The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Nuclear factor-κB in cancer development and progression
Abstract
Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“When NF-κB is activated, transcription of proinflammatory immune response genes such as Tnfα and Il1 occurs, which leads to translation and production of proinflammatory cytokines that serve to coordinate the inflammatory response (Karin, 2006).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Karin, 2006
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Self-citationDanial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citationNF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
Self-citationAn Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Self-citationTNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
The two NF-κB activation pathways and their role in innate and adaptive immunity
Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535
Self-citationNF-κB in cancer: from innocent bystander to major culprit
Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476
Self-citationIKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Self-citationNF-κB functions as a tumour promoter in inflammation-associated cancer
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., & Ben‐Neriah, Y. (2004) · Nature · doi:10.1038/nature02924 · Cited by 2,423
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,423
Self-citationInterleukin-1 polymorphisms associated with increased risk of gastric cancer
El-Omar, E. M., Carrington, M. N., Chow, W. H., McColl, K. E. L., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C., Rothman, N., et al. (2000) · Nature · doi:10.1038/35006081 · Cited by 2,368
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Self-citationKamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792
Self-citationSmoldering and polarized inflammation in the initiation and promotion of malignant disease
Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582
The IKK NF-κB system: a treasure trove for drug development
Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364
Self-citationActivation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361
Self-citationMaeda, S., Kamata, H., Luo, J., Leffert, H. L., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2005.04.014 · Cited by 1,160
Self-citationInnate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
Karin, M., Lawrence, T., & Nizet, V. (2006) · Cell · doi:10.1016/j.cell.2006.02.016 · Cited by 938
Self-citationRas-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
Sparmann, A., & Bar‐Sagi, D. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.028 · Cited by 880
NF-κB Signals Induce the Expression of c-FLIP
Micheau, O., Lens, S. M. A., Gaide, O., Alevizopoulos, K., & Tschopp, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5299-5305.2001 · Cited by 809
Infections as a major preventable cause of human cancer
Kuper, H., Adami, H. ‐., & Trichopoulos, D. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00742.x · Cited by 740
TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726
Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell · doi:10.1016/j.cell.2006.01.021 · Cited by 706
Self-citationPham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.017 · Cited by 663
Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation
Covert, M. W., Leung, T., Gaston, J. E., & Baltimore, D. (2005) · Science · doi:10.1126/science.1112304 · Cited by 612
Luo, J., Maeda, S., Hsu, L.-C., Yagita∥, H., & Karin, M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.012 · Cited by 598
Self-citationThe NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus
Rothwarf, D., & Karin, M. (1999) · Science's STKE · doi:10.1126/stke.1999.5.re1 · Cited by 553
Self-citationRuland, J., Duncan, G. S., Elia, A., Barrantes, I. D. B., Nguyen, L. T., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A. C., Ohashi, P. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00189-1 · Cited by 545
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
Dajee, M., Lazarov, M., Zhang, J. Y., Cai, T., Green, C. L., Russell, A. J., Marinkovich, M. P., Tao, S., Lin, Q., Kubo, Y., et al. (2003) · Nature · doi:10.1038/nature01283 · Cited by 535
Tumor necrosis factor or tumor promoting factor?
Balkwill, F. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00020-x · Cited by 520
Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity
Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 509
Chen, L.-W., Egan, L. J., Li, Z.-W., Greten, F. R., Kagnoff, M. F., & Karin, M. (2003) · Nature Medicine · doi:10.1038/nm849 · Cited by 483
Self-citationCao, Y., Bonizzi, G., Seagroves, T. N., Greten, F. R., Johnson, R. S., Schmidt, E. V., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00599-2 · Cited by 479
Self-citationThe Rel/NF-κB signal transduction pathway: introduction
Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203237 · Cited by 437
Lucas, P. C., Yonezumi, M., Inohara, N., McAllister‐Lucas, L. M., Abazeed, M. E., Chen, F. F., Yamaoka, S., Seto, M., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009984200 · Cited by 417
Makris, C., Godfrey, V., Krähn‐Senftleben, G., Takahashi, T., Roberts, J. L., Schwarz, T., Feng, L., Johnson, R. S., & Karin, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80262-2 · Cited by 393
Self-citationCARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Thome, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1352 · Cited by 391
NF-κB and cell-cycle regulation: the cyclin connection
JOYCE, D., ALBANESE, C., Steer, J. H., Fu, M., Bouzahzah, B., & Pestell, R. G. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00018-6 · Cited by 390
Neri, A., Chang, C.-C., Lombardi, L. T., Salina, M., Corradini, P., Maiolo, A. T., Chaganti, R. S. K., & Dalla‐Favera, R. (1991) · Cell · doi:10.1016/0092-8674(91)90285-7 · Cited by 390
The epidemiology of gastric cancer
Roder, D. M. (2002) · Gastric Cancer · doi:10.1007/s10120-002-0203-6 · Cited by 369
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
Garkavtsev, I., Kozin, S. V., Chernova, O. B., Xu, L., Winkler, F., Brown, E. B., Barnett, G. H., & Jain, R. K. (2004) · Nature · doi:10.1038/nature02329 · Cited by 353
Th, M., van Nieuwkerk, C. M., Dingemans, K. P., Smit, J. J., Schinkel, A. H., Notenboom, R. G. E., Weerman, M. A. V. D. B., VERKRUISEN, R. P., Groen, A. K., & Elferink, R. P. J. O. (1994) · PubMed Central · Cited by 352
Park, J. M., Greten, F. R., Wong, A. W., Westrick, R. J., Arthur, J. S. C., Otsu, K., Hoffmann, A., Montminy, M., & Karin, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.08.010 · Cited by 324
Self-citationCK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response
Kato, T., Delhase, M., Hoffmann, A., & Karin, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00358-7 · Cited by 313
Self-citationvan Hogerlinden, M., Rozell, B., Ährlund‐Richter, L., & Toftgård, R. (1999) · PubMed · Cited by 277
Inflammation-associated cancer: NF-κB is the lynchpin
Li, Q., Withoff, S., & Verma, I. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.003 · Cited by 270
Promotion of colorectal neoplasia in experimental murine ulcerative colitis.
Okayasu, I., Ohkusa, T., Kajiura, K., Kanno, J., & Sakamoto, S. (1996) · Gut · doi:10.1136/gut.39.1.87 · Cited by 231
The gastric marginal zone B-cell lymphoma of MALT type
Zucca, E., Bertoni, F., Roggero, E., & Cavalli, F. (2000) · Blood · doi:10.1182/blood.v96.2.410.014k22_410_419 · Cited by 227
Lavon, I., Goldberg, I., Amit, S., Landsman, L., Jung, S., Tsuberi, B., Barshack, I., Kopolovic, J., Galun, E., Bujard, H., et al. (2000) · Nature Medicine · doi:10.1038/75057 · Cited by 182
Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway
Arnott, C. H., Scott, K. A., Moore, R. J., Hewer, A. J., Phillips, D. H., Parker, P. J., Balkwill, F. R., & Owens, D. M. (2002) · Oncogene · doi:10.1038/sj.onc.1205588 · Cited by 166
Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk
Sun, J., Wiklund, F., Zheng, S. L., Chang, B., Bälter, K. A., Li, L., Johansson, J.-E., Li, G., Adami, H., Liu, W., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji070 · Cited by 161
The gastric marginal zone B-cell lymphoma of MALT type
Zucca, E., Bertoni, F., Roggero, E., & Cavalli, F. (2000) · Blood · doi:10.1182/blood.v96.2.410 · Cited by 142
NF-κB RelA opposes epidermal proliferation driven by TNFR1 and JNKPreprint
Zhang, J. Y., Green, C. L., Tao, S., & Khavari, P. A. (2004) · Genes & Development · doi:10.1101/gad.1160904 · Cited by 122
Lind, M. H., Rozell, B., Wallin, R. P. A., van Hogerlinden, M., Ljunggren, H., Toftgård, R., & Sur, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307106101 · Cited by 113
The Rel/NF-κB/IκB Signal Transduction Pathway and Cancer
Gilmore, T. D. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_10 · Cited by 91
Demicco, E. G., Kavanagh, K. T., Romieu, R., Wang, X., Shin, S. R., Landesman‐Bollag, E., Seldin, D. C., & Sonenshein, G. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10136-10147.2005 · Cited by 89
Oshima, M., Oshima, H., Matsunaga, A., & Taketo, M. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1936 · Cited by 66
Holla, V. R., Wang, D., Brown, J. R., Mann, J. R., Katkuri, S., & DuBois, R. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407403200 · Cited by 61
van Hogerlinden, M., Auer, G., & Toftgård, R. (2002) · Oncogene · doi:10.1038/sj.onc.1205620 · Cited by 46
Respiratory health consequences of environmental tobacco smoke
Dhala, A. F., Pinsker, K. L., & Prezant, D. J. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.06.005 · Cited by 44
Risk of cancer in ulcerative colitis
Ekbom, A. (1998) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(98)80067-x · Cited by 38
Flagged first, then by citations
Cited by
Sorted by citations
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Self-citationShared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,954
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
Metadata
- Authors
- Karin, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Karin, Michael
- ORCID
- Karin, Michael
- Venue
- Nature
- Published
- 2006-05
- Volume
- 441
- Issue
- 7092
- Pages
- 431-436
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2315613727
- Cited by
- 3,519
- References
- 71
- Citations by year
- 2026: 60 · 2025: 97 · 2024: 111 · 2023: 118 · 2022: 118 · 2021: 159 · 2020: 162 · 2019: 133 · 2018: 168 · 2017: 149 · 2016: 192 · 2015: 235 · 2014: 203 · 2013: 231 · 2012: 250
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- NF-κB, carcinogenesis, tumor progression, inflammation and cancer, apoptosis resistance, tumor surveillance, tumor angiogenesis, tumour invasiveness, chemoprevention, chemotherapeutic target, NF-κB signaling
- MeSH terms
- Animals, Humans, Inflammation, Liver Neoplasms, Neoplasms, Skin Neoplasms, NF-kappa B, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
