Cited by 2,836DNA Repair MechanismsCancer-related Molecular PathwaysMicrotubule and mitosis dynamics

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Cell-cycle checkpoints and cancer

Kastan, Michael B., Bartek, Jiri·2004·Nature

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Abstract

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.

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Authors: Kastan, M. B., & Bartek, J.
Affiliations: St. Jude Children's Research Hospital (US)
ORCID: Kastan, Michael B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-11
Volume: 432
Issue: 7015
Pages: 316-323
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03097
OpenAlex: W1965239527
Cited by: 2,836
References: 98
Citations by year: 2026: 61 · 2025: 71 · 2024: 70 · 2023: 111 · 2022: 132 · 2021: 151 · 2020: 144 · 2019: 119 · 2018: 114 · 2017: 130 · 2016: 141 · 2015: 138 · 2014: 151 · 2013: 141 · 2012: 164
FWCI: 9.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: cell cycle checkpoints, DNA damage response, DNA repair, cancer, DNA-damaging agents, radiation, cancer therapy toxicity, carcinogenesis
MeSH terms: Animals, Cell Cycle, DNA Damage, Humans, Neoplasms, Signal Transduction

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