The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The oral metagenome in health and disease
Open accessAbstract
The oral cavity of humans is inhabited by hundreds of bacterial species and some of them have a key role in the development of oral diseases, mainly dental caries and periodontitis. We describe for the first time the metagenome of the human oral cavity under health and diseased conditions, with a focus on supragingival dental plaque and cavities. Direct pyrosequencing of eight samples with different oral-health status produced 1 Gbp of sequence without the biases imposed by PCR or cloning. These data show that cavities are not dominated by Streptococcus mutans (the species originally identified as the ethiological agent of dental caries) but are in fact a complex community formed by tens of bacterial species, in agreement with the view that caries is a polymicrobial disease. The analysis of the reads indicated that the oral cavity is functionally a different environment from the gut, with many functional categories enriched in one of the two environments and depleted in the other. Individuals who had never suffered from dental caries showed an over-representation of several functional categories, like genes for antimicrobial peptides and quorum sensing. In addition, they did not have mutans streptococci but displayed high recruitment of other species. Several isolates belonging to these dominant bacteria in healthy individuals were cultured and shown to inhibit the growth of cariogenic bacteria, suggesting the use of these commensal bacterial strains as probiotics to promote oral health and prevent dental caries.
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Citations
Cites
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Versatile and open software for comparing large genomes
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Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Periodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
Chen, T., Yu, W.-H., Izard, J., Baranova, O. V., Lakshmanan, A., & Dewhirst, F. E. (2010) · Database · doi:10.1093/database/baq013 · Cited by 1,162 · cited 2×
“All the available complete and WGS genomes were retrieved from the human oral microbiome database (Chen et al., 2010), as well as the RefSeq of NCBI containing all bacterial and archaea genomes (june 2010), and were used to build a local database to perform taxonomic model constructions and…”
MethodCharacterization of the oral fungal microbiome (mycobiome) in healthy individuals
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet, P. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000713 · Cited by 1,150 · cited 1×
“No rRNA reads were identified from Candida or other fungi that are regular inhabitants of the oral cavity, indicating that although these organisms are frequently detected by PCR amplification (Ghannoum et al., 2010), they are probably present at low proportions.”
BackgroundDental plaque as a biofilm and a microbial community—Implications for health and disease
Marsh, P. D. (2006) · BMC Oral Health · doi:10.1186/1472-6831-6-s1-s14 · Cited by 1,094
Bacteria of Dental Caries in Primary and Permanent Teeth in Children and Young Adults
Aas, J. A., Griffen, A. L., Dardis, S. R., Lee, A. M., Olsen, I., Dewhirst, F. E., Leys, E. J., & Paster, B. J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01410-07 · Cited by 952 · cited 5×
“Recent molecular work has confirmed this finding and expanded the list of potential cariogenic bacteria to other species like Veillonella, Propionibacterium and Atopobium (Aas et al., 2008), most of them are poorly studied bacteria.”
BackgroundResultInfluentialComparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869
Cited by
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Cabrera-Rubio, R., Collado, M. C., Laitinen, K., Salminen, S., Isolauri, E., & Mira, A. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037382 · Cited by 886
Self-citationThe human microbiome: Our second genome
Grice, E. A., & Segre, J. A. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163814 · Cited by 759
Type VI secretion system effectors: poisons with a purpose
Russell, A. B., Peterson, S. B., & Mougous, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3185 · Cited by 729
The oral microbiome and the immunobiology of periodontal disease and caries
Costalonga, M., & Herzberg, M. C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.017 · Cited by 645
Metadata
- Authors
- Belda-Ferre, P., Alcaraz, L. D., Cabrera-Rubio, R., Romero, H., Simón-Soro, A., Pignatelli, M., & Mira, A.
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-30
- Volume
- 6
- Issue
- 1
- Pages
- 46-56
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- OpenAlex
- W2088347903
- Cited by
- 539
- References
- 13
- FWCI
- 39.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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