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Molecular basis for SNX‐BAR‐mediated assembly of distinct endosomal sorting tubules

van Weering, Jan R T, Sessions, Richard B, Traer, Colin J, Kloer, Daniel P, Bhatia, Vikram K, Stamou, Dimitrios, Carlsson, Sven R, Hurley, James H, Cullen, Peter J·2012·The EMBO Journal
DOI 10.1038/emboj.2012.283PMC PMC3512392
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Crossref · 10.1038/emboj.2012.283

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  • Specific endosomal membrane sub-domains are enriched for either degradative components such as ESCRT or recycling machinery including Retromer, Retriever, the CCC complex, and WASH-dependent actin patches.

    “A number of studies have shown that specific endosomal membrane sub-domains are enriched for either degradative components such as ESCRT or recycling machinery including Retromer, Retriever, the CCC complex, and WASH-dependent actin patches9,34–44”

    From Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway (2024) · cites this paper as [38]

    The Introduction and Discussion (page numbers unavailable) describe molecularly distinct endosomal tubules involved in recycling, including SNX-BAR–retromer-associated tubules. Our copy does not establish the claimed enrichment of degradative ESCRT components or identify Retriever, the CCC complex, or WASH-dependent actin patches as machinery in those subdomains. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Retromer associates with accessory proteins and cargo adaptors including sorting nexins, the WASH complex, RAB GTPase regulators including TBC1D5 and ANKRD27/VARP, and RME8.

    “To function, Retromer associates with accessory proteins and cargo adaptors including sorting nexins (SNXs) [24][25][26][27][28][29][30][31][32][33][34], the WASH complex [35][36][37][38][39], RAB GTPase regulators including TBC1D5 and ANKRD27/VARP [40][41][42][43][44][45][46], and RME8 [47].”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [33]

  • SNX17 and SNX31 are most closely related and both important in recycling of various integrins.

    “Of these, SNX17 and SNX31 are the most closely related (although SNX31 expression is restricted, with high expression in the urinary tract) and both are important in the recycling of various integrins50, 55.”

    From Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling (2017) · cites this paper as [55]

    The Introduction and Results passages discuss SNX-BAR proteins, including SNX4, SNX7, and SNX30, but do not address SNX17 or SNX31. Searches for SNX17 and SNX31 with integrin recycling, close relatedness, and urinary-tract expression found no passage addressing the claim. Page numbers were not available in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Citations

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Research works printed but not linked: 45

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Metadata

Authors
van Weering, J. R. T., Sessions, R. B., Traer, C. J., Kloer, D. P., Bhatia, V. K., Stamou, D., Carlsson, S. R., Hurley, J. H., & Cullen, P. J.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2012-10-19
Volume
31
Issue
23
Pages
4466-4480
ISSN
  • 0261-4189
  • 1460-2075
DOI
10.1038/emboj.2012.283
PMC
PMC3512392
Cited by
200
References
1
Language
en
Licence

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