Cited by 1,378Inflammasome and immune disordersImmune Response and InflammationIL-33, ST2, and ILC Pathways

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Molecular mechanisms regulating NLRP3 inflammasome activation

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Jo, Eun-Kyeong, Kim, Jin Kyung, Shin, Dong-Min, Sasakawa, Chihiro·2016·Cellular & Molecular Immunology

DOI 10.1038/cmi.2015.95PMC PMC4786634

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Abstract

Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inflammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome.

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Authors: Jo, E.-K., Kim, J. K., Shin, D.-M., & Sasakawa, C.
Affiliations: Chungnam National University (KR)
Chiba University (JP)
Corresponding author: Jo, Eun-Kyeong
ORCID: Jo, Eun-Kyeong
Kim, Jin Kyung
Sasakawa, Chihiro
Venue: Cellular & Molecular Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-11-09
Volume: 13
Issue: 2
Pages: 148-159
ISSN: 1672-7681 (ISSN-L)
2042-0226
DOI: 10.1038/cmi.2015.95
PMC: PMC4786634
OpenAlex: W2118918019
Cited by: 1,378
References: 139
Citations by year: 2026: 127 · 2025: 125 · 2024: 157 · 2023: 162 · 2022: 145 · 2021: 173 · 2020: 171 · 2019: 122 · 2018: 97 · 2017: 61 · 2016: 36
FWCI: 6.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Cellular and Molecular Immunology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: NLRP3 inflammasome, inflammasome activation, caspase-1, autoinflammatory disease, autoimmune disease, anti-inflammatory therapy, inflammasome assembly, inflammatory diseases
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Autoimmune Diseases, Cytosol, Humans, Inflammation, Signal Transduction, Interleukin-1beta, Inflammasomes

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Molecular mechanisms regulating NLRP3 inflammasome activation

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