Neuropsychiatric Disorders in Chronic Kidney Disease

Simões e Silva, Ana Cristina; Miranda, Aline Silva; Rocha, Natalia Pessoa; Teixeira, Antônio Lúcio

doi:10.3389/fphar.2019.00932

Cited by 124Dialysis and Renal Disease ManagementDementia and Cognitive Impairment ResearchChronic Kidney Disease and Diabetes

Neuropsychiatric Disorders in Chronic Kidney Disease

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Simões e Silva, Ana Cristina, Miranda, Aline Silva, Rocha, Natalia Pessoa, Teixeira, Antônio Lúcio·2019·Frontiers in Pharmacology

DOI 10.3389/fphar.2019.00932PMC PMC6707423

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Abstract

Neuropsychiatric conditions including depression, anxiety disorders, and cognitive impairment are prevalent in patients with chronic kidney disease (CKD). These conditions often make worse the quality of life and also lead to longer hospitalizations and higher mortality. Over the past decades, some hypotheses have tried to explain the connection between CKD and neuropsychiatric disorders. The most common hypothesis is based on the occurrence of cerebrovascular disease and accumulated uremic toxins in adult patients with CKD. However, the lack of a direct association between known vascular risk factors (e.g., diabetes and hypertension) with CKD-related cognitive deficits suggests that other mechanisms may also play a role in the pathophysiology shared by renal and neuropsychiatric diseases. This hypothesis is corroborated by the occurrence of neuropsychiatric comorbidities in pediatric patients with CKD preceding vascular damage, and the inconsistent findings on neuroprotective effects of antihypertensives. The aim of this narrative review was to summarize clinical evidence and potential mechanisms that links CKD and brain disorders, specifically in regard to cognitive impairment, anxiety, and depression.

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Neuropsychiatric conditions such as depression, anxiety, psychosis, and cognitive impairment are often prevalent in patients with chronic kidney disease, non-alcoholic fatty liver disease, and autoimmune disorders.
“Neuropsychiatric conditions, such as depression, anxiety, psychosis, and cognitive impairment, are often prevalent in patients with chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and autoimmune disorders”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Simões e Silva et al., 2019
The Introduction and “Brain-Renal Axis: An Evolving Concept” sections describe depression, anxiety, and cognitive impairment as common or prevalent in CKD. The paper does not establish that psychosis is prevalent in CKD, or address the claimed prevalence of these conditions in NAFLD or autoimmune disorders. (LLM, conf=0.90)
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Authors: Simões e Silva, A. C., Miranda, A. S., Rocha, N. P., & Teixeira, A. L.
Affiliations: Universidade Federal de Minas Gerais (BR)
ORCID: Miranda, Aline Silva
Teixeira, Antônio Lúcio
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2019-08-16
Volume: 10
Pages: 932-932
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2019.00932
PMC: PMC6707423
OpenAlex: W2964181807
Cited by: 124
References: 118
Citations by year: 2026: 10 · 2025: 25 · 2024: 21 · 2023: 22 · 2022: 24 · 2021: 16 · 2020: 6
FWCI: 1.80
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico (406041/2018-0, 301037/2016-7)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Topics: Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: chronic kidney disease, neuropsychiatric disorders, depression, anxiety disorders, cognitive impairment, uremic toxins, cerebrovascular disease, vascular risk factors, pediatric chronic kidney disease, pathophysiology

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Neuropsychiatric Disorders in Chronic Kidney Disease

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