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Dosage sensitivity and the evolution of gene families in yeast

Papp, Balázs, Pál, Csaba, Hurst, Laurence D.·2003·Nature
DOI 10.1038/nature01771
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Abstract

According to what we term the balance hypothesis, an imbalance in the concentration of the subcomponents of a protein-protein complex can be deleterious. If so, there are two consequences: first, both underexpression and overexpression of protein complex subunits should lower fitness, and second, the accuracy of transcriptional co-regulation of subunits should reflect the deleterious consequences of imbalance. Here we show that all these predictions are upheld in yeast (Saccharomyces cerevisiae). This supports the hypothesis that dominance is a by-product of physiology and metabolism rather than the result of selection to mask the deleterious effects of mutations. Beyond this, single-gene duplication of protein subunits is expected to be harmful, as this, too, leads to imbalance. As then expected, we find that members of large gene families are rarely involved in complexes. The balance hypothesis therefore provides a single theoretical framework for understanding components both of dominance and of gene family size.

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Crossref · 10.1038/nature01771

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Proteins participating in multimeric functional complexes are often sensitive to expression levels since the balance of subunits is crucial for correctly assembling the oligomeric structure.

    “Proteins participating in multimeric functional complexes are often sensitive to expression levels since the balance of subunits is crucial for correctly assembling the oligomeric structure (Papp et al., 2003).”

    From Alterations of EHD1/EHD4 Protein Levels Interfere with L1/NgCAM Endocytosis in Neurons and Disrupt Axonal Targeting (2010) · cites this paper as Papp et al., 2003

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Metadata

Authors
Papp, B., Pál, C., & Hurst, L. D.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2003-07
Volume
424
Issue
6945
Pages
194-197
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature01771
Cited by
753
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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