The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Open accessAbstract
While bile acids (BAs) have long been known to be essential in dietary lipid absorption and cholesterol catabolism, in recent years an important role for BAs as signalling molecules has emerged. BAs activate mitogen-activated protein kinase pathways, are ligands for the G-protein-coupled receptor (GPCR) TGR5 and activate nuclear hormone receptors such as farnesoid X receptor alpha (FXR-alpha; NR1H4). FXR-alpha regulates the enterohepatic recycling and biosynthesis of BAs by controlling the expression of genes such as the short heterodimer partner (SHP; NR0B2) that inhibits the activity of other nuclear receptors. The FXR-alpha-mediated SHP induction also underlies the downregulation of the hepatic fatty acid and triglyceride biosynthesis and very-low-density lipoprotein production mediated by sterol-regulatory-element-binding protein 1c. This indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators. Here we show that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This novel metabolic effect of BAs is critically dependent on induction of the cyclic-AMP-dependent thyroid hormone activating enzyme type 2 iodothyronine deiodinase (D2) because it is lost in D2-/- mice. Treatment of brown adipocytes and human skeletal myocytes with BA increases D2 activity and oxygen consumption. These effects are independent of FXR-alpha, and instead are mediated by increased cAMP production that stems from the binding of BAs with the G-protein-coupled receptor TGR5. In both rodents and humans, the most thermogenically important tissues are specifically targeted by this mechanism because they coexpress D2 and TGR5. The BA-TGR5-cAMP-D2 signalling pathway is therefore a crucial mechanism for fine-tuning energy homeostasis that can be targeted to improve metabolic control.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, TGR5 has an important role in regulating energy expenditure and lipid metabolism,47”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [47]
In the citing paper
“Recently, a new role in TH-mediated thermogenesis was observed in response to bile acids 147.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [147]
In the citing paper
“It has been described that BA secretion increases energy expenditure in BAT by enhancing the enzymatic activity of DIO2 and therefore regulating thyroid hormone metabolism in BAT 97.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [97]
Citations
Cites
Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853
Self-citationEndogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Self-citationBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425
Self-citationIdentification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993
Holt, J. A., Luo, G., Billin, A. N., Bisi, J., McNeill, Y. Y., Kozarsky, K., Donahee, M. H., Wang, D. Y., Mansfield, T. A., Kliewer, S. A., et al. (2003) · Genes & Development · doi:10.1101/gad.1083503 · Cited by 714
Cited by
Sorted by citations
Items 701–800 of 1,008
Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus
van Olden, C. C., Groen, A. K., & Nieuwdorp, M. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.008 · Cited by 61
The Multiple Facets of the Fat Tissue
Rocha, V. Z., & Libby, P. (2008) · Thyroid · doi:10.1089/thy.2007.0296 · Cited by 61
Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health
Geng, W., & Lin, J. (2016) · Animal Health Research Reviews · doi:10.1017/s1466252316000153 · Cited by 61
The Gut Microbial Endocrine Organ in Type 2 Diabetes
Massey, W. J., & Brown, J. M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa235 · Cited by 61
Role of thyroid receptor β in lipid metabolism
Pramfalk, C., Pedrelli, M., & Parini, P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.019 · Cited by 60
Cao, H., Chen, Z., Wang, K., Ning, M., Zou, Q., Feng, Y., Ye, Y., Leng, Y., & Shen, J. (2016) · Scientific Reports · doi:10.1038/srep28676 · Cited by 60
Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats
Yang, J., Sun, L., Wang, L., Hassan, H. M., Wang, X., Hylemon, P. B., Wang, T., Zhou, H., Zhang, L., & Jiang, Z. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00260 · Cited by 60
Determinants of postprandial plasma bile acid kinetics in human volunteers
Fiamoncini, J., Yiorkas, A. M., Gedrich, K., Rundle, M., Alsters, S., Roeselers, G., van den Broek, T. J., Clavel, T., Lagkouvardos, I., Wopereis, S., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00157.2017 · Cited by 60
Selective Thyromimetics Using Receptor and Tissue Selectivity Approaches: Prospects for Dyslipidemia
Joharapurkar, A. A., Dhote, V. V., & Jain, M. R. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2004706 · Cited by 59
Integrated omics analysis reveals the alteration of gut microbe–metabolites in obese adults
Li, R., Huang, X., Xiao, L., Su, M., Lai, K. P., & Chen, J. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa165 · Cited by 60
Song, Y., Selak, M. A., Watson, C. T., Coutts, C. A., Scherer, P. C., Panzer, J. A., Gibbs, S. M., Scott, M. O., Willer, G. B., Gregg, R. G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008329 · Cited by 59
Noguchi, Y., Nishikata, N., Shikata, N., Kimura, Y., Alemán, J. O., Young, J. D., Koyama, N., Kelleher, J. K., Takahashi, M., & Stephanopoulos, G. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012057 · Cited by 59
Roda, A., Pellicciari, R., Gioiello, A., Neri, F., Camborata, C., Passeri, D., Franco, F., Spinozzi, S., Colliva, C., Adorini, L., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214650 · Cited by 59
Nonmuscle Tissues Contribution to Cancer Cachexia
Argilés, J. M. A., Stemmler, B., López-Soriano, F. J., & Busquets, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/182872 · Cited by 59
Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice
Fu, Z. D., & Klaassen, C. D. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.020 · Cited by 59
Fu, S., Fan, J., Blanco, J., Giménez-Cassina, A., Danial, N. N., Watkins, S. M., & Hotamışlıgil, G. S. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002902 · Cited by 60
Repurposing Drugs to Target the Diabetes Epidemic
Turner, N. A., Zeng, X., Osborne, B., Rogers, S., & Ye, J.-M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.007 · Cited by 59
Elias, I., Ferré, T., Vilà, L., MUÑOZ, S. A., Casellas, A., García, M., Molas, M., Agudo, J., Roca, C., Ruberte, J., et al. (2016) · Diabetes · doi:10.2337/db16-0040 · Cited by 59
Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Jena, P. K., Sheng, L., Li, Y., & Wan, Y.-J. Y. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.09.07 · Cited by 59
Nondigestible Oligosaccharides with Anti-Obesity Effects
Liu, Y., Chen, J., Tan, Q., Deng, X., Tsai, P.-J., Chen, P.-H., Ye, M., Guo, J., & Su, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b06079 · Cited by 58
Ye, J., Wu, Z., Zhao, Y., Zhang, S., Liu, W.-T., & Su, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1029890 · Cited by 58
He, Y., Chen, X., Li, Y., Liang, Y., Hong, T., Yang, J., Cao, Z., Mai, H., Yao, J., Zhang, T., et al. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.05.017 · Cited by 58
The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis
Cariou, B. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74605-6 · Cited by 58
Cystic Fibrosis Related Liver Disease—Another Black Box in Hepatology
Staufer, K., Halilbasic, E., Trauner, M., & Kazemi-Shirazi, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813529 · Cited by 58
Keitel, V., & Häussinger, D. (2011) · Digestive Diseases · doi:10.1159/000324127 · Cited by 58
Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients
Sonne, D. P., Hare, K. J., Martens, P. C., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2012 · Cited by 58
Obesity diabetes and the role of bile acids in metabolism
TOMKIN, G. H., & Owens, D. (2016) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2016-0018 · Cited by 58
Somm, E., Henry, H., Bruce, S. J., Aeby, S., Rosikiewicz, M., Sykiotis, G. P., Asrih, M., Jornayvaz, F. R., Denechaud, P., Albrecht, U., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91809 · Cited by 58
Self-citationLapa, C., Arias-Loza, P.-A., Hayakawa, N., Wakabayashi, H., Werner, R. A., Chen, X., Shinaji, T., Herrmann, K., Pelzer, T., & Higuchi, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-17148-w · Cited by 58
Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis
Cheng, S. L., Li, X., Lehmler, H., Phillips, B., Shen, D. D., & Cui, J. Y. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy208 · Cited by 58
Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK
Kim, K.-D., Jung, H., Ryu, H. G., Kim, B., Jeon, J., Hyunju, Y. O. O., Park, C. H., Choi, B.-H., Hyun, C., Kim, K., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.12.001 · Cited by 58
Self-citationGut Microbiota-Derived Metabolites in the Development of Diseases
Shen, G., Wu, J., Ye, B., & Qi, N. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/6658674 · Cited by 58
The gut microbiota–brain axis: Role of the gut microbial metabolites of dietary food in obesity
Song, X., Wang, L., Liu, Y., Zhang, X., Weng, P., Liu, L., Zhang, R., & Wu, Z. (2022) · Food Research International · doi:10.1016/j.foodres.2022.110971 · Cited by 57
Bile acids induce hepatic differentiation of mesenchymal stem cells
Sawitza, I., Kordes, C., Götze, S., Herebıan, D., & Häussinger, D. (2015) · Scientific Reports · doi:10.1038/srep13320 · Cited by 57
Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5
Herbert, M. R., Siegel, D. L., Staszewski, L. M., Cayanan, C. S., Banerjee, U., Dhamija, S., Anderson, J., Fan, A., Wang, L., Rix, P. J., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.08.014 · Cited by 57
Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons
Ortega, E., Pannacciulli, N., Bogardus, C., & Krakoff, J. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.440 · Cited by 57
Guo, C., Su, J., Li, Z., Xiao, R., Wen, J.-X., Li, Y., Zhang, M., Zhang, X., Yu, D. D., Huang, W., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5353 · Cited by 57
Bocco, B. M. L. C., Louzada, R. A. N., Silvestre, D. H., Santos, M. C. S., Anne‐Palmer, E., Rangel, I. F., Abdalla, S. M., Ferreira, A. C. F., Ribeiro, M. O., Gereben, B., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272440 · Cited by 57
Self-citationFiorucci, S., Zampella, A., Cirino, G., Bucci, M., & Distrutti, E. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00577.2016 · Cited by 57
Wang, Y., Li, J., Matye, D. J., Zhang, Y., Dennis, K. L., Ding, W., & Li, T. (2018) · JCI Insight · doi:10.1172/jci.insight.99676 · Cited by 57
Liu, M., Zhang, G., Wu, S. A., Song, M., Wang, J., Cai, W., Mi, S., & Liu, C. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112776 · Cited by 57
Clinical application of transcriptional activators of bile salt transporters
Baghdasaryan, A., Chiba, P., & Trauner, M. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.12.001 · Cited by 57
Contribution of Gut Bacteria to Lipid Levels
Allayee, H., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.115.307409 · Cited by 57
Kundu, S., Kumar, S., & Bajaj, A. (2015) · IUBMB Life · doi:10.1002/iub.1399 · Cited by 56
Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism
Lee, Y., & Lee, H. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0220 · Cited by 56
Zangerolamo, L., Carvalho, M. U. W. B. D., & Barbosa, H. C. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146547 · Cited by 56
Gai, Z., Chu, L., Hiller, C., Arsenijevic, D., Penno, C. A., Montani, J., Odermatt, A., & Kullak-Ublick, G. A. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00114.2013 · Cited by 56
Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
Stanimirov, B., Stankov, K., & Mikov, M. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60307-6 · Cited by 56
Patented TGR5 modulators: a review (2006 – present)
Gioiello, A., Rosatelli, E., Nuti, R., Macchiarulo, A., & Pellicciari, R. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.733000 · Cited by 56
Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T., & Hutchinson, D. S. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500251 · Cited by 56
Intestinal bile acid receptors are key regulators of glucose homeostasis
Trabelsi, M.-S., Lestavel, S., Staels, B., & Collet, X. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116002834 · Cited by 56
Yin, S., Su, M., Xie, G., Li, X., Wei, R., Liu, C., Lan, K., & Jia, W. P. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0489-1 · Cited by 56
Carino, A., Marchianò, S., Biagioli, M., Bucci, M., Vellecco, V., Brancaleone, V., Fiorucci, C., Zampella, A., Monti, M. C., Distrutti, E., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801373rr · Cited by 56
Montandon, S. A., Somm, E., Loizides‐Mangold, U., Vito, C. D., Dibner, C., & Jornayvaz, F. R. (2019) · Scientific Reports · doi:10.1038/s41598-019-53346-4 · Cited by 57
Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome
Portincasa, P., Ciaula, A. D., Garruti, G., Vacca, M., Angelis, M. D., & Wang, D. Q. ‐. (2020) · Nutrients · doi:10.3390/nu12123709 · Cited by 56
Matsuda, A., Wang, Z., Takahashi, S., Tokuda, T., Miura, N., & Hasegawa, J. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.04.004 · Cited by 56
Capuco, A. V., Connor, E. E., & Wood, D. L. (2008) · Experimental Biology and Medicine · doi:10.3181/0803-rm-85 · Cited by 56
5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)
Chen, M., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.01.013 · Cited by 55
Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes
Hansen, M., Sonne, D. P., & Knop, F. K. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0482-4 · Cited by 55
Bile acids in regulation of intestinal physiology
Keating, N., & Keely, S. J. (2009) · Current Gastroenterology Reports · doi:10.1007/s11894-009-0057-8 · Cited by 55
Sugita, T., Amano, K., Nakano, M., Masubuchi, N., Sugihara, M., & Matsuura, T. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/717431 · Cited by 55
Prawitt, J., Caron, S., & Staels, B. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.007 · Cited by 55
Carino, A., Cipriani, S., Marchianò, S., Biagioli, M., Scarpelli, P. T., Zampella, A., Monti, M. C., & Fiorucci, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-13102-y · Cited by 55
In Vitro Modeling of Bile Acid Processing by the Human Fecal Microbiota
Martin, G., Kolida, S., Marchesi, J. R., Want, E. J., Sidaway, J. E., & Swann, J. R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01153 · Cited by 55
New approaches targeting brown adipose tissue transplantation as a therapy in obesity
Soler‐Vázquez, M. C., Mera, P., Zagmutt, S., Serra, D., & Herrero, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.022 · Cited by 55
Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases
Jia, E., Liu, Z.-Y., Pan, M., Lu, J., & Ge, Q. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900073 · Cited by 55
Davison, K., Lung, Y., Lin, S., Tong, H., Kobayashi, K. M., & Fuller‐Thomson, E. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2309-y · Cited by 55
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT–liver communication
Sponton, C. H., Hosono, T., Taura, J., Jedrychowski, M. P., Yoneshiro, T., Wang, Q., Takahashi, M., Matsui, Y., Ikeda, K., Oguri, Y., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949828 · Cited by 55
Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism
Chen, M., Liu, C., Wan, Y., Yang, L., Jiang, S., Qian, D., & Duan, J. (2020) · Steroids · doi:10.1016/j.steroids.2020.108757 · Cited by 55
Li, Y., Ji, X., Wu, H., Xiang, L., Zhang, H., & Tang, D. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114207 · Cited by 55
Hu, J., Zhang, Y., Yi, S., Wang, C., Huang, X., Pan, S., Yang, J., Yuan, G., Tan, S., & Li, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.71287 · Cited by 54
Bile acid metabolism regulatory network orchestrates bone homeostasis
Xiang, T., Deng, Z., Yang, C. H., Tan, J., Dou, C., Luo, F., & Chen, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106943 · Cited by 54
Bile acid metabolism in type 2 diabetes mellitus
Sandoval, M. C., & Haeusler, R. A. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01067-8 · Cited by 54
Erichsen, T. J., Aehlen, A., Ehmer, U., Kalthoff, S., Manns, M. P., & Strassburg, C. P. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.01.010 · Cited by 54
Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat
Goncalves, D., Barataud, A., Vadder, F. D., Vinera, J., Zitoun, C., Duchampt, A., & Mithieux, G. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001121 · Cited by 54
Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage
Reich, M., Klindt, C., Deutschmann, K., Spomer, L., Häussinger, D., & Keitel, V. (2017) · Digestive Diseases · doi:10.1159/000450917 · Cited by 54
Reciprocal interactions between bile acids and gut microbiota in human liver diseases
Ikegami, T., & Honda, A. (2017) · Hepatology Research · doi:10.1111/hepr.13001 · Cited by 54
McNeill, B. T., Suchacki, K. J., & Stimson, R. H. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1439 · Cited by 55
Malnutrition in Pediatric Chronic Cholestatic Disease: An Up-to-Date Overview
Tessitore, M., Sorrentino, E., di Cola, G. S., Colucci, A., Vajro, P., & Mandato, C. (2021) · Nutrients · doi:10.3390/nu13082785 · Cited by 54
The Influence of the Western Diet on Microbiota and Gastrointestinal Immunity
Heras, V. L., Melgar, S., MacSharry, J. A., & Gahan, C. G. M. (2022) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-052720-011032 · Cited by 53
Dietary Fiber and Its Potential Role in Obesity: A Focus on Modulating the Gut Microbiota
Tian, S., Chu, Q., Ma, S., Ma, H., & Song, H. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03923 · Cited by 53
Lieu, T., Jayaweera, G., & Bunnett, N. W. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12426 · Cited by 53
Sakamoto, K., Mikami, H., & Kimura, J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.192 · Cited by 53
