Cited by 3,519NF-κB Signaling PathwaysSignaling Pathways in DiseaseNatural Compounds in Disease Treatment

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Nuclear factor-κB in cancer development and progression

Karin, Michael·2006·Nature

Open this paper in CoChat — free account

Abstract

Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

Integrity signals

Registry

Crossref · 10.1038/nature04870

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Self-citation
Cell Death
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Self-citation
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
Self-citation

Flagged first, then by citations

Show all 71 references

Sorted by citations

Items 101–200 of 1,010

Angiogenesis and chronic inflammation: cause or consequence?
Costa, C., Incio, J., & Soares, R. A. (2007) · Angiogenesis · doi:10.1007/s10456-007-9074-0 · Cited by 510
Overview of macroautophagy regulation in mammalian cells
Mehrpour, M., Esclatine, A., Beau, I., & Codogno, P. (2010) · Cell Research · doi:10.1038/cr.2010.82 · Cited by 516
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
Alvero, A. B., Chen, R., Fu, H., Montagna, M. K., Schwartz, P. E., Rutherford, T., Silasi, D., Steffensen, K. D., Waldstrøm, M., Visintin, I., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.1.7533 · Cited by 488
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486
Self-citation
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
Vereecke, L., Beyaert, R., & Loo, G. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.007 · Cited by 490
Myeloid-Derived Suppressor Cells
Parker, K. H., Beury, D. W., & Ostrand‐Rosenberg, S. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.002 · Cited by 490
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
Matsumoto, Y. M., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I., Honjo, T., & Chiba, T. (2007) · Nature Medicine · doi:10.1038/nm1566 · Cited by 480
NF-κB addiction and its role in cancer: ‘one size does not fit all’
Chaturvedi, M., Sung, B., Yadav, V. R., Kannappan, R., & Aggarwal, B. B. (2010) · Oncogene · doi:10.1038/onc.2010.566 · Cited by 485
Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage
Grivennikov, S. I., & Karin, M. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140145 · Cited by 560
Self-citation
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci45785 · Cited by 462
Role of the NFκB-signaling pathway in cancer
Xia, L., Tan, S., Zhou, Y., Lin, J., Wang, H., Oyang, L., Tian, Y., Liu, L., Su, M., Wang, H., et al. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s161109 · Cited by 473
Clinical implications of mucosal healing for the management of IBD
de Chambrun, G. P., Peyrin‐Biroulet, L., Lémann, M., & Colombel, J. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.203 · Cited by 458
Inflammation and oncogenesis: a vicious connection
Grivennikov, S. I., & Karin, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.11.004 · Cited by 474
Self-citation
Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery
Ayati, A., Emami, S., Asadipour, A., Shafiee, A., & Foroumadi, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.015 · Cited by 454
The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor FamilyPreprint
Negishi, H., Taniguchi, T., & Yanai, H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028423 · Cited by 467
Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Ooi, C.-H., Ivanova, T., Wu, J., Lee, M., Tan, I. B., Tao, J., Ward, L. C., Koo, J. H., Gopalakrishnan, V., Zhu, Y., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000676 · Cited by 444
Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression
Chen, Y., Wang, D., Peng, H., Chen, X., Han, X., Yu, J., Wang, W., Liang, L., Liu, Z., Zheng, Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0930-x · Cited by 439
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.008 · Cited by 445
Self-citation
Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
Luo, J., Tan, W., Ricono, J. M., Korchynskyi, O., Zhang, M., Gonias, S. L., Cheresh, D. A., & Karin, M. (2007) · Nature · doi:10.1038/nature05656 · Cited by 436
Self-citation
Pathways connecting inflammation and cancer
Allavena, P., Garlanda, C., Borrello, M. G., Sica, A., & Mantovani, A. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.01.003 · Cited by 437
IL-18 production downstream of the NLRP3 inflammasome confers protection against colorectal tumor formation
Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M., & Kanneganti, T.-D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002046 · Cited by 411
Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Slavich, G. M., Way, B. M., Eisenberger, N. I., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009164107 · Cited by 418
Chronic Stress Promotes Cancer Development
Dai, S., Mo, Y., Wang, Y., Xiang, B., Liao, Q., Zhou, M., Li, X., Li, Y., Xiong, W., Li, G., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01492 · Cited by 405
Effect of tumor cells and tumor microenvironment on NK‐cell function
Vitale, M., Cantoni, C., Pietra, G., Mingari, M. C., & Moretta, L. (2014) · European Journal of Immunology · doi:10.1002/eji.201344272 · Cited by 425
The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages
Capece, D., Fischietti, M., Verzella, D., Gaggiano, A., Cicciarelli, G., Tessitore, A., Zazzeroni, F., & Alesse, E. (2012) · BioMed Research International · doi:10.1155/2013/187204 · Cited by 414
Molecular mechanisms of cisplatin resistance in cervical cancer
Zhu, X., Zhu, H., Luo, H., Zhang, W., Shen, Z., & Hu, X. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s106412 · Cited by 412
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407
NF-κB Signaling Pathway, Inflammation and Colorectal Cancer
Wang, S.-L., Liu, Z., Lunshan, W., & Zhang, X. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.43 · Cited by 414
Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy
Wang, D., Wang, T., Liu, J., Yu, H., Jiao, S., Feng, B., Zhou, F., Fu, Y., Yin, Q., Zhang, P., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b01994 · Cited by 409
Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
He, G., Yu, G.-Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavljevic, M., Leffert, H. L., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.048 · Cited by 427
Self-citation
Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance
Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
Mauro, C., Leow, S. C., Ansó, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., Smaele, E. D., Beg, A. A., Tergaonkar, V., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2324 · Cited by 405
Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma
Iqbal, J., Weisenburger, D. D., Greiner, T. C., Vose, J. M., McKeithan, T. W., Küçük, C., Geng, H., Deffenbacher, K. E., Smith, L. M., Dybkær, K., et al. (2009) · Blood · doi:10.1182/blood-2009-06-227579 · Cited by 391
Inflammation and Liver Cancer
Berasain, C., Castillo, J., Perugorria, M. J., Latasa, M. U., Prìeto, J., & Avila, M. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03704.x · Cited by 396
Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent
López‐Lázaro, M. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700238 · Cited by 393
Factors in the Pathophysiology of the Liver Ischemia-Reperfusion Injury
Montalvo-Jave, E. E., Escalante-Tattersfield, T., Ortega-Salgado, J. A., Piña, E., & Geller, D. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.06.015 · Cited by 389
Periostin promotes chronic allergic inflammation in response to Th2 cytokines
増岡, 美., Shiraishi, H., Ohta, S., Suzuki, S., Arima, K., Aoki, S., Toda, S., Inagaki, N., Kurihara, Y., Hayashida, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58978 · Cited by 392
FXR: a metabolic regulator and cell protector
Wang, Y.-D., Chen, W.-D., Moore, D. D., & Huang, W. (2008) · Cell Research · doi:10.1038/cr.2008.289 · Cited by 389
TNF: A master switch for inflammation to cancer
Sethi, G. (2008) · Frontiers in Bioscience · doi:10.2741/3066 · Cited by 458
Dysregulated molecular networks in head and neck carcinogenesis
Molinolo, A., Amornphimoltham, P., SQUARIZE, C. H., CASTILHO, R. M., Patel, V., & Gutkind, J. S. (2008) · Oral Oncology · doi:10.1016/j.oraloncology.2008.07.011 · Cited by 387
The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy
Lin, Y., Bai, L., Chen, W., & Xu, S. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903431069 · Cited by 380
Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment
Allavena, P., & Mantovani, A. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04515.x · Cited by 399
Cell type-specific function of TAK1 in innate immune signaling
Alagbala, A. A., Wang, H. Y., & Wang, R. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.007 · Cited by 380
The molecular biology of pancreatic adenocarcinoma: Translational challenges and clinical perspectives
Wang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369
Protumor vs Antitumor Functions of IL-17
Murugaiyan, G., & Saha, B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901017 · Cited by 374
The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases
Soares, J., Pimentel‐Nunes, P., Roncon‐Albuquerque, R., & Leite-Moreira, A. F. (2010) · Hepatology International · doi:10.1007/s12072-010-9219-x · Cited by 378
