Molecular mechanisms regulating NLRP3 inflammasome activation

The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Autophagy and Viruses: Adversaries or Allies?

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Immunological and inflammatory functions of the interleukin-1 family

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Inflammasomes: Guardians of the Body

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

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Sensing and reacting to microbes through the inflammasomes

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome

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Nox proteins in signal transduction

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Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

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Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

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Novel role of PKR in inflammasome activation and HMGB1 release

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NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

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Mechanism of NLRP3 inflammasome activation

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

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Influenza virus activates inflammasomes via its intracellular M2 ion channel

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Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

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Redox regulation of mitochondrial function

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Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

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Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

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The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

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GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals

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Blocking IL-1 in systemic inflammation

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Mechanisms of inflammasome activation: recent advances and novel insights

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Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

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Emerging inflammasome effector mechanisms

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NLRP3 inflammasomes link inflammation and metabolic disease

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Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

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The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

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The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

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Mitochondria: diversity in the regulation of the NLRP3 inflammasome

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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

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TRPM2 links oxidative stress to NLRP3 inflammasome activation

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Differential Expression of NLRP3 among Hematopoietic Cells

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Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

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A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

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RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

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Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

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Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

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Critical functions of priming and lysosomal damage for NLRP3 activation

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Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection

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NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

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Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

Finucane, O. M., Lyons, C. L., Murphy, A. M., Reynolds, C. M., Klinger, R. W., Healy, N. P., Cooke, A. A., Coll, R. C., McAllan, L., Nilaweera, K. N., et al. (2015) · Diabetes · doi:10.2337/db14-1098 · Cited by 281

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

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ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

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3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

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Mitochondrial ROS fuel the inflammasome

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Inflammasome activation in nadph oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

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Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

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Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

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NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

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The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

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The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

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Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

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TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

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The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

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Human nlrp3 inflammasome activation is nox1-4 independent

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Secreted aspartic proteases of C andida albicans activate the NLRP 3 inflammasome

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