Schizophrenia Genetics: Where Next?
Open accessAbstract
The purpose of this invited review is to summarize the state of genetic research into the etiology of schizophrenia (SCZ) and to consider options for progress. The fundamental uncertainty in SCZ genetics has always been the nature of the beast, the underlying genetic architecture. If this were known, studies using the appropriate technologies and sample sizes could be designed with an excellent chance of producing high-confidence results. Until recently, few pertinent data were available, and the field necessarily relied on speculation. However, for the first time in the complex and frustrating history of inquiry into the genetics of SCZ, we now have empirical data about the genetic basis of SCZ that implicate specific loci and that can be used to plan the next steps forward.
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Estimates from two different methods indicated that the risk profile component for SCZ contributes between a quarter and a third of the overall variance in liability to SCZ, a substantial fraction of the 65-81% heritability of SCZ.
“Finally, estimates from two different methods indicated that the risk profile component for SCZ contributes between a quarter and a third of the overall variance in liability to SCZ, 69,130 a substantial fraction of the 65–81% heritability of SCZ. 179,180”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [130]
Common variant SNP effects have been estimated to explain large proportions of the phenotypic heritability for a wide range of diseases: BIP and SCZ; T1DM, T2DM, Crohn's disease, rheumatoid arthritis, celiac disease, and coronary artery disease; and continuous traits (height, intelligence, and body mass).
“Common variant SNP effects have been estimated to explain large proportions of the phenotypic heritability for a wide range of diseases: BIP and SCZ; 69,130 T1DM, T2DM, Crohn’s disease, rheumatoid arthritis, celiac disease, and coronary artery disease; 70,77 and continuous traits (height, intelligence, and body mass). 70,131,132”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [130]
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- Authors
- Kim, Y., Zerwas, S., Trace, S. E., & Sullivan, P. F.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Sullivan, P. F.
- ORCID
- Zerwas, S.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-19
- Volume
- 37
- Issue
- 3
- Pages
- 456-463
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3080692
- OpenAlex
- W2143173461
- Cited by
- 101
- References
- 46
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 14 · 2013: 16 · 2012: 24
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (MH076694)
- National Institute of Mental Health (R01MH077139, MH077139, T32MH076694, R01MH080403)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12-HD-01441, K12HD001441)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia genetics
- MeSH terms
- Humans, Schizophrenia, Genome, Human, Genetic Predisposition to Disease, Genome-Wide Association Study
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