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Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery
Open accessAbstract
The hepatoprotective effect of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) has been well documented. However, reports on the role of IL-6/STAT3 in liver regeneration are conflicting probably due to the fact that the model of Stat3 knockout mice were complicated with obesity and fatty liver, which may cause some secondary effects on liver regeneration. To study the direct role of STAT3 and to circumvent the problems of obesity and fatty liver in liver regeneration, we generated conditional STAT3 knockout in the liver (L-Stat3(-/-)) using a transthyretin-driven Cre-lox method. The L-Stat3(-/-) mice were born with the expected Mendelian frequency and showed no obesity or other obvious phenotype. After partial hepatectomy, mortality in the L-Stat3(-/-) mice was significantly higher than the littermate Stat3(f/+) controls in the early time points (<24 h). Hepatocyte DNA synthesis in the survived L-Stat3(-/-) mice slightly decreased as compared with Stat3(f/+) mice at 40 h after partial hepatectomy, whereas similar hepatocyte DNA synthesis was found at other time points and liver mass could be completely recovered in the L-Stat3(-/-) mice. In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl(4)), hepatocyte DNA synthesis in the CCl(4)-treated L-Stat3(-/-) mice also decreased as compared with Stat3(f/+) mice at 40 h after injection but not at other time points. In addition, infiltration of neutrophils and monocyte increased in the liver of CCl(4)-treated L-Stat3(-/-) mice compared to wild-type mice. In conclusion, STAT3 is required for survival in the acute stage after 70% hepatectomy and plays a role in inflammatory reaction after hepatocyte necrosis. However, the hepatocytic STAT3 may have limited role in liver mass recovery although DNA synthesis may be impaired.
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“Successful LR depends on an intact TNF-NFκB-IL-6-STAT3 pathway.”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [29]
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“Insulin resistance; impaired liver regeneration”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Moh et al., 2007
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“By contrast, the effect of liver-specific Stat3 deletion was relatively modest (71, 72)”
From Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2 (2022) · cites this paper as [72]
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Cites
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323
INTERLEUKIN-6: From Basic Science to Medicine—40 Years in Immunology
Kishimoto, T. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115806 · Cited by 1,040
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944
Radaeva, S., Sun, R., Pan, H., Hong, F., & Gao, B. (2004) · Hepatology · doi:10.1002/hep.20184 · Cited by 638
Self-citationPositional cloning: Let's not call it reverse anymore
Collins, F. S. (1992) · Nature Genetics · doi:10.1038/ng0492-3 · Cited by 480
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
Inoue, H., Ogawa, W., Ozaki, M., Haga, S., Matsumoto, M., Furukawa, K., Hashimoto, N., Kido, Y., Mori, T., Sakaue, H., et al. (2004) · Nature Medicine · doi:10.1038/nm980 · Cited by 384
Roles of STAT3 defined by tissue-specific gene targeting
Akira, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203478 · Cited by 343
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Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M., & Hooper, L. V. (2017) · Science · doi:10.1126/science.aan0677 · Cited by 456
Establishment, maintenance, and recall of inflammatory memory
Larsen, S. B., Cowley, C. J., Sajjath, S. M., Barrows, D., Yang, Y., Carroll, T. S., & Fuchs, E. V. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.07.001 · Cited by 327
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314
Regulation of liver regeneration by growth factors and cytokines
Böhm, F., Köhler, U. A., Speicher, T., & Werner, S. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000085 · Cited by 285
Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
Wang, H., Lafdil, F., Kong, X., & Gao, B. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.536 · Cited by 270
Self-citationThe microbiota coordinates diurnal rhythms in innate immunity with the circadian clock
Brooks, J. F., Behrendt, C. L., Ruhn, K. A., Lee, S., Raj, P., Takahashi, J. S., & Hooper, L. V. (2021) · Cell · doi:10.1016/j.cell.2021.07.001 · Cited by 226
STAT3 in the systemic inflammation of cancer cachexia
Zimmers, T. A., Fishel, M. L., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 231
CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
Huseni, M. A., Wang, L., Klementowicz, J. E., Yuen, K. C. Y., Bréart, B., Orr, C., Liu, L.-F., Li, Y., Gupta, V., Li, C., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100878 · Cited by 199
STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
Gao, B., Wang, H., Lafdil, F., & Feng, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.01.029 · Cited by 180
Self-citationAcute inflammation stimulates a regenerative response in the neonatal mouse heart
Han, C., Nie, Y., Lian, H., Liu, R., He, F., Huang, H., & Hu, S. (2015) · Cell Research · doi:10.1038/cr.2015.110 · Cited by 179
STAT3 pathway in cancers: Past, present, and future
Wang, H., Man, Q., Huo, F., Gao, X., Lin, H., Li, S.-R., Wang, J., Su, F., Cai, L., Shi, Y., et al. (2022) · MedComm · doi:10.1002/mco2.124 · Cited by 175
Self-citationRegulating billions of blood platelets: glycans and beyond
Grozovsky, R., Giannini, S., Falet, H., & Hoffmeister, K. M. (2015) · Blood · doi:10.1182/blood-2015-01-569129 · Cited by 154
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
Paris, A. J., Hayer, K. E., Oved, J. H., Avgousti, D. C., Toulmin, S. A., Zepp, J. A., Zacharias, W. J., Katzen, J. B., Basil, M. C., Kremp, M. M., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0569-x · Cited by 149
Lu, X., Cao, X., Zhu, Y., Wu, Z., Zhuang, X., Shao, M., Xu, Q., Zhou, Y., Ji, H., Lu, Q.-R., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0428-x · Cited by 146
Genetic determinants of hepatic steatosis in man
Hooper, A. J., Adams, L. A., & Burnett, J. R. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r008896 · Cited by 149
Li, L., Cui, L., Lin, P., Liu, Z., Bao, S., Ma, X., Nan, H., Zhu, W., Cen, J., Mao, Y., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.01.009 · Cited by 134
Role of platelets on liver regeneration after 90% hepatectomy in mice
Myronovych, A., Murata, S., Chiba, M., Matsuo, R., Ikeda, O., Watanabe, M., Hisakura, K., Nakano, Y., Kohno, K., Kawasaki, T., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.04.019 · Cited by 131
Cross-talk between KLF4 and STAT3 regulates axon regeneration
Qin, S., Zou, Y., & Zhang, C. (2013) · Nature Communications · doi:10.1038/ncomms3633 · Cited by 132
Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
Zhou, M., Yang, H., Learned, R. M., Tian, H., & Ling, L. (2017) · Nature Communications · doi:10.1038/ncomms15433 · Cited by 123
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma
Harb, H., Victor, E. S., Crestani, E., Benamar, M., Massoud, A. H., Cui, Y., Charbonnier, L., Arbag, S. N., Barış, S., Cunnigham, A., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0777-3 · Cited by 124
Petty, A. J., Dai, R., Lapalombella, R., Baiocchi, R. A., Benson, D. M., Li, Z., Huang, X., & Yang, Y. (2021) · JCI Insight · doi:10.1172/jci.insight.146707 · Cited by 117
p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species
Tormos, A. M., Taléns‐Visconti, R., Nebreda, Á. R., & Sastre, J. (2013) · Free Radical Research · doi:10.3109/10715762.2013.821200 · Cited by 112
Izumi, T., Imai, J., Yamamoto, J., Kawana, Y., Endo, A., Sugawara, H., Kohata, M., Asai, Y., Takahashi, K., Kodama, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07747-0 · Cited by 109
IL-22 is involved in liver regeneration after hepatectomy
Ren, X., Hu, B., & Colletti, L. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00075.2009 · Cited by 109
Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives
Hora, S., & Wüestefeld, T. (2023) · Cells · doi:10.3390/cells12172129 · Cited by 109
Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis
Wu, X., Lai, Y., Chen, S., Zhou, C., Tao, C., Fu, X., Li, J., Huang, J., Tong, W., 田洪涛, et al. (2022) · Nature Aging · doi:10.1038/s43587-021-00165-w · Cited by 104
Self-citationZhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108433 · Cited by 91
Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2
Cheng, N., Kim, K.-H., & Lau, L. F. (2022) · JCI Insight · doi:10.1172/jci.insight.158207 · Cited by 87
“By contrast, the effect of liver-specific Stat3 deletion was relatively modest (71, 72), suggesting that Yap may play a more important role than Stat3 in”
Wang, X., Yang, C., Wang, X., Miao, J., Chen, W., Zhou, Y., Xu, Y., An, Y., Cheng, A., Ye, W., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.028 · Cited by 86
Self-citationSuppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Wang, L., Astone, M., Alam, S. K., Zhu, Z., Pei, W., Frank, D. A., Burgess, S. M., & Hoeppner, L. H. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.049029 · Cited by 81
Genetically modified mouse models for the study of nonalcoholic fatty liver disease
Nagarajan, P. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i11.1141 · Cited by 83
Hackett, A. R., Lee, D.-H., Dawood, A., Rodriguez, M., Funk, L. H., Tsoulfas, P., & Lee, J. K. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.017 · Cited by 79
da Silva, C. G., Studer, P., Skroch, M., Mahiou, J., Minussi, D. C., Peterson, C. R., Wilson, S. W., Patel, V. I., Ma, A., Csizmadia, E., et al. (2013) · Hepatology · doi:10.1002/hep.26197 · Cited by 77
Ching, C. B., Gupta, S., Li, B., Cortado, H. H., Mayne, N. R., Jackson, A. R., McHugh, K. M., & Becknell, B. (2018) · Kidney International · doi:10.1016/j.kint.2017.12.006 · Cited by 78
An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after myocardial infarction
Sun, J.-Y., Du, L., Shi, X., Zhang, Y., Liu, Y., Wang, Y.-L., Chen, B., Liu, T., Zhu, H., Liu, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade4110 · Cited by 77
Distinctive role of inflammation in tissue repair and regeneration
Choi, B., Lee, C., & Yu, J. (2023) · Archives of Pharmacal Research · doi:10.1007/s12272-023-01428-3 · Cited by 77
Anti‐Inflammatory and Anti‐Apoptotic Roles of Endothelial Cell STAT3 in Alcoholic Liver Injury
Miller, A. M., Wang, H., Park, O., Horiguchi, N., Lafdil, F., Mukhopadhyay, P., Moh, A., Fu, X. Y., Kunos, G., Pacher, P., et al. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01141.x · Cited by 69
Self-citationMechanisms and biomarkers of liver regeneration after drug-induced liver injury
Clemens, M. M., McGill, M. R., & Apte, U. M. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.03.001 · Cited by 67
Novel mechanisms of platelet clearance and thrombopoietin regulation
Grozovsky, R., Giannini, S., Falet, H., & Hoffmeister, K. M. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000170 · Cited by 66
Hénique, C., Bollée, G., Loyer, X., Grahammer, F., Dhaun, N., Camus, M., Vernerey, J., Guyonnet, L., Gaillard, F., Lazareth, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01885-7 · Cited by 67
IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
Zhang, P., Liu, J., Lee, A. A., Tsaur, I., Ohira, M., Duong, V., Vo, N., Watari, K., Su, H., Kim, J. Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.08.012 · Cited by 65
Kim, J. H., Qu, A., Reddy, J. K., Gao, B., & Gonzalez, F. J. (2013) · Hepatology · doi:10.1002/hep.26683 · Cited by 57
Self-citationOh, R. S., Haak, A. J., Smith, K. M. J., Ligresti, G., Choi, K. M., Xie, T., Wang, S., Walters, P., Thompson, M. A., Freeman, M., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.209932 · Cited by 57
