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The respiratory tract microbiome and lung inflammation: a two-way street.
Open accessAbstract
The lungs are not sterile or free from bacteria; rather, they harbor a distinct microbiome whose composition is driven by different ecological rules than for the gastrointestinal tract. During disease, there is often a shift in community composition towards Gammaproteobacteria, the bacterial class that contains many common lung-associated gram-negative "pathogens." Numerous byproducts of host inflammation are growth factors for these bacteria. The extracellular nutrient supply for bacteria in the lungs, which is severely limited during health, markedly increases due to the presence of mucus and vascular permeability. While Gammaproteobacteria benefit from airway inflammation, they also encode molecular components that promote inflammation, potentially creating a cyclical inflammatory mechanism. In contrast, Prevotella species that are routinely acquired via microaspiration from the oral cavity may participate in immunologic homeostasis of the airways.vAreas of future research include determining for specific lung diseases (1) whether an altered lung microbiome initiates disease pathogenesis, promotes chronic inflammation, or is merely a marker of injury and inflammation, (2) whether the lung microbiome can be manipulated therapeutically to change disease progression, (3) what molecules (metabolites) generated during an inflammatory response promote cross-kingdom signaling, and (4) how the lung "ecosystem" collapses during pneumonia, to be dominated by a single pathogen.
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“Prevotella from microaspiration, can also participate in the immune homeostasis of the respiratory tract (Huffnagle et al., 2017).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Huffnagle et al., 2017
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Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“Many Gammaproteobacteria also encode TLR5-binding flagellins, as well as TLR9-binding unmethylated CpG motifs.(50,51) Thus, a feedback loop can develop where bacteria that contain the most immunostimulatory microbe-associated molecular patterns are also the ones that benefit most metabolically from an inflammatory env…”
BackgroundMetabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352
Topographical and Temporal Diversity of the Human Skin Microbiome
Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., Program, N. C. S., Bouffard, G. G., Blakesley, R. W., Murray, P. R., et al. (2009) · Science · doi:10.1126/science.1171700 · Cited by 2,953
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
Disordered Microbial Communities in Asthmatic Airways
Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,874
Inflammation and wound healing: the role of the macrophage
Koh, T. J., & DiPietro, L. A. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001943 · Cited by 1,667
Flagged first, then by citations
Cited by
Sorted by citations
Microbes, Metabolites, and the Gut-Lung Axis
Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
Mazziotta, C., Tognon, M., Martini, F., Torreggiani, E., & Rotondo, J. C. (2023) · Cells · doi:10.3390/cells12010184 · Cited by 889
The Role of Lung and Gut Microbiota in the Pathology of Asthma
Barcik, W., Boutin, R. C. T., Sokołowska, M., & Finlay, B. B. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.007 · Cited by 636
The influence of the microbiome on respiratory health
Wypych, T. P., Wickramasinghe, L. C., & Marsland, B. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0451-9 · Cited by 611
Regulation of immune responses by the airway epithelial cell landscape
Hewitt, R. J., & Lloyd, C. M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00477-9 · Cited by 627
Shen, Z., Xiao, Y., Kang, L., Ma, W., Shi, L., Zhang, L., Zhou, Z., Yang, J., Zhong, J., Yang, D., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa203 · Cited by 513
Functional effects of the microbiota in chronic respiratory disease
Budden, K. F., Shukla, S. D., Rehman, S. F., Bowerman, K. L., Keely, S., Hugenholtz, P., Armstrong-James, D. P. H., Adcock, I. M., Chotirmall, S. H., Chung, K. F., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30510-1 · Cited by 453
Lung microbiome: new insights into the pathogenesis of respiratory diseases
Li, R., Li, J., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01722-y · Cited by 483
Bowerman, K. L., Rehman, S. F., Vaughan, A., Lachner, N., Budden, K. F., Kim, R., Wood, D., Gellatly, S. L., Shukla, S. D., Wood, L. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19701-0 · Cited by 441
Sözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 455
Pathogenesis of pneumonia and acute lung injury
Long, M. E., Mallampalli, R. K., & Horowitz, J. C. (2022) · Clinical Science · doi:10.1042/cs20210879 · Cited by 418
Dysbiosis of the gut and lung microbiome has a role in asthma
Hufnagl, K., Pali‐Schöll, I., Roth‐Walter, F., & Jensen‐Jarolim, E. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-019-00775-y · Cited by 394
Goblet cells: multifaceted players in immunity at mucosal surfaces
Knoop, K. A., & Newberry, R. D. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0039-y · Cited by 323
Unexpected guests in the tumor microenvironment: microbiome in cancer
Wong-Rolle, A., Wei, H. K., Zhao, C. N., & Jin, C. (2020) · Protein & Cell · doi:10.1007/s13238-020-00813-8 · Cited by 327
Integrative Physiology of Pneumonia
Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 330
Huang, Y. J., & Boushey, H. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.011 · Cited by 280
Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection
Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01840 · Cited by 207
Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections?
