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Evolving concepts of rheumatoid arthritis

Firestein, Gary S.·2003·Nature

DOI 10.1038/nature01661

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856 · cited 1×
“For instance, T-cell activation leads to a RANKL-mediated increase in osteoclasts and bone loss in rat adjuvant arthriti”
Background
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis
Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1422 · Cited by 1,359
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
Pettit, A. R., Ji, H., von Stechow, D., Müller, R., Goldring, S. R., Choi, Y., Benoist, C., & Gravallese, E. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63016-7 · Cited by 807
Osteoclasts are essential for TNF-α-mediated joint destruction.
Redlich, K., Hayer, S., Ricci, R., David, J.-P., Tohidast-Akrad, M., Kollias, G., Steiner, G., Smolen, J. S., Wagner, E. F., & Schett, G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215582 · Cited by 474
High levels of osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor α treatment.
Ziolkowska, M., Kurowska, M., Radzikowska, A., Luszczykiewicz, G., Wiland, P., Dziewczopolski, W., Filipowicz‐Sosnowska, A., Pazdur, J., Szechinski, J., Kowalczewski, J., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10388 · Cited by 200

Show all 6 references

Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
The JAK/STAT signaling pathway: from bench to clinic
Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633
Five Years of GWAS Discovery
Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
Immunopathogenesis of Rheumatoid Arthritis
Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301
Self-citation
Dectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894
Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis.
Choy, E. (2012) · Rheumatology · doi:10.1093/rheumatology/kes113 · Cited by 816
TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Plenge, R. M., Seielstad, M., Padyukov, L., Lee, A. T., Remmers, E. F., Ding, B., Liew, A., Khalili, H., Chandrasekaran, A., Davies, L. R. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073491 · Cited by 823
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
Naugler, W. E., & Karin, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.007 · Cited by 730
Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine
Ziental, D., Czarczynska-Goslinska, B., Mlynarczyk, D. T., Glowacka-Sobotta, A., Stanisz, B., Goslinski, T., & Sobotta, L. (2020) · doi:10.20944/preprints202002.0271.v1 · Cited by 721
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 715
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
Chromatin marks identify critical cell types for fine mapping complex trait variants
Trynka, G., Sandor, C., Han, B., Xu, H., Stranger, B. E., Liu, X. S., & Raychaudhuri, S. (2013) · Nature Genetics · doi:10.1038/ng.2504 · Cited by 580
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
Okamoto, K., Nakashima, T., Shinohara, M., Negishi-Koga, T., Komatsu, N., Terashima, A., Sawa, S., Nitta, T., & Takayanagi, H. (2017) · Physiological Reviews · doi:10.1152/physrev.00036.2016 · Cited by 534
Hypoxia Regulates Macrophage Functions in Inflammation
Murdoch, C., Muthana, M., & Lewis, C. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6257 · Cited by 455
The IL-23-IL-17 axis in inflammatory arthritis
Lubberts, E. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.53 · Cited by 442
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438
Complement and Its Receptors: New Insights into Human Disease
Holers, V. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120154 · Cited by 430
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
Zhu, S., Pan, W., Song, X., Liu, Y., Shao, X., Tang, Y., Liang, D., He, D., Wang, H., Liu, W., et al. (2012) · Nature Medicine · doi:10.1038/nm.2815 · Cited by 396
MicroRNA‐124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast‐like synoviocytes from patients with rheumatoid arthritis
Nakamachi, Y., Kawano, S., Takenokuchi, M., Nishimura, K., Sakai, Y., Chin, T., Saura, R., Kurosaka, M., & Kumagai, S. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24475 · Cited by 332
Supplementation of fish oil and olive oil in patients with rheumatoid arthritis
Berbert, A. A., Kondo, C. R. M., Almendra, C. L., Matsuo, T., & Dichi, I. (2005) · Nutrition · doi:10.1016/j.nut.2004.03.023 · Cited by 287
Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis
Deng, C., Zhang, Q., He, P., Zhou, B., He, K., Sun, X., Lei, G., Gong, T., & Zhang, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-22454-z · Cited by 252
The role of cytokines in the pathogenesis of rheumatoid arthritis – Practical and potential application of cytokines as biomarkers and targets of personalized therapy
Brzustewicz, E., & Bryl, E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.08.260 · Cited by 196
Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells
Sawa, S.-I., Kamimura, D., Jin, G.-H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M., & Hirano, T. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052187 · Cited by 176
“20052187 1459 Autoimmune diseases comprise a heterogeneous group of poorly understood disorders that are controlled by genetic and environmental factors (1, 2).”
Background
Th17 cytokines and arthritis.
Lubberts, E. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-009-0189-9 · Cited by 173
Role of Epigenetics in Inflammation-Associated diseases
Shanmugam, M. K., & Sethi, G. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-4525-4_27 · Cited by 141
Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis
Jakus, Z., Simon, E., Frommhold, D., Sperandio, M., & Mócsai, A. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081859 · Cited by 119
Imbalance of osteoclastogenesis-regulating factors in patients with celiac disease.
Taranta, A., Fortunati, D., Longo, M., Rucci, N., Iacomino, E., Aliberti, F., Facciuto, E., Migliaccio, S., Bardella, M. T., Dubini, A., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040319 · Cited by 118
