Cited by 3,519NF-κB Signaling PathwaysSignaling Pathways in DiseaseNatural Compounds in Disease Treatment

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Nuclear factor-κB in cancer development and progression

Karin, Michael·2006·Nature

Open this paper in CoChat — free account

Abstract

Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

Integrity signals

Registry

Crossref · 10.1038/nature04870

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Self-citation
Cell Death
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citation
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
Self-citation

Show all 71 references

Sorted by citations

Items 201–300 of 1,010

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65
Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V., & Stark, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912493107 · Cited by 286
Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB
Mott, J. L., Kurita, S., Cazanave, S. C., Bronk, S. F., Werneburg, N. W., & Fernandez‐Zapico, M. E. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22630 · Cited by 282
Oncogenic EGFR Signaling Activates an mTORC2–NF-κB Pathway That Promotes Chemotherapy Resistance
Tanaka, K., Babić, I., Nathanson, D. A., Akhavan, D., Guo, D., Gini, B., Dang, J. H. T., Zhu, S., Yang, H., Jesus, J. D., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0124 · Cited by 279
Metabolic Regulation and Function of Glutathione Peroxidase-1
Lei, X. G., Cheng, W., & McClung, J. P. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093716 · Cited by 278
Redox signaling in the gastrointestinal tract
Pérez, S., Taléns‐Visconti, R., Rius‐Pérez, S., Finamor, I., & Sastre, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.048 · Cited by 277
The growing challenge of obesity and cancer: an inflammatory issue
Harvey, A. E., Lashinger, L. M., & Hursting, S. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06096.x · Cited by 278
Regulation of autophagy by stress-responsive transcription factors
Pietrocola, F., Izzo, V., Niso‐Santano, M., Vacchelli, E., Galluzzi, L., Maiuri, M. C., & Kroemer, G. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.008 · Cited by 277
The Multifaceted Role of MTDH/AEG-1 in Cancer Progression
Hu, G., Wei, Y., & Kang, Y. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0049 · Cited by 267
Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells
Germano, G., Frapolli, R., Simone, M., Tavecchio, M., Erba, E., Pesce, S., Pasqualini, F., Grosso, F., Sanfilippo, R. G., Casali, P. G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2335 · Cited by 268
The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia
Espinosa, L., Cathelin, S., D’Altri, T., Trimarchi, T., Statnikov, A., Guiu, J., Rodilla, V., Inglés‐Esteve, J., Nomdedeu, J. F., Bellosillo, B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.006 · Cited by 278
Functions of Immune Checkpoint Molecules Beyond Immune Evasion
Zhang, Y., & Zheng, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3266-5_9 · Cited by 267
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
Biton, S., & Ashkenazi, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.023 · Cited by 262
Tumor Promotion via Injury- and Death-Induced Inflammation
Kuraishy, A. I., Karin, M., & Grivennikov, S. I. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.006 · Cited by 270
Self-citation
Modulation of Inflammatory Genes by Natural Dietary Bioactive Compounds
Pan, M., Lai, C., Dushenkov, S., & Ho, C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900612n · Cited by 262
Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer
Abdollahzadeh, R., Daraei, A., Mansoori, Y., Sepahvand, M., Amoli, M. M., & Tavakkoly‐Bazzaz, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27941 · Cited by 260
Heme oxygenase-1 in tumor biology and therapy
Was, H., Dulak, J., & Jozkowicz, A. (2010) · Current Drug Targets · doi:10.2174/1389450111009011551 · Cited by 259
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
Zou, Z., Huang, B., Wu, X., Zhang, H., Qi, J., Bradner, J. E., Nair, S. K., & Chen, L.-F. (2013) · Oncogene · doi:10.1038/onc.2013.179 · Cited by 269
Anti–Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis
Egberts, J. D., Cloosters, V., Noack, A., Schniewind, B., Thon, L., Klose, S., Kettler, B., von Forstner, C., Kneitz, C., Tepel, J., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5704 · Cited by 259
Gender Disparity of Hepatocellular Carcinoma: The Roles of Sex Hormones
