu, S., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2019) · Science Advances · doi:10.1126/sciadv.aaw2238 · Cited by 500
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Du, J., Wang, T., Li, Y., Zhou, Y., Wang, X., Yu, X., Ren, X., An, Y., Wu, Y., Sun, W., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.011 · Cited by 487
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Zhang, Z., Yao, Z., Wang, L., Ding, H., Shao, J., Chen, A., Zhang, F., & Zheng, S. (2018) · Autophagy · doi:10.1080/15548627.2018.1503146 · Cited by 476
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Weiland, A., Wang, Y., Wu, W., Lan, X., Han, X., Li, Q., & Wang, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1403-3 · Cited by 473
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Zhao, Y., Li, Y., Zhang, R., Wang, F., Wang, T., & Jiao, Y. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s254995 · Cited by 468
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Anandhan, A., Dodson, M. B., Schmidlin, C. J., Liu, P., & Zhang, D. D. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.011 · Cited by 442
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Tong, L., Yu, H., Huang, X., Shen, J., Xiao, G., Chen, L., Wang, H., Xing, L., & Chen, D. (2022) · Bone Research · doi:10.1038/s41413-022-00226-9 · Cited by 437
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021) · Autophagy · doi:10.1080/15548627.2021.1911016 · Cited by 439
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
Wang, Y., Zhang, M., Bi, R., Su, Y., Quan, F., Lin, Y., Yue, C., Cui, X., Zhao, Q., Liu, S., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102262 · Cited by 444
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Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 474
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Dai, E., Han, L., Liu, J., Xie, Y., Zeh, H. J., Kang, R., Bai, L., & Tang, D. (2020) · Nature Communications · doi:10.1038/s41467-020-20154-8 · Cited by 440
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Xu, M., Tao, J., Yang, Y., Tan, S., Liu, H., Jiang, J., Zheng, F., & Wu, B. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2299-1 · Cited by 433
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Tian, Y., Lü, J., Hao, X., Li, H., Zhang, G., Liu, X., Li, X., Zhao, C., Kuang, W., Chen, D., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00929-z · Cited by 436
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio‐Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 431
Dong, H., Qiang, Z., Chai, D., Peng, J., Xia, Y., Hu, R., & Jiang, H. (2020) · Aging · doi:10.18632/aging.103378 · Cited by 425
Necroptosis: a crucial pathogenic mediator of human disease
Choi, M. E., Price, D. R., Ryter, S. W., & Choi, A. M. K. (2019) · JCI Insight · doi:10.1172/jci.insight.128834 · Cited by 428
Metadata
- Authors
- Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D.
- Affiliations
- Central South University (CN)
- University of Pittsburgh (US)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Corresponding author
- Kang, R
- Tang, D
- Venue
- Cell Death & Differentiation
- Published
- 2016-01-22
- Volume
- 23
- Issue
- 3
- Pages
- 369-379
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC5072448
- OpenAlex
- W2265062179
- Cited by
- 3,727
- References
- 47
- Citations by year
- 2026: 295 · 2025: 482 · 2024: 644 · 2023: 618 · 2022: 588 · 2021: 470 · 2020: 284 · 2019: 157 · 2018: 94 · 2017: 60 · 2016: 30
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Natural Science Foundation of China (201508020258, R01GM115366, 201400000003, R01CA160417, 31171229, U1132005)
- National Institutes of Health
- National Cancer Institute (R01CA160417)
- National Institute of General Medical Sciences (R01GM115366)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ferroptosis, regulated cell death, lipid peroxidation, reactive oxygen species, iron metabolism, GPX4, NADPH oxidase, p53, NF-E2-related factor 2, mitochondrial membrane damage, mitochondrial voltage-dependent anion channel, endoplasmic reticulum stress, iron chelators, ferroptosis inhibitors, cancer cell death, neurodegenerative diseases, drug-induced liver injury, ischemia-reperfusion injury, T cell immunity
- MeSH terms
- Animals, Humans, Iron, Iron Chelating Agents, Mitochondria, Lipid Peroxidation, Signal Transduction, Cell Death, Reactive Oxygen Species, Oxidative Stress, Endoplasmic Reticulum Stress
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