Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases

Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesisPreprint

Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K., Donahee, M. H., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., et al. (2003) · Genes & Development · doi:10.1101/gad.1083503 · Cited by 714

Time-restricted feeding regulates molecular mechanisms with involvement of circadian rhythm to prevent metabolic diseases

Zeb, F., Wu, X., Fatima, S., Zaman, M. H., Khan, S. A., Safdar, M., Alam, I., & Feng, Q. (2021) · Nutrition · doi:10.1016/j.nut.2021.111244 · Cited by 51

Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet

Hu, Y., Xu, J., Sheng, Y., Liu, J., Li, H., Guo, M., Xu, W., Luo, Y., Huang, K., & He, X. (2022) · Nutrients · doi:10.3390/nu14091868 · Cited by 51

Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention

Li, Q., & Chen, Y. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac659 · Cited by 51

Chemogenomics Approaches to Rationalizing the Mode-of-Action of Traditional Chinese and Ayurvedic Medicines

Fauzi, F. M., Koutsoukas, A., Lowe, R., Joshi, K., Fan, T., Glen, R. C., & Bender, A. (2013) · Journal of Chemical Information and Modeling · doi:10.1021/ci3005513 · Cited by 51

Cross-talk between liver and intestine in control of cholesterol and energy homeostasis

Groen, A. K., Bloks, V. W., Verkade, H. J., & Kuipers, F. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.02.001 · Cited by 51

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice

Volynets, V., Spruss, A., Kanuri, G., Wagnerberger, S., Bischoff, S. C., & Bergheim, I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m007179 · Cited by 51

The Gut Microbiota

Martinez, K., Pierre, J. F., & Chang, E. B. (2016) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.07.001 · Cited by 51

Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats

Yan, J., Xie, G., Liang, C., Hu, Y., Zhao, A., Huang, F., Hu, P., Liu, P., Jia, W. P., & Wang, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-04536-5 · Cited by 51

Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice

Frano, M. R. L., Hernandez, A. M., Weber, N., Borkowski, K., Pedersen, T. L., Osborn, O., & Newman, J. W. I. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.07.006 · Cited by 51

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

Ceddia, R. P., & Collins, S. (2020) · Clinical Science · doi:10.1042/cs20190579 · Cited by 51

Gut microbiota and metabolites in the pathogenesis of endocrine disease

Fenneman, A. C., Rampanelli, E., Yin, Y. S., Ames, J., Blaser, M. J., Fliers, E., & Nieuwdorp, M. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190686 · Cited by 51

Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice

Winston, J. A., Rivera, A. J., Cai, J., Patterson, A. D., & Theriot, C. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246161 · Cited by 51

Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR‐knockout mice

Shih, D. M., Shaposhnik, Z., Meng, Y., Rosales, M., Wang, X., Wu, J., Ratiner, B., Zadini, F., Zadini, G., & Lusis, A. J. (2013) · The FASEB Journal · doi:10.1096/fj.12-223008 · Cited by 52

Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers

Ábrigo, J., Olguín, H. C., Gutiérrez, D., Tacchi, F., Arrese, M. A., Cabrera, D., Valero‐Breton, M., Elorza, Á. A., Simón, F., & Cabello‐Verrugio, C. (2022) · Antioxidants · doi:10.3390/antiox11091706 · Cited by 50

The role of bile acids in regulating glucose and lipid metabolism

Yu, H., Nie, R., & Shen, C. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0544 · Cited by 52

Bile acid metabolism in health and ageing-related diseases

Li, X., Fang, C., Zhao, R., Zou, L., Miao, H., & Zhao, Y. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116313 · Cited by 50

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Vandewynckel, Y., Laukens, D., Devisscher, L., Paridaens, A., Bogaerts, E., Verhelst, X., den Bussche, A. V., Raevens, S., Steenkiste, C. V., Troys, M. V., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4377 · Cited by 50

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Piotrowski, D. W., Futatsugi, K., Warmus, J. S., Orr, S. T. M., Freeman‐Cook, K. D., Londregan, A. T., Wei, L., Jennings, S. M., Herr, M., Coffey, S. B., et al. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300277t · Cited by 50

Functional Specificities of Brm and Brg-1 Swi/Snf ATPases in the Feedback Regulation of Hepatic Bile Acid Biosynthesis

Miao, J., Fang, S., Lee, J., Comstock, C. E. S., Knudsen, K. E., & Kemper, J. K. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00825-09 · Cited by 50

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice

Akinrotimi, O., Riessen, R., VanDuyne, P., Park, J. E., Lee, Y., Wong, L., Zavacki, A. M., Schoonjans, K., & Anakk, S. (2017) · Hepatology · doi:10.1002/hep.29305 · Cited by 50

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Teng, Y., Ellis, J. M., Coleman, R., & Zeisel, S. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.303255 · Cited by 50

Effects of kefir lactic acid bacteria-derived postbiotic components on high fat diet-induced gut microbiota and obesity

Seo, K., Lee, H. G., Eor, J. Y., Jeon, H. J., YOKOYAMA, W. H., & Kim, H. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111445 · Cited by 49

Red ginseng extracts ameliorate high-fat diet-induced obesity and insulin resistance by activating the intestinal TGR5-mediated bile acids signaling pathway

Li, W., Zhuang, T., Wang, Z., Wang, X., Liu, L., Luo, Y., Wang, R., Li, L., Huang, W., Wang, Z., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154982 · Cited by 49

Comparison of serum biochemical parameters between two broiler chicken lines divergently selected for abdominal fat content1

Dong, J. Q., Zhang, H., Jiang, X., Wang, S. Z., Du, Z., Wang, Z. P., Leng, L., Cao, Z. P., Li, Y. M., Luan, P., et al. (2015) · Journal of Animal Science · doi:10.2527/jas.2015-8871 · Cited by 49

A combination of Lactobacillus mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice

Chen, Y., Yang, N., Lin, Y., Ho, S., Li, K., Lin, J., Liu, J., & Chen, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-23844-y · Cited by 49

Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders

Eslami, M., Bahar, A., Hemati, M., Nejad, Z. R., Mehranfar, F., Karami, S., Kobyliak, N. M., & Yousefi, B. (2020) · Diabetic Medicine · doi:10.1111/dme.14415 · Cited by 49

Bariatric surgery and the liver—Mechanisms, benefits, and risks

Lefere, S., Onghena, L., Vanlander, A., Nieuwenhove, Y. V., Devisscher, L., & Geerts, A. M. (2021) · Obesity Reviews · doi:10.1111/obr.13294 · Cited by 49

Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity

Cunningham, A., Stephens, J. W., & Harris, D. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00858-4 · Cited by 49

Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway

Horiba, T., Katsukawa, M., Mita, M., & Sato, R. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.022 · Cited by 49

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

Svensson, P., Olsson, M. M., Andersson‐Assarsson, J. C., Taube, M., Pereira, M. J., Froguel, P., & Jacobson, P. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.031 · Cited by 49

Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?

Conceição-Furber, E., Coskun, T., Sloop, K. W., & Samms, R. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.868037 · Cited by 48

Skeletal muscle deiodinase type 2 regulation during illness in mice

Kwakkel, J., van Beeren, H. C., Ackermans, M. T., Platvoet-ter Schiphorst, M. C., Fliers, E., Wiersinga, W. M., & Boelen, A. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0118 · Cited by 48

Identification of Chemerin as a Novel FXR Target Gene Down-Regulated in the Progression of Nonalcoholic Steatohepatitis

Deng, Y., Wang, H., Lu, Y., Liu, S., Zhang, Q., Huang, J. V., Zhu, R., Yang, J., Zhang, R., Zhang, D., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2126 · Cited by 48

Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach

Aw, W., & Fukuda, S. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0456-2 · Cited by 48

Monitoring Bile Acid Transport in Single Living Cells Using a Genetically Encoded FöRster Resonance Energy Transfer Sensor

van der Velden, L. M., Golynskiy, M. V., Bijsmans, I. T. G. W., van Mil, S. W. C., Klomp, L. W. J., Merkx, M., & van de Graaf, S. F. J. (2012) · Hepatology · doi:10.1002/hep.26012 · Cited by 48

Chenodeoxycholic acid reduces feed intake and modulates the expression of hypothalamic neuropeptides and hepatic lipogenic genes in broiler chickens

Piekarski, A., Decuypere, E. M. P., Buyse, J. G., & Dridi, S. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.03.007 · Cited by 48

TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells

Yang, Z., Xiong, F., Wang, Y., Gong, W., Huang, J., Chen, C., Liu, P., & Huang, H. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.05.035 · Cited by 48

Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery

Flynn, C. R., Albaugh, V. L., & Abumrad, N. N. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.014 · Cited by 48

Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice

Hui, S., Huang, L., Wang, X., Zhu, X., Zhou, M., Chen, M., Yi, L., & Mi, M. (2020) · The FASEB Journal · doi:10.1096/fj.201902618rr · Cited by 48

Linking liver metabolic and vascular disease via bile acid signaling

Fiorucci, S., & Distrutti, E. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.10.005 · Cited by 48

Effect of tea catechins on body fat accumulation in rats fed a normal diet

Ito, Y., Ichikawa, T., Morohoshi, Y., Nakamura, T., Saegusa, Y., & ISHIHARA, K. (2008) · Biomedical Research · doi:10.2220/biomedres.29.27 · Cited by 48

Reinventing gut health: leveraging dietary bioactive compounds for the prevention and treatment of diseases

Wang, Q., Huang, H., Yang, Y., Yang, X., Li, X., Zhong, W., Wen, B., He, F., & Li, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1491821 · Cited by 51

Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?

Sabatino, L., & Vassalle, C. (2025) · Biomolecules · doi:10.3390/biom15030361 · Cited by 47

Review: Miglitol has potential as a therapeutic drug against obesity

Sugimoto, S., Nakajima, H., Kosaka, K., & Hosoi, H. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0048-8 · Cited by 47

Potential Mechanisms Mediating Sustained Weight Loss Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Makaronidis, J., & Batterham, R. L. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.04.006 · Cited by 48

The Associations between Circulating Bile Acids and the Muscle Volume in Patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Kobayashi, Y., Hara, N., Sugimoto, R., Mifuji‐Moroka, R., Tanaka, H., Eguchi, A., Iwasa, M., Hasegawa, H., Iwata, K., Takei, Y., et al. (2017) · Internal Medicine · doi:10.2169/internalmedicine.56.7796 · Cited by 47

Cholestatic Alterations in the Critically Ill

Jenniskens, M., Langouche, L., & den Berghe, G. V. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.08.018 · Cited by 47

Effects of corilagin on alleviating cholestasis via farnesoid X receptor‐associated pathways in vitro and in vivo

Yang, F., Wang, Y., Li, G., Xue, J., Chen, Z., Jin, F., Luo, L., Zhou, X., Ma, Q., Cai, X., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14126 · Cited by 47

Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study

Shima, K. R., Ota, T., Kato, K., Takeshita, Y., Misu, H., Kaneko, S., & Takamura, T. (2018) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2017-000469 · Cited by 47

NTCP deficiency in mice protects against obesity and hepatosteatosis

Donkers, J. M., Kooijman, S., Slijepcevic, D., Kunst, R. F., Abbing, R. L. P. R., Haazen, L. C. J. M., de Waart, D. R., Levels, J. H. M., Schoonjans, K., Rensen, P. C. N., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127197 · Cited by 47

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice

Sasaki, T., Watanabe, Y., Kuboyama, A., Oikawa, A., Shimizu, M., Yamauchi, Y., & Sato, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016203 · Cited by 47

Liver-Targeted Near-Infrared Fluorescence/Photoacoustic Dual-Modal Probe for Real-Time Imaging of In Situ Hepatic Inflammation

Zhang, Y., Li, W., Chen, X., Xiong, S., Bian, Y., Yuan, L., Gao, X., & Su, D. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05476 · Cited by 47

The Thyroid Hormone-Inactivating Deiodinase Functions as a Homodimer

Sagar, G. D. V., Gereben, B., Callebaut, I., Mornon, J., Zeöld, A., Curcio‐Morelli, C., Harney, J. W., Luongo, C., Mulcahey, M. A., Larsen, P. R., et al. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0490 · Cited by 47

Effects of dietary oat supplementation on carcass traits, muscle metabolites, amino acid profiles, and its association with meat quality of Small-tail Han sheep

Wang, L., Su, S., Zhao, J., He, X., Fu, S.-Y., Wang, B., Wang, D., Wang, D.-Q., Yun, N.-N., Chen, X., et al. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135456 · Cited by 46

Transcriptome Analysis Reveals Regulation of Gene Expression for Lipid Catabolism in Young Broilers by Butyrate Glycerides

Yin, F., Yu, H., Lepp, D., Shi, X., Yang, X., Hu, J., Leeson, S., Yang, C., Nie, S., Hou, Y., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160751 · Cited by 46

A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats

Watanabe, S., Kumazaki, S., Kusunoki, K., Inoue, T., Maeda, Y., Usui, S., Shinohata, R., Ohtsuki, T., Hirohata, S., Kusachi, S., et al. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.40956 · Cited by 46

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

da‐Silva, W. S., Ribich, S. A., Drigo, R. A. E., Castillo, M., Patti, M., & Bianco, A. C. (2011) · FEBS Letters · doi:10.1016/j.febslet.2010.12.044 · Cited by 46

Targeting cancer cachexia: Molecular mechanisms and clinical study

Wang, Y., An, Z.-Y., Lin, D., & Jin, W. (2022) · MedComm · doi:10.1002/mco2.164 · Cited by 45

Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation

Aoi, W., Inoüe, R., Mizushima, K., Honda, A., Björnholm, M., Takagi, T., & Naito, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106251 · Cited by 45

MetALD: Clinical aspects, pathophysiology and treatment

Gratacós‐Ginès, J., Ariño, S., Sancho‐Bru, P., Bataller, R. A., & Pose, E. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101250 · Cited by 45

Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases

Swanson, H. I., Wada, T., Xie, W., Renga, B., Zampella, A., Distrutti, E., Fiorucci, S., Kong, B., Thomas, A., Guo, G. L., et al. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.048694 · Cited by 45

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists

Marino, S. D., Carino, A., Masullo, D., Finamore, C., Marchianò, S., Cipriani, S., Leva, F. S. D., Catalanotti, B., Novellino, E., Limongelli, V., et al. (2017) · Scientific Reports · doi:10.1038/srep43290 · Cited by 45

Exploring the Preventive Effect and Mechanism of Senile Sarcopenia Based on “Gut–Muscle Axis”

Liao, X., Wu, M., Hao, Y., & Hong, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.590869 · Cited by 45

Ligustrum robustum Alleviates Atherosclerosis by Decreasing Serum TMAO, Modulating Gut Microbiota, and Decreasing Bile Acid and Cholesterol Absorption in Mice

Liu, S., He, F., Zheng, T., Wan, S., Chen, J., Yang, F., Xu, X., & Pei, X. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100014 · Cited by 45

Redox‐Dependent Effects in the Physiopathological Role of Bile Acids

Orozco-Aguilar, J., Simón, F., & Cabello‐Verrugio, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4847941 · Cited by 45

Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway

Wang, S., Yang, Z., Xiong, F., Chen, C., Chao, X., Huang, J., & Huang, H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.019 · Cited by 45

Peripheral targets in obesity treatment: a comprehensive update

Chatzigeorgiou, A., Kandaraki, E., Papavassiliou, A. G., & Koutsilieris, M. (2014) · Obesity Reviews · doi:10.1111/obr.12163 · Cited by 44

Type II iodothyronine deiodinase provides intracellular 3,5,3′-triiodothyronine to normal and regenerating mouse skeletal muscle

Marsili, A., Tang, D., Harney, J. W., Singh, P. K., Zavacki, A. M., Dentice, M., Salvatore, D., & Larsen, P. R. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00292.2011 · Cited by 44

The HPA axis response to critical illness: New study results with diagnostic and therapeutic implications

Peeters, B., Boonen, E., Langouche, L., & den Berghe, G. V. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.012 · Cited by 44

Novel bile acid therapeutics for the treatment of chronic liver diseases

Hegade, V. S., Speight, A., Etherington, R. E., & Jones, D. E. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16630712 · Cited by 44

Roles of Ileal ASBT and OSTα-OSTβ in Regulating Bile Acid Signaling

Dawson, P. A. (2017) · Digestive Diseases · doi:10.1159/000450987 · Cited by 44

Identification and quantification of oxo-bile acids in human faeces with liquid chromatography–mass spectrometry: A potent tool for human gut acidic sterolbiome studies

Franco, P., Porru, E., Fiori, J., Gioiello, A., Cerra, B., Roda, G., Caliceti, C., Simoni, P., & Roda, A. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.11.038 · Cited by 44

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Yang, H.-W., Fernando, K. H. N., Oh, J.-Y., Li, X., Jeon, Y., & Ryu, B. (2019) · Marine Drugs · doi:10.3390/md17040202 · Cited by 44

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Lefort, C., & Cani, P. D. (2021) · Cells · doi:10.3390/cells10020400 · Cited by 44

Bile Acids Have the Gall to Function as Hormones

Vallim, T. Q. D. A., & Edwards, P. A. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.005 · Cited by 44

Intercellular Lipid Mediators and GPCR Drug Discovery

Im, D. (2013) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2013.080 · Cited by 44

Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry

Yin, P., Mohemaiti, P., Chen, J., Zhao, X., Lu, X., Yimiti, A., Upur, H., & Xu, G. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.05.043 · Cited by 44

Beyond glucose: metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats

Lin, S., Yang, Z., Liu, H., Tang, L., & Cai, Z. (2011) · Molecular BioSystems · doi:10.1039/c0mb00246a · Cited by 43

Surgery in the treatment of type 2 diabetes mellitus

Maleckas, A., Venclauskas, L., Wallenius, V., Lönroth, H., & Fändriks, L. (2015) · Scandinavian Journal of Surgery · doi:10.1177/1457496914561140 · Cited by 43

Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5

Ladurner, A., Zehl, M., Grienke, U., Hofstadler, C., Faur, N., Pereira, F. C., Berry, D., Dirsch, V. M., & Rollinger, J. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00468 · Cited by 43

Multiple effects of cold exposure on livers of male mice

Grefhorst, A., van den Beukel, J. C., Dijk, W., Steenbergen, J., Voortman, G. J., Leeuwenburgh, S., Visser, T. J., Kersten, S., Friesema, E. C. H., Themmen, A. P. N., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0076 · Cited by 43

Evidence That the Length of Bile Loop Determines Serum Bile Acid Concentration and Glycemic Control After Bariatric Surgery

Mika, A., Kaska, Ł., Proczko-Stepaniak, M., Chomiczewska, A., Świerczyński, J., Smolenski, R. T., & Śledziński, T. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3314-9 · Cited by 43

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

Ye, Y., Haija, M. A. E., Morgan, D. A., Guo, D., Song, Y., Frank, A. P., Tian, L., Riedl, R. A., Burnett, C. M.-L., Gao, Z., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108270 · Cited by 43

Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

Mikami, T., Kim, J., Park, J.-H., Lee, H., Yaicharoen, P., Suidasari, S., Yokozawa, M., & Yamauchi, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-90589-6 · Cited by 43

Modulation of Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles

Zhang, B., Kuipers, F., de Boer, J. F., & Kuivenhoven, J. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010004 · Cited by 43

Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism

Wang, M., Cha, R., Hao, W., Du, R., Zhang, P., Hu, Y., & Jiang, X. (2022) · ACS Nano · doi:10.1021/acsnano.2c05809 · Cited by 43

Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States

Montie, E. W., Fair, P. A., Bossart, G. D., Mitchum, G. B., Houde, M., Muir, D. C. G., Letcher, R. J., McFee, W. E., Starczak, V. R., Stegeman, J. J., et al. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.12.004 · Cited by 43

Synthesis, Characterization, and Receptor Interaction Profiles of Enantiomeric Bile Acids

Katona, B. W., Cummins, C. L., Ferguson, A. D., Li, T., Schmidt, D. R., Mangelsdorf, D. J., & Covey, D. F. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0707931 · Cited by 43

Bile acids and insulin resistance: implications for treating nonalcoholic fatty liver disease

Wei, J., Qiu, D., & Ma, X. (2009) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2009.00369.x · Cited by 43

Targeting adipose tissue

Haas, B., Schlinkert, P., Mayer, P. E., & Eckstein, N. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-43 · Cited by 43

Role of the Gut Microbiome in Skeletal Muscle Physiology and Pathophysiology

Lefevre, C., & Bindels, L. B. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00752-9 · Cited by 41

Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications

García-Gutiérrez, E., O’Mahony, A. K., dos Santos, R. S., Marroquí, L., & Cotter, P. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2401654 · Cited by 43

Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation

Iguchi, Y., Nishimaki‐Mogami, T., Yamaguchi, M., Teraoka, F., Kaneko, T., & Une, M. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1 · Cited by 42

Bile acid-FXRα pathways regulate male sexual maturation in mice

Baptissart, M., Martinot, E., Vega, A., Sèdes, L., Rouaisnel, B., Haze, A. D., Baron, S., Schoonjans, K., Caira, F., & Volle, D. H. (2016) · Oncotarget · doi:10.18632/oncotarget.7153 · Cited by 42

Metabolic Effects of Bariatric Surgery

Sinclair, P., Docherty, N. G., & le Roux, C. W. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.272336 · Cited by 42

Cancer-Associated Cachexia: A Systemic Consequence of Cancer Progression

Biswas, A., & Acharyya, S. (2019) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033642 · Cited by 42

Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan

Gong, X., Zhang, Q., Ruan, Y., Hu, M., Liu, Z., & Gong, L. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa005 · Cited by 42

The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling

Wang, L. X., Frey, M. R., & Kohli, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.799648 · Cited by 42

Type 2 Diabetes and the Microbiome

Barlow, G. M., & Mathur, R. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac184 · Cited by 41

The emerging role of bile acids as integrators of intermediary metabolism

Groen, A. K. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.06.001 · Cited by 6

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

Ockenga, J., Valentini, L., Schuetz, T., Wohlgemuth, F., Glaeser, S., Omar, A., Kasim, E., DuPlessis, D., Featherstone, K., Davis, J. R., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2329 · Cited by 74

Bile acids heat things up

Baxter, J. D., & Webb, P. (2006) · Nature · doi:10.1038/439402a · Cited by 23

Acting Locally

(2006) · Science s STKE · doi:10.1126/stke.3202006tw41 · Cited by 1

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Broeders, E. P. M., Nascimento, E. B. M., Havekes, B., Brans, B. T., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.002 · Cited by 452