Cited by 3,888interferon and immune responsesImmune Response and InflammationRNA regulation and disease

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, Hiroki, Takeuchi, Osamu, Sato, Shintaro, Yoneyama, Mitsutoshi, Yamamoto, Masahiro, Matsui, Kosuke, Uematsu, Satoshi, Jung, Andreas, Kawai, Taro, Ishii, Ken J., Yamaguchi, Osamu, Otsu, Kinya, Tsujimura, Tohru, Koh, Chang-Sung, Reis e Sousa, Caetano, Matsuura, Yoshiharu, Fujita, Takashi, Akira, Shizuo·2006·Nature

DOI 10.1038/nature04734

Open this paper in CoChat — free account

Abstract

The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA) and triggers antiviral responses. The cytoplasmic helicase proteins RIG-I (retinoic-acid-inducible protein I, also known as Ddx58) and MDA5 (melanoma-differentiation-associated gene 5, also known as Ifih1 or Helicard) have been implicated in viral dsRNA recognition. In vitro studies suggest that both RIG-I and MDA5 detect RNA viruses and polyinosine-polycytidylic acid (poly(I:C)), a synthetic dsRNA analogue. Although a critical role for RIG-I in the recognition of several RNA viruses has been clarified, the functional role of MDA5 and the relationship between these dsRNA detectors in vivo are yet to be determined. Here we use mice deficient in MDA5 (MDA5-/-) to show that MDA5 and RIG-I recognize different types of dsRNAs: MDA5 recognizes poly(I:C), and RIG-I detects in vitro transcribed dsRNAs. RNA viruses are also differentially recognized by RIG-I and MDA5. We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection. Furthermore, RIG-I-/- and MDA5-/- mice are highly susceptible to infection with these respective RNA viruses compared to control mice. Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses.

Integrity signals

Registry

Crossref · 10.1038/nature04734

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 4,022
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Self-citation
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401

