BCL-2 family proteins: changing partners in the dance towards death

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Souers, A. J., Leverson, J. D., Boghaert, E. R., Ackler, S. L., Catron, N. D., Chen, J., Dayton, B. D., Ding, H., Enschede, S. H., Fairbrother, W. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3048 · Cited by 3,058

Caspase Functions in Cell Death and DiseasePreprint

McIlwain, D. R., Berger, T., & Mak, T. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008656 · Cited by 2,702

Mitochondria and cell death: outer membrane permeabilization and beyond

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ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

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Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

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Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

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Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

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BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis

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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells

Uzhytchak, M., Lunová, M., Smolková, B., Jirsa, M., Dejneka, A., & Lunov, O. (2023) · Nanoscale Advances · doi:10.1039/d3na00071k · Cited by 16

ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis

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αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis

Guo, X., He, L., Xu, W., Wang, W., Feng, X., Fu, Y., Zhang, X., Ding, R., Qi, X., Bao, J., et al. (2024) · Marine Drugs · doi:10.3390/md22060252 · Cited by 15

Future Treatment Strategies for Cancer Patients Combining Targeted Alpha Therapy with Pillars of Cancer Treatment: External Beam Radiation Therapy, Checkpoint Inhibition Immunotherapy, Cytostatic Chemotherapy, and Brachytherapy

Winter, R., Amghar, M., Wacker, A. S., Bakos, G., Taş, H., Roscher, M., Kelly, J. M., & Benešová, M. (2024) · Pharmaceuticals · doi:10.3390/ph17081031 · Cited by 16

The Effect of Pomegranate Peel Extract on the Oxidative and Inflammatory Status in the Spleens of Rats with Metabolic Syndrome

Rak-Pasikowska, A., Hałucha, K., Kamińska, M., Niewiadomska, J., Noszczyk-Nowak, A., & Bil‐Lula, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212253 · Cited by 15

Autophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis

Lamsira, H. K., Sabatini, A., Ciolfi, S., Ciccosanti, F., Sacchi, A., Piacentini, M., & Nardacci, R. (2025) · Cells · doi:10.3390/cells14050351 · Cited by 17

Anticancer potential of Ferula hezarlalehzarica Y. Ajani fraction in Raji lymphoma cell line: induction of apoptosis, cell cycle arrest, and changes in mitochondrial membrane potential

Asemani, Y., Azadmehr, A., Hajiaghaee, R., & Amirghofran, Z. (2018) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-018-0219-z · Cited by 15

Effect of IL‑7 on Th17 cell responses in a mouse model of neutrophilic asthma

Zhang, X., Zhang, M., Jiang, M., & Nong, G. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11191 · Cited by 15

Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR‐1227‐5p

Yang, L., Wang, X., Jiao, X., Tian, B., Zhang, M., Zhou, C., Wang, R., Chen, H., Wang, B., Li, J., et al. (2020) · Cancer Science · doi:10.1111/cas.14627 · Cited by 15

Profilin 1 and Mitochondria—Partners in the Pathogenesis of Coronary Artery Disease?

Paszek, E., Zajdel, W., Rajs, T., Zmudka, K. F., Legutko, J., & Kleczyński, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031100 · Cited by 15

Selective BCL-X L Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs

Ren, Y., Huang, S.-H., Macedo, A. B., Ward, A. R., Alberto, W. D. C., Klevorn, T., Leyre, L., Copertino, D. C., Mota, T. M., Chan, D., et al. (2021) · Journal of Virology · doi:10.1128/jvi.02425-20 · Cited by 15

Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression

Yu, W. S., Kwon, S., Agadagba, S. K., Chan, L.-L.-H., Wong, K.-H., & Lim, L. W. (2021) · Cells · doi:10.3390/cells10092492 · Cited by 16

Cardioprotective Effects of Glucagon-like Peptide-1 (9-36) Against Oxidative Injury in H9c2 Cardiomyoblasts: Potential Role of the PI3K/Akt/NOS Pathway

Nuamnaichati, N., Parichatikanond, W., & Mangmool, S. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001159 · Cited by 15

Phytochemical identification, acute and subchronic oral toxicity assessments of hydroalcoholic extract of Acroptilon repens in BALB/c mice: A toxicological and mechanistic study

Dashti, A., Shokrzadeh, M., Karami, M. Y., & Habibi, E. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08940 · Cited by 15

Advancing the standard: venetoclax combined with intensive induction and consolidation therapy for acute myeloid leukemia

Lachowiez, C. A., Atluri, H., & Dinardo, C. D. (2022) · Therapeutic Advances in Hematology · doi:10.1177/20406207221093964 · Cited by 15

Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells

Vilková, M., Michalková, R., Kello, M., Sabolová, D., Takáč, P., Kudlicková, Z., Garberová, M., Tvrdoňová, M., Béreš, T., & Mojžíš, J. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02911-0 · Cited by 15

BCL2 G quadruplex-binding small molecules: current status and prospects for the development of next-generation anticancer therapeutics.

Singh, M., Gupta, R., Comez, L., Paciaroni, A., Rani, R., & Kumar, V. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.06.002 · Cited by 13

The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas

Gatti, V., Bernassola, F., Talora, C., Melino, G., & Peschiaroli, A. (2020) · Cancers · doi:10.3390/cancers12061595 · Cited by 15

EcTI impairs survival and proliferation pathways in triple-negative breast cancer by modulating cell-glycosaminoglycans and inflammatory cytokines

Lobo, Y. A., Bonazza, C., Batista, F. P., Castro, R. A., Bonturi, C. R., Salu, B. R., Sinigaglia‐Coimbra, R., Toma, L., Vicente, C. M., Pidde, G., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.08.017 · Cited by 15

Fungal cell death: The beginning of the end

Rico-Ramírez, A. M., Gonçalves, A. P., & Glass, N. L. (2022) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2022.103671 · Cited by 16

Mitochondrial bioenergetics and networks in melanoma: an update

Giannitti, G., Paganoni, A. J. J., Marchesi, S., Garavaglia, R., & Fontana, F. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02155-4 · Cited by 15

From Discovery to Diagnosis: A Perspective for Circulating Tumor Cells in Personalized Oncology

Alix‐Panabières, C., & Pantel, K. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0164 · Cited by 18

Medical findings of nasopharyngeal carcinoma patients and anti-tumor benefits of formononetin

Ying, K., Liu, Y., Zhang, C., & Shangguan, M. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172619 · Cited by 14

Anti‐cancer effect of astrakurkurol from a folklore tribal mushroom on human hepatocellular carcinoma cells via mediating cell cycle inhibition, apoptosis, and migration

Nandi, S., Adhikary, A., & Acharya, K. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.14021 · Cited by 14

Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently

Kim, S., Park, H.-S., & Oh, B. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.06.021 · Cited by 15

Bok: real killer or bystander with non-apoptotic roles?

Bonzerato, C. G., & Wojcikiewicz, R. J. H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1161910 · Cited by 14

The effects of non-functionalized polystyrene nanoparticles of different diameters on the induction of apoptosis and mTOR level in human peripheral blood mononuclear cells

Malinowska, K., Sicińska, P., Michałowicz, J., & Bukowska, B. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139137 · Cited by 16

Bcl-2 dependent modulation of Hippo pathway in cancer cells

D’Aguanno, S., Brignone, M., Scalera, S., Chiacchiarini, M., Martile, M. D., Valentini, E., Nicola, F. D., Ricci, A., Pelle, F., Botti, C., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01647-1 · Cited by 14

PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives

Vicente, A. T. S., & Salvador, J. A. R. (2024) · MedComm · doi:10.1002/mco2.575 · Cited by 14

Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1

Lucas, S. C. C., Milbradt, A. G., Blackwell, J. H., Bonomo, S., Brierley, A., Cassar, D. J., Freeman, J., Hadfield, T. E., Morrill, L. A., Riemens, R., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00781 · Cited by 15

Molecular mechanisms of Sepsis attacking the immune system and solid organs

Yang, Z., Gao, Y., Zhao, L., Lv, X., & Du, Y. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1429370 · Cited by 14

Treatment of neurological pathology and inflammation in Machado–Joseph disease through in vivo self-assembled siRNA

Li, Z., Du, X., Yang, Y., Li, Z., Chen, P., Kan, Y., Pan, J., Lin, L., Liu, D. X., Jiang, X., et al. (2024) · Brain · doi:10.1093/brain/awae304 · Cited by 14

CISD2 counteracts the inhibition of ER-mitochondrial calcium transfer by anti-apoptotic BCL-2

Loncke, J., de Ridder, I., Kale, J., Wagner, L. E., Kaasik, A., Parys, J. B., Kerkhofs, M., Andrews, D. W., Yule, D. I., Vervliet, T., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119857 · Cited by 14

Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions

Belenichev, I. F., Popazova, O., Bukhtiyarova, N. V., Ryzhenko, V. P., Pavlov, S. V., Suprun, E. V., Oksenych, V., & Kamyshnyi, O. (2025) · Antioxidants · doi:10.3390/antiox14010108 · Cited by 25

Fundamental mechanisms of cell death for polycystic ovary syndrome

Li, Y., Peng, Y., Yang, Y., Xu, N., Shi, T., Liu, R., Luan, Y., & Yin, C.-H. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102043 · Cited by 14

Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway

Qi, Q., Xue, Y., Lv, J., Sun, D., Du, J., Cai, S., Li, Y., Gu, T., & Wang, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.8177 · Cited by 14

Nonantioxidant Tetramethoxystilbene Abrogates α-Synuclein-Induced Yeast Cell Death but Not That Triggered by the Bax or βA4 Peptide

Derf, A., Mudududdla, R., Akintade, D. D., Williams, I. S., Abdullaha, M., Chaudhuri, B., & Bharate, S. B. (2018) · ACS Omega · doi:10.1021/acsomega.8b01154 · Cited by 14

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Disrupts Control of Cell Proliferation and Apoptosis in a Human Model of Adult Liver Progenitors

Svobodová, J., Procházková, J., Kabátková, M., Krkoška, M., Šmerdová, L., Líbalová, H., Topinka, J., Kléma, J., Kozubı́k, A., Machala, M., et al. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz202 · Cited by 14

Quantifying the insertion of membrane proteins into lipid bilayer nanodiscs using a fusion protein strategy

Häusler, E., Fredriksson, K., Goba, I., Peters, C., Raltchev, K., Sperl, L. E., Steiner, A., Weinkauf, S., & Hagn, F. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183190 · Cited by 14

A pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF ‐7 breast cancer cells

Anaya‐Eugenio, G. D., Carcache, P. J. B., Ninh, T. N., Ren, Y., Soejarto, D. D., & Kinghorn, A. D. (2020) · Phytotherapy Research · doi:10.1002/ptr.6930 · Cited by 14

Pyrazole (1, 2-diazole) induce apoptosis in lymphoma cells by targeting BCL-2 and BCL-XL genes and mitigate murine solid tumour development by regulating cyclin-D1 and Ki-67 expression

Vishnu, W. K., Abeesh, P., & Guruvayoorappan, C. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115491 · Cited by 14

Anti-cancer therapy with cyclin-dependent kinase inhibitors: impact and challenges

Reinius, M., & Smyth, E. C. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.3 · Cited by 14

Transcript-Level Dysregulation of BCL2 Family Genes in Acute Myeloblastic Leukemia