Yeh, S., & Chen, P. (2010) · Oncology · doi:10.1159/000315247 · Cited by 261
Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells
Ma, Z., Vocadlo, D. J., & Vosseller, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470047 · Cited by 255
Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer
Talero, E., García‐Mauriño, S., Ávila‐Román, J., Rodríguez-Luna, A., Alcaide, A. M., & Motilva, V. (2015) · Marine Drugs · doi:10.3390/md13106152 · Cited by 265
Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
Noonan, D. M., Barbaro, A. D. L., Vannini, N., Mortara, L., & Albini, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9108-5 · Cited by 255
MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway
Kumar, M., Sahu, S. K., Kumar, R., Subuddhi, A., Maji, R. K., Jana, K., Gupta, P., Raffetseder, J., Lerm, M., Ghosh, Z., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.007 · Cited by 259
The Role of Inflammation in Lung Cancer
Gomes, M. P., Teixeira, A. L., Coelho, A., Araújo, A., & Medeiros, R. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_1 · Cited by 257
Ageing: from inflammation to cancer
Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241
“Chronic inflammation is, thus, associated with all stages of cancer development increasing its risk, supporting cancer initiation, promoting cancer progression, and supporting metastatic diffusion [10].”
Background
Cellular and molecular pathways linking inflammation and cancer
Porta, C., Larghi, P., Rimoldi, M., Totaro, M. G., Allavena, P., Mantovani, A., & Sica, A. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.06.014 · Cited by 262
Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials
Potts, B. C. M., Albitar, M. X., Anderson, K. C., Baritaki, S., Berkers, C. R., Bonavida, B., Chandra, J., Chauhan, D., Cusack, J. C., Fenical, W., et al. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911794519716 · Cited by 247
Manipulation of the nuclear factor-κB pathway and the innate immune response by viruses
Hiscott, J. B., Nguyen, T.-L. A., Argüello, M., Nakhaei, P., & Paz, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209941 · Cited by 251
A20: from ubiquitin editing to tumour suppression
Hymowitz, S. G., & Wertz, I. E. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2775 · Cited by 252
RIP kinases: key decision makers in cell death and innate immunity
Humphries, F., Yang, S., Wang, B., & Moynagh, P. N. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.126 · Cited by 249
EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis
Yang, W., Xia, Y., Cao, Y. J., Zheng, Y., Bu, W., Zhang, L., You, M. J., Koh, M. Y., Cote, G. J., Aldape, K., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.028 · Cited by 250
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
Hu, F., Song, D., Yan, Y., Huang, C., Shen, C., Lan, J., Chen, Y., Liu, A., Wu, Q., Sun, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23923-1 · Cited by 235
Does autophagy have a license to kill mammalian cells?
Scarlatti, F., Granata, R., Meijer, A. J., & Codogno, P. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.101 · Cited by 248
The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth
Dietrich, C., & Kaina, B. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq028 · Cited by 249
The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response
Formentini, L., Sánchez‐Aragó, M., Sánchez-Cenizo, L., & Cuezva, J. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.008 · Cited by 240
Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations
He, D., Wang, D., Lü, P., Yang, N., Xue, Z., Zhu, X., Zhang, P., & Fan, G. (2020) · Oncogene · doi:10.1038/s41388-020-01528-0 · Cited by 249
Significance of Heparanase in Cancer and Inflammation
Vlodavsky, I., Beckhove, P., Lerner, I., Pisano, C., Meirovitz, A., Ilan, N., & Elkin, M. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0082-7 · Cited by 246
Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response
Hiscott, J. B. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.002 · Cited by 239
Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPAR α ) as a case study
Corton, J. C., Cunningham, M. L., Hummer, B. T., Lau, C. S., Meek, B., Peters, J. M., Popp, J. A., Rhomberg, L. R., Seed, J. G., & Klaunig, J. E. (2013) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.835784 · Cited by 246
The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma
Wu, J., Li, J., Salcedo, R., Mivechi, N. F., Trinchieri, G., & Horuzsko, A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0938 · Cited by 247