van den Berg, S. W., Dollé, M. E. T., Imholz, S., van der A, D. L., Slot, R. V. ‘., Wijmenga, C., Verschuren, W. M. M., Strien, C., Siezen, C. L. E., Hoebee, B., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.152 · Cited by 53
Nie, H., Song, C., Wang, D., Cui, S., Ren, T., Cao, Z., Liu, Q., Chen, Z., Chen, X., & Zhou, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.020 · Cited by 53
Spexin Acts as Novel Regulator for Bile Acid Synthesis
Lin, C., Zhao, L., Huang, T., Lü, L., Khan, M., Liu, J., Zhong, L. L. D., Cai, Z., Fan, B., Wong, A., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00378 · Cited by 53
Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease
Yu, Q., Jiang, Z., & Zhang, L. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.04.005 · Cited by 53
Campos, F., Ábrigo, J., Aguirre, F. S., Garcés, B., Arrese, M. A., Karpen, S. J., Cabrera, D., Andía, M. E., Simón, F., & Cabello‐Verrugio, C. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2167-3 · Cited by 53
Sharpe, L. J., Howe, V., Scott, N. A., Luu, W., Phan, L., Berk, J. M., Hochstrasser, M., & Brown, A. J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005069 · Cited by 53
Serum Metabolomic Patterns in Patients with Autoimmune Thyroid Disease
Liu, J., Fu, J. H., Jia, Y., Yang, N., Li, J., & Wang, G. (2019) · Endocrine Practice · doi:10.4158/ep-2019-0162 · Cited by 53
Metabolomic signatures after bariatric surgery – a systematic review
Vaz, M. E. D. L., Pereira, S. S., & Monteiro, M. P. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09695-5 · Cited by 53
Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
Tveter, K. M., Mezhibovsky, E., Wu, Y., & Roopchand, D. E. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108457 · Cited by 52
Hamamah, S., Iatcu, O. C., & Covașă, M. (2024) · Nutrients · doi:10.3390/nu17010143 · Cited by 52
PPARγ and MEK Interactions in Cancer
Burgermeister, E., & Seger, R. (2008) · PPAR Research · doi:10.1155/2008/309469 · Cited by 52
TGR5 in inflammation and cardiovascular disease
Pols, T. W. H. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130279 · Cited by 52
Occupational exposure to pesticides and other biocides and risk of thyroid cancer
Zeng, F., Lerro, C. C., Lavoué, J., Huang, H., Siemiatycki, J., Zhao, N., Ma, S., Deziel, N. C., Friesen, M. C., Udelsman, R., et al. (2017) · Occupational and Environmental Medicine · doi:10.1136/oemed-2016-103931 · Cited by 52
Bartke, A., Brannan, S., Hascup, E. R., Hascup, K. N., & Darcy, J. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200112 · Cited by 52
The human microbiota is associated with cardiometabolic risk across the epidemiologic transition
Fei, N., Bernabé, B. P., Lie, L., Baghdan, D., Bedu-Addo, K., Plange‐Rhule, J., Forrester, T., Lambert, E. V., Bovet, P., Gottel, N., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215262 · Cited by 52
Kim, S., Choi, S., Dutta, M., Asubonteng, J. O., Polunas, M., Goedken, M. J., Gonzalez, F. J., Cui, J. Y., & Gyamfi, M. A. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114698 · Cited by 52
Yang, X., Dong, B., An, L., Zhang, Q., Chen, Y., Wang, H., & Song, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.756491 · Cited by 52
Metadata
- Authors
- Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., Schoonjans, K., Bianco, A. C., & Auwerx, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Brigham and Women's Hospital (US)
- National Institute of Health and Nutrition (JP)
- The University of Tokyo (JP)
- Corresponding author
- Auwerx, Johan
- ORCID
- Venue
- Nature
- Published
- 2006-01
- Volume
- 439
- Issue
- 7075
- Pages
- 484-489
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2081028309
- Cited by
- 2,220
- References
- 26
- Citations by year
- 2026: 108 · 2025: 112 · 2024: 118 · 2023: 121 · 2022: 140 · 2021: 150 · 2020: 135 · 2019: 128 · 2018: 132 · 2017: 144 · 2016: 126 · 2015: 131 · 2014: 101 · 2013: 102 · 2012: 87
- FWCI
- 47.28
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, energy expenditure, thyroid hormone activation, TGR5, cAMP signaling, brown adipose tissue, thermogenesis, obesity, insulin resistance, enterohepatic circulation, metabolic homeostasis
- MeSH terms
- Iodothyronine Deiodinase Type II, Cyclic AMP, Animals, Bile Acids and Salts, Body Weight, Adipose Tissue, Brown, Carbon Dioxide, Dietary Fats, Energy Metabolism, Homeostasis, Humans, Iodide Peroxidase, Liver, Mice, Inbred C57BL, Oxygen Consumption, Thyroid Hormones, Gene Deletion, Muscle, Skeletal, Cholic Acid, Muscle Cells, Receptors, G-Protein-Coupled, Adiposity, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
