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Cited by 90Tryptophan and brain disordersStress Responses and CortisolCardiac Health and Mental Health

C-reactive protein is elevated in atypical but not nonatypical depression: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Hickman, Ruth J., Khambaty, Tasneem, Stewart, Jesse C.·2014·Journal of Behavioral Medicine
DOI 10.1007/s10865-013-9510-0
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Abstract

Little is known about the association of depression subtypes with inflammatory markers predictive of coronary artery disease. In a sample of younger adults representative of the U.S. population, we examined differences in serum C-reactive protein (CRP) among individuals with atypical major depressive disorder (MDD; n = 16), nonatypical MDD (n = 93), and no MDD (n = 1,682). Adults with atypical MDD exhibited higher CRP levels than those with no MDD (mean difference = 1.56 mg/L) or nonatypical MDD (mean difference = 1.40 mg/L), even after adjustment for potential cofounders, anxiety disorders, body mass, and smoking. Nearly twice as many adults with atypical MDD had CRP levels in the high cardiovascular risk range than did those with no MDD or nonatypical MDD. CRP levels of adults with nonatypical MDD or no MDD did not differ. Individuals with atypical depression may be partially driving the overall depression-inflammation relationship and may be a subgroup at elevated risk for coronary artery disease.

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  • In 16 patients with atypical MDD, 93 with nonatypical MDD, and 1682 healthy individuals, subjects with atypical MDD exhibited higher CRP levels than those without MDD (mean difference = 1.56 mg/L) or nonatypical MDD (mean difference = 1.40 mg/L), even after adjusting for confounders, anxiety disorders, BMI, and smoking.

    “A US-population-based study coming from the National Health and Nutrition Examination Survey (NHANES), recruited 16 patients with atypical MDD, 93 with nonatypical MDD and 1682 healthy individuals, to measure CRP levels [58]. Subjects with atypical MDD exhibited higher CRP levels than those subjects without MDD (mean difference = 1.56 mg/L) or nonatypical MDD (mean difference = 1.40 mg/L) control,”

    From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [58]

  • Large cohort studies report higher CRP concentrations in depressed patients, making heightened CRP levels in obesity one of the best predictors of depression onset, particularly atypical depression.

    “Notably, large cohort studies report higher CRP concentrations in depressed patients, making heightened CRP levels in obesity one of the best predictors of depression onset, particularly atypical depression [66].”

    From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [66]

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Authors
Hickman, R. J., Khambaty, T., & Stewart, J. C.
Affiliations
  • Indiana University School of Medicine (US)
  • Indiana University – Purdue University Indianapolis (US)
Corresponding author
Stewart, Jesse C.
ORCID
Venue
Journal of Behavioral Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-04-30
Volume
37
Issue
4
Pages
621-629
ISSN
  • 0160-7715 (ISSN-L)
  • 1573-3521
DOI
10.1007/s10865-013-9510-0
OpenAlex
W1973788838
Cited by
90
References
65
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 3
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Behavioral Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
C-reactive protein, atypical depression, major depressive disorder, depression subtypes, inflammation, coronary artery disease risk, cardiovascular risk, serum inflammatory markers, young adults
MeSH terms
Adult, C-Reactive Protein, Coronary Artery Disease, Major Depressive Disorder, Female, Humans, Male, Nutrition Surveys, Risk Factors, Biomarkers, Case-Control Studies, Young Adult

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