The metastasis-promoting roles of tumor-associated immune cells
Smith, H. A., & Kang, Y. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1021-5 · Cited by 380
Cancer chemoprevention: a rapidly evolving field
Steward, W. P., & Brown, K. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.280 · Cited by 372
Targeting Inflammation in Cancer Prevention and Therapy
Todoric, J., Antonucci, L., & Karin, M. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0209 · Cited by 379
Self-citation
Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
Cheung, K. L., & Kong, A. T. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9162-8 · Cited by 365
Multi-targeted therapy of cancer by omega-3 fatty acids
Berquin, I. M., Edwards, I. J., & Chen, Y. Q. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.044 · Cited by 368
Induction of MET by Ionizing Radiation and Its Role in Radioresistance and Invasive Growth of Cancer
Bacco, F. D., Luraghi, P., Médico, E., Reato, G., Girolami, F., Perera, T. P. S., Gabriele, P., Comoglio, P. M., & Boccaccio, C. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr093 · Cited by 374
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
Li, Y., Li, P., Roberts, M. J., Arend, R. C., Samant, R. S., & Buchsbaum, D. J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.04.003 · Cited by 367
A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
Hirsch, H. A., Iliopoulos, D., Joshi, A., Zhang, Y., Jaeger, S. A., Bulyk, M. L., Tsichlis, P. N., Liu, X. S., & Struhl, K. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.022 · Cited by 366
Role and regulation of autophagy in cancer
Chen, N., & Karantza‐Wadsworth, V. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.013 · Cited by 368
Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma
Zhou, S., Dai, Z., Zhou, Z., Wang, X., Yang, G., Wang, Z., Huang, X., Fan, J., & Zhou, J. (2012) · Hepatology · doi:10.1002/hep.25907 · Cited by 358
Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
Garvey, J., Taylor, C. T., & McNicholas, W. T. (2009) · European Respiratory Journal · doi:10.1183/09031936.00111208 · Cited by 367
Epithelial–mesenchymal transition and the invasive potential of tumors
Gavert, N. S., & Ben‐Ze'ev, A. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.03.004 · Cited by 358
Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
Mantovani, A., Sica, A., Allavena, P., Garlanda, C., & Locati, M. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.02.008 · Cited by 354
ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK
Tam, A. B., Mercado, E. L., Hoffmann, A., & Niwa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045078 · Cited by 355
Imiquimod: mode of action
Schön, M. P., & Schön, M. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08265.x · Cited by 357
Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
Kannaiyan, R., Shanmugam, M. K., & Sethi, G. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.10.025 · Cited by 351
Life, death, and autophagy in cancer: NF-κB turns up everywhere
Verzella, D., Pescatore, A., Capece, D., Vecchiotti, D., Ursini, M. V., Franzoso, G., Alesse, E., & Zazzeroni, F. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2399-y · Cited by 354
Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy
Mortezaee, K., Salehi, E., Mirtavoos‐Mahyari, H., Motevaseli, E., Najafi, M., Farhood, B., Rosengren, R. J., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28122 · Cited by 355
The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway
Chen, C., Kao, C., & Liu, C.-M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092729 · Cited by 351
Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer
Yao, D., Dong, M., Dai, C., & Wu, S. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz149 · Cited by 337
Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Vilimas, T., Mascarenhas, J., Palomero, T., Mandal, M., Buonamici, S., Meng, F., Thompson, B. J., Spaulding, C., Macaroun, S., Alegre, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1524 · Cited by 335
Multifaceted link between cancer and inflammation
Sethi, G., Shanmugam, M. K., Ramachandran, L., Kumar, A. P., & Tergaonkar, V. (2011) · Bioscience Reports · doi:10.1042/bsr20100136 · Cited by 337
The Role of Inflammation in CKD
Kadatane, S., Satariano, M., Massey, M., Mongan, K., & Raina, R. (2023) · Cells · doi:10.3390/cells12121581 · Cited by 350
Adipose tissue, obesity and adipokines: role in cancer promotion
Booth, A. D., Magnuson, A. M., Fouts, J. K., & Foster, M. T. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0037 · Cited by 351