NF-kappaB: Two Sides of the Same Coin
Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M., & Abdelhay, E. S. F. W. (2018) · Genes · doi:10.3390/genes9010024 · Cited by 243
NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target
Chen, W. (2010) · Frontiers in bioscience · doi:10.2741/3782 · Cited by 234
Pevonedistat ( MLN 4924), a First‐in‐Class NEDD 8‐activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study
Swords, R. T., Erba, H. P., DeAngelo, D. J., Bixby, D. L., Altman, J. K., Maris, M. B., Hua, Z., Blakemore, S. J., Faessel, H. M., Sedarati, F., et al. (2015) · British Journal of Haematology · doi:10.1111/bjh.13323 · Cited by 238
Inflammation and cancer: Role of nuclear factor‐kappaB activation
Maeda, S., & Omata, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00763.x · Cited by 236
The Pathophysiology of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β in Normal and Malignant Mammary Epithelial Cells
Taylor, M. A., Parvani, J. G., & Schiemann, W. P. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9181-1 · Cited by 235
Phase I Study of Vorinostat in Combination with Bortezomib for Relapsed and Refractory Multiple Myeloma
Badros, A. Z., Burger, A. M., Philip, S., Niesvizky, R., Kolla, S. S., Goloubeva, O. G., Harris, C., Zwiebel, J. A., Wright, J. J., Espinoza‐Delgado, I., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2850 · Cited by 231
Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells
Dayem, A. A., Choi, H.-Y., Kim, J., & Cho, S. (2010) · Cancers · doi:10.3390/cancers2020859 · Cited by 232
Pharmacological and therapeutic effects of A3 adenosine receptor agonists
Fishman, P., Bar‐Yehuda, S., Liang, B. T., & Jacobson, K. A. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.007 · Cited by 229
Nuclear receptors versus inflammation: mechanisms of transrepression
Pascual, G., & Glass, C. K. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.08.005 · Cited by 225
New insights into chronic inflammation-induced immunosuppression
Kanterman, J., Sade-Feldman, M., & Baniyash, M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.008 · Cited by 234
NF-κB Signaling Pathway and Its Therapeutic Implications in Human Diseases
Sarkar, F. H., Li, Y., Wang, Z. P., & Kong, D. (2008) · International Reviews of Immunology · doi:10.1080/08830180802276179 · Cited by 234
Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity
Kagoya, Y., Yoshimi, A., Kataoka, K., Nakagawa, M. M., Kumano, K., Arai, S., Kobayashi, H., Saito, T., Iwakura, Y., & Kurokawa, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci68101 · Cited by 233
Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer
Berx, G., Raspé, E., Christofori, G., Thiery, J. P., & Sleeman, J. P. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9114-6 · Cited by 232
PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Ying, H., Elpek, K. G., Vinjamoori, A., Zimmerman, S. M., Chu, G. C., Yan, H., Fletcher-Sananikone, E., Zhang, H., Liu, Y., Wang, W., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0031 · Cited by 223
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-κB pathway
Endo, T., Nishio, M., Enzler, T., Cottam, H. B., Fukuda, T., James, D. F., Karin, M., & Kipps, T. J. (2006) · Blood · doi:10.1182/blood-2006-06-027755 · Cited by 225
Self-citation
A Dietary Anthocyanidin Delphinidin Induces Apoptosis of Human Prostate Cancer PC3 Cells In vitro and In vivo: Involvement of Nuclear Factor-κB Signaling
Hafeez, B. B., Siddiqui, I. A., Asim, M., Malik, A., Afaq, F., Adhami, V. M., Saleem, M., Din, M., & Mukhtar, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2232 · Cited by 220
HDAC inhibitors as anti‐inflammatory agents
Adcock, I. M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707166 · Cited by 217
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
Tu, D., Zhu, Z., Zhou, A. Y., Yun, C., Lee, K., Toms, A. V., Li, Y., Dunn, G. P., Chan, E. M., Thai, T. C., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.033 · Cited by 222
Chemokines in cancer related inflammation
Allavena, P., Germano, G., Marchesi, F., & Mantovani, A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.11.013 · Cited by 220
miR-146b is Highly Expressed in Adult Papillary Thyroid Carcinomas with High Risk Features Including Extrathyroidal Invasion and the BRAF V600E Mutation
Chou, C., Chen, R., Chou, F., Chang, H., Chen, Y., Lee, Y.-F., Yang, K. D., Cheng, J., Huang, C., & Liu, R. (2010) · Thyroid · doi:10.1089/thy.2009.0027 · Cited by 215
NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells
Maier, H. J., Schmidt-Straßburger, U., Huber, M. A., Wiedemann, E. M., Beug, H., & Wirth, T. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.003 · Cited by 215
Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement
Calzone, L., Tournier, L., Fourquet, S., Thieffry, D., Zhivotovsky, B., Barillot, E., & Zinovyev, A. Y. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000702 · Cited by 220
Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy
Torricelli, C., Salvadori, S., Valacchi, G., Souček, K., Slabáková, E., Muscettola, M., Volpi, N., & Maioli, E. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/980658 · Cited by 214
Retracted
Small-molecule SMAC mimetics as new cancer therapeutics
Bai, L., Smith, D. C., & Wang, S. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.007 · Cited by 218
Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications
Hei, T. K., Zhou, H., Chai, Y., Ponnaiya, B., & Ivanov, V. N. (2011) · Current Molecular Pharmacology · doi:10.2174/1874467211104020096 · Cited by 224
Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword
Dajon, M., Iribarren, K., & Cremer, I. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.06.009 · Cited by 215
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-κB and Prox1
Flister, M. J., Wilber, A. C., Hall, K. L., Iwata, C., Miyazono, K., Nisato, R. E., Pepper, M. S., Zawieja, D. C., & Ran, S. (2009) · Blood · doi:10.1182/blood-2008-12-196840 · Cited by 211
The role of gut microbiota in the pathogenesis of colorectal cancer
Zhu, Q., Gao, R., Wu, W., & Qin, H. (2013) · Tumor Biology · doi:10.1007/s13277-013-0684-4 · Cited by 217
The neutrophil gelatinase-associated lipocalin (NGAL), a NF-κB-regulated gene, is a survival factor for thyroid neoplastic cells
Iannetti, A., Pacifico, F., Acquaviva, R., Lavorgna, A., Crescenzi, E., Vascotto, C., Tell, G., Salzano, A. M., Scaloni, A., Vuttariello, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710846105 · Cited by 210
Inflammation, Cancer, and Targets of Ginseng
Hofseth, L. J., & Wargovich, M. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.183s · Cited by 209
NF-κB inhibitors in treatment and prevention of lung cancer
Rasmi, R. R., Sakthivel, K. M., & Guruvayoorappan, C. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110569 · Cited by 212
Epigenetic regulation of airway inflammation
Adcock, I. M., Tsaprouni, L., Bhavsar, P. K., & Ito, K. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.016 · Cited by 210
Inflammation and p53: A Tale of Two Stresses
Gudkov, A. V., Gurova, K. V., & Komarova, E. A. (2011) · Genes & Cancer · doi:10.1177/1947601911409747 · Cited by 211
Role of COX-2 in epithelial–stromal cell interactions and progression of ductal carcinoma in situ of the breast
Hu, M. S., Peluffo, G., Chen, H., Gelman, R. S., Schnitt, S. J., & Polyák, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813306106 · Cited by 205
Adjuvant Therapy with Bioavailability‐Boosted Curcuminoids Suppresses Systemic Inflammation and Improves Quality of Life in Patients with Solid Tumors: A Randomized Double‐Blind Placebo‐Controlled Trial
Panahi, Y., Saadat, A., Beiraghdar, F., & Sahebkar, A. (2014) · Phytotherapy Research · doi:10.1002/ptr.5149 · Cited by 205
Phosphoinositide 3‐kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
Yu, H., Ai, Y., Yu, L., Zhou, X., Liu, J., Li, J., Xu, X., Liu, S., Chen, J., Liu, F., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.23049 · Cited by 203
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin
Zhang, L., & Wang, H. (2015) · Marine Drugs · doi:10.3390/md13074310 · Cited by 202
Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad
Chang, S., Chang, C. A., Lee, D., Lee, P., Yeh, Y.-M., Yeh, C., Cheng, C., Chien, S., & Chiu, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712353105 · Cited by 213
Radiation, Inflammation, and Immune Responses in Cancer
Multhoff, G., & Radons, J. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00058 · Cited by 206
Upregulation of Glt1 Attenuates Cue-Induced Reinstatement of Cocaine-Seeking Behavior in Rats
Sari, Y., Smith, K. D., Ali, P. K., & Rebec, G. V. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1746-09.2009 · Cited by 200
Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer
Danese, S., & Mantovani, A. (2010) · Oncogene · doi:10.1038/onc.2010.109 · Cited by 203
Targeted Regulation of PI3K/Akt/mTOR/NF-κB Signaling by Indole Compounds and their Derivatives: Mechanistic Details and Biological Implications for Cancer Therapy
Ahmad, A., Biersack, B., Li, Y., Kong, D., Bao, B., Schobert, R., Padhyé, S., & Sarkar, F. H. (2013) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990078 · Cited by 207
Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization
Formentini, L., Santacatterina, F., de Arenas, C. N., Stamatakis, K., Martínez, D. L., Logan, A., Fresno, M., Smits, R., Murphy, M. P., & Cuezva, J. M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.036 · Cited by 202
PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma
Asgarova, A., Asgarov, K., Godet, Y., Peixoto, P., Nadaradjane, A., Boyer‐Guittaut, M., Galaine, J., Guenat, D., Mougey, V., Perrard, J., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2017.1423170 · Cited by 203
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
Fuxe, J., & Karlsson, M. C. I. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.05.004 · Cited by 198
Crystal structure of inhibitor of κB kinase β
Xu, G., Lo, Y.-C., Li, Q., Napolitano, G., Wu, X., Jiang, X., Dréano, M., Karin, M., & Wu, H. (2011) · Nature · doi:10.1038/nature09853 · Cited by 199
Self-citation
Tumor immunoediting and immunosculpting pathways to cancer progression
Reiman, J. M., Kmieciak, M., Manjili, M. H., & Knutson, K. L. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.06.009 · Cited by 200
Inflammation-mediated promotion of invasion and metastasis
Solinas, G., Marchesi, F., Garlanda, C., Mantovani, A., & Allavena, P. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9227-2 · Cited by 205
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 215
TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets
Song, L., Liu, L., Wu, Z., Li, Y., Ying, Z., Lin, C., Wu, J., Hu, B., Cheng, S., Li, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62339 · Cited by 199
Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells
Weisz, L., Damalas, A., Liontos, M., Karakaidos, P., Fontemaggi, G., Maor-Aloni, R., Kalis, M. L., Levrero, M., Strano, S., Gorgoulis, V. G., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2425 · Cited by 205
NF-κB in cancer therapy
Li, F., Zhang, J., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Kumar, A. P., Ahn, K. S., & Sethi, G. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1470-4 · Cited by 199
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
Puar, Y., Shanmugam, M. K., Fan, L., Arfuso, F., Sethi, G., & Tergaonkar, V. (2018) · Biomedicines · doi:10.3390/biomedicines6030082 · Cited by 200
Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)
Fernandes, J. V., Fernandes, T. A. A. D. M., de Azevedo, J. C. V., Cobucci, R. N., de Carvalho, M. G. F., Andrade, V. S., & de Araújo, J. M. G. (2015) · Oncology Letters · doi:10.3892/ol.2015.2884 · Cited by 205
Roles of NF-κB in health and disease: mechanisms and therapeutic potential
Wong, E. T., & Tergaonkar, V. (2009) · Clinical Science · doi:10.1042/cs20080502 · Cited by 196
Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies
Marquardt, J. U., Galle, P. R., & Teufel, A. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.007 · Cited by 194
Nanotechnology-based drug delivery systems for treatment of oral cancer: a review
Calixto, G. M. F., Fonseca‐Santos, B., Chorilli, M., & Bernegossi, J. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s61670 · Cited by 202
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, M. G., Biondi, F., et al. (2015) · Nutrients · doi:10.3390/nu7042589 · Cited by 198

Authors: Karin, M.
Affiliations: University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Karin, Michael
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-05
Volume: 441
Issue: 7092
Pages: 431-436
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04870
OpenAlex: W2315613727
Cited by: 3,519
References: 71
Citations by year: 2026: 60 · 2025: 97 · 2024: 111 · 2023: 118 · 2022: 118 · 2021: 159 · 2020: 162 · 2019: 133 · 2018: 168 · 2017: 149 · 2016: 192 · 2015: 235 · 2014: 203 · 2013: 231 · 2012: 250
FWCI: 15.68
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: NF-κB, carcinogenesis, tumor progression, inflammation and cancer, apoptosis resistance, tumor surveillance, tumor angiogenesis, tumour invasiveness, chemoprevention, chemotherapeutic target, NF-κB signaling
MeSH terms: Animals, Humans, Inflammation, Liver Neoplasms, Neoplasms, Skin Neoplasms, NF-kappa B, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nuclear factor-κB in cancer development and progression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks