Current status and future prospects for epigenetic psychopharmacology
Open accessAbstract
Mounting evidence suggest that epigenetic regulation of brain functions is important in the etiology of psychiatric disorders. These epigenetic regulatory mechanisms, such as DNA methylation and histone acetylation, are influenced by many pharmaceutical compounds including psychiatric drugs. It is therefore of interest to investigate how psychiatric drugs are of influence and what the potential is of new epigenetic drugs for psychiatric disorders. With this targeted review we summarize the current state of knowledge in order to provide insight in this developing field. Several traditional psychiatric drugs have been found to alter the epigenome and in a variety of animal studies, experimental compounds with epigenetic targets have been investigated as potential psychiatric drugs. After discussion of the most relevant epigenetic mechanisms we present the evidence for epigenetic effects for the most relevant classes of drugs.
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Epigenetic mechanisms respond to environmental triggers.
“respond to environmental triggers”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Boks et al., 2012
Epigenetic mechanisms are modifiable and potentially reversible by psychopharmacological interventions.
“are modifiable -and potentially reversible -by (psycho-)pharmacological interventions”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Boks et al., 2012
MAO inhibitors or valproic acid are known to affect DNA methylation.
“both of which are known to affect DNA methylation (for review see Boks et al., 2012).”
From Epigenome-wide DNA methylation in unipolar depression: predictive biomarker of antidepressant treatment response? (2024) · cites this paper as Boks et al., 2012
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The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review
Webb, L. M., Phillips, K. E., Ho, M. C., Veldic, M., & Blacker, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030826 · Cited by 84 · see citing works
Kofink, D., Boks, M. P. M., Timmers, H. T. M., & Kas, M. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.020 · Cited by 83 · see citing works
Self-citationBiomarkers of post-traumatic stress disorder from emotional trauma: A systematic review
Paganin, W., & Signorini, S. (2023) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2023.100328 · Cited by 16 · see citing works
Schiele, M. A., Crespo Salvador, O., Lipovsek, J., Schwarte, K., Schlosser, P., Zwanzger, P., Arolt, V., Baune, B. T., Köttgen, A., & Domschke, K. (2024) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae045 · Cited by 13 · see citing works
- Authors
- Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- King's College London (GB)
- University of California, Los Angeles (US)
- Corresponding author
- Boks, Marco P.
- ORCID
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2012-01
- Volume
- 7
- Issue
- 1
- Pages
- 20-28
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- PMC
- PMC3329498
- OpenAlex
- W1980556194
- Cited by
- 89
- References
- 82
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 8
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epigenetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- U.S. Public Health Service (R01 MG078075)
- National Institute of Mental Health (RO1 MG078075)
- National Institute on Drug Abuse (R01DA028526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- DNA methylation, histone acetylation, psychiatric medication, epigenetic drugs, mental illness, epigenome, animal models
- MeSH terms
- Animals, Mental Disorders, Histones, Humans, Psychopharmacology, DNA Methylation, Histone Code, Epigenesis, Genetic
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