Kohjima, M., Tsai, T.-H., Tackett, B. C., Thevananther, S., Li, L., Chang, B. H.-J., & Chan, L. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.025 · Cited by 55
Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
Sookoian, S. C., Castaño, G. O., Gianotti, T. F., Gemma, C., Rosselli, M. S., & Pirola, C. J. (2008) · Cytokine · doi:10.1016/j.cyto.2008.08.001 · Cited by 54
Maternal hepatic growth response to pregnancy in the mouse
Dai, G., Bustamante, J. J., Zou, Y., Myronovych, A., Bao, Q., Kumar, S., & Soares, M. J. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011076 · Cited by 54
STAT3 Sensitizes Insulin Signaling by Negatively Regulating Glycogen Synthase Kinase-3β
Moh, A., Zhang, W., Yu, S. S. B., Wang, J., Xu, X., Li, J., & Fu, X.-Y. (2008) · Diabetes · doi:10.2337/db06-1582 · Cited by 53
Self-citationChen, X., Meng, Q., Wang, C., Liu, Q., Sun, H., Huo, X., Sun, P., Yang, X., Peng, J., & Liu, K. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1483-3 · Cited by 53
STAT3 but not STAT4 is critical for γδT17 cell responses and skin inflammation
Agerholm, R., Rizk, J., Viñals, M. T., & Bekiaris, V. (2019) · EMBO Reports · doi:10.15252/embr.201948647 · Cited by 50
GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury
Hata, T., Rehman, F. K., Hori, T., & Nguyen, J. H. (2018) · Journal of Surgical Research · doi:10.1016/j.jss.2018.11.047 · Cited by 50
NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
Clark, S. E., Burrack, K. S., Jameson, S. C., Hamilton, S. E., & Lenz, L. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02087 · Cited by 45
Boles, M. K., Wilkinson, B. M., Wilming, L. G., Liu, B., Probst, F. J., Harrow, J., Grafham, D. V., Hentges, K. E., Woodward, L. P., Maxwell, A., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000759 · Cited by 44
The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis
Cineus, R., Luo, Y., Saliutina, M., Manna, S., Cancino, C., Blázquez, L. V., Wang, L., Bösel, D., Abdelrahman, A., Klementowicz, J. E., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02149-z · Cited by 43
Transforming growth factor‐β in liver cancer stem cells and regeneration
Rao, S., Zaidi, S., Banerjee, J., Jogunoori, W. S., Sebastian, R., Mishra, B., Nguyen, B.-N. H., Wu, R., White, J. C., Deng, C., et al. (2017) · Hepatology Communications · doi:10.1002/hep4.1062 · Cited by 45
Allonso, D., Belgrano, F. S., Calzada, N., Guzmán, M. G., Vázquez, S., & Mohana‐Borges, R. (2012) · Journal of Clinical Virology · doi:10.1016/j.jcv.2012.07.010 · Cited by 42
Su, Y., Zhang, W., Patro, C. P. K., Zhao, J., Mu, T., Ma, Z., Xu, J., Ban, K. H.-K., Yi, C., & Zhou, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00362 · Cited by 41
Self-citationWang, H., Park, O., Lafdil, F., Shen, K., Horiguchi, N., Yin, S., Fu, X.-Y., Kunos, G., & Gao, B. (2009) · Hepatology · doi:10.1002/hep.23430 · Cited by 41
Self-citationMeng, Q., Chen, X., Wang, C., Liu, Q., Sun, H., Sun, P., Huo, X., Liu, Z., & Liu, K. (2015) · Food & Function · doi:10.1039/c5fo00082c · Cited by 39
Hepatocyte growth control by SOCS1 and SOCS3
Khan, M. G. M., Ghosh, A., Variya, B. C., Santharam, M. A., Kandhi, R., Ramanathan, S., & Ilangumaran, S. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154733 · Cited by 38
Kumar, A., Lualdi, M., Lyozin, G. T., Sharma, P., Lončarek, J., Fu, X.-Y., & Kuehn, M. R. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.12.016 · Cited by 38
Self-citationShen, K., Zheng, S.-S., Park, O., Wang, H., Sun, Z., & Gao, B. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00554.2007 · Cited by 37
Self-citationYadav, P., Singh, S. K., Rajput, S., Allawadhi, P., Khurana, A., Weiskirchen, R., & Navik, U. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108563 · Cited by 39
Kim, A. R., I1 Park, J., Oh, H. T., Kim, K. M., Hwang, J., Jeong, M. G., Kim, E., Hwang, E. S., & Hong, J. (2019) · The FASEB Journal · doi:10.1096/fj.201801256rr · Cited by 35
Cai, Z., Simons, D. L., Fu, X.-Y., Feng, G.-S., Wu, S. M., & Zhang, X. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05054-11 · Cited by 34
Self-citationKostromina, E. Y., Petersen, N., Wang, X., Lim, C.-Y., Radda, G. K., Li, C., & Han, W. (2010) · Endocrinology · doi:10.1210/en.2009-1199 · Cited by 35
Liver Regeneration and Immunity: A Tale to Tell
Di-Iacovo, N., Pieroni, S., Piobbico, D., Castelli, M., Scopetti, D., Ferracchiato, S., Fazia, M. A. D., & Servillo, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021176 · Cited by 37
Intrahepatic T‐Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration
Liang, Q. D., Liu, Z., Zhu, C., Wang, B., Liu, X., Yang, Y., Lv, X., Mu, H., & Wang, K. (2018) · Hepatology · doi:10.1002/hep.30067 · Cited by 32
Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance
Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31
Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration
Min, J. S., DeAngelis, R. A., Reis, E. S., Gupta, S., Maurya, M. R., Evans, C. R., Das, A. K., Burant, C., Lambris, J. D., & Subramaniam, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600628 · Cited by 28
Liu, N. Q., Lin, Y., Li, L., Lu, J., Geng, D., Zhang, J., Jashashvili, T., Buser, Z., Magallanes, J., Tassey, J., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02944-y · Cited by 28
Obayashi, Y., Arisaka, H., Yoshida, S., Mori, M., & Takahashi, M. (2012) · Amino Acids · doi:10.1007/s00726-012-1317-8 · Cited by 28
Tob1 is a constitutively expressed repressor of liver regeneration
Ho, K. J., Do, N. L., Otu, H. H., Dib, M. J., Ren, X., Enjyoji, K., Robson, S. C., Terwilliger, E. F., & Karp, S. J. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092434 · Cited by 27
Qiu, X., Zhou, J.-Q., Xu, H., Li, Y.-Y., Ma, S.-D., Qiao, H., Zeng, K., Wang, Q.-Q., Ouyang, J., Liu, Y.-H., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.07.012 · Cited by 25
Zhou, J., Chong, P. S. Y., Lu, X., Cheong, L.-L., Bi, C., Liu, S.-C., Zhou, Y., Tan, T. Z., Yang, H. H., Chung, T., et al. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.08.001 · Cited by 24
Stat3 Regulates Liver Progenitor Cell-Driven Liver Regeneration in Zebrafish
Khaliq, M., Ko, S., Liu, Y., Wang, H., Sun, Y., Solnica‐Krezel, L., & Shin, D. (2018) · Gene Expression · doi:10.3727/105221618x15242506133273 · Cited by 25
Reisinger, S. N., Sideromenos, S., Horváth, O., Derdak, S. V., Cicvaric, A., Monje, F. J., Bilban, M., Häring, M., Glat, M. J., & Pollak, D. D. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00904-2 · Cited by 23
Autonomic nervous system network and liver regeneration
Kamimura, K., Inoue, R., Nagoya, T., Sakai, N., Goto, R., Ko, M., Niwa, Y., & Terai, S. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i15.1616 · Cited by 23
Regulation of Signal Transduction and Role of Platelets in Liver Regeneration
Nowatari, T., Fukunaga, K., & Ohkohchi, N. (2012) · International Journal of Hepatology · doi:10.1155/2012/542479 · Cited by 23
Wang, N., Yang, C., Sun, Z.-Z., Wang, X., & Chen, S. (2010) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2010.10.017 · Cited by 19
Jiao, Y., Ye, D. Z., Li, Z., Teta‐Bissett, M., Peng, Y., Taub, R. A., Greenbaum, L. E., & Kaestner, K. H. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00084.2014 · Cited by 18
Ma, J., Xia, S., Zhang, B., Luo, F., Guo, L., Yang, Y., Gong, H., & Yan, M. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154893 · Cited by 17
Zhang, Y. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i6.2081 · Cited by 17
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation
Fu, H., Dong, R., Zhang, Y., Xu, J., Liu, M., & Chen, P. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2018.12.013 · Cited by 17
Huang, P. C., Huo, Y., Lou, X., Li, H., Barnstable, C. J., Zhang, C., & Zhang, S. S.-M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.015 · Cited by 17
Self-citationInflammatory liver diseases and susceptibility to sepsis
Lü, H. (2024) · Clinical Science · doi:10.1042/cs20230522 · Cited by 18
Long Non-Coding RNAs in Liver Cancer and Nonalcoholic Steatohepatitis
Uchida, S., & Kauppinen, S. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030034 · Cited by 16
Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons
Junyent, F., Alvira, D., Yeste‐Velasco, M., de la Torre, A. V., Beas‐Zárate, C., Sureda, F. X., Folch, J., Pallàs, M., Camins, A., & Verdaguer, E. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.08.015 · Cited by 16
Hao, L., Zhong, W. H., Sun, X., & Zhou, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709002 · Cited by 15
Inoue, R., Kamimura, K., Nagoya, T., Sakai, N., Yokoo, T., Goto, R., Ogawa, K., Shinagawa‐Kobayashi, Y., Watanabe‐Mori, Y., Sakamaki, A., et al. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12382 · Cited by 14
RetractedOgiso, H., Ito, H., Kanbe, A., Ando, T., Hara, A., Shimizu, M., Moriwaki, H., & Seishima, M. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4651-6 · Cited by 13
Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats
Lonati, C., Carlin, A., Leonardi, P., Valenza, F., Bòsari, S., Catania, A., & Gatti, S. (2013) · Peptides · doi:10.1016/j.peptides.2013.10.014 · Cited by 13
Liver regeneration accelerates hepatitis B virus‐related tumorigenesis of hepatocellular carcinoma
Teng, C., Chang, H., Tsai, H., Hsieh, W., Kuo, Y., Su, I., & Lin, Y. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12318 · Cited by 13
Dynamic Changes in pStat3 Are Involved in Meiotic Spindle Assembly in Mouse Oocytes
Haraguchi, S., Ikeda, M., Akagi, S., & Hirao, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041220 · Cited by 9
Kasper, P., Selle, J., Vohlen, C., Wilke, R., Kuiper-Makris, C., Klymenko, O., Bae‐Gartz, I., Schömig, C., Quaas, A., Schumacher, B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105609 · Cited by 12
Sulczewski, F. B., Martino, L. A., Salles, D., Yamamoto, M. M., Rosa, D. S., & Boscardin, S. B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006996 · Cited by 11
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling
Park, S.-J., Garcia Diaz, J., Comlekoglu, T., & Hahn, Y. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1528382 · Cited by 10
Hu, K., Xu, J., Fan, K., Zhou, D., Li, L., Tang, L. P., Peng, X., Zhang, L., & Wang, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117561 · Cited by 10
Chen, X., Xu, C., Zhang, F., & Ma, J. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0111 · Cited by 10
Wen, X., Huan, H.-B., Wang, X., Chen, X., Wu, L., Zhang, Y., Liu, W., Bie, P., & Xia, F. (2016) · Biomedical Materials · doi:10.1088/1748-6041/11/6/065007 · Cited by 10
Metadata
- Authors
- Moh, A., Iwamoto, Y., Chai, G.-X., Zhang, S. S.-M., Kano, A., Yang, D. D., Zhang, W., Wang, J., Jacoby, J. J., Gao, B., Flavell, R. A., & Fu, X.-Y.
- Affiliations
- Indiana University School of Medicine (US)
- Yale University (US)
- National Institutes of Health (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fu, Xin-Yuan
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 87
- Issue
- 10
- Pages
- 1018-1028
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W2090563155
- Cited by
- 147
- References
- 39
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Yale University
- National Institutes of Health (5r01ar044906-05, DK34989)
- U.S. Army
- National Institute of Allergy and Infectious Diseases (R01AI34522, R01AI034522)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-34989, P30DK034989)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR-44906)
- Yale Liver Center (DK34989)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- STAT3, liver regeneration, interleukin-6, partial hepatectomy, carbon tetrachloride, hepatocyte DNA synthesis, hepatocyte viability, liver inflammation, neutrophil infiltration, monocyte infiltration, liver necrosis
- MeSH terms
- Animals, Carbon Tetrachloride, Digestive System, Disease Models, Animal, DNA, Hepatectomy, Inflammation, Liver, Liver Regeneration, Gene Deletion, Mice, Knockout, Integrases, Hepatocytes, Hepatic Insufficiency, STAT1 Transcription Factor, STAT3 Transcription Factor, Mice
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