Cited by 3,519NF-κB Signaling PathwaysSignaling Pathways in DiseaseNatural Compounds in Disease Treatment

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Nuclear factor-κB in cancer development and progression

Karin, Michael·2006·Nature

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Abstract

Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

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Authors: Karin, M.
Affiliations: University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Karin, Michael
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-05
Volume: 441
Issue: 7092
Pages: 431-436
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04870
OpenAlex: W2315613727
Cited by: 3,519
References: 71
Citations by year: 2026: 60 · 2025: 97 · 2024: 111 · 2023: 118 · 2022: 118 · 2021: 159 · 2020: 162 · 2019: 133 · 2018: 168 · 2017: 149 · 2016: 192 · 2015: 235 · 2014: 203 · 2013: 231 · 2012: 250
FWCI: 15.68
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: NF-κB, carcinogenesis, tumor progression, inflammation and cancer, apoptosis resistance, tumor surveillance, tumor angiogenesis, tumour invasiveness, chemoprevention, chemotherapeutic target, NF-κB signaling
MeSH terms: Animals, Humans, Inflammation, Liver Neoplasms, Neoplasms, Skin Neoplasms, NF-kappa B, Disease Progression

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