Handschuh, L., Wojciechowski, P., Kaźmierczak, M., & Lewandowski, K. (2021) · Cancers · doi:10.3390/cancers13133175 · Cited by 14

Smad4 mediates Bmf involvement in sheep granulosa cell apoptosis

Li, M., Liang, W., Zhu, C., & Qin, S. (2022) · Gene · doi:10.1016/j.gene.2022.146231 · Cited by 15

Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters

Krivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Miazina, A. V., Krivokolysko, S. G., Vasilin, V. K., Pankov, A. A., Aksenov, N. A., & Aksenova, I. V. (2021) · Russian Journal of General Chemistry · doi:10.1134/s1070363221120306 · Cited by 14

Hispidin in the Medicinal Fungus Protects Dopaminergic Neurons from JNK Activation-Regulated Mitochondrial-Dependent Apoptosis in an MPP+-Induced In Vitro Model of Parkinson’s Disease

Lai, M.-C., Liu, W.-Y., Liou, S., & Liu, I.-M. (2023) · Nutrients · doi:10.3390/nu15030549 · Cited by 14

Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation

Ma, L., Hu, S., He, X., Yang, N., Chen, L., Yang, C., Ye, F., Wei, T., & Li, M. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02223 · Cited by 14

Botrytis cinerea methyl isocitrate lyase mediates oxidative stress tolerance and programmed cell death by modulating cellular succinate levels

Oren‐Young, L., Llorens, E., Bi, K. S., Zhang, M., & Sharon, A. (2020) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2020.103484 · Cited by 13

LRH-1 (liver receptor homolog-1) derived affinity peptide ligand to inhibit interactions between β-catenin and LRH-1 in pancreatic cancer cells: from computational design to experimental validation

Pouraghajan, K., Mahdiuni, H., Ghobadi, S., & Khodarahmi‬, R. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1845241 · Cited by 14

Differential toxicity of abrin in human cell lines of different organ origin

Saxena, N., Phatak, P., & Chauhan, V. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105250 · Cited by 14

Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells

Jin, Y., Zhou, Q., Geng, J., Meng, Q., Wei, Z., Ding, M., Zhou, J., Zeng, Y., Cao, W., Liu, F., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.792360 · Cited by 14

A naringin-derived bioink enhances the shape fidelity of 3D bioprinting and efficiency of cartilage defect repair

Huang, Y., Meng, X., Zhou, Z. Y., Zhu, W., Chen, X., He, Y., He, N., Han, X., Zhou, D., Duan, X., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01247b · Cited by 14

Rapid Imaging of BCL-2 Family Interactions in Live Cells Using FLIM-FRET

Osterlund, E. J., Hirmiz, N., Tardif, C., & Andrews, D. W. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8861-7_19 · Cited by 14

Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis

Liu, Z.-F., Liu, Y., Kang, X., Li, L., & Xiang, Y.-C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020198 · Cited by 14

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury

He, Y., Yang, X., Zhang, C., Deng, M., Tu, B., Liu, Q., Cai, J., Zhang, Y., Li, S., Yang, Z., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.04.009 · Cited by 14

Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and Therapeutic Implications

Tang, M., Outissint, I., Chen, Y., & Gong, X. (2025) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70056 · Cited by 15

Effects of Cardiolipin on the Conformational Dynamics of Membrane-Anchored Bcl-xL

Tyagi, V., Vasquez‐Montes, V., Freites, J. A., Kyrychenko, A. V., Tobias, D. J., & Ladokhin, A. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179388 · Cited by 13

Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways

Ye, C., Wei, M., Huang, H., Wang, Y., Zhang, L., Yang, C., Huang, Y., & Luo, J. (2022) · Biological Chemistry · doi:10.1515/hsz-2022-0148 · Cited by 13

Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

Parker, E., Judge, M. A., Pastor, L., de la Fuente, L., Jairoce, C., Carter, K. W., Anderson, D. R., Mandomando, I., Clifford, H. D., Naniche, D., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1074847 · Cited by 13

In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Focus on Autophagy and Apoptosis

Abruscato, G., Chiarelli, R., Lazzara, V., Punginelli, D., Sugár, S. N., Mauro, M., Librizzi, M., Stefano, V. A. D., Arizza, V., Vizzini, A., et al. (2023) · Biology · doi:10.3390/biology12040616 · Cited by 19

Mitochondria in cell senescence: A Friend or Foe?

