Cited by 2,836DNA Repair MechanismsCancer-related Molecular PathwaysMicrotubule and mitosis dynamics

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

Cell-cycle checkpoints and cancer

Kastan, Michael B., Bartek, Jiri·2004·Nature

Open this paper in CoChat — free account

Abstract

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

Integrity signals

Registry

Crossref · 10.1038/nature03097

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466
Self-citation
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Flagged first, then by citations

Show all 98 references

Research works printed but not linked: 1

Ford, J. M. Clinical Oncology (eds Abeloff, M. et al.) Ch. 11, 191–205 (Elsevier, Philadelphia, 2004).

Sorted by citations

Items 901–1,000 of 1,008

Knockdown of Checkpoint Kinase 1 Is Associated with the Increased Radiosensitivity of Glioblastoma Stem-Like Cells
Wu, J., Lai, G., Wan, F., Xiao, Z., Zeng, L., Wang, X., Ye, F., & Lei, T. (2012) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.226.267 · Cited by 41
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS
Zhang, X.-H., Cheng, Y., Shin, J.-Y., Kim, J.-O., Oh, J., & Kang, J. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.24592 · Cited by 41
The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma
Hahm, E., Jin, D., Kang, J. S., Kim, Y., Hong, S., Lee, S. K., Kim, H., Jung, D. J., Kim, J. E., Shin, D. H., et al. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21336 · Cited by 42
Radioprotection by Hymenialdisine-Derived Checkpoint Kinase 2 Inhibitors
Nguyen, T. N., Saleem, R. S. Z., Luderer, M. J., Hovde, S., Henry, R. W., & Tepe, J. J. (2011) · ACS Chemical Biology · doi:10.1021/cb200320c · Cited by 41
Prexasertib, a Chk1/Chk2 inhibitor, increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia
di Rorà, A. G. L., Iacobucci, I., Imbrogno, E., Papayannidis, C., Derenzini, E., Ferrari, A., Guadagnuolo, V., Robustelli, V., Parisi, S., Sartor, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10535 · Cited by 41
Histone Deacetylase Inhibitors and Rational Combination Therapies
Grant, S., & Dai, Y. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-394387-3.00006-9 · Cited by 42
Stabilization of c-myc G-Quadruplex DNA, inhibition of telomerase activity, disruption of mitochondrial functions and tumor cell apoptosis by platinum(II) complex with 9-amino-oxoisoaporphine
Qin, J.-L., Qin, Q., Wei, Z., Yu, Y.-C., Meng, T., Wu, C., Liang, Y., Liang, H., & Chen, Z. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.08.054 · Cited by 41
Electrodeformation-Based Biomechanical Chip for Quantifying Global Viscoelasticity of Cancer Cells Regulated by Cell Cycle
Teng, Y., Zhu, K., Xiong, C., & Huang, J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00584 · Cited by 41
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency
Araki, R., Hoki, Y., Suga, T., Obara, C., Sunayama, M., Imadome, K., Fujita, M., Kamimura, S., Nakamura, M., Wakayama, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13830-x · Cited by 42
Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
Karaayvaz, M., Silberman, R. E., Langenbucher, A., Saladi, S. V., Ross, K. N., Zarcaro, E., Desmond, A. J., Yıldırım, M., Vivekanandan, V., Ravichandran, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay2611 · Cited by 42
PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC)
Zhang, C., Zhang, Y., Li, Y., Zhu, H., Wang, S., Cai, W. L., Zhu, J., Ozaki, T., & Bu, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.139 · Cited by 41
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor
Fitzgerald, J., Moureau, S., Drogaris, P., O’Connell, E., Abshiru, N. A., Verreault, A., Thibault, P., Grenon, M., & Lowndes, N. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014714 · Cited by 41
Pathway analysis using random forests with bivariate node-split for survival outcomes
Pang, H., Datta, D., & Zhao, H. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp640 · Cited by 41