Mast Cells and Innate Cytokines are Associated with Susceptibility to Autoimmune Heart Disease Following Coxsackievirus B3 Infection
Fairweather, D., Frisancho-Kiss, S., Gatewood, S., Njoku, D., Steele, R., Barrett, M., & Rose, N. R. (2004) · Autoimmunity · doi:10.1080/0891693042000196200 · Cited by 115
Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways
Shen, Y., Teng, L., Qu, Y., Liu, J., Zhu, X., Chen, S., Yang, L., Huang, Y., Song, Q., & Fu, Q. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114791 · Cited by 113
Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ PUFA, inflammatory processes and rheumatoid arthritis: Symposium on ‘The challenge of translating nutrition research into public health nutrition’
Calder, P. C. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108008690 · Cited by 111
Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
Biniecka, M., Fox, E., Gao, W., Ng, C. T., Veale, D. J., Fearon, U., & O'Sullivan, J. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30395 · Cited by 109
Polydeoxyribonucleotide reduces cytokine production and the severity of collagen‐induced arthritis by stimulation of adenosine A 2A receptor
Bitto, A., Polito, F., Irrera, N., D'Ascola, A., Avenoso, A., Nastasi, G., Campo, G. M., Micali, A., Bagnato, G., Minutoli, L., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30538 · Cited by 105
Genome‐wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
Julià, A., Ballina, J., Cañete, J. D., Balsa, A., Tornero‐Molina, J., Naranjo, A., Alperi‐López, M., Erra, A., Pascual‐Salcedo, D., Barceló, P., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23623 · Cited by 104
Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease‐discordant monozygotic twins
Haas, C. S., Creighton, C. J., Pi, X., Maine, I., Koch, A. E., Haines, G. K., Ling, S., Chinnaiyan, A. M., & Holoshitz, J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21953 · Cited by 102
Anti-Rheumatoid Arthritic Effect of Madecassoside on Type II Collagen-Induced Arthritis in Mice
Liu, M., Dai, Y., Yao, X., Li, Y., Luo, Y., Xia, Y., & Gong, Z. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.06.011 · Cited by 87
Population Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I and II Clinical Trials
Klünder, B., Mohamed, M.-E. F., & Othman, A. A. (2018) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0605-6 · Cited by 83
Genome-Wide Expression Analysis of Placental Malaria Reveals Features of Lymphoid Neogenesis during Chronic Infection
Muehlenbachs, A., Fried, M., Lachowitzer, J., Mutabingwa, T. K., & Duffy, P. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.557 · Cited by 81
Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes
Da Sylva, T. R., Connor, A., Mburu, Y., Keystone, E., & Wu, G. E. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1752 · Cited by 73
Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis
Meyer, P. W. A., Hodkinson, B., Ally, M., Musenge, E., Wadee, A. A., Fickl, H., Tikly, M., & Anderson, R. (2010) · Mediators of Inflammation · doi:10.1155/2010/158514 · Cited by 58
Pomegranate seed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatory drug
Ferreira, L. M., Sari, M. H. M., Cervi, V. F., Gehrcke, M., Barbieri, A. V., Zborowski, V. A., Beck, R. C. R., Nogueira, C. W., & Cruz, L. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.04.008 · Cited by 54
Effect of smoking on concentrations of receptor activator of nuclear factor κ B ligand and osteoprotegerin in human gingival crevicular fluid
Tang, T. H., Fitzsimmons, T. R., & Bartold, P. M. (2009) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01444.x · Cited by 52
A Comprehensive Gene Expression Meta-analysis Identifies Novel Immune Signatures in Rheumatoid Arthritis Patients
Afroz, S., Giddaluru, J., Vishwakarma, S., Naz, S., Khan, A. A., & Khan, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00074 · Cited by 50
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Wang, Q., & Xu, R. (2019) · BMC Genomics · doi:10.1186/s12864-019-5510-y · Cited by 46
Human CD4+Tcells maintain specific functions even under conditions of extremely restricted ATP production
Tripmacher, R., Gaber, T., Dziurla, R., Häupl, T., Erekul, K., Grützkau, A., Tschirschmann, M., Scheffold, A., Radbruch, A., Burmester, G., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200738047 · Cited by 46
Ovariectomy-induced bone loss in TNFα and IL6 gene knockout mice is regulated by different mechanisms
Zhu, S., He, H., Gao, C., Luo, G., Xie, Y., Wang, H., Tian, L., Chen, X., Yu, X., & He, C. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0218 · Cited by 44
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Schwarzbich, M.-A., Gutknecht, M., Salih, J., Salih, H. R., Brossart, P., Rittig, S. M., & Grünebach, F. (2012) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-011-1096-1 · Cited by 42
Untitled work
(2006) · PubMed · Cited by 41
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Sun, Y., & Li, L. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12970 · Cited by 38
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Ishihara, K. (2004) · International Immunology · doi:10.1093/intimm/dxh045 · Cited by 21
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Lee, S. Y., Park, S.-H., Lee, S. W., Lee, S. H., Son, M. K., Choi, Y. H., Chung, W. T., & Yoo, Y. H. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0365-x · Cited by 17
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Authors: Firestein, G. S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2003-05
Volume: 423
Issue: 6937
Pages: 356-361
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01661
OpenAlex: W2074438676
Cited by: 3,605
References: 6
FWCI: 58.47
Type: journal article
Language: en
Open access: closed

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Evolving concepts of rheumatoid arthritis

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