Flagged first, then by citations

Show all 28 references

Sorted by citations

Items 401–500 of 1,007

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Bartok, E., & Hartmann, G. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.014 · Cited by 190
T Cell Trafficking in Allergic Asthma: The Ins and Outs
Medoff, B. D., Thomas, S. Y., & Luster, A. D. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090312 · Cited by 190
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
Zhu, Q., Egelston, C. A., Aravindhan, V., Uematsu, S., Akira, S., Klinman, D. M., Belyakov, I. M., & Berzofsky, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805325105 · Cited by 183
Innate sensing of viruses by pattern recognition receptors in birds
Chen, S., Cheng, A., & Wang, M. (2013) · Veterinary Research · doi:10.1186/1297-9716-44-82 · Cited by 179
Antiviral responses induced by the TLR3 pathway
Matsumoto, M., Oshiumi, H., & Seya, T. (2011) · Reviews in Medical Virology · doi:10.1002/rmv.680 · Cited by 186
IL-21 and T follicular helper cells
Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 192
DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication
Fullam, A., & Schröder, M. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.03.012 · Cited by 182
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation
Karki, R., Lee, E., Place, D. E., Samir, P., Mavuluri, J., Sharma, B. R., Balakrishnan, A., Malireddi, R. K. S., Geiger, R., Zhu, Q., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.055 · Cited by 183
SARS-CoV-2, the autoimmune virus
Halpert, G., & Shoenfeld, Y. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102695 · Cited by 184
Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling
Kalali, B. N., Köllisch, G. V., Mages, J., Müller, T. R., Bauer, S., Wagner, H., Ring, J., Lang, R., Mempel, M., & Ollert, M. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2694 · Cited by 186
TLR3 immunity to infection in mice and humans
Zhang, S., Casadio, M., Ciancanelli, M. J., de Diego, R. P., Sancho‐Shimizu, V., Abel, L., & Casanova, J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.11.001 · Cited by 178
Hantavirus‐induced immunity in rodent reservoirs and humans
Schönrich, G., Rang, A., Lütteke, N., Raftery, M. J., Charbonnel, N., & Ulrich, R. G. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00694.x · Cited by 179
RIG‐I detects infection with live Listeria by sensing secreted bacterial nucleic acids
Abdullah, Z., Schlee, M., Roth, S., Mraheil, M. A., Barchet, W., Böttcher, J. P., Hain, T., Geiger, S., Hayakawa, Y., Fritz, J. H., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.274 · Cited by 183
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment
Blank, T., Detje, C. N., Spieß, A., Hagemeyer, N., Brendecke, S. M., Wolfart, J., Staszewski, O., Zöller, T., Papageorgiou, I. E., Schneider, J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.005 · Cited by 182
STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response
Wang, W., Levy, D. E., & Lee, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004128 · Cited by 179
Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells
Tormo, D., Chęcińska, A., Alonso‐Curbelo, D., Pérez‐Guijarro, E., Cañón, E., Riveiro‐Falkenbach, E., Calvo, T. G., Larribère, L., Megı́as, D., Mulero, F., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.004 · Cited by 183
How microorganisms tip the balance between interleukin-12 family members
Goriely, S., Neurath, M. F., & Goldman, M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2225 · Cited by 185
The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation
Zhong, B., Zhang, Y., Tan, B., Liu, T., Wang, Y., & Shu, H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903748 · Cited by 177
TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response
Yang, K. S., Shi, H.-X., Liu, X.-Y., Shan, Y.-F., Wei, B., Chen, S., & Wang, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803126 · Cited by 177
Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN‐β induction via X‐box binding protein 1
Smith, J., Turner, M., Delay, M., Klenk, E. I., Sowders, D. P., & Colbert, R. (2008) · European Journal of Immunology · doi:10.1002/eji.200737882 · Cited by 168
Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis
Fensterl, V., Wetzel, J. L., Ramachandran, S., Ogino, T., Stohlman, S. A., Bergmann, C. C., Diamond, M., Virgin, H. W., & Sen, G. C. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002712 · Cited by 181
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase
Fan, Y., Mao, R., Yang, Y., Liu, S., Shi, Z., Cheng, J. Q., Zhang, H., An, L., Zhao, Y., Xu, X., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20122844 · Cited by 176
TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
Lang, X., Tang, T., Jin, T., Ding, C., Zhou, R., & Jiang, W. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160592 · Cited by 177
STING-dependent translation inhibition restricts RNA virus replication
Franz, K. M., Neidermyer, W. J., Tan, Y., Whelan, S. P. J., & Kagan, J. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716937115 · Cited by 183
Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense
Arimoto, K., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., & Shimotohno, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004621107 · Cited by 178
ORIGINAL ARTICLE: Activation of TLR3 in the Trophoblast is Associated with Preterm Delivery
Koga, K., Cardenas, I., Aldo, P. B., Abrahams, V. M., Peng, B., Malfertheiner, S. F., Romero, R. J., & Mor, G. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2008.00682.x · Cited by 170
Pathogen subversion of cell-intrinsic innate immunity
Roy, C. R., & Mocarski, E. S. (2007) · Nature Immunology · doi:10.1038/ni1528 · Cited by 174
Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
Tacken, P. J., Zeelenberg, I. S., Cruz, L. J., Hout-Kuijer, M. A. V., van de Glind, G. C., Fokkink, R. G., Lambeck, A. J. A., & Figdor, C. G. (2011) · Blood · doi:10.1182/blood-2011-07-367615 · Cited by 172
Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages
Cheng, X., Xia, Y., Serti, E., Block, P. D., Chung, M. T. M., Chayama, K., Rehermann, B., & Liang, T. J. (2017) · Hepatology · doi:10.1002/hep.29348 · Cited by 178
Antiviral Approaches against Influenza Virus
Kumari, R., Sharma, S. D., Kumar, A., Ende, Z. S., Mishina, M., Wang, Y., Falls, Z., Samudrala, R., Pohl, J., Knight, P. R., et al. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-22 · Cited by 176
Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L., & Bowie, A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002247 · Cited by 176
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria
Liu, X.-Y., Wei, B., Shi, H.-X., Shan, Y.-F., & Wang, C. (2010) · Cell Research · doi:10.1038/cr.2010.103 · Cited by 171
Evasion of Interferon Responses by Ebola and Marburg Viruses
Basler, C. F., & Amarasinghe, G. K. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2009.0076 · Cited by 173
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
Roberts, Z. J., Goutagny, N., Perera, P., Kato, H., Kumar, H., Kawai, T., Akira, S., Savan, R., Echo, D. V., Fitzgerald, K. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061845 · Cited by 167
Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity
Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, N. C., Scheuner, D. L., Kato, H., Takeuchi, O., Akira, S., Kaufman, R. J., & Sousa, C. R. E. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.04.007 · Cited by 170
Innate immunity and adjuvants
Akira, S. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0106 · Cited by 177
Cellular and molecular regulation of innate inflammatory responses
Liu, J., & Cao, X. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.58 · Cited by 171
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity
Kuniyoshi, K., Takeuchi, O., Pandey, S., Satoh, T., Iwasaki, H., Akira, S., & Kawai, T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401674111 · Cited by 169
CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis
Zhang, B., Chan, Y., Lu, B., Diamond, M. S., & Klein, R. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2641 · Cited by 169
Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
Op, Z., & Klenk, H. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0071-y · Cited by 170
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
Pippig, D. A., Hellmuth, J. C., Cui, S., Kirchhofer, A., Lammens, K., Lammens, A., Schmidt, A., Rothenfußer, S., & Hopfner, K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp059 · Cited by 167
Innate control of adaptive immunity: Dendritic cells and beyond
Lee, H. K., & Iwasaki, A. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2006.12.001 · Cited by 167
Characterization of Chicken Mda5 Activity: Regulation of IFN-β in the Absence of RIG-I Functionality
Karpala, A. J., Stewart, C. R., McKay, J. C., Lowenthal, J. W., & Bean, A. G. D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003712 · Cited by 169
The RIG-I-like Receptor LGP2 Recognizes the Termini of Double-stranded RNA
Li, X., Ranjith-Kumar, C. T., Brooks, M. T., Dharmaiah, S., Herr, A. B., Kao, C. C., & Li, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900818200 · Cited by 166
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production
Chen, K., Xiao, F., Hu, D., Ge, W., Tian, M., Wang, W., Pan, P., Wu, K., & Wu, J. (2020) · Viruses · doi:10.3390/v13010047 · Cited by 177
A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus
Shi, Z., Cai, Z., Sanchez, A., Zhang, T., Wen, S., Wang, J., Yang, J., Fu, S., & Zhang, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159590 · Cited by 166
Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response
Swanson, C. L., Wilson, T. J., Strauch, P., Colonna, M., Pelanda, R., & Torres, R. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092695 · Cited by 162
Norwalk Virus RNA Is Infectious in Mammalian Cells
Guix, S., Asanaka, M., Katayama, K., Crawford, S. E., Neill, F. H., Atmar, R. L., & Estes, M. K. (2007) · Journal of Virology · doi:10.1128/jvi.01489-07 · Cited by 166
Intracellular Pathogen Detection by RIG-I-Like Receptors
Dixit, E., & Kagan, J. C. (2013) · Advances in immunology · doi:10.1016/b978-0-12-410524-9.00004-9 · Cited by 172
Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2
Bamming, D., & Horvath, C. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807365200 · Cited by 164
A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus
Yordy, B., Iijima, N., Huttner, A. J., Leib, D. A., & Iwasaki, A. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.013 · Cited by 167
Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells
Okabayashi, T., Kojima, T., Masaki, T., Yokota, S., Imaizumi, T., Tsutsumi, H., Himi, T., Fujii, N., & Sawada, N. (2011) · Virus Research · doi:10.1016/j.virusres.2011.07.011 · Cited by 170
Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses
Lei, X., Xiao, X., Xue, Q., Jin, Q., He, B., & Wang, J. (2012) · Journal of Virology · doi:10.1128/jvi.01855-12 · Cited by 164
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy
Koerner, J., Horvath, D. J., Herrmann, V. L., MacKerracher, A., Gander, B. A., Yagita∥, H., Rohayem, J., & Groettrup, M. (2021) · Nature Communications · doi:10.1038/s41467-021-23244-3 · Cited by 169
Principles of intracellular viral recognition
Saito, T., & Gale, M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.11.003 · Cited by 166
Human Toll‐like receptor‐dependent induction of interferons in protective immunity to viruses
Zhang, S., Jouanguy, E., Sancho‐Shimizu, V., von Bernuth, H., Yang, K., Abel, L., Pïcard, C., Puel, A., & Casanova, J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00564.x · Cited by 171
The Interferon Inducible Gene: Viperin
Fitzgerald, K. A. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0127 · Cited by 163
Interplay between Interferon-Mediated Innate Immunity and Porcine Reproductive and Respiratory Syndrome Virus
Sun, Y., Han, M., Kim, C., Calvert, J. G., & Yoo, D. (2012) · Viruses · doi:10.3390/v4040424 · Cited by 169
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling
Yoo, Y., Park, Y., Kim, J., Cho, H., Kim, S., Lee, H., Kim, T.-H., Kim, Y. S., Lee, Y., Chul-Joong, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms8910 · Cited by 161
Toll-like receptor–mediated activation of neutrophils by influenza A virus
Wang, J. P., Bowen, G. N., Padden, C., Cerny, A., Finberg, R. W., Newburger, P. E., & Kurt‐Jones, E. A. (2008) · Blood · doi:10.1182/blood-2008-01-132860 · Cited by 169
Bacterial Ligands Generated in a Phagosome Are Targets of the Cytosolic Innate Immune System
Herskovits, A. A., Auerbuch, V., & Portnoy, D. A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030051 · Cited by 162
Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway
Pothlichet, J., Chignard, M., & Si‐Tahar, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2034 · Cited by 165
Pathobiology of Japanese encephalitis virus infection
Sharma, K. B., Vrati, S., & Kalia, M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100994 · Cited by 162
MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus
Wang, J. P., Cerny, A., Asher, D. R., Kurt‐Jones, E. A., Bronson, R. T., & Finberg, R. W. (2009) · Journal of Virology · doi:10.1128/jvi.00631-09 · Cited by 161
Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5
Shigemoto, T., Kageyama, M., Hirai, R., Zheng, J., Yoneyama, M., & Fujita, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809449200 · Cited by 161
InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins
Versteeg, G. A., Benke, S., García‐Sastre, A., & Rajsbaum, R. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.08.001 · Cited by 160
RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation
He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., Zhang, P., Zhang, X., Liu, N., Peng, Y., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100978 · Cited by 157
Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity
Saito, T., & Gale, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081210 · Cited by 160
Antiviral effects of the interferon‐induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein†
Itsui, Y., Sakamoto, N., Kakinuma, S., Nakagawa, M., Sekine‐Osajima, Y., Tasaka‐Fujita, M., Nishimura‐Sakurai, Y., Suda, G., Karakama, Y., Mishima, K., et al. (2009) · Hepatology · doi:10.1002/hep.23195 · Cited by 159
DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation
Yoo, J., Takahasi, K., Ng, C. S., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J. C., Lattmann, S., Nagamine, Y., Matsui, T., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004012 · Cited by 159
Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties
Sun, B., Robertsen, B., Wang, Z., & Liu, B. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.10.001 · Cited by 161
TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils
Alagbala, A. A., Wang, Q., Cui, J., Zou, J., Xia, X., Wang, M., Tong, Y., Hui, W., Liu, D., Su, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.010 · Cited by 160
Sensing Infection by Adenovirus: Toll-Like Receptor-Independent Viral DNA Recognition Signals Activation of the Interferon Regulatory Factor 3 Master Regulator
Nociari, M., Ocheretina, O., Schoggins, J. W., & Falck-Pedersen, E. (2007) · Journal of Virology · doi:10.1128/jvi.02685-06 · Cited by 159
Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling
Wang, D., Fang, L., Li, K., Zhong, H., Fan, J., Ouyang, C., Zhang, H., Duan, E., Luo, R., Zhang, Z., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00722-12 · Cited by 156
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus
Bender, S., Reuter, A., Eberle, F., Einhorn, E., Binder, M., & Bartenschlager, R. F. W. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005264 · Cited by 157
Severe viral respiratory infections in children with IFIH1 loss-of-function mutations
Asgari, S., Schlapbach, L. J., Anchisi, S., Hammer, C., Bartha, I., Junier, T., Mottet-Osman, G., Posfay-Barbe, K. M., Longchamp, D., Stocker, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704259114 · Cited by 155
No Love Lost Between Viruses and Interferons
Fensterl, V., Chattopadhyay, S., & Sen, G. C. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-055249 · Cited by 167
B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity
Moseman, E. A., Iannacone, M., Bosurgi, L., Tonti, E., Chevrier, N., Tumanov, A. V., Fu, Y., Hacohen, N., & von Andrian, U. H. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.013 · Cited by 155
Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities
Uzri, D., & Gehrke, L. (2009) · Journal of Virology · doi:10.1128/jvi.02449-08 · Cited by 155
Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction
Fan, L., Briese, T., & Lipkin, W. I. (2009) · Journal of Virology · doi:10.1128/jvi.01362-09 · Cited by 156
Directing Dendritic Cell Immunotherapy Towards Successful Cancer Treatment
Sabado, R. L., & Bhardwaj, N. (2009) · Immunotherapy · doi:10.2217/imt.09.43 · Cited by 155
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
Molony, R. D., Nguyen, J. T., Kong, Y., Montgomery, R. R., Shaw, A. C., & Iwasaki, A. (2017) · Science Signaling · doi:10.1126/scisignal.aan2392 · Cited by 154
Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR‐ and type‐I IFN‐dependent and ‐independent pathways
Ittah, M., Miceli‐Richard, C., Gottenberg, J., Sellam, J., Eid, P., Lebon, P., Pallier, C., Lepajolec, C., & Xavier Mariette, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200738013 · Cited by 154
Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen recognition and signal transduction
Hippenstiel, S., Opitz, B., Schmeck, B., & Suttorp, N. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-97 · Cited by 158
Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity
Bourquin, C., Anz, D., Zwiorek, K., Lanz, A.-L., Fuchs, S. P., Weigel, S., Wurzenberger, C., von der Borch, P., Golić, M., Moder, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.2990 · Cited by 152
Interferon and cytokine responses to SARS-coronavirus infection
Thiel, V., & Weber, F. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.01.001 · Cited by 150
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
Lamborn, I. T., Jing, H., Zhang, Y., Drutman, S. B., Abbott, J. K., Munir, S., Bade, S., Murdock, H. M., Santos, C. P., Brock, L. G., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161759 · Cited by 156
Peste des Petits Ruminants Virus
Baron, M. D., Diallo, A., Lancelot, R., & Libeau, G. (2016) · Advances in virus research · doi:10.1016/bs.aivir.2016.02.001 · Cited by 153
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I–mediated type I interferon-dependent innate immunity
Nitta, S., Sakamoto, N., Nakagawa, M., Kakinuma, S., Mishima, K., Kusano‐Kitazume, A., Kiyohashi, K., Murakawa, M., Nishimura‐Sakurai, Y., Azuma, S., et al. (2012) · Hepatology · doi:10.1002/hep.26017 · Cited by 152
The Ubiquitin-Specific Protease USP15 Promotes RIG-I–Mediated Antiviral Signaling by Deubiquitylating TRIM25
Pauli, E.-K., Chan, Y., Davis-Gardner, M. E., Gableske, S., Wang, M. K., Feister, K. F., & Gack, M. U. (2014) · Science Signaling · doi:10.1126/scisignal.2004577 · Cited by 153
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
Mutz, P., Metz, P., Lempp, F. A., Bender, S., Qu, B., Schöneweis, K., Seitz, S., Tu, T., Restuccia, A., Frankish, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.01.044 · Cited by 152
Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses
Kumar, H., Koyama, S., Ishii, K. J., Kawai, T., & Akira, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.683 · Cited by 149
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
Mueller, S., Gausson, V., Vodovar, N., Deddouche, S., Troxler, L., Perot, J., Pfeffer, S., Hoffmann, J. A., Saleh, M., & Imler, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014378107 · Cited by 151
Engineered nanomaterials for synergistic photo-immunotherapy
Guo, R., Wang, S., Zhao, L., Zong, Q., Li, T., Ling, G., & Zhang, P. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121425 · Cited by 151
Fifty Years of Interferon Research: Aiming at a Moving Target
Vilček, J. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.008 · Cited by 151
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
Ferreira, R. C., Pan‐Hammarström, Q., Graham, R., Gateva, V., Fontán, G., Lee, A. T., Ortmann, W. A., Urcelay, E., Fernández‐Arquero, M., Núñez, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.644 · Cited by 151
Innate and Adaptive Immune Responses to Herpes Simplex Virus
Chew, T., Taylor, K. E., & Mossman, K. L. (2009) · Viruses · doi:10.3390/v1030979 · Cited by 150
Negative regulation of TBK1‐mediated antiviral immunity
Zhao, W. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.052 · Cited by 151
Global virus outbreaks: Interferons as 1st responders
Wang, B. X., & Fish, E. N. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101300 · Cited by 149
Subunit Vaccines of the Future: the Need for safe, Customized and Optimized Particulate Delivery Systems
Foged, C. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.68 · Cited by 148