AtmDeficiency Affects Both Apoptosis and Proliferation to Augment Myc-Induced Lymphomagenesis
Maclean, K. H., Kastan, M. B., & Cleveland, J. L. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0058 · Cited by 43
Self-citation
Tumor development: Haploinsufficiency and local network assembly
Smilenov, L. B. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.08.015 · Cited by 41
Resistance to 3‐HTMC‐Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX‐2/PGE2 Pathways in Human HT‐29 and HCT116 Colorectal Cancer Cells
Semaan, J., Pinon, A., Rioux, B., Hassan, L., Limami, Y., Pouget, C., Fagnère, C., Sol, V., Diab‐Assaf, M., Simon, A., et al. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25600 · Cited by 41
Identification of novel, selective and potent Chk2 inhibitors
Larson, G., Yan, S., Chen, H., Rong, F., Hong, Z., & Wu, J. Z. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.09.067 · Cited by 41
Chromatin modulation and the DNA damage response
Costelloe, T., Fitzgerald, J., Murphy, N., Flaus, A., & Lowndes, N. F. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.031 · Cited by 41
Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation
Yan, Y., Hein, A. L., Etekpo, A., Burchett, K. M., Lin, C. H., Enke, C. A., Batra, S. K., Cowan, K. H., & Ouellette, M. M. (2014) · Oncotarget · doi:10.18632/oncotarget.2500 · Cited by 40
Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining
Chakraborty, S., Stark, J. M., Sun, C., Modi, H., Chen, W., O'Connor, T. R., Forman, S. J., Bhatia, S., & Bhatia, R. (2012) · Blood · doi:10.1182/blood-2011-05-352252 · Cited by 40
Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN-01
On, K. F., Chen, Y., Ma, H. T., Chow, J. P. H., & Poon, R. Y. C. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0809 · Cited by 42
EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage
Ramesh, R., Kuroda, S., Tam, J., Sokolov, K., & Roth, J. A. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s65990 · Cited by 40
Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells
Han, Y. H., Moon, H. J., You, B. R., Kim, S. Z., Kim, S. H., & Park, W. H. (2009) · Toxicology · doi:10.1016/j.tox.2009.10.001 · Cited by 40
RETRACTED: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line
Fiorito, F., Ciarcia, R., Granato, G. E., Marfè, G., Iovane, V., Florio, S., Martino, L. D., & Pagnini, U. (2011) · Toxicology · doi:10.1016/j.tox.2011.10.004 · Cited by 40
Retracted
Inherited Predisposition of Lung Cancer: A Hierarchical Modeling Approach to DNA Repair and Cell Cycle Control Pathways
Hung, R. J., Baragatti, M., Thomas, D. C., McKay, J., Szeszenia‐Dąbrowska, N., Zaridze, D. G., Lissowska, J., Rudnai, P., Fabiánová, E., Mateș, D., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0494 · Cited by 40
Tumor-suppressing Function of Caspase-2 Requires Catalytic Site Cys-320 and Site Ser-139 in Mice
Ren, K., Lu, J., Porollo, A., & Du, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.347625 · Cited by 40
Favorable Prognostic Impact in Loss of TP53 and PIK3CA Mutations after Neoadjuvant Chemotherapy in Breast Cancer
Jiang, Y., Yu, K., Bao, J., Peng, W.-T., & Shao, Z. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0092 · Cited by 40
Synthesis and antiproliferative activity of 9-benzylamino-6-chloro-2-methoxy-acridine derivatives as potent DNA-binding ligands and topoisomerase II inhibitors
Zhang, W., Zhang, B., Zhang, W., Yang, T., Wang, N., Gao, C., Tan, C., Liu, H., & Jiang, Y. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.03.066 · Cited by 40
DNA Damage Repair System in Plants: A Worldwide Research Update
Giménez, E., & Manzano-Agugliaro, F. R. (2017) · Genes · doi:10.3390/genes8110299 · Cited by 40
Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells
Du, J., Shi, H.-R., Ren, F., Wang, J.-L., Wu, Q., Li, X., & Zhang, R. (2017) · BMC Cancer · doi:10.1186/s12885-017-3840-1 · Cited by 40
Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway
Zhou, J., Zhang, C.-J., Sui, X., Cao, S., Tang, F. R., Sun, S., Wang, S., & Chen, B. (2018) · Investigational New Drugs · doi:10.1007/s10637-017-0552-y · Cited by 40
The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation
Feldman, M., Vershinin, Z., Goliand, I., Elia, N., & Levy, D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804407116 · Cited by 40
Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability
Auslander, N., Wolf, Y. I., & Koonin, E. V. (2020) · Nature Communications · doi:10.1038/s41467-020-15094-2 · Cited by 41
Epigenetic based synthetic lethal strategies in human cancers
Gao, A., & Guo, M. (2020) · Biomarker Research · doi:10.1186/s40364-020-00224-1 · Cited by 40
Nitrogen-containing bisphosphonate-loaded micro-arc oxidation coating for biodegradable magnesium alloy pellets inhibits osteosarcoma through targeting of the mevalonate pathway
Li, M., Yao, M., Wang, W., Wan, P., Chu, X., Zheng, Y., Yang, K., & Zhang, Y. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.019 · Cited by 40
2α-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action
Hegazy, M. F., Dawood, M., Mahmoud, N., Elbadawi, M., Sugimoto, Y., Klauck, S. M., Mohamed, N. S., & Efferth, T. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153409 · Cited by 40
IKKα Regulates Estrogen-induced Cell Cycle Progression by Modulating E2F1 Expression
Tu, Z., Prajapati, S., Park, K.-J., Kelly, N. J., Yamamoto, Y., & Gaynor, R. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512439200 · Cited by 40
Imidazole-4,5-dicarboxamide Derivatives with Antiproliferative Activity against HL-60 Cells
Perchellet, E. M., Perchellet, J., & Baures, P. W. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050160r · Cited by 40
Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells
Liao, M.-H., Lin, W., Wen, H.-C., & Pu, H. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.11.002 · Cited by 40
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
Nakada, S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25716e1 · Cited by 40
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
Nakada, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25716 · Cited by 40
Up-Regulation of Kin17 Is Essential for Proliferation of Breast Cancer
Zeng, T., Gao, H.-Y., Yu, P., He, H., Ouyang, X., Deng, L., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025343 · Cited by 39
Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae
Conde, F., Ontoso, D., Acosta, I., Gallego-Sánchez, A., Bueno, A., & San-Segundo, P. A. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.07.003 · Cited by 40
Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Takashima, S., Saito, H., Takahashi, N., Imai, K., Kudo, S., Atari, M., Saito, Y., Motoyama, S., & Minamiya, Y. (2013) · Tumor Biology · doi:10.1007/s13277-013-1556-7 · Cited by 39
Screening of Hub Genes and Pathways in Colorectal Cancer with Microarray Technology
Wang, Y., & Zheng, T. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-013-9739-5 · Cited by 39
DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Ma, X., Han, Y., Song, X., Do, T., Yang, Z., Ni, J., & Xie, T. (2016) · Development · doi:10.1242/dev.141069 · Cited by 39
Antitumor potential of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles in human bladder cancer cells
Tessmann, J. W., Buss, J. H., Begnini, K. R., Berneira, L. M., Paula, F. R., de Pereira, C. M. P., Collares, T. V., & Seixas, F. K. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.07.060 · Cited by 39
Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review
Panou, V., & Røe, O. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124327 · Cited by 40
Structure-activity relationships of Wee1 inhibitors: A review
Du, X., Li, J., Luo, X., Li, R., Li, F., Zhang, Y., Shi, J., & He, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112524 · Cited by 39
Signaling pathways involved in cell cycle arrest during the DNA breaks
Sadoughi, F., Hallajzadeh, J., Asemi, Z., Mansournia, M. A., Alemi, F., & Yousefi, B. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103047 · Cited by 40
DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1
Zhang, H., He, C., Guo, X., Fang, Y., Lai, Q., Wang, X., Pan, X., Li, H., Qin, K., Li, A., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00827-7 · Cited by 39
DNA damage and cellular differentiation: More questions than responses
Simonatto, M., Latella, L., & Puri, P. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21275 · Cited by 39
Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia
Koorstra, J.-B. M., Hong, S., Shi, C., Meeker, A. K., Ryu, J. K., Offerhaus, G. J. A., Goggins, M., Hruban, R. H., & Maitra, A. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.114 · Cited by 39
Regulation of Claspin degradation by the ubiquitin‐proteosome pathway during the cell cycle and in response to ATR‐dependent checkpoint activation
Bennett, L. N., & Clarke, P. R. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.071 · Cited by 39
p53 control of bone remodeling
Liu, H., & Li, B. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22749 · Cited by 39
STAT1 activation in squamous cell cancer of the oral cavity
Laimer, K., Spizzo, G., Obrist, P., Gastl, G. A., Brunhuber, T., Schäfer, G., Norer, B., Rasse, M., Haffner, M. C., & Doppler, W. (2007) · Cancer · doi:10.1002/cncr.22813 · Cited by 40
Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2
Zhang, Y., Qian, D., Li, Z., Huang, Y., Wu, Q., Ru, G., Chen, M., & Wang, B. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0693-5 · Cited by 39
Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.
Jiang, J., Matranga, C. B., Cai, D. D., Latham, V. M., Zhang, X., Lowell, A. M., Martelli, F., & Shapiro, G. I. (2003) · PubMed · Cited by 39
Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway
Iwamoto, K., Tashima, Y., Hamada, H., Eguchi, Y., & Okamoto, M. (2008) · Biosystems · doi:10.1016/j.biosystems.2008.05.016 · Cited by 39
Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms
Rowe, B. P., & Glazer, P. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2566 · Cited by 39
Spi-1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage
Rimmelé, P., Komatsu, J., Hupé, P., Roulin, C., Barillot, E., Dutreix, M., Conseiller, E., Bensimon, A., Moreau-Gachelin, F., & Guillouf, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4691 · Cited by 38
XPA-Mediated Regulation of Global Nucleotide Excision Repair by ATR Is p53-Dependent and Occurs Primarily in S-Phase
Li, Z., Musich, P. R., Serrano, M. A., Dong, Z., & Zou, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028326 · Cited by 38
Seize the engine: Emerging cell cycle targets in breast cancer
Fuentes‐Antrás, J., Bedard, P. L., & Cescon, D. W. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1544 · Cited by 40
Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC).
Zhang, B.-Y., Wang, Y., Gong, H. F., Zhao, H., Lv, X., Yuan, G.-H., & Han, S.-R. (2015) · Europe PMC (PubMed Central) · Cited by 38
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy
Yang, H., Yoon, S. J., Jin, J., Choi, S. H., Seol, H. J., Lee, J.-I., Nam, D., & Yoo, H. Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.106 · Cited by 38
Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles
Zhang, H., Ji, Y., Chen, Q., Jiao, X., Hou, L., Zhu, X., & Zhang, Z. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1016437 · Cited by 38
DNA damage stress response in germ cells: role of c-Abl and clinical implications
Gonfloni, S. (2010) · Oncogene · doi:10.1038/onc.2010.410 · Cited by 39
Restoration of paclitaxel resistance by CDK1 intervention in drug-resistant ovarian cancer
Bae, T., Weon, K.-Y., Lee, J., Eum, K., Kim, S., & Choi, J. W. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv140 · Cited by 38
Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death
Yu, P., Zhang, C., Gao, C., Ma, T., Zhang, H., Zhou, M., Yang, Y.-W., Yang, L., & Kong, L. (2017) · Oncotarget · doi:10.18632/oncotarget.19299 · Cited by 38
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats
Han, B., Pei, Z., Shi, L., Wang, Q., Li, C., Zhang, B., Su, X., Zhang, N., Zhou, L., Zhao, B., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s254969 · Cited by 38
Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy
Xu, F., Xi, H., Liao, M., Zhang, Y., Ma, H., Wu, M., Xue, Q., Sun, H., Zhang, Y., & Xia, Y. (2022) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-021-04386-z · Cited by 38
The role of ATM and 53BP1 as predictive markers in cervical cancer
Roossink, F., Wieringa, H. W., Noordhuis, M. G., ten Hoor, K. A., Kok, M., Slagter‐Menkema, L., Hollema, H., de Bock, G. H., Pras, E., de Vries, E. G. E., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27488 · Cited by 38
SMARCAL1 and replication stress
Bansbach, C. E., Boerkoel, C. F., & Cortez, D. (2010) · Nucleus · doi:10.4161/nucl.1.3.11739 · Cited by 38
Mitotic catastrophe induced in HeLa cells by photodynamic treatment with Zn(II)-phthalocyanine
Acedo, P., Villanueva, Á., Cañete, M., Stockert, J., & Rello‐Varona, S. (1992) · International Journal of Oncology · doi:10.3892/ijo.32.6.1189 · Cited by 39
1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells
Das, D. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i42.7374 · Cited by 38
Increased expression of p21WAF1/CIP1 in kidney proximal tubules mediates fibrosis
Megyesi, J. K., Tarcsafalvi, A., Li, S., Hodeify, R. F., Seng, N. S. H. L., Portilla, D., & Price, P. M. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00489.2014 · Cited by 39
Fangchinoline Induced G1/S Arrest by Modulating Expression of p27, PCNA, and Cyclin D in Human Prostate Carcinoma Cancer PC3 Cells and Tumor Xenograft
Chang-Dong, W. A. N. G., Huang, J., Gao, X., Li, Y., Zhou, S., Xu, Y. L., An, Z. O. U., Chang, J., Wang, Y., Yang, G., et al. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90490 · Cited by 38
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response
Schepeler, T., Lamy, P., Hvidberg, V., Laurberg, J. R., Fristrup, N., Reinert, T., Bártková, J., Tropia, L., Bártek, J., Halazonetis, T. D., et al. (2012) · Oncogene · doi:10.1038/onc.2012.381 · Cited by 39
Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45
Rodrı́guez, R., Gagou, M. E., & Meuth, M. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.4 · Cited by 38
Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis
Liu, W., Jiang, F., Bi, X., & Zhang, Y. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds307 · Cited by 38
Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside
Sriramulu, S., Thoidingjam, S., Brown, S. L., Siddiqui, F., Movsas, B., & Nyati, S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114126 · Cited by 39
Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer
Wang, Y., Wang, C., Liu, T., Qi, H., Chen, S., Cai, X., Zhang, M., Aliper, A., Ren, F., Ding, X., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01476 · Cited by 39
Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression
Bouças, J., Fritz, C., Schmitt, A., Riabinska, A., Thelen, L., Peifer, M., Leeser, U., Nüernberg, P., Altmueller, J., Gaestel, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125745 · Cited by 37
LW-213 induces G2/M cell cycle arrest through AKT/GSK3β/β-catenin signaling pathway in human breast cancer cells
Zhao, L., Miao, H., Li, W., Sun, Y., Huang, S., Li, Z., & Guo, Q. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22321 · Cited by 37
ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage
Medhurst, A. L., Warmerdam, D. O., Akerman, İ., Verwayen, E. H., Kanaar, R., Smits, V. A. J., & Lakin, N. D. (2008) · Journal of Cell Science · doi:10.1242/jcs.033688 · Cited by 39
Comparative Analyses of SUV420H1 Isoforms and SUV420H2 Reveal Differences in Their Cellular Localization and Effects on Myogenic Differentiation
Tsang, L. W. K., Hu, N., & Underhill, D. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014447 · Cited by 39
MLN8054, A Small Molecule Inhibitor of Aurora Kinase A, Sensitizes Androgen-Resistant Prostate Cancer to Radiation
Moretti, L., Niermann, K. J., Schleicher, S. M., Giacalone, N. J., Varki, V., Kim, K. W., Kopsombut, P., Jung, D. K., & Lü, B. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.01.060 · Cited by 37
miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBPα expression
Lin, H., Gong, J., Su, R. J., Chen, M., Song, L., Shen, C., Wang, F., Ma, Y., Zhao, H.-L., Yu, J., et al. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0514-240r · Cited by 37
Preferential killing of p53-deficient cancer cells by reversine
Jèmaà, M., Galluzzi, L., Kepp, O., Boilève, A., Lissa, D., Senovilla, L., Harper, F., Pierron, G., Berardinelli, F., Antoccia, A., et al. (2012) · Cell Cycle · doi:10.4161/cc.20621 · Cited by 38
Methanol extract of the ethnopharmaceutical remedy Smilax spinosa exhibits anti-neoplastic activity
Seelinger, M., Popescu, R., Giessrigl, B., Jarukamjorn, K., Unger, C., Wallnöfer, B., Fritzer‐Szekeres, M., Szekeres, T., Díaz, R. E., Jäger, W. R., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1538 · Cited by 37
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3436 · Cited by 37
Antitumor effect of gemcitabine-loaded albumin nanoparticle on gemcitabine-resistant pancreatic cancer induced by low hENT1 expression
Guo, Z., Wang, F., Yang, D., Yao, L., Yu, X., Fu, D., Li, J., & Jin, C. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s166769 · Cited by 37
A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer
Byun, W. S., Jin, M., Yu, J., Kim, W. K., Song, J., Chung, H., Jeong, L. S., & Lee, S. K. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.002 · Cited by 37
The Role of p38γ in Cancer: From review to outlook
Xu, W., Liu, R., Dai, Y., Hong, S., Dong, H., & Wang, H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.63537 · Cited by 37
Cell Cycle as a Target of Antineoplastic Drugs
Falco, M. D., & Luca, A. D. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791033914 · Cited by 37
A Novel ATM/TP53/p21-Mediated Checkpoint Only Activated by Chronic γ-Irradiation
Cao, L., Kawai, H., Sasatani, M., Iizuka, D., Masuda, Y., Inaba, T., Suzuki, K., Ootsuyama, A., Umata, T., Kamiya, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104279 · Cited by 37
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress
Lin, Z. P., Belcourt, M. F., Carbone, R., Eaton, J. S., Penketh, P. G., Shadel, G. S., Cory, J. G., & Sartorelli, A. C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.014 · Cited by 38
Nuclear Chk1 prevents premature mitotic entry
Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N., & Inagaki, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.086488 · Cited by 38
E2F4 Function in G2 Maintaining G2-arrest to Prevent Mitotic Entry with Damaged DNA
Plesca, D. C., Crosby, M. E., Gupta, D., & Almasan, A. (2007) · Cell Cycle · doi:10.4161/cc.6.10.4259 · Cited by 37
Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy
Şahin, İ. H., Iacobuzio–Donahue, C. A., & O'Reilly, E. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1094057 · Cited by 39

Authors: Kastan, M. B., & Bartek, J.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Kastan, Michael B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11
Volume: 432
Issue: 7015
Pages: 316-323
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03097
OpenAlex: W1965239527
Cited by: 2,836
References: 98
Citations by year: 2026: 61 · 2025: 71 · 2024: 70 · 2023: 111 · 2022: 132 · 2021: 151 · 2020: 144 · 2019: 119 · 2018: 114 · 2017: 130 · 2016: 141 · 2015: 138 · 2014: 151 · 2013: 141 · 2012: 164
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: cell cycle checkpoints, DNA damage response, DNA repair, cancer, DNA-damaging agents, radiation, cancer therapy toxicity, carcinogenesis
MeSH terms: Animals, Cell Cycle, DNA Damage, Humans, Neoplasms, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cell-cycle checkpoints and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks