The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Abstract
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA) and triggers antiviral responses. The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I, also known as Ddx58) and MDA5 (melanoma-differentiation-associated gene 5, also known as Ifih1 or Helicard) have been implicated in viral dsRNA recognition. In vitro studies suggest that both RIG-I and MDA5 detect RNA viruses and polyinosine-polycytidylic acid (poly(I:C)), a synthetic dsRNA analogue. Although a critical role for RIG-I in the recognition of several RNA viruses has been clarified, the functional role of MDA5 and the relationship between these dsRNA detectors in vivo are yet to be determined. Here we use mice deficient in MDA5 (MDA5-/-) to show that MDA5 and RIG-I recognize different types of dsRNAs: MDA5 recognizes poly(I:C), and RIG-I detects in vitro transcribed dsRNAs. RNA viruses are also differentially recognized by RIG-I and MDA5. We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection. Furthermore, RIG-I-/- and MDA5-/- mice are highly susceptible to infection with these respective RNA viruses compared to control mice. Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, several RNA structural features have been described as immunostimulatory due to interactions with various RNA sensors such as Toll-like receptors, RIG-I, and PKR.”
From Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals (2015) · cites this paper as [11]
Citations
Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Self-citationCardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 1,007
Pestal, K., Funk, C. C., Snyder, J. M., Price, N. D., Treuting, P. M., & Stetson, D. B. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.001 · Cited by 514
Thess, A., Grund, S., Mui, B. L., Hope, M. J., Baumhof, P., Fotin-Mleczek, M., & Schlake, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.103 · Cited by 513
Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
Huppa, J. B., Axmann, M., Moertelmaier, M., Lillemeier, B. F., Newell, E. W., Brameshuber, M. O., Klein, L. O., Schütz, G. J., & Davis, M. M. (2010) · Nature · doi:10.1038/nature08746 · Cited by 516
Essential role of IPS-1 in innate immune responses against RNA viruses
Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K. J., Takeuchi, O., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060792 · Cited by 503
The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I
Cui, S., Eisenächer, K., Kirchhofer, A., Brzózka, K. D., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K., Krug, A., & Hopfner, K. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.10.032 · Cited by 509
Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections
Ishii, K. J., Koyama, S., Nakagawa, A., Coban, C., & Akira, S. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.003 · Cited by 509
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Li, C., Lee, A., Grigoryan, L., Arunachalam, P. S., Scott, M. K. D., Trisal, M., Wimmers, F., Sanyal, M., Weidenbacher, P. A., Feng, Y., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01163-9 · Cited by 505
Association of RIG-I with innate immunity of ducks to influenza
Barber, M. R. W., Aldridge, J. R., Webster, R. G., & Magor, K. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001755107 · Cited by 495
Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency
Ciancanelli, M. J., Huang, S. X. L., Luthra, P., Garner, H., Itan, Y., Volpi, S., Lafaille, F. G., Trouillet, C., Schmolke, M., Albrecht, R. A., et al. (2015) · Science · doi:10.1126/science.aaa1578 · Cited by 475
Zhong, B., Zhang, L., Lei, C., Li, Y., Mao, A., Yang, Y. F., Wang, Y., Zhang, X., & Shu, H. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.008 · Cited by 487
Immune cell crosstalk in type 1 diabetes
Lehuen, A., Diana, J., Zaccone, P., & Cooke, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2787 · Cited by 478
Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., & Sousa, C. R. E. (2009) · Journal of Virology · doi:10.1128/jvi.00770-09 · Cited by 469
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Baccalà, R., Hoebe, K. H. N., Kono, D. H., Beutler, B., & Theofilopoulos, A. N. (2007) · Nature Medicine · doi:10.1038/nm1590 · Cited by 471
Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses
Takahasi, K., Yoneyama, M., Nishihori, T., Hirai, R., Kumeta, H., Narita, R., Gale, M., Inagaki, F., & Fujita, T. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.028 · Cited by 474
Lipid-based systemic delivery of siRNA
Tseng, Y.-C., Mozumdar, S., & Huang, L. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.003 · Cited by 468
Innate immune response to viral infection
Koyama, S., Ishii, K. J., Coban, C., & Akira, S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.009 · Cited by 462
Innate Immunity in the Respiratory Epithelium
Parker, D., & Prince, A. S. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0011rt · Cited by 474
Chemical Modification of siRNAs for In Vivo Use
Behlke, M. A. (2008) · Oligonucleotides · doi:10.1089/oli.2008.0164 · Cited by 464
Viral evasion of intracellular DNA and RNA sensing
Chan, Y., & Gack, M. U. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.45 · Cited by 458
A Deubiquitinase That Regulates Type I Interferon Production
Kayagaki, N., Phung, Q. T., Chan, S. B., Chaudhari, R., Quan, C., O’Rourke, K. M., Eby, M. T., Pietras, E. M., Cheng, G., Bazán, J. F., et al. (2007) · Science · doi:10.1126/science.1145918 · Cited by 452
Negishi, H., Taniguchi, T., & Yanai, H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028423 · Cited by 467
Robbins, M., Judge, A. D., & MacLachlan, I. (2009) · Oligonucleotides · doi:10.1089/oli.2009.0180 · Cited by 463
NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways
Cui, J., Zhu, L., Xia, X., Wang, H. Y., Legras, X. D., Hong, J. K., Ji, J., Shen, P., Zheng, S. S., Chen, Z. J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.040 · Cited by 455
Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids
Tan, J. X., Sun, L., Chen, J., & Chen, Z. J. (2018) · Annual Review of Microbiology · doi:10.1146/annurev-micro-102215-095605 · Cited by 449
Goffic, R. L., Pothlichet, J., Vitour, D., Fujita, T., MEURS, E. F., Chignard, M., & Si‐Tahar, M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3368 · Cited by 448
Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction
Weekes, M. P., Tomašec, P., Huttlin, E. L., Fielding, C. A., Nusinow, D. P., Stanton, R. J., Wang, E. C. Y., Aicheler, R., Murrell, I., Wilkinson, G. W. G., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.028 · Cited by 436
Baum, A., Sachidanandam, R., & García‐Sastre, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005077107 · Cited by 424
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
Onomoto, K., Onoguchi, K., & Yoneyama, M. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00602-7 · Cited by 440
RIG-I in RNA virus recognition
Kell, A. M., & Gale, M. (2015) · Virology · doi:10.1016/j.virol.2015.02.017 · Cited by 424
Recognition of viruses by cytoplasmic sensors
Wilkins, C. R., & Gale, M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.12.003 · Cited by 428
Devaraj, S. G., Wang, N., Chen, Z., Chen, Z., Tseng, M., Barretto, N., Lin, R., Peters, C. J., Tseng, C.-T. K., Baker, S. C., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704870200 · Cited by 411
Ten Strategies of Interferon Evasion by Viruses
García‐Sastre, A. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.012 · Cited by 417
Central roles of NLRs and inflammasomes in viral infection
Kanneganti, T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2851 · Cited by 435
Structural Insights into RNA Recognition by RIG-I
Luo, D., Ding, S. C., Vela, A., Kohlway, A. S., Lindenbach, B. D., & Pyle, A. M. (2011) · Cell · doi:10.1016/j.cell.2011.09.023 · Cited by 428
Ubiquitination in signaling to and activation of IKK
Chen, Z. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01108.x · Cited by 433
Skin cancer and new treatment perspectives: A review
Simões, M. F., Sousa, J., & Pais, A. A. C. C. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.11.001 · Cited by 421
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 451
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5
Reikine, S., Nguyen, J. B., & Modis, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00342 · Cited by 409
Mitochondria in innate immune signaling
Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410
Jiang, X., Kinch, L. N., Brautigam, C. A., Chen, X., Du, F., Grishin, N. V., & Chen, Z. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.022 · Cited by 407
Type III interferons disrupt the lung epithelial barrier upon viral recognition
Broggi, A., Ghosh, S., Sposito, B., Spreafico, R., Balzarini, F., Cascio, A. L., Clementi, N., Santis, M. D., Mancini, N., Granucci, F., et al. (2020) · Science · doi:10.1126/science.abc3545 · Cited by 403
5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J. C., Cui, S., Wenzel, M., Hoffmann, F. S., Michallet, M.-C., Besch, R., Hopfner, K.-P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900971106 · Cited by 398
Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses
Venkataraman, T., Valdes, M., Elsby, R., Kakuta, S., Cáceres, G., Saijo, S., Iwakura, Y., & Barber, G. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6444 · Cited by 400
Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1876 · Cited by 409
Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses
Kumagai, Y., Takeuchi, O., Kato, H., Kumar, H., Matsui, K., Morii, E., Aozasa, K., Kawai, T., & Akira, S. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.013 · Cited by 390
Immunopathological mechanisms in dengue and dengue hemorrhagic fever
Green, S., & Rothman, A. L. (2006) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000244047.31135.fa · Cited by 389
Hu, S., Xie, Z., Onishi, A., Yu, X., Jiang, L., Lin, J., Rho, H., Woodard, C. L., Wang, H., Jeong, J. S., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.037 · Cited by 390
Inflammation and fibrosis in murine models of heart failure
Bacmeister, L., Schwarzl, M., Warnke, S., Stoffers, B., Blankenberg, S., Westermann, D., & Lindner, D. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0722-5 · Cited by 391
Takeda, K., & Akira, S. (2007) · Current Protocols in Immunology · doi:10.1002/0471142735.im1412s77 · Cited by 380
Zhang, Z., Kim, T., Bao, M., Facchinetti, V., Jung, S. Y., Ghaffari, A. A., Qin, J., Cheng, G., & Liu, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.027 · Cited by 387
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activation
Schröder, M., Baran, M., & Bowie, A. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.143 · Cited by 374
Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Odendall, C., Dixit, E., Stavru, F., Bierne, H., Franz, K. M., Durbin, A. F., Boulant, S., Gehrke, L., Cossart, P., & Kagan, J. C. (2014) · Nature Immunology · doi:10.1038/ni.2915 · Cited by 382
Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Chen, H., Sun, H., You, F., Sun, W., Zhou, X., Chen, L., Yang, J., Wang, Y., Tang, H., Guan, Y., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.022 · Cited by 383
Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate–Dependent Translocase on Double-Stranded RNA
Myong, S., Cui, S., Cornish, P. V., Kirchhofer, A., Gack, M. U., Jung, J. U., Hopfner, K., & Ha, T. (2009) · Science · doi:10.1126/science.1168352 · Cited by 368
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
McEwan, W. A., Tam, J. C. H., Watkinson, R. E., Bidgood, S. R., Mallery, D. L., & James, L. C. (2013) · Nature Immunology · doi:10.1038/ni.2548 · Cited by 384
Approaching the Asymptote: 20 Years Later
Medzhitov, R. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.004 · Cited by 380
Chien, Y., Kim, S., Bumeister, R., Loo, Y., Kwon, S. W., Johnson, C., Balakireva, M. G., Roméo, Y., Kopelovich, L., Gale, M., et al. (2006) · Cell · doi:10.1016/j.cell.2006.08.034 · Cited by 367
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Brisse, M. E., & Ly, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01586 · Cited by 379
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid SensorsPreprint
Pandey, S., Kawai, T., & Akira, S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016246 · Cited by 387
Allen, I. C., Moore, C. B., Schneider, M., Lei, Y. L., Davis, B. K., Scull, M. A., Gris, D., Roney, K. E., Zimmermann, A. G., Bowzard, J. B., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.026 · Cited by 365
Nakahira, K., Kim, H. P., Geng, X. H., Nakao, A., Wang, X., Murase, N., Drain, P. F., Wang, X., Sasidhar, M., Nabel, E. G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060845 · Cited by 362
Epidemiology and Immune Pathogenesis of Viral Sepsis
Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S. S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J., et al. (2008) · Nature Medicine · doi:10.1038/nm.1887 · Cited by 387
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism
Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354
Oshiumi, H., Matsumoto, M., Hatakeyama, S., & Seya, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804259200 · Cited by 353
Onomoto, K., Jogi, M., Yoo, J., Narita, R., Morimoto, S., Takemura, A., Sambhara, S. R., Kawaguchi, A., Osari, S., Nagata, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043031 · Cited by 359
Translation inhibition and stress granules in the antiviral immune response
McCormick, C., & Khaperskyy, D. A. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.63 · Cited by 353
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
Jin, Y., Birlea, S. A., Fain, P. R., Ferrara, T. M., Ben, S., Riccardi, S. L., Cole, J. B., Gowan, K., Holland, P. J., Bennett, D. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2272 · Cited by 357
Santo, C. D., Salio, M., Masri, S. H., Lee, L. Y.-H., Dong, T., Speak, A. O., Porubský, Š., Booth, S., Veerapen, N., Besra, G. S., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36264 · Cited by 362
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3424 · Cited by 313
Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses
Matsuo, A., Oshiumi, H., Tsujita, T., Mitani, H., Kasai, H., Yoshimizu, M., Matsumoto, M., & Seya, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3474 · Cited by 347
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311669110 · Cited by 344
Recognition of viruses by innate immunity
Takeuchi, O., & Akira, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00562.x · Cited by 341
RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA
Kato, H., Takahasi, K., & Fujita, T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01052.x · Cited by 340
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
You, F., Sun, H., Zhou, X., Sun, W., Liang, S., Zhai, Z., & Jiang, Z. (2009) · Nature Immunology · doi:10.1038/ni.1815 · Cited by 340
Li, S., Wang, L., Berman, M. A., Kong, Y., & Dorf, M. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.014 · Cited by 334
siRNA Conjugate Delivery Systems
Jeong, J. H., Mok, H., Oh, Y., & Park, T. G. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800278e · Cited by 345
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
Wang, Z., Choi, M. K., Ban, T., Yanai, H., Negishi, H., Lu, Y., Tamura, T., Takaoka, A., Nishikura, K., & Taniguchi, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801295105 · Cited by 337
Kim, T., Pazhoor, S., Bao, M., Zhang, Z., Hanabuchi, S., Facchinetti, V., Bover, L. C., Plumas, J., Chaperot, L., Qin, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006539107 · Cited by 332
Nakashima, R., Imura, Y., Kobayashi, S., Yukawa, N., Yoshifuji, H., Nojima, T., Kawabata, D., Ohmura, K., Usui, T., Fujii, T., et al. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep375 · Cited by 334
Habjan, M., Andersson, I., Klingström, J., Schümann, M., Arnold, M., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Mühlberger, E., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002032 · Cited by 331
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
Maelfait, J., Vercammen, E., Janssens, S., Schotte, P., Haegman, M., Magez, S., & Beyaert, R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071632 · Cited by 335
Fredericksen, B. L., Keller, B. C., Fornek, J. L., Katze, M. G., & Gale, M. (2007) · Journal of Virology · doi:10.1128/jvi.01305-07 · Cited by 328
Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
Schilte, C., Couderc, T., Chrétien, F. C., Sourisseau, M., Gangneux, N., Guivel‐Benhassine, F., Kraxner, A., Tschopp, J., Higgs, S., Michault, A., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090851 · Cited by 326
Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor
Yang, Y., Liang, Y., Qu, L., Chen, Z., Yi, M., Li, K., & Lemon, S. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611506104 · Cited by 319
Zhang, S., Boisson‐Dupuis, S., Chapgier, A. L. A., Yang, K., Bustamante, J. C., Puel, A., Pïcard, C., Abel, L., Jouanguy, E., & Casanova, J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00698.x · Cited by 334
An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives
Facciolà, A., Visalli, G., Laganà, A., & Pietro, A. D. (2022) · Vaccines · doi:10.3390/vaccines10050819 · Cited by 321
RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection
Nasirudeen, A. M. A., Wong, H. H., Thien, P., Xu, S., Lam, K., & Liu, D. X. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000926 · Cited by 314
A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
Dias, A. G., Sampaio, N. G., & Rehwinkel, J. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.08.007 · Cited by 309
The Ebola Virus VP35 Protein Is a Suppressor of RNA Silencing
Haasnoot, J., de Vries, W., Geutjes, E.-J., Prins, M., de Haan, P., & Berkhout, B. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030086 · Cited by 311
Slater, L., Bartlett, N. W., Haas, J., Zhu, J., Message, S. D., Walton, R. P., Sykes, A., Dahdaleh, S., Clarke, D. L., Belvisi, M. G., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001178 · Cited by 330
Translational control of the innate immune response through IRF-7
Colina, R., Costa‐Mattioli, M., Dowling, R. J. O., Jaramillo, M., Tai, L., Breitbach, C. J., Martineau, Y., Larsson, O. S., Rong, L., Svitkin, Y. V., et al. (2008) · Nature · doi:10.1038/nature06730 · Cited by 316
Targeting cell signaling in allergic asthma
Athari, S. S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0079-0 · Cited by 324
Administration, distribution, metabolism and elimination of polymer therapeutics
Markovsky, E., Baabur‐Cohen, H., Eldar‐Boock, A., Omer, L., Tiram, G., Ferber, S., Ofek, P., Polyak, D., Scomparin, A., & Satchi‐Fainaro, R. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.021 · Cited by 315
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
Peisley, A., Lin, C., Wu, B., Orme-Johnson, M., Liu, M., Walz, T., & Hur, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113651108 · Cited by 312
Schuberth-Wagner, C., Ludwig, J., Bruder, A. K., Herzner, A., Zillinger, T., Goldeck, M., Schmidt, T., Schmid-Burgk, J. L., Kerber, R., Wolter, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.015 · Cited by 311
Function of RIG-I-like Receptors in Antiviral Innate Immunity
Yoneyama, M., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700007200 · Cited by 307
Delaloye, J., Roger, T., Steiner, Q., Roy, D. L., Reymond, M. K., Akira, S., Pétrilli, V., Gómez, C. E., Perdiguero, B., Tschopp, J., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000480 · Cited by 307
Retracted
Metadata
- Authors
- Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.-S., Reis e Sousa, C., Matsuura, Y., Fujita, T., & Akira, S.
- Affiliations
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Japan Science and Technology Agency (JP)
- Kyoto University (JP)
- The University of Osaka (JP)
- Hyogo Medical University (JP)
- Shinshu University (JP)
- Corresponding author
- Akira, Shizuo
- ORCID
- Venue
- Nature
- Published
- 2006-04-09
- Volume
- 441
- Issue
- 7089
- Pages
- 101-105
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2028575270
- Cited by
- 3,888
- References
- 28
- Citations by year
- 2026: 143 · 2025: 156 · 2024: 146 · 2023: 163 · 2022: 176 · 2021: 204 · 2020: 182 · 2019: 169 · 2018: 169 · 2017: 175 · 2016: 169 · 2015: 182 · 2014: 233 · 2013: 218 · 2012: 236
- FWCI
- 88.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- MDA5, RIG-I, double-stranded RNA recognition, antiviral innate immunity, interferon production, poly(I:C), paramyxovirus, influenza virus, Japanese encephalitis virus, picornavirus, viral susceptibility
- MeSH terms
- DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Animals, Encephalitis Virus, Japanese, Encephalomyocarditis virus, Immunity, Innate, RNA Viruses, RNA, Double-Stranded, RNA, Viral, RNA Helicases, Mice, DEAD-box RNA Helicases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review