Cited by 2,836DNA Repair MechanismsCancer-related Molecular PathwaysMicrotubule and mitosis dynamics

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

Cell-cycle checkpoints and cancer

Kastan, Michael B., Bartek, Jiri·2004·Nature

Open this paper in CoChat — free account

Abstract

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

Integrity signals

Registry

Crossref · 10.1038/nature03097

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Doll, R., & Peto, R. (1981) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/66.6.1192 · Cited by 3,927
The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today
Peto, R. (1983) · Springer eBooks · doi:10.1007/978-1-4757-1117-2_30 · Cited by 3,504
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466
Self-citation
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Flagged first, then by citations

Show all 98 references

Research works printed but not linked: 1

Ford, J. M. Clinical Oncology (eds Abeloff, M. et al.) Ch. 11, 191–205 (Elsevier, Philadelphia, 2004).

Sorted by citations

Items 101–200 of 1,008

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
Carvalho, S., Vítor, A. C., Sridhara, S. R. C., Martins, F. B., Raposo, A. C., Desterro, J. M. P., Ferreira, J. A., & de Almeida, S. F. (2014) · eLife · doi:10.7554/elife.02482 · Cited by 282
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262
SALMON: survival analysis learning with multi-omics neural networks on breast cancer
Huang, Z., Zhan, X., Xiang, S., Johnson, T. S., Helm, B., Yu, C. Y., Zhang, J., Salama, P., Rizkalla, M., Han, Z., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00166 · Cited by 262
Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2
Zhang, X., Zhang, Y., He, Z., Yin, K., Li, B., Zhang, L., & Xu, Z. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2030-2 · Cited by 261
ATM is down-regulated by N-Myc–regulated microRNA-421
Hu, H., Du, L., Nagabayashi, G., Seeger, R. C., & Gatti, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907763107 · Cited by 267
Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
Baliga, M. S., & Dsouza, J. J. (2011) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32834473f4 · Cited by 259
Biological mechanisms of gold nanoparticle radiosensitization
Rosa, S., Connolly, C., Schettino, G., Butterworth, K. T., & Prise, K. M. (2017) · Cancer Nanotechnology · doi:10.1186/s12645-017-0026-0 · Cited by 258
Cancer and the Circadian Clock
Shafi, A. A., & Knudsen, K. E. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0566 · Cited by 264
The ATR pathway: Fine-tuning the fork
PAULSEN, R., & Cimprich, K. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.015 · Cited by 266
Multiple roles of ATM in monitoring and maintaining DNA integrity
Derheimer, F. A., & Kastan, M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.031 · Cited by 265
Self-citation
Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents
Charrier, J., Durrant, S. J., Golec, J. M. C., Kay, D. P., Knegtel, R. M. A., MacCormick, S., Mortimore, M., O'Donnell, M. E., Pinder, J. L., Reaper, P. M., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101488z · Cited by 261
Identification of pathways regulating cell size and cell-cycle progression by RNAi
Björklund, M., Taipale, M., Varjosalo, M. T., Saharinen, J., Lahdenperä, J., & Taipale, J. (2006) · Nature · doi:10.1038/nature04469 · Cited by 257
Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects
Evers, B., & Jonkers, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209871 · Cited by 264
Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways
Morgan, M. A., & Lawrence, T. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3229 · Cited by 262
Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair
Potts, P. R., & Yu, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7021-7032.2005 · Cited by 252
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksPreprint
Bansbach, C. E., Betous, R., Lovejoy, C. A., Glick, G. G., & Cortez, D. (2009) · Genes & Development · doi:10.1101/gad.1839909 · Cited by 254
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangementsPreprint
Zhang, C., Leibowitz, M. L., & Pellman, D. S. (2013) · Genes & Development · doi:10.1101/gad.229559.113 · Cited by 258
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247
Participation of DNA repair in the response to 5-fluorouracil
Wyatt, M. D., & Wilson, D. M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8557-5 · Cited by 248
Genes involved in human premature ovarian failure
Persani, L., Rossetti, R., & Cacciatore, C. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0070 · Cited by 245
Analysis of a Generic Model of Eukaryotic Cell-Cycle Regulation
Csikász‐Nagy, A., Battogtokh, D., Chen, K. C., Novák, B., & Tyson, J. J. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.081240 · Cited by 242
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
Larsen, D. H., Poinsignon, C., Guðjόnsson, Þ., Dinant, C., Payne, M., Hari, F. J., Danielsen, J. M. R., Ménard, P., Sand, J. C., Stucki, M., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912135 · Cited by 251
p62: a versatile multitasker takes on cancer
Moscat, J., & Díaz-Meco, M. T. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.02.008 · Cited by 250
Putting Cancer to Sleep at Night: The Neuroendocrine/Circadian Melatonin Signal
Blask, D. E., Dauchy, R. T., & Sauer, L. A. (2005) · Endocrine · doi:10.1385/endo:27:2:179 · Cited by 238
Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis
Allan, L. A., & Clarke, P. R. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.019 · Cited by 237
Chk1 regulates the density of active replication origins during the vertebrate S phase
Maya‐Mendoza, A., Petermann, E., Gillespie, D. A., Caldecott, K. W., & Jackson, D. A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601714 · Cited by 236
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1
Tripathi, D. N., Chowdhury, R., Trudel, L. J., Tee, A. R., Slack, R. S., Walker, C. L., & Wogan, G. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307736110 · Cited by 238
New therapeutic strategies for the treatment of acute lymphoblastic leukaemia
Pui, C., & Jeha, S. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2240 · Cited by 235
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 234
Self-citation
Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
De Angelis, P. M., Svendsrud, D. H., Kravik, K. L., & Stokke, T. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-20 · Cited by 233
ATM regulates ATR chromatin loading in response to DNA double-strand breaks
Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., & Fernandez-Capetillo, O. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051923 · Cited by 232
A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.
Stilmann, M., Hinz, M., Arslan, S. Ç., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.032 · Cited by 232
CtIP Links DNA Double-Strand Break Sensing to Resection
You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y.-W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., & Hunter, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.002 · Cited by 231
Targeting tumour-supportive cellular machineries in anticancer drug development
Dobbelstein, M., & Moll, U. M. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4201 · Cited by 233
DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
Reinhardt, H. C., Hasskamp, P., Schmedding, I., Morandell, S., van Vugt, M. A. T. M., Wang, X., Linding, R., Ong, S., Weaver, D. T., Carr, S. A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.018 · Cited by 234
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint
van Vugt, M. A. T. M., Gardino, A. K., Linding, R., Ostheimer, G. J., Reinhardt, H. C., Ong, S.-E., Tan, C. S. H., Miao, H., Keezer, S. M., Li, J., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000287 · Cited by 236
The Repair and Signaling Responses to DNA Double-Strand Breaks
Goodarzi, A. A., & Jeggo, P. A. (2013) · Advances in genetics · doi:10.1016/b978-0-12-407676-1.00001-9 · Cited by 245
Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma
Panou, V., Gadiraju, M., Wolin, A. R., Weipert, C. M., Skarda, E., Husain, A. N., Patel, J. D., Rose, B., Zhang, S. R., Weatherly, M., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2018.78.5204 · Cited by 228
The intra-S phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses
Seiler, J. A., Conti, C., Syed, A., Aladjem, M. I., & Pommier, Y. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02278-06 · Cited by 226
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
Melander, F., Bekker‐Jensen, S., Falck, J., Bártek, J., Mailand, N., & Lukas, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708210 · Cited by 231
Genetics of primary ovarian insufficiency
Rossetti, R., Ferrari, I., Bonomi, M., & Persani, L. (2016) · Clinical Genetics · doi:10.1111/cge.12921 · Cited by 225
The ubiquitous role of ubiquitin in the DNA damage response
Al-Hakim, A., Escribano‐Diaz, C., Landry, M.-C., O’Donnell, L., Panier, S., Szilard, R. K., & Durocher, D. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.011 · Cited by 240
The CHEK2 gene and inherited breast cancer susceptibility
Nevanlinna, H. A., & Bártek, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209877 · Cited by 228
Cell cycle control as a basis for cancer chemoprevention through dietary agents
Meeran, S. M. (2007) · Frontiers in bioscience · doi:10.2741/2834 · Cited by 222
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells
Belgnaoui, S. M., Gosden, R. G., Semmes, O. J., & Haoudi, A. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-13 · Cited by 219
Non–Small Cell Lung Cancers with Kinase Domain Mutations in the Epidermal Growth Factor Receptor Are Sensitive to Ionizing Radiation
Das, A. K., Sato, M., Story, M. D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A. F., Shay, J. W., Minna, J. D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2627 · Cited by 217
Cyclin-Dependent Kinase 1-Mediated Bcl-x L /Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis
Terrano, D. T., Upreti, M., & Chambers, T. C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00882-09 · Cited by 220
Tel2 Regulates the Stability of PI3K-Related Protein Kinases
Takai, H., Wang, R. C., Takai, K., Yang, H., & de Lange, T. (2007) · Cell · doi:10.1016/j.cell.2007.10.052 · Cited by 226
MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Wang, W., Wu, S.-P., Liu, J., Shi, Y., Huang, X. P., Zhang, Q.-B., & Yao, K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1408 · Cited by 217
Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases
Schmidt, M., Rohe, A., Platzer, C., Najjar, A., Erdmann, F., & Sippl, W. (2017) · Molecules · doi:10.3390/molecules22122045 · Cited by 221
Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells
Swift, L. H., & Golsteyn, R. M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033403 · Cited by 230
The checkpoint response to replication stress
Branzei, D., & Foiani, M. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.014 · Cited by 214
Low-Dose Hyper-Radiosensitivity: Past, Present, and Future
Marples, B., & Collis, S. J. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.11.071 · Cited by 213
Where excludability matters: Material versus intellectual property in academic biomedical research
Walsh, J. P., Cohen, W. M., & Cho, C. (2007) · Research Policy · doi:10.1016/j.respol.2007.04.006 · Cited by 213
Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study
Lee, J., Nair, J. R., Zimmer, A. S., Lipkowitz, S., Annunziata, C. M., Merino, M. J., Swisher, E. M., Harrell, M. I., Trepel, J. B., Lee, M.-J., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30009-3 · Cited by 207
Functional interaction between FOXO3a and ATM regulates DNA damage response
Tsai, W.-B., Chung, Y. M., Takahashi, Y. K., Xu, Z., & Hu, M. C. ‐. (2008) · Nature Cell Biology · doi:10.1038/ncb1709 · Cited by 210
DNA damage tolerance: a double-edged sword guarding the genome.
Ghosal, G., & Chen, J. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.04.01 · Cited by 215
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Hanna, A., & Shevde, L. A. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0509-3 · Cited by 206
Radiation-induced signaling pathways that promote cancer cell survival (Review)
HEIN, A. L., OUELLETTE, M. M., & YAN, Y. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2614 · Cited by 201
Signalling cell cycle arrest and cell death through the MMR System
O’Brien, V., & Brown, R. E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi298 · Cited by 203
Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970
Hall, A. B., Newsome, D., Wang, Y., Boucher, D. M., Eustace, B. K., Gu, Y., Hare, B. J., Johnson, M., Li, H. Y., Milton, S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2158 · Cited by 204
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress
Qian, W., Choi, S., Gibson, G. A., Watkins, S. C., Bakkenist, C. J., & Houten, B. V. (2012) · Journal of Cell Science · doi:10.1242/jcs.109769 · Cited by 204
Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage
Shao, Q., Herrlinger, S. A., Yang, S., Lai, F., Moore, J. M., Brindley, M. A., & Chen, J.-F. (2016) · Development · doi:10.1242/dev.143768 · Cited by 203
New therapeutic strategies to treat human cancers expressing mutant p53 proteins
Blandino, G., & Agostino, S. D. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0705-7 · Cited by 203
Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
Peasland, A., Wang, L.-Z., Rowling, E. J., Kyle, S., Chen, T., Hopkins, A. P., Cliby, W. A., Sarkaria, J. N., Beale, G., Edmondson, R. J., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.243 · Cited by 202
The role of m6A methylation in therapy resistance in cancer
Zhuang, H., Yu, B., Tao, D., Xu, X., Xu, Y., Wang, J., Jiao, Y., & Wang, L. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01782-2 · Cited by 197
Cellular UV damage responses—Functions of tumor suppressor p53
Latonen, L., & Laiho, M. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.04.003 · Cited by 200
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
Canaud, G., & Bonventre, J. V. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu230 · Cited by 200
Non-apoptotic functions of BCL-2 family proteins
Gross, A., & Katz, S. G. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.22 · Cited by 202
Cancer Drug Discovery and Development
Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195
Human Cytomegalovirus Protein UL38 Inhibits Host Cell Stress Responses by Antagonizing the Tuberous Sclerosis Protein Complex
Moorman, N. J., Cristea, I. M., Terhune, S. S., Rout, M. P., Chait, B. T., & Shenk, T. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.03.002 · Cited by 194
Deconstructing p53 transcriptional networks in tumor suppression
Bieging, K. T., & Attardi, L. D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.006 · Cited by 194
DNA Damage Responses: Mechanisms and Roles in Human Disease
Kastan, M. B. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0020 · Cited by 198
Self-citation
Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets
Banik, K., Ranaware, A. M., Deshpande, V., Nalawade, S. P., Padmavathi, G., Bordoloi, D., Sailo, B. L., Shanmugam, M. K., Fan, L., Arfuso, F., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.004 · Cited by 191
Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall
Yu, C., Gan, H., Han, J., Zhou, Z.-X., Jia, S., Chabes, A., Farrugia, G., Ördög, T., & Zhang, Z. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.017 · Cited by 190
Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
Schmidt, M., & Bastians, H. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.06.003 · Cited by 191
Targeting the cell cycle in breast cancer: towards the next phase
Thu, K. L., Soria‐Bretones, I., Mak, T. W., & Cescon, D. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1502567 · Cited by 192
RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint
Olson, E. E., Nievera, C. J., Klimovich, V., Fanning, E., & Wu, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605121200 · Cited by 195
Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation
Zhu, C.-Q., Shih, W., Ling, C.-H., & Tsao, M. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.031351 · Cited by 187
The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
Zhang, Y.-W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M. P., Aslanian, A., Manning, G., Abraham, R. T., & Hunter, T. R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.030 · Cited by 193
Signaling Pathways that Regulate Cell DivisionPreprint
Rhind, N., & Russell, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005942 · Cited by 195
Chk1 and p21 Cooperate to Prevent Apoptosis during DNA Replication Fork Stress
Rodríguez, R., & Meuth, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0594 · Cited by 189
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1
Cheng, L., Wu, Q., Huang, Z., Guryanova, O. A., Huang, Q., Shou, W., Rich, J. N., & Bao, S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.10 · Cited by 195
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 190
Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models
Kim, S., & Choi, K. (2013) · Toxicological Research · doi:10.5487/tr.2013.29.4.229 · Cited by 181
Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase
Petermann, E., Maya‐Mendoza, A., Zachos, G., Gillespie, D. A., Jackson, D. A., & Caldecott, K. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3319-3326.2006 · Cited by 181
Dormancy of Solitary Metastatic Cells
Townson, J. L., & Chambers, A. F. (2006) · Cell Cycle · doi:10.4161/cc.5.16.2864 · Cited by 181
Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer
Becchetti, A. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00047.2011 · Cited by 187
Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma
Ding, X., He, Z., Zhou, K., Cheng, J., Yao, H., Lu, D., Cai, R., Jin, Y., Dong, B., Xu, Y., et al. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq217 · Cited by 179
MicroRNAs: new players in the DNA damage response
Hu, H., & Gatti, R. A. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq042 · Cited by 186
BRCA1 haploinsufficiency for replication stress suppression in primary cells
Pathania, S., Bade, S., Guillou, M. L., Burke, K. A., Reed, R., Bowman-Colin, C., Su, Y., Ting, D. T., Polyák, K., Richardson, A. L., et al. (2014) · Nature Communications · doi:10.1038/ncomms6496 · Cited by 183
Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit
Leung‐Pineda, V., Ryan, C. E., & Piwnica-Worms, H. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00447-06 · Cited by 182
p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.
Aliouat-Denis, C.-M., Dendouga, N., Van den Wyngaert, I., Goehlmann, H., Steller, U., van de Weyer, I., Van Slycken, N., Andries, L., Kass, S., Luyten, W., et al. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0121 · Cited by 177
The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH
Park (2009) · Oncology Reports · doi:10.3892/or_00000427 · Cited by 175
The anti-cancer effects and mechanisms of lactic acid bacteria exopolysaccharides in vitro: A review
Wu, J., Zhang, Y., Ye, L., & Wang, C. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117308 · Cited by 178
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 180
Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology
Eisch, A. J., & Harburg, G. C. (2006) · Hippocampus · doi:10.1002/hipo.20161 · Cited by 176
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
Pires, I. M., Olcina, M. M., Anbalagan, S., Pollard, J. R., Reaper, P. M., Charlton, P., McKenna, W. G., & Hammond, E. M. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.265 · Cited by 175
Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage
Choi, M., Shi, J., Jung, S. H., Chen, X. X., & Cho, K. (2012) · Science Signaling · doi:10.1126/scisignal.2003363 · Cited by 170

Authors: Kastan, M. B., & Bartek, J.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Kastan, Michael B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11
Volume: 432
Issue: 7015
Pages: 316-323
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03097
OpenAlex: W1965239527
Cited by: 2,836
References: 98
Citations by year: 2026: 61 · 2025: 71 · 2024: 70 · 2023: 111 · 2022: 132 · 2021: 151 · 2020: 144 · 2019: 119 · 2018: 114 · 2017: 130 · 2016: 141 · 2015: 138 · 2014: 151 · 2013: 141 · 2012: 164
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: cell cycle checkpoints, DNA damage response, DNA repair, cancer, DNA-damaging agents, radiation, cancer therapy toxicity, carcinogenesis
MeSH terms: Animals, Cell Cycle, DNA Damage, Humans, Neoplasms, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cell-cycle checkpoints and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks