The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study
Open accessAbstract
Objective To investigate whether the intestinal microbiota composition in early infancy is associated with subsequent weight development in children.Methods Analyses were conducted within the KOALA Birth Cohort Study (n = 2834). This cohort originates from two recruitments groups: pregnant women with a conventional lifestyle (no selection based on lifestyle) and pregnant women recruited through alternative channels (organic shops, anthroposophic clinicians/midwives, Steiner schools and relevant magazines). From 909 one-month-old infants, fecal samples were collected and analyzed by quantitative PCR targeting bifidobacteria, Bacteroides fragilis group, Clostridium difficile, Escherichia coli, Lactobacilli and total bacteria counts. Between the ages of 1 and 10 years, parent-reported weight and height was collected at 7 time points. Age- and gender-standardized body mass index (BMI) z-scores were calculated. Data were analyzed using generalized estimating equation.Results Colonization with B. fragilis group was borderline significantly associated with a higher BMI z-score of 0.15 (95% confidence interval (CI): -0.02 to 0.31), in the conventional subcohort. After stratification for fiber intake (P(forinteraction) = 0.003), colonization with B. fragilis group was associated with a 0.34 higher BMI z-score among children with a low-fiber intake in this subcohort (95% CI: 0.17-0.53). Higher counts among colonized children were positively associated with BMI z-score only in children within the conventional subcohort and a high-fiber diet (BMI z-score 0.08; 95% CI: 0.01-0.14), but inversely associated in children with a low-fiber diet (BMI z-score -0.05; 95% CI: -0.10 to 0.00), and in children recruited through alternative channels (BMI z-score -0.10; 95% CI: -0.17 to -0.03). The other bacteria were not associated with BMI z-scores, regardless of subcohort.Conclusion Using a targeted approach, we conclude that the intestinal microbiota, particularly the B. fragilis group, is associated with childhood weight development. To identify the potential impact of additional bacterial taxa, further prospective studies applying an unconstrained in-depth characterization of the microbiota are needed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
1 retracted
Million, M., Maraninchi, M., Henry, M., Armougom, F., Richet, H., Carrieri, P., Valéro, R., Raccah, D., Vialettes, B., & Raoult, D. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.153 · Cited by 684
RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Tracking of childhood overweight into adulthood: a systematic review of the literature
Singh, A. S., Mulder, C., Twisk, J. W. R., van Mechelen, W., & Chinapaw, M. J. M. (2008) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00475.x · Cited by 2,495
Spear, B. A., Winick, M., Phillips, C., & Wilfley, D. E. (1975) · Cited by 2,495
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Self-citationNadkarni, M. A., Martin, F. E., Jacques, N. A., & Hunter, N. (2002) · Microbiology · doi:10.1099/00221287-148-1-257 · Cited by 1,931
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880
Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood
Baker, J. L., Olsen, L. W., & Sørensen, T. I. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072515 · Cited by 1,679
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222
Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease
Bastien, M., Poirier, P., Lemieux, I., & Després, J.-P. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.10.016 · Cited by 1,125
Validity of self-reported height and weight in 4808 EPIC–Oxford participants
Spencer, E. A., Appleby, P. N., Davey, G. K., & Key, T. J. (2002) · Public Health Nutrition · doi:10.1079/phn2001322 · Cited by 1,082
Early differences in fecal microbiota composition in children may predict overweight
Kalliomäki, M. A., Collado, M. C., Salminen, S., & Isolauri, E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,056
Rinttilä, T., Kassinen, A., Malinen, E., Krogius-Kurikka, L., & Palva, A. (2004) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2004.02409.x · Cited by 1,048
Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Chari, R. S., Sears, M. R., Becker, A. B., Scott, J. A., & Kozyrskyj, A. L. (2013) · Canadian Medical Association Journal · doi:10.1503/cmaj.121189 · Cited by 989
Armougom, F., Henry, M., Vialettes, B., Raccah, D., & Raoult, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007125 · Cited by 905
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.894 · Cited by 878
Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868
Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637002100 · Cited by 745
Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0040 · Cited by 583
The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight
Karlsson, C., Önnerfält, J., Xu, J., Molin, G., Ahrné, S., & Thorngren‐Jerneck, K. (2012) · Obesity · doi:10.1038/oby.2012.110 · Cited by 556
Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents
Santacruz, A., Marcos, A., Wärnberǵ, J., Martí, A., Martín‐Matillas, M., Campoy, C., Moreno, L. A., Veiga, Ó. L., Redondo-Figuero, C. G., Garagorri, J. M., et al. (2009) · Obesity · doi:10.1038/oby.2009.112 · Cited by 484
Differences in gut microbiota composition between obese and lean children: a cross-sectional study
Bervoets, L., Hoorenbeeck, K. V., Kortleven, I., Noten, C. V., Hens, N., Vael, C., Goossens, H., Desager, K., & Vankerckhoven, V. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-10 · Cited by 467
Nyholm, M., Gullberg, B., Merlo, J., Lundqvist‐Persson, C., Råstam, L., & Lindblad, U. (2007) · Obesity · doi:10.1038/oby.2007.536 · Cited by 392
Schönbeck, Y., Talma, H., van Dommelen, P., Bakker, B., Buitendijk, S. E., Hirasing, R. A., & van Buuren, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027608 · Cited by 352
Nadal, I., Santacruz, A., Marcos, A., Wärnberǵ, J., Garagorri, M., Moreno, L. A., Martín‐Matillas, M., Campoy, C., Martí, A., Moleres, A., et al. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.260 · Cited by 346
Lakshman, R., Elks, C. E., & Ong, K. K. (2012) · Circulation · doi:10.1161/circulationaha.111.047738 · Cited by 318
Diamant, M., Blaak, E. E., & de Vos, W. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00797.x · Cited by 308
Etiology and prognosis of pregnancy-related pelvic girdle pain; design of a longitudinal study
Bastiaanssen, J. M., de Bie, R. A., Bastiaenen, C. H. G., Heuts, A., Kroese, M., Essed, G. G. M., & van den Brandt, P. A. (2005) · BMC Public Health · doi:10.1186/1471-2458-5-1 · Cited by 288
Storage conditions of intestinal microbiota matter in metagenomic analysis
Cardona, S. T., Eck, A., Cassellas, M., Gallart, M., Alastrue, C., Dore, J. M., Azpiroz, F., Roca, J., Guarner, F., & Manichanh, C. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-158 · Cited by 285
Ford, A. L., Hunt, L. P., Cooper, A. R., & Hamilton-Shield, J. P. (2009) · Archives of Disease in Childhood · doi:10.1136/adc.2009.165340 · Cited by 278
Ismail, N. A., Ragab, S. H., ElBaky, A. A., Shoeib, A. R. S., Alhosary, Y., & Fekry, D. (2011) · Archives of Medical Science · doi:10.5114/aoms.2011.23418 · Cited by 277
Reinehr, T., de Sousa, G., Toschke, A. M., & Andler, W. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.490 · Cited by 243
The tracking of nutrient intake in young children: the Framingham Children's Study.
Singer, M. R., Moore, L. L., Garrahie, E. J., & Ellison, R. C. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.12.1673 · Cited by 232
The intestinal microbiota and obesity
Kallus, S. J., & Brandt, L. J. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823711fd · Cited by 210
Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children
Ramadass, B., George, G., Kabeerdoss, J., Hepsiba, J., Chandragunasekaran, A. M. S., & Ramakrishna, B. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992182 · Cited by 209
Mai, V., McCrary, Q. M., Sinha, R. R., & Glei, M. (2009) · Nutrition Journal · doi:10.1186/1475-2891-8-49 · Cited by 171
Vael, C., Verhulst, S. L., Nelen, V., Goossens, H., & Desager, K. (2011) · Gut Pathogens · doi:10.1186/1757-4749-3-8 · Cited by 154
Ott, S. J., Musfeldt, M., Ullmann, U., Hampe, J., & Schreiber, S. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.6.2566-2572.2004 · Cited by 148
Etiology of atopy in infancy: The KOALA Birth Cohort Study
Kummeling, I., Thijs, C. T., Penders, J., Snijders, B. E. P., Stelma, F. F., Reimerink, J. H. J., Koopmans, M., Dagnelie, P. C., Huber, M., Jansen, M. C. J. F., et al. (2005) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00333.x · Cited by 147
Self-citationRousseau, C., Levenez, F., Fouqueray, C., Dore, J. M., Collignon, A., & Lepage, P. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01507-10 · Cited by 138
Correlation of intestinal microbiota with overweight and obesity in Kazakh school children
Xu, P., Li, M., Zhang, J., & Zhang, T. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-283 · Cited by 120
Scholtens, S., Brunekreef, B., Visscher, T. L. S., Smit, H. A., Kerkhof, M., de Jongste, J. C., Gerritsen, J., & Wijga, A. H. (2006) · European Journal of Public Health · doi:10.1093/eurpub/ckl253 · Cited by 115
Luoto, R., Kalliomäki, M. A., Laitinen, K., Delzenne, N. M., Cani, P. D., Salminen, S., & Isolauri, E. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181f3457f · Cited by 110
Obesity pandemics and the modification of digestive bacterial flora
Raoult, D. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-008-0490-x · Cited by 97
Gut bacteria alteration in obese people and its relationship with gene polymorphism
Zuo, H. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i8.1076 · Cited by 94
Dutman, A. E., Stafleu, A., Kruizinga, A. G., Brants, H. A. M., Westerterp, K. R., Kistemaker, C., Meuling, W. J. A., & Goldbohm, R. A. (2010) · Public Health Nutrition · doi:10.1017/s1368980010002119 · Cited by 86
White, R. A., Bjørnholt, J. V., Baird, D. D., Midtvedt, T., Harris, J. R., Pagano, M., Hide, W. A., Rudi, K., Moen, B., Iszatt, N., et al. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003042 · Cited by 85
Bjelland, M., Brantsæter, A. L., Haugen, M. A., Meltzer, H. M., Nystad, W., & Andersen, L. F. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-793 · Cited by 72
Obesity estimates for children based on parent-reported versus direct measures.
Shields, M. E., Gorber, S. C., Janssen, I., & Tremblay, M. S. (2011) · PubMed · Cited by 60
Timmermans, S. H., Mommers, M., Gubbels, J. S., Kremers, S., Stafleu, A., Stehouwer, C. D. A., Prins, M. H., Penders, J., & Thijs, C. T. (2013) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00141.x · Cited by 39
Self-citationDe CBO-richtlijn ‘Diagnostiek en behandeling van obesitas bij volwassenen en kinderen’
Renders, C. M., Bulk-Bunschoten, A. M. W., & van Mil, E. (2010) · Tijdschrift voor kindergeneeskunde · doi:10.1007/bf03089885 · Cited by 21
Obesity estimates for children based on parent-report versus direct measures
Shields, M., Gorber, S. C., Janssen, I., & Tremblay, M. S. (2011) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(11)52024-6 · Cited by 12
Cited by
Sorted by citations
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
Pannaraj, P. S., Li, F., Cerini, C., Bender, J. M., Yang, S., Rollie, A., Adisetiyo, H., Zabih, S., Lincez, P. J., Bittinger, K. L., et al. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.0378 · Cited by 1,112
The Gut Microbiota in the First Decade of Life
Derrien, M., Alvarez, A., & de Vos, W. M. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.08.001 · Cited by 682
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review
Indiani, C. M. D. S. P., Rizzardi, K. F., Castelo, P. M., Ferraz, L. F. C., Darrieux, M., & Parisotto, T. M. (2018) · Childhood Obesity · doi:10.1089/chi.2018.0040 · Cited by 460
The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases
Sarkar, A., Yoo, J. Y., Dutra, S. V. O., Morgan, K. H., & Groer, M. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030459 · Cited by 371
Metadata
- Authors
- Scheepers, L. E. J. M., Penders, J., Mbakwa, C. A., Thijs, C., Mommers, M., & Arts, I. C. W.
- Affiliations
- Maastricht University (NL)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Scheepers, L E J M
- Venue
- International Journal of Obesity
- Published
- 2014-10-09
- Volume
- 39
- Issue
- 1
- Pages
- 16-25
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2000570799
- Cited by
- 162
- References
- 61
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 20 · 2021: 21 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 21 · 2016: 12 · 2015: 11
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- ZonMw ((2100.0090), 3.2.07.022)
- FrieslandCampina
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, childhood obesity, BMI z-score, Bacteroides fragilis group, infant gut colonization, dietary fiber intake, Bifidobacterium, lactobacilli, Escherichia coli, Clostridium difficile, Bacteroides fragilis, early infancy
- MeSH terms
- Bacteroides fragilis, Body Weight, Child, Child, Preschool, Diet, Escherichia coli, Feces, Female, Humans, Infant, Intestines, Lactobacillus, Life Style, Male, Netherlands, Prospective Studies, Surveys and Questionnaires, Cohort Studies, Weight Gain, Body Mass Index, Clostridioides difficile, Parenting, Pediatric Obesity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