Chen, Q., Young, L. H., & Barsotti, R. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.019 · Cited by 15

Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy

Carelock, M. E., Master, R. P., Kim, M., Jin, Z., Wang, L. A., Maharjan, C. K., Hua, N., De, U., Kolb, R. H., Xiao, Y., et al. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad019 · Cited by 13

Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies

Dey, A. K., Banarjee, R., Boroumand, M., Rutherford, D. V., Strassheim, Q., Nyunt, T., Olinger, B., & Basisty, N. (2023) · Biology · doi:10.3390/biology12101301 · Cited by 12

AML under the Scope: Current Strategies and Treatment Involving FLT3 Inhibitors and Venetoclax-Based Regimens

Milnerowicz, S., Milnerowicz, J., Skowera, P., Stelmach, M., & Lejman, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115849 · Cited by 13

Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types

He, Y., Fu, L., Jiang, C., Gong, F., Wu, Z., & Ostrikov, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-54020-0 · Cited by 13

Ursolic acid alleviates paclitaxel-induced peripheral neuropathy through PPARγ activation

Yang, Y., He, Z., & Wu, S. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116883 · Cited by 13

Recent advances in canonical versus non-canonical Ca2+-signaling-related anti-apoptotic Bcl-2 functions and prospects for cancer treatment

Cauwelier, C., de Ridder, I., & Bultynck, G. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119713 · Cited by 14

Exploring caspase functions in mouse models

Švandová, E., Veselá, B., Janečková, E., Chai, Y., & Matalová, E. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01976-z · Cited by 14

c-Jun N-terminal kinase 1/P53 signaling mediates intrinsic apoptosis of largemouth bass (Micropterus salmoides) hepatocytes under heat stress

Lin, Z., Cai, Z., Li, L., Wei, Y., & Ling, Q. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174664 · Cited by 14

Bactericidal, anti-hemolytic, and anticancerous activities of phytofabricated silver nanoparticles of glycine max seeds

Kumar, K. B. V., Varadaraju, K. R., Shivaramu, P. D., Kumar, C. M. H., Prakruthi, H. R., Shekara, B. M. C., Shreevatsa, B., Wani, T. A., Prakasha, K. C., Kollur, S. P., et al. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1427797 · Cited by 13

Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5

Rühl, S., Li, Z., Srivastava, S., Mari, L., Guy, C. S., Yang, M., Moldoveanu, T., & Green, D. R. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01386-3 · Cited by 13

Assessment of cytotoxic, apoptotic, enzyme inhibitory, and antioxidant properties, and phytochemical characterization of ethanolic extract from Cionura erecta

Erdoğan, M. K., Toy, Y., Gündoğdu, R., Geçibesler, İ. H., SEVER, A., Yapar, Y., Behçet, L., & Zengin, G. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106082 · Cited by 13

Effect of ABT-263 on Intestinal Fibrosis in Human Myofibroblasts, Human Intestinal Organoids, and the Mouse Salmonella typhimurium Model

Johnson, L. A., Rodansky, E. S., Tran, A., Collins, S., Eaton, K. A., Malamet, B. J., Steiner, C. A., Huang, S., Spence, J. R., & Higgins, P. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab166 · Cited by 13

Xanthohumol targets the JNK1 /2 signaling pathway in apoptosis of human nasopharyngeal carcinoma cells

Hsieh, M., Hsieh, M., Lo, Y., Lin, C., Chuang, Y., Chen, M., & Chou, M. (2022) · Environmental Toxicology · doi:10.1002/tox.23502 · Cited by 13

Chloroxylon swietenia (Roxb.) DC induces cell death and apoptosis by down‐regulating the NF‐κB pathway in MCF ‐7 breast cancer cells: In vitro and in vivo investigations

Kamble, S. S., Choudhari, J., Nimma, R., Kumar, T. V. S., Patil, K. K., Hese, S. V., Dawane, B. S., & Gacche, R. N. (2022) · Cancer Reports · doi:10.1002/cnr2.1600 · Cited by 13

High Levels of Progesterone Receptor B in MCF-7 Cells Enable Radical Anti-Tumoral and Anti-Estrogenic Effect of Progestin

Bajalović, N., Or, Y. Z., Woo, A. R. E., Lee, S. H., & Lin, V. C. L. (2022) · Biomedicines · doi:10.3390/biomedicines10081860 · Cited by 13

Novel gold(I) complexes induce apoptosis in leukemia cells via the ROS-induced mitochondrial pathway with an upregulation of Harakiri and overcome multi drug resistances in leukemia and lymphoma cells and sensitize drug resistant tumor cells to apoptosis in vitro

Ahrweiler-Sawaryn, M.-C., Biswas, A., Frias, C., Frias, J., Wilke, N. L., Wilke, N., Berkessel, A., & Prokop, A. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114507 · Cited by 13

Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway

Lee, Y., Chiou, J., Wang, L., Chen, Y., & Chang, L. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116625 · Cited by 13

Macrophage Origin, Metabolic Reprogramming and IL-1β Signaling: Promises and Pitfalls in Lung Cancer

Guilbaud, E., Gautier, E. L., & Yvan‐Charvet, L. (2019) · Cancers · doi:10.3390/cancers11030298 · Cited by 14

Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from Penicillium aurantiacobrunneum

Anaya‐Eugenio, G. D., Tan, C. Y., Harinantenaina, L., & de Blanco, E. J. C. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110124 · Cited by 16

Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses?

Barillé‐Nion, S., Lohard, S., & Juin, P. P. (2020) · Biomolecules · doi:10.3390/biom10081109 · Cited by 16

Apoptosis and Cell Proliferation Markers in Inflammatory-Fibroproliferative Diseases of the Vessel Wall (Review)

Klimentova, E. A., Suchkov, I. A., Egorov, A. A., & Kalinin, R. E. (2020) · Современные технологии в медицине · doi:10.17691/stm2020.12.4.13 · Cited by 34

Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells

Huang, S., Tuergong, G., Zhu, H., Wang, X. B., Weng, G., & Yu, R. (2020) · Acta Pharmaceutica · doi:10.2478/acph-2021-0012 · Cited by 13

Proteome profiling of different rat brain regions reveals the modulatory effect of prolonged maternal separation on proteins involved in cell death-related processes

Drastichová, Z., Rudajev, V., Pallag, G., & Novotný, J. (2021) · Biological Research · doi:10.1186/s40659-021-00327-5 · Cited by 12

Rotenone-induced cell apoptosis via endoplasmic reticulum stress and PERK-eIF2α-CHOP signalling pathways in TM3 cells

Tian, M., Cao, H., Gao, H., Zhu, L., Wu, Y., & Li, G. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116972 · Cited by 12

Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro

Shatta, M. A., El-Derany, M. O., Gibriel, A. A., & EL-Mesallamy, H. O. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04619-6 · Cited by 13

Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIMEL to attenuate apoptosis in BEAS-2B cells

Liang, Y., Qian, Y., Tang, J., Yao, C., Yu, S., Qu, J., Wei, H., Chen, G., & Han, Y. K. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110304 · Cited by 13

Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy

Scimeca, M., Rovella, V., Palumbo, V., Scioli, M. P., Bonfiglio, R., Melino, G., Piacentini, M., Frati, L., Agostini, M., Candi, E., et al. (2023) · Cancers · doi:10.3390/cancers15143638 · Cited by 14

Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5‐Fluorouracil

Mazandarani, A., Taravati, A., Mohammadnejad, J., & Yazdian, F. A. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300659 · Cited by 12

CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signaling

Cao, L., Wu, Y.-K., Lin, T.-X., Lin, M., Chen, Y., Wang, L.-Q., Wang, J., Lin, J., Lü, J., Chen, Q., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03112-4 · Cited by 12

Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma

Wang, X., Meng, F., & Mao, J. (2024) · World Journal of Hepatology · doi:10.3389/fonc.2024.1445222 · Cited by 13

Bid Protein: A Participant in the Apoptotic Network with Roles in Viral Infections

Wyżewski, Z., Gregorczyk-Zboroch, K. P., Mielcarska, M. B., Świtlik, W. Z., & Niedzielska, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062385 · Cited by 12

Age-Dependent Differential Expression of Apoptotic Markers in Rat Oral Mucosa

Elias, W. Y. (2018) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2018.19.11.3245 · Cited by 12

Sulfiredoxin-1 protects spinal cord neurons against oxidative stress in the oxygen-glucose deprivation/reoxygenation model through the bax/cytochrome c/caspase 3 apoptosis pathway

Lan, W., Lin, J., Liu, W., Wang, F., & Xie, Y. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135615 · Cited by 12

Computational study on novel natural inhibitors targeting BCL2

Lv, X., Jiang, Y., Wang, X., Xie, H., Dou, G., Wang, J., Yang, W., Wang, H., Li, Z., Zhang, X., et al. (2021) · Medical Oncology · doi:10.1007/s12032-021-01513-x · Cited by 12

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma

Zhang, X., Xie, J., Sun, H., Wei, Q., & Nong, G. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1928183 · Cited by 12

Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells

Momeny, M., Shamsaiegahkani, S., Kashani, B., Hamzehlou, S., Esmaeili, F., Yousefi, H., Irani, S., Mousavi, S. A., & Ghaffari, S. H. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120100 · Cited by 12

Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors

Senichkin, V. V., Pervushin, N. V., Zamaraev, A. V., Sazonova, E. V., Zuev, A. P., Streletskaia, A. Y., Prikazchikova, T. A., Zatsepin, T. S., Kovaleva, O. V., Tchevkina, E. M., et al. (2021) · Cancers · doi:10.3390/cancers14010181 · Cited by 12

Suppressive effects of thymoquinone on the initiation stage of diethylnitrosamine hepatocarcinogenesis in rats

Ibrahim, S., Fahim, S. A., Tadros, S. A., & Badary, O. A. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23078 · Cited by 12

Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway

Jang, W. Y., Kim, D. S., Park, S. H., Yoon, J. H., Shin, C. Y., Huang, L., Nang, K., Kry, M., Byun, H.-W., Lee, B., et al. (2022) · Molecules · doi:10.3390/molecules27134086 · Cited by 12

Mechanisms of Action of Bcl-2 Family Proteins

Shamas-Din, A., Kale, J., Leber, B., & Andrews, D. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008714 · Cited by 705

Counting on Death – Quantitative aspects of Bcl‐2 family regulation

Hantusch, A., Rehm, M., & Brunner, T. (2018) · FEBS Journal · doi:10.1111/febs.14516 · Cited by 17

Many players in BCL-2 family affairs

Moldoveanu, T., Follis, A. V., Kriwacki, R. W., & Green, D. R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.006 · Cited by 421

Discoveries and controversies in BCL ‐2 protein‐mediated apoptosis

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Mechanisms of BCL-2 family proteins in mitochondrial apoptosis

Czabotar, P. E., & García‐Sáez, A. J. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00629-4 · Cited by 739