Leptin actions on food intake and body temperature are mediated by IL-1

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660 · see citing works

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works

Leptin regulates proinflammatory immune responses

Loffreda, S., Yang, S., Lin, H., Karp, C. L., Brengman, M. L., Wang, D., Klein, A. S., Bulkley, G. B., Bao, C., Noble, P. W., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.57 · Cited by 1,251 · see citing works

Leptin enters the brain by a saturable system independent of insulin

Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222 · see citing works

Fever: Role of Pyrogens and Cryogens

Kluger, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.93 · Cited by 1,220 · see citing works

Cytokines and the nervous system II: actions and mechanisms of action

Rothwell, N. J., & Hopkins, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93890-a · Cited by 922 · see citing works

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

Grünfeld, C., Zhao, C., Fuller, J., Pollack, A., Moser, A. H., Friedman, J. M., & Kr, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118653 · Cited by 862 · see citing works

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 810 · see citing works

Cytokines and the nervous system I: expression and recognition

Hopkins, S. J., & Rothwell, N. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80029-2 · Cited by 793 · see citing works

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.171 · Cited by 791 · see citing works

Interleukin 1 signaling occurs exclusively via the type I receptor.

Sims, J. E., Gayle, M. A., Slack, J. L., Alderson, M. R., Bird, T. A., Giri, J. G., Colotta, F., Re, F., Mantovani, A., & Shanebeck, K. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6155 · Cited by 610 · see citing works

Leptin regulates proinflammatory immune responses

Loffreda, S., Yang, S., Lin, H., et al. (1998) · The FASEB Journal · doi:10.1096/fsb2fasebj.12.1.57 · Cited by 527 · see citing works

Melanocortin receptors in leptin effects

Seeley, R. J., Yagaloff, K. A., Fisher, S. L., Burn, P., Thiele, T. E., van Dijk, G., Baskin, D. G., & Schwartz, M. W. (1997) · Nature · doi:10.1038/37016 · Cited by 522 · see citing works

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

Campfield, L. A., Smith, F., & Burn, P. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979867 · Cited by 505 · see citing works

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.

Glaccum, M. B., Stocking, K., Charrier, K., Smith, J., Willis, C., Maliszewski, C., Livingston, D., Peschon, J., & Morrissey, P. (1997) · Journal of Immunology · doi:10.4049/jimmunol.159.7.3364 · Cited by 418 · see citing works

Leptin

Auwerx, J. H., & Staels, B. (1998) · The Lancet · doi:10.1016/s0140-6736(97)06348-4 · Cited by 391 · see citing works

Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.

Hellerstein, M. K., Meydani, S. N., Meydani, M., Wu, K., & Dinarello, C. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114145 · Cited by 326 · see citing works

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

Harris, R. B. S., Zhou, J. F., Redmann, S. M., Smagin, G. N., Smith, S. R., Rodgers, E. V., & Zachwieja, J. J. (1998) · Endocrinology · doi:10.1210/endo.139.1.5675 · Cited by 311 · see citing works

IL-1β mediates leptin induction during inflammation.

Faggioni, R., Fantuzzi, G., Fuller, J., Dinarello, C., Feingold, K., & Grunfeld, C. (1998) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.1.r204 · Cited by 290 · see citing works

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253 · see citing works

Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology

Rothwell, N. J., Luheshi, G., & Toulmond, S. (1996) · Pharmacology &amp; Therapeutics · doi:10.1016/0163-7258(95)02033-0 · Cited by 233 · see citing works

Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice

Kozak, W., Conn, C. A., & Kluger, M. J. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.1.r125 · Cited by 215 · see citing works

Anorexia induced by interleukin 1: involvement of corticotropin-releasing factor

Uehara, A., Sekiya, C., Takasugi, Y., Namiki, M., & Arimura, A. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.3.r613 · Cited by 185 · see citing works

In Vivo and in Vitro Evidence for the Involvement of Tumor Necrosis Factor-α in the Induction of Leptin by Lipopolysaccharide*

Finck, B. N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (1998) · Endocrinology · doi:10.1210/endo.139.5.6012 · Cited by 176 · see citing works

Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat

Luheshi, G. N., Miller, A. J., Brouwer, S., Dascombe, M. J., Rothwell, N. J., & Hopkins, S. J. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e91 · Cited by 155 · see citing works

Interleukin-6 is a centrally acting endogenous pyrogen in the rat

Rothwell, N. J., Busbridge, N. J., Feuvre, R. A. L., Hardwick, A. J., Gauldie, J., & Hopkins, S. J. (1991) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y91-219 · Cited by 147 · see citing works

Enhanced Expression of Rat Obese (ob) Gene in Adipose Tissues of Ventromedial Hypothalamus-Lesioned Rats

Funahashi, T., Shimomura, I., Hiraoka, H., Arai, T., Takahashi, M., Nakamura, T., Nozaki, S., Yamashita, S., Takemura, K., Tokunaga, K., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1837 · Cited by 126 · see citing works

Anorexic effects of interleukin 1 in the rat

Mrosovsky, N., Molony, L., Conn, C. A., & Kluger, M. J. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.6.r1315 · Cited by 112 · see citing works

CNS regulation of thermogenesis.

Rothwell, N. J. (1994) · PubMed · Cited by 103 · see citing works

Leptin and OB-R: Body weight regulation by a cytokine receptor

White, D. W., & Tartaglia, L. A. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00040-8 · Cited by 97 · see citing works

Leptin affects food intake via CRF-receptor-mediated pathways

Gardner, J. D., Rothwell, N. J., & Luheshi, G. N. (1998) · Nature Neuroscience · doi:10.1038/353 · Cited by 93 · see citing works

Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats

McCarthy, D. O., Kluger, M. J., & Vander, A. J. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90363-x · Cited by 87 · see citing works

Endotoxin-stimulated production of rat hypothalamic interleukin-1β in vivo and in vitro , measured by specific immunoradiometric assay

Hagan, P., Poole, S., & Bristow, A. F. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0110031 · Cited by 85 · see citing works

Leptin in human plasma is derived in part from the brain, and cleared by the kidneys

Esler, M., Vaz, M. A. P., Collier, G. R., Nestel, P. J., Jennings, G., Kaye, D. M., Seals, D. R., & Lambert, G. W. (1998) · The Lancet · doi:10.1016/s0140-6736(05)70289-0 · Cited by 80 · see citing works

Overlapping and distinct signals through leptin receptor (OB‐R) and a closely related cytokine signal transducer, gp130

Nakashima, K., Narazaki, M., & Taga, T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01430-5 · Cited by 50 · see citing works

Central administration of ibuprofen failed to block the anorexia induced by interleukin-1

Shimizu, H., Yutaka, U., Shimomura, Y., et al. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90547-4 · Cited by 24 · see citing works

Age-related differences in the thermogenic and ponderal effects following the administration of fragment peptides from the rat ob protein

Frühbeck, G., García‐Granero, M., & Martínez, J. A. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01061-6 · Cited by 8 · see citing works

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Relationship between Adipocyte Size and Adipokine Expression and Secretion

Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288 · see citing works

Interleukin-6-deficient mice develop mature-onset obesity

Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213 · see citing works

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

Wang, T., & He, C. (2018) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.002 · Cited by 1,034 · see citing works

Leptin in the regulation of immunity, inflammation, and hematopoiesis

Fantuzzi, G., & Faggioni, R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.4.437 · Cited by 980 · see citing works

Is obesity an inflammatory condition?

Das, U. N. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00672-4 · Cited by 799 · see citing works

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483 · see citing works

The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works

The role of interleukins in insulin resistance and type 2 diabetes mellitus

Fève, B., & Bastard, J.-P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.62 · Cited by 343 · see citing works

Cytokine, sickness behavior, and depression

Dantzer, R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.003 · Cited by 340 · see citing works

IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?

Meier, C. A., Bobbioni, E., Gabay, C., Assimacopoulos-Jeannet, F., Golay, A., & Dayer, J.-M. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.87.3.8351 · Cited by 287 · see citing works

Hypothalamic inflammation and energy homeostasis: Resolving the paradox

Thaler, J. P., Choi, S. J., Schwartz, M. W., & Wisse, B. E. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.002 · Cited by 144 · see citing works

Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice

Somm, E., Henrichot, E., Pernin, A., Juge-Aubry, C. E., Muzzin, P., Dayer, J.-M., Nicklin, M. J. H., & Meier, C. A. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3503 · Cited by 114 · see citing works

Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents

Somm, E., Cettour-Rose, P., Asensio, C., Charollais, A., Klein, M., Theander-Carrillo, C., Juge-Aubry, C. E., Dayer, J. M., Nicklin, M. J. H., Meda, P., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0046-x · Cited by 111 · see citing works

Increased core body temperature in astronauts during long-duration space missions

Stahn, A. C., Werner, A., Opatz, O., Maggioni, M. A., Steinach, M., von Ahlefeld, V. W., Moore, A., Crucian, B. E., Smith, S. M., Zwart, S. R., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15560-w · Cited by 100 · see citing works

Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation

Rummel, C., Inoue, W., Poole, S., & Luheshi, G. N. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.98 · Cited by 88 · see citing works

Stress-induced cytokine responses and central adiposity in young women

Brydon, L., Wright, C. E., O'Donnell, K., Zachary, I., Wardle, J., & Steptoe, A. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803767 · Cited by 72 · see citing works

Normal Leptin Expression, Lower Adipogenic Ability, Decreased Leptin Receptor and Hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis

Liang, G., Gao, W., Liang, A., Ye, W., Peng, Y., Zhang, L., Sharma, S., Su, P., & Huang, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036648 · Cited by 34 · see citing works

Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish

Prokop, J. W., Duff, R. J., Ball, H. C., Copeland, D. L., & Londraville, R. L. (2012) · Peptides · doi:10.1016/j.peptides.2012.10.002 · Cited by 93 · see citing works

Phenotypic Consequences of a Nonsense Mutation in the Leptin Receptor Gene (fak) in Obese Spontaneously Hypertensive Koletsky Rats (SHROB)

Ishizuka, T., Ernsberger, P. R., Liu, S., Bedol, D., Lehman, T. M., Koletsky, R. J., & Friedman, J. E. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2299 · Cited by 58 · see citing works

Mapping leptin's link to reproduction

Könner, A. C., & Brüning, J. C. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.08.001 · Cited by 4 · see citing works

The effect of four weeks restricted diet on serum soluble leptin receptor levels and adipocyte leptin receptor density in normoweight rattus norvegicus strain Wistar

Indra, M. R., & Riawan, W. (2006) · Medical Journal of Indonesia · doi:10.13181/mji.v15i3.229