Sampson, V., Kamona, N., & Sampson, A. (2020) · BDJ · doi:10.1038/s41415-020-1747-8 · Cited by 205
Role of probiotics to combat viral infections with emphasis on COVID-19
Sundararaman, A., Ray, M., Veeranna, R. P., & Halami, P. M. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10832-4 · Cited by 186
The Human Respiratory System and its Microbiome at a Glimpse
Santacroce, L., Charitos, I. A., Ballini, A., Inchingolo, F., Luperto, P., Nitto, E. D., & Topi, S. (2020) · Biology · doi:10.3390/biology9100318 · Cited by 203
The Lung Microbiome during Health and Disease
Yagi, K., Huffnagle, G. B., Lukacs, N. W., & Asai, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910872 · Cited by 182
Self-citationOral-lung microbiome interactions in lung diseases.
Mammen, M. J., Scannapieco, F. A., & Sethi, S. (2020) · Periodontology 2000 · doi:10.1111/prd.12301 · Cited by 179
Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results
Caruana, G., Croxatto, A., Coste, A. T., Opota, O., Lamoth, F., Jaton, K., & Greub, G. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.06.019 · Cited by 162
Zagorulya, M., Yim, L., Morgan, D. M., Edwards, A. W., Torres-Mejia, E., Momin, N., McCreery, C. V., Zamora, I., Horton, B. L., Fox, J. G., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.010 · Cited by 160
The gut–airway microbiome axis in health and respiratory diseases
Özçam, M., & Lynch, S. V. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01048-8 · Cited by 164
Schmid‐Hempel, P. (2021) · doi:10.1093/oso/9780198832140.001.0001 · Cited by 137
Improving Pulmonary Infection Diagnosis with Metagenomic Next Generation Sequencing
Qian, Y., Wang, H., Zhou, Y., Zhang, H.-C., Zhu, Y., Zhou, X., Yue, Y., Cui, P., Wu, H., Zhang, W., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.567615 · Cited by 129
Belizário, J. E., Faintuch, J., & Garay-Malpartida, M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.564194 · Cited by 121
Könönen, E., & Gürsoy, U. K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.798763 · Cited by 128
Macrophage metabolic reprogramming during chronic lung disease
Ogger, P. P., & Byrne, A. J. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00356-5 · Cited by 123
Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer
Forder, A., Zhuang, R., Souza, V. G. P., Brockley, L. J., Pewarchuk, M. E., Telkar, N., Stewart, G. L., Benard, K., Marshall, E. A., Reis, P. P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032859 · Cited by 116
Verma, A., Bhagchandani, T., Rai, A., Nikita, N., Sardarni, U. K., Bhavesh, N. S., Gulati, S., Malik, R., & Tandon, R. (2024) · ACS Omega · doi:10.1021/acsomega.3c05846 · Cited by 127
Tongue microbiota and oral health status in community-dwelling elderly adults.
Asakawa, M., Takeshita, T., Furuta, M., Kageyama, S., Takeuchi, K., Hata, J., Ninomiya, T., & Yamashita, Y. (2018) · mSphere · doi:10.1128/msphere.00332-18 · Cited by 113
Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases
Thomas, C., Minty, M., Vinel, A., Canceill, T., Loubières, P., Burcelin, R., Kaddech, M., Blasco‐Baqué, V., & Laurencin‐Dalicieux, S. (2021) · Diagnostics · doi:10.3390/diagnostics11081376 · Cited by 122
Gut-derived immune cells and the gut-lung axis in ARDS
Ziaka, M., & Exadaktylos, A. K. (2024) · Critical Care · doi:10.1186/s13054-024-05006-x · Cited by 118
Kell, D. B., & Pretorius, E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12407 · Cited by 117
Viral and Bacterial Co-Infections in the Lungs: Dangerous Liaisons
Oliva, J., & Terrier, O. (2021) · Viruses · doi:10.3390/v13091725 · Cited by 113
Mucosa-interfacing electronics
Nan, K., Feig, V. R., Ying, B., Howarth, J. G., Kang, Z., Yang, Y., & Traverso, G. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00477-2 · Cited by 105
Li, K., Chen, Z., Huang, Y. H., Zhang, R., Luan, X.-Q., Lei, T., & Chen, L. (2019) · Respiratory Research · doi:10.1186/s12931-019-1246-0 · Cited by 110
Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications
Khatiwada, S., & Subedi, A. (2020) · Human Microbiome Journal · doi:10.1016/j.humic.2020.100073 · Cited by 105
Regulation of Tissue Inflammation by 12-Lipoxygenases
Kulkarni, A., Nadler, J. L., Mirmira, R. G., & Casimiro, I. (2021) · Biomolecules · doi:10.3390/biom11050717 · Cited by 103
Zhai, T., Shizhen, L., Hu, W., Li, D., & Leng, S. (2018) · Nutrients · doi:10.3390/nu10070813 · Cited by 99
Pneumonia prevention in the elderly patients: the other sides
Chebib, N., Cuvelier, C., Malézieux-Picard, A., Parent, T., Roux, X., Fassier, T., Müller, F., & Prendki, V. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-019-01437-7 · Cited by 113
Mousavi, S. E., Delgado-Saborit, J. M., Adivi, A., Pauwels, S., & Godderis, L. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151654 · Cited by 98
The Microbiome and Tuberculosis: Early Evidence for Cross Talk
Namasivayam, S., Sher, A., Glickman, M. S., & Wipperman, M. F. (2018) · mBio · doi:10.1128/mbio.01420-18 · Cited by 97
Lung Microbiome in Asthma: Current Perspectives
Loverdos, K., Bellos, G., Kokolatou, L., Vasileiadis, I., Giamarellos‐Bourboulis, E. J., Pecchiari, M., Koulouris, N. G., Koutsoukou, A., & Rovina, N. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111967 · Cited by 91
Kyo, M., Nishioka, K., Nakaya, T., Kida, Y., Tanabe, Y., Ohshimo, S., & Shime, N. (2019) · Respiratory Research · doi:10.1186/s12931-019-1203-y · Cited by 93
Future Research Directions in Pneumonia. NHLBI Working Group Report
Cruz, C. S. D., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K. A., Doerschuk, C. M., Evans, S. E., Goldstein, D. R., Khatri, P., Kobzik, L., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0139ws · Cited by 89
Lloréns‐Rico, V., Gregory, A., Weyenbergh, J. V., Jansen, S., Buyten, T. V., Qian, J., Braz, M., Menezes, S. M., Mol, P. V., Vanderbeke, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26500-8 · Cited by 84
Caspase-11 promotes allergic airway inflammation
Zasłona, Z., Flis, E., Wilk, M. M., Carroll, R. G., Pålsson‐McDermott, E. M., Hughes, M. M., Diskin, C., Banahan, K., Ryan, D. G., Hooftman, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14945-2 · Cited by 83
Hernández‐Terán, A., Mejía-Nepomuceno, F., Herrera, M. T., Barreto, O., García, E., Castillejos-López, M. D. J., Boukadida, C., Matías‐Florentino, M., Rincón-Rubio, A., Ávila‐Ríos, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00851-0 · Cited by 82
Nasopharyngeal Microbial Communities of Patients Infected With SARS-CoV-2 That Developed COVID-19
Ventero, M. P., Cuadrat, R. R. C., Vidal, I., Andrade, B. G. N., Molina-Pardines, C., Haro-Moreno, J. M., Coutinho, F. H., Merino, E., Regitano, L. C. D. A., Silveira, C. B., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.637430 · Cited by 81
Functional lower airways genomic profiling of the microbiome to capture active microbial metabolism
Sulaiman, I., Wu, B. G., Li, Y., Tsay, J.-C. J., Sauthoff, M., Scott, A. S., Ji, K., Koralov, S. B., Weiden, M. D., Clemente, J. C., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.03434-2020 · Cited by 83
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma
Qian, G., Jiang, W., Zou, B., Feng, J., Cheng, X., Gu, J., Chu, T., Niu, C., He, R., Chu, Y., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172225 · Cited by 74
Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients
Zhong, H., Wang, Y., Shi, Z., Zhang, L., Ren, H., He, W., Zhang, Z., Zhu, A., Zhao, J., Xiao, F., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00257-2 · Cited by 73
Probiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 80
The gut microbiome is a significant risk factor for future chronic lung disease
Liu, Y., Teo, S. M., Méric, G., Tang, H. H. F., Zhu, Q., Sanders, J. G., Vázquez‐Baeza, Y., Verspoor, K. M., Vartiainen, V. A., Jousilahti, P., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.12.810 · Cited by 76
Pseudomonas aeruginosa polymicrobial interactions during lung infection
Bisht, K., Baishya, J., & Wakeman, C. A. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.01.014 · Cited by 70
Yüksel, N., Gelmez, B., & Yıldız-Peköz, A. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00323 · Cited by 75
The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease
van Rijn, A. L., van Boheemen, S., Sidorov, I. A., Carbo, E. C., Pappas, N., Mei, H., Feltkamp, M. C. W., Aanerud, M., Bakke, P. S., Claas, E. C. J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223952 · Cited by 77
Alghetaa, H., Mohammed, A. K., Zhou, J., Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105548 · Cited by 74
Bacterial acetate metabolism and its influence on human epithelia.
Hosmer, J., McEwan, A. G., & Kappler, U. (2024) · PubMed Central · doi:10.1042/etls20220092 · Cited by 78
Merenstein, C., Bushman, F. D., & Collman, R. G. (2022) · Microbiome · doi:10.1186/s40168-022-01342-8 · Cited by 66
More of the Gut in the Lung: How Two Microbiomes Meet in ARDS.
Mukherjee, S., & Hanidziar, D. (2018) · Europe PMC (PubMed Central) · Cited by 70
Daniel, S., Phillippi, D., Schneider, L. J., Nguyen, K. N., Mirpuri, J., & Lund, A. K. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00393-9 · Cited by 67
The role of microbiota in respiratory health and diseases, particularly in tuberculosis
Shah, T., Shah, Z., Baloch, Z., & Cui, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112108 · Cited by 73
The Blood Microbiome and Health: Current Evidence, Controversies, and Challenges
Cheng, H. S., Tan, S. P., Wong, D. M. K., Koo, W. L. Y., Wong, S. H., & Tan, N. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065633 · Cited by 68
Alessandrini, F., Vennemann, A., Gschwendtner, S., Neumann, A. U., Rothballer, M., Seher, T., Wimmer, M., Kublik, S., Traidl‐Hoffmann, C., Schloter, M., et al. (2017) · Nanomaterials · doi:10.3390/nano7100300 · Cited by 63
Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome
Fonseca, W., Lukacs, N. W., & Ptaschinski, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00226 · Cited by 63
Self-citationMartínez, J. E., Vargas, A., Pérez, T., Encío, I., Cabello-Olmo, M., & Barajas, M. (2021) · Nutrients · doi:10.3390/nu13092905 · Cited by 69
The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment
Gao, F., Yu, B., Rao, B., Sun, Y. H., Yu, J., Wang, D., Cui, G., & Ren, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051987 · Cited by 63
The emerging role of the microbiota in the ICU
Wolff, N. S., Hugenholtz, F., & Wiersinga, W. J. (2018) · Critical Care · doi:10.1186/s13054-018-1999-8 · Cited by 63
Microbiome dysbiosis and epigenetic modulations in lung cancer: From pathogenesis to therapy
Khan, F. H., Bhat, B. A., Sheikh, B. A., Tariq, L., Padmanabhan, R., Verma, J. P., Shukla, A. C., Dowlati, A., & Abbas, A. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.005 · Cited by 59
Stricker, S., Hain, T., Chao, C., & Rudloff, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126791 · Cited by 64
Involvement and repair of epithelial barrier dysfunction in allergic diseases
Lu, H.-F., Zhou, Y.-C., Yang, L., Zhou, Q., Wang, X.-J., Qiu, S., Cheng, B., & Zeng, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1348272 · Cited by 62
Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics
Shi, C. Y., Yu, C.-H., Yu, W. Y., & Ying, H. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/9278441 · Cited by 59
Metagenomic analysis of the lung microbiome in pulmonary tuberculosis - a pilot study
Hu, Y., Cheng, M., Liu, B., Dong, J., Sun, L., Yang, J., Yang, F., Chen, X., & Jin, Q. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1783188 · Cited by 57
The microbiota and immune‐mediated diseases: Opportunities for therapeutic intervention
Fitzgibbon, G., & Mills, K. H. G. (2020) · European Journal of Immunology · doi:10.1002/eji.201948322 · Cited by 59
The human microbiome in clinical translation: from bench to bedside
Bautista, J., Echeverría, C. E., Maldonado-Noboa, I., Ojeda-Mosquera, S., Hidalgo-Tinoco, C., & López-Cortés, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1632435 · Cited by 55
Deciphering the Ecology of Cystic Fibrosis Bacterial Communities: Towards Systems-Level Integration
Bevivino, A., Bacci, G., Dřevínek, P., Nelson, M. T., Hoffman, L. R., & Mengoni, A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.07.008 · Cited by 57
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Metadata
- Authors
- Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Huffnagle, G.B.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 10
- Issue
- 2
- Pages
- 299-306
- ISSN
- 1933-0219 (ISSN-L)
- PMC
- PMC5765541
- OpenAlex
- W2561758149
- Cited by
- 535
- References
- 75
- Citations by year
- 2026: 42 · 2025: 60 · 2024: 73 · 2023: 60 · 2022: 84 · 2021: 94 · 2020: 61 · 2019: 21 · 2018: 26 · 2017: 12
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Michigan (UL1TR000433)
- National Institutes of Health (UL1TR000433)
- National Heart, Lung, and Blood Institute (U01HL098961, ROI-HL114447, R01HL114858, K23HL130641, R01HL114447, T32HL007749)
- National Institute of Allergy and Infectious Diseases (AI-036302, R01AI036302)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- airway microbiome, lung inflammation, Gammaproteobacteria, Gram-negative pathogens, Prevotella, mucus, vascular permeability, host-microbe interactions, chronic inflammation, pneumonia, microaspiration
- MeSH terms
- Animals, Capillary Permeability, Homeostasis, Humans, Lung Diseases, Pneumonia, Respiratory System, Prevotella, Gammaproteobacteria, Host-Pathogen Interactions, Microbiota, Dysbiosis
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