Authors: Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.-S., Reis e Sousa, C., Matsuura, Y., Fujita, T., & Akira, S.
Affiliations: Research Institute for Microbial Diseases, The University of Osaka (JP)
Japan Science and Technology Agency (JP)
Kyoto University (JP)
The University of Osaka (JP)
Hyogo Medical University (JP)
Shinshu University (JP)
Corresponding author: Akira, Shizuo
ORCID: Kato, Hiroki
Takeuchi, Osamu
Sato, Shintaro
Yoneyama, Mitsutoshi
Yamamoto, Masahiro
Uematsu, Satoshi
Kawai, Taro
Ishii, Ken J.
Yamaguchi, Osamu
Otsu, Kinya
Tsujimura, Tohru
Matsuura, Yoshiharu
Fujita, Takashi
Akira, Shizuo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-04-09
Volume: 441
Issue: 7089
Pages: 101-105
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04734
OpenAlex: W2028575270
Cited by: 3,888
References: 28
Citations by year: 2026: 143 · 2025: 156 · 2024: 146 · 2023: 163 · 2022: 176 · 2021: 204 · 2020: 182 · 2019: 169 · 2018: 169 · 2017: 175 · 2016: 169 · 2015: 182 · 2014: 233 · 2013: 218 · 2012: 236
FWCI: 88.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: MDA5, RIG-I, double-stranded RNA recognition, antiviral innate immunity, interferon production, poly(I:C), paramyxovirus, influenza virus, Japanese encephalitis virus, picornavirus, viral susceptibility
MeSH terms: DEAD Box Protein 58, Interferon-Induced Helicase, IFIH1, Animals, Encephalitis Virus, Japanese, Encephalomyocarditis virus, Immunity, Innate, RNA Viruses, RNA, Double-Stranded, RNA, Viral, RNA Helicases, Mice, DEAD-box RNA Helicases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks