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Cited by 86Fatty Acid Research and HealthLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Isotope tracer measures of meal fatty acid metabolism: reproducibility and effects of the menstrual cycle

Uranga, Ana Paola, Levine, James, Jensen, Michael·2005·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00340.2004
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Abstract

Oxidation and adipose tissue uptake of dietary fat can be measured by adding fatty acid tracers to meals. These studies were conducted to measure between-study variability of these types of experiments and assess whether dietary fatty acids are handled differently in the follicular vs. luteal phase of the menstrual cycle. Healthy normal-weight men ( n = 12) and women ( n = 12) participated in these studies, which were block randomized to control for study order, isotope ([3 H]triolein vs. [14 C]triolein), and menstrual cycle. Energy expenditure (indirect calorimetry), meal fatty acid oxidation, and meal fatty acid uptake into upper body and lower body subcutaneous fat (biopsies) 24 h after the experimental meal were measured. A greater portion of meal fatty acids was stored in upper body subcutaneous adipose tissue (24 ± 2 vs. 16 ± 2%, P < 0.005) and lower body fat (12 ± 1 vs. 7 ± 1%, P < 0.005) in women than in men. Meal fatty acid oxidation (3 H 2 O generation) was greater in men than in women (52 ± 3 vs. 45 ± 2%, P = 0.04). Leg adipose tissue uptake of meal fatty acids was 15 ± 2% in the follicular phase of the menstrual cycle and 10 ± 1% in the luteal phase ( P = NS). Variance in meal fatty acid uptake was somewhat ( P = NS) greater in women than in men, although menstrual cycle factors did not contribute significantly. We conclude that leg uptake of dietary fat is slightly more variable in women than in men, but that there are no major effects of menstrual cycle on meal fatty acid disposal.

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  • In resting conditions, men oxidize circulating free fatty acids.

    “In contrast, in these same resting conditions, men will oxidize circulating FFA [18].”

    From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [18]

  • At rest and during the post-absorptive state, women tend to incorporate free fatty acids into triglyceride, which helps store fat.

    “At rest and during the post-absorptive state, women tend to incorporate free fatty acids (FFA) into triglyceride (TG) which helps store fat.”

    From Sex differences in metabolic homeostasis, diabetes, and obesity (2015) · cites this paper as [18]

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Authors
Uranga, A. P., Levine, J., & Jensen, M.
Affiliations
Mayo Clinic (US)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2005-03
Volume
288
Issue
3
Pages
E547-E555
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00340.2004
OpenAlex
W2024443715
Cited by
86
References
30
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 5 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 5
FWCI
3.61
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, DK 45343, DK50456, R01DK045343)
  • National Center for Research Resources (RR 0585, M01RR000585)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
dietary fat metabolism, menstrual cycle, follicular phase, luteal phase, sex differences, subcutaneous adipose tissue, isotope tracers, reproducibility, energy expenditure
MeSH terms
Abdomen, Adipose Tissue, Adult, Basal Metabolism, Blood Glucose, Body Composition, Buttocks, Carbon Isotopes, Dietary Fats, Energy Metabolism, Fatty Acids, Female, Follicular Phase, Humans, Insulin, Leg, Luteal Phase, Male, Menstrual Cycle, Oxidation-Reduction, Sex Factors, Triglycerides, Triolein, Tritium, Reproducibility of Results

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