Cited by 2,836DNA Repair MechanismsCancer-related Molecular PathwaysMicrotubule and mitosis dynamics

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Cell-cycle checkpoints and cancer

Kastan, Michael B., Bartek, Jiri·2004·Nature

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Abstract

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

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The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466
Self-citation
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Show all 98 references

Research works printed but not linked: 1

Ford, J. M. Clinical Oncology (eds Abeloff, M. et al.) Ch. 11, 191–205 (Elsevier, Philadelphia, 2004).

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“c c d p ially neurological defects [13,14]; it is thus not surprising that hese pathways are extremely conserved throughout evolution Table 1).”
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Authors: Kastan, M. B., & Bartek, J.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Kastan, Michael B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11
Volume: 432
Issue: 7015
Pages: 316-323
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03097
OpenAlex: W1965239527
Cited by: 2,836
References: 98
Citations by year: 2026: 61 · 2025: 71 · 2024: 70 · 2023: 111 · 2022: 132 · 2021: 151 · 2020: 144 · 2019: 119 · 2018: 114 · 2017: 130 · 2016: 141 · 2015: 138 · 2014: 151 · 2013: 141 · 2012: 164
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: cell cycle checkpoints, DNA damage response, DNA repair, cancer, DNA-damaging agents, radiation, cancer therapy toxicity, carcinogenesis
MeSH terms: Animals, Cell Cycle, DNA Damage, Humans, Neoplasms, Signal Transduction

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