Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies
Open accessAbstract
Prevalence estimates of depression in chronic kidney disease (CKD) vary widely in existing studies. We conducted a systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD. We searched MEDLINE and Embase (through January 2012). Random-effects meta-analysis was used to estimate the prevalence of depressive symptoms. We also limited the analyses to studies using clinical interview and prespecified criteria for diagnosis. We included 249 populations (55,982 participants). Estimated prevalence of depression varied by stage of CKD and the tools used for diagnosis. Prevalence of interview-based depression in CKD stage 5D was 22.8% (confidence interval (CI), 18.6-27.6), but estimates were somewhat less precise for CKD stages 1-5 (21.4% (CI, 11.1-37.2)) and for kidney transplant recipients (25.7% (12.8-44.9)). Using self- or clinician-administered rating scales, the prevalence of depressive symptoms for CKD stage 5D was higher (39.3% (CI, 36.8-42.0)) relative to CKD stages 1-5 (26.5% (CI, 18.5-36.5)) and transplant recipients (26.6% (CI, 20.9-33.1)) and suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting. Thus, interview-defined depression affects approximately one-quarter of adults with CKD. Given the potential prevalence of depression in the setting of CKD, randomized trials to evaluate effects of interventions for depression on patient-centered outcomes are needed.
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Symptoms of depression and anxiety are common in end-stage kidney disease (ESKD).
“Symptoms of depression (Palmer et al . 2013) and anxiety (Cukor et al . 2008) are common in end-stage kidney disease (ESKD)”
From Improving Distress in Dialysis (iDiD): A tailored CBT self-management treatment for patients undergoing dialysis. (2016) · cites this paper as Palmer et al . 2013
Diabetes complications are linked to depression, anxiety, reduced autonomy, role impairment, and lower overall physical function and quality of life.
“Diabetes complications, including peripheral neuropathy, foot ulcers, limb amputation, diabetic kidney disease, vision impairment, stroke, and heart attack, are associated with depression, anxiety, reduced autonomy, role impairment, and reduced overall physical function and quality of life (119–122).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [121]
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- Authors
- Palmer, S., Vecchio, M., Craig, J. C., Tonelli, M., Johnson, D. W., Nicolucci, A., Pellegrini, F., Saglimbene, V., Logroscino, G., Fishbane, S., & Strippoli, G. F. M.
- Affiliations
- University of Otago (NZ)
- Mario Negri Sud Foundation (IT)
- The University of Sydney (AU)
- University of Alberta (CA)
- The University of Queensland (AU)
- Casa Sollievo della Sofferenza (IT)
- University of Bari Aldo Moro (IT)
- Hofstra University (US)
- Corresponding author
- Strippoli, Giovanni F.M.
- ORCID
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 84
- Issue
- 1
- Pages
- 179-191
- ISSN
- 0085-2538 (ISSN-L)
- OpenAlex
- W2148640119
- Semantic Scholar
- 4cf51004db15df18181b12c1bb8f0e7f83c53d46
- Cited by
- 925
- References
- 108
- Citations by year
- 2026: 70 · 2025: 108 · 2024: 97 · 2023: 101 · 2022: 92 · 2021: 85 · 2020: 75 · 2019: 65 · 2018: 75 · 2017: 33 · 2016: 57 · 2015: 32 · 2014: 24 · 2013: 7
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- depression, chronic kidney disease, depressive symptoms, prevalence, kidney transplant recipients, dialysis, CKD staging, self-report scale
- MeSH terms
- Adult, Aged, Depression, Female, Humans, Male, Middle Aged, Prognosis, Quality of Life, Severity of Illness Index, Prevalence, Evidence-Based Medicine, Renal Insufficiency, Chronic, Observational Studies as Topic
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