Enhancers: emerging roles in cell fate specification
Open accessAbstract
Enhancers are regulatory DNA elements that dictate the spatial and temporal patterns of gene expression during development. Recent evidence suggests that the distinct chromatin features of enhancer regions provide the permissive landscape required for the differential access of diverse signalling molecules that drive cell-specific gene expression programmes. The epigenetic patterning of enhancers occurs before cell fate decisions, suggesting that the epigenetic information required for subsequent differentiation processes is embedded within the enhancer element. Lineage studies indicate that the patterning of enhancers might be regulated by the intricate interplay between DNA methylation status, the binding of specific transcription factors to enhancers and existing histone modifications. In this review, we present insights into the mechanisms of enhancer function, which might ultimately facilitate cell reprogramming strategies for use in regenerative medicine.
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Active and primed enhancers are marked by H3K4me1 in a cell type-specific manner.
“In mammalian cells, active and primed enhancers are marked by monomethylation of histone 3 (H3) at lysine 4 (K4) (H3K4me1) in a cell type-specific manner.”
From HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements (2024) · cites this paper as [31]
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Thakur, A., Park, K., Cullum, R., Fuglerud, B. M., Khoshnoodi, M., Drissler, S., Stephan, T. L., Lotto, J., Kim, D., Gonzalez, F. J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05835-0 · Cited by 10 · see citing works
The Role of Nucleosomes in Epigenetic Gene Regulation
Giles, K., & Taberlay, P. (2019) · Clinical Epigenetics · doi:10.1007/978-981-13-8958-0_4 · Cited by 5 · see citing works
McDonald, S. I., Beachum, A. N., Hinnant, T. D., Blake, A. J., Bynum, T., Hickman, E., Barnes, J., Churchill, K. L., Roberts, T. S., Zangwill, D. E., et al. (2019) · Gene Expression Patterns · doi:10.1016/j.gep.2019.119074 · Cited by 9 · see citing works
Core conserved transcriptional regulatory networks define the invasive trophoblast cell lineage
Vu, H. T. H., Scott, R. L., Iqbal, K., Soares, M. J., & Tuteja, G. (2023) · Development · doi:10.1242/dev.201826 · Cited by 9 · see citing works
A conserved transcription factor regulatory program promotes tendon fate
Niu, X., Melendez, D. L., Raj, S., Cai, J., Senadeera, D., Mandelbaum, J., Shestopalov, I. A., MARTIN, S. D., Zon, L. I., Schlaeger, T. M., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.08.006 · Cited by 8 · see citing works
Epigenetic reorganization during early embryonic lineage specification
Fang, H., Luo, Z., & Lin, C. (2022) · Genes & Genomics · doi:10.1007/s13258-021-01213-w · Cited by 7 · see citing works
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- Authors
- Ong, C., & Corces, V. G.
- Affiliations
- Emory University (US)
- Corresponding author
- Corces, Victor G
- Venue
- The EMBO Reports
- Published
- 2012-04-10
- Volume
- 13
- Issue
- 5
- Pages
- 423-430
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC3343362
- OpenAlex
- W2163732711
- Cited by
- 144
- References
- 86
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 10 · 2015: 16 · 2014: 17 · 2013: 15 · 2012: 5
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (GM-35463, R01GM035463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- enhancers, cell fate specification, chromatin, epigenetic regulation, DNA methylation, histone modifications, transcription factors, developmental gene expression, cell differentiation, cellular reprogramming, regenerative medicine
- MeSH terms
- Animals, Cell Differentiation, Chromatin, Enhancer Elements, Genetic, Histones, Humans, Epigenomics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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