Inflammation: A driving force speeds cancer metastasis
Wu, Y., & Zhou, B. P. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9699 · Cited by 327
Regulation of NF‐κB by ubiquitination and degradation of the IκBs
Kanarek, N., & Ben‐Neriah, Y. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01098.x · Cited by 327
Intestinal Stem Cells
Umar, S. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0130-3 · Cited by 354
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species
Jin, Y., Lu, Z., Ding, K., Li, J., Du, X., Chen, C., Sun, X., Wu, Y., Zhou, J., & Pan, J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3950 · Cited by 325
Mechanism of radiation-induced bystander effects: a unifying model
Hei, T. K., Zhou, H., Ivanov, V. N., Hong, M., Lieberman, H. B., Brenner, D. J., Amundson, S. A., & Geard, C. R. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.8.0001 · Cited by 321
Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes
Lee, S., Su, Z. Z., Emdad, L., Gupta, P., Sarkar, D., Borjabad, A., Volsky, D. J., & Fisher, P. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707697200 · Cited by 318
Mechanisms of the Epithelial–Mesenchymal Transition by TGF-β
Wendt, M. K., Allington, T. M., & Schiemann, W. P. (2009) · Future Oncology · doi:10.2217/fon.09.90 · Cited by 325
Cancer Stem Cells: The Promise and the Potential
Ajani, J. A., Song, S., Höchster, H. S., & Steinberg, I. B. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2015.01.001 · Cited by 318
Helicobacter pylori and gastric cancer: mechanisms and new perspectives
Duan, Y., Xu, Y., Dou, Y., & Xu, D. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01654-2 · Cited by 311
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer
Marquardt, J. U., Gómez-Quiroz, L. E., Camacho, L. O. A., Pinna, F., Lee, Y., Kitade, M., Domínguez, M. P., Castven, D., Breuhahn, K., Conner, E. A., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.018 · Cited by 313
Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents
Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.001 · Cited by 358
Glutathione peroxidases in different stages of carcinogenesis
Brigelius‐Flohé, R., & Kipp, A. P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.006 · Cited by 311
Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?
Bui, J. D., & Schreiber, R. D. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.02.001 · Cited by 319
Functional and genetic deconstruction of the cellular origin in liver cancer
Marquardt, J. U., Andersen, J. B., & Thorgeirsson, S. S. (2015) · Nature reviews. Cancer · doi:10.1038/nrc4017 · Cited by 306
TLR7 and TLR8 as targets in cancer therapy
Schön, M., & Schön, M. (2008) · Oncogene · doi:10.1038/sj.onc.1210913 · Cited by 302
The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases
Sayan, M., & Mossman, B. T. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0162-4 · Cited by 308
Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment
O’Hayre, M., Salanga, C. L., Handel, T. M., & Allen, S. J. (2008) · Biochemical Journal · doi:10.1042/bj20071493 · Cited by 303
Molecular mechanisms of viral oncogenesis in humans
Krump, N. A., & You, J. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0064-6 · Cited by 311
Celastrol: Molecular targets of Thunder God Vine
Salminen, A., Lehtonen, M., Paimela, T., & Kaarniranta, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.050 · Cited by 295
Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
Coutinho, D. D. S., Pacheco, M. T., Frozza, R. L., & Bernardi, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061812 · Cited by 308
Comprehensive Expression Profiling of Tumor Cell Lines Identifies Molecular Signatures of Melanoma Progression
Ryu, B., Kim, D. S., DeLuca, A. M., & Alani, R. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000594 · Cited by 289
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats
Zhang, H.-L., Yu, L.-X., Yang, W., Tang, L., Lin, Y., Wu, H., Zhai, B., Tan, Y.-X., Shan, L., Liu, Q., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.011 · Cited by 281
Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP
Zhu, G., Wu, C.-J., Zhao, Y., & Ashwell, J. D. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.041 · Cited by 282
Macrophages, Inflammation, and Lung Cancer
Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S. C., Lam, W. L., & Bennewith, K. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1545ci · Cited by 295
Portrait of inflammatory response to ionizing radiation treatment
Maggio, F. M. D., Minafra, L., Forte, G. I., Cammarata, F. P., Lio, D., Messa, C., Gilardi, M. C., & Bravatà, V. (2015) · Journal of Inflammation · doi:10.1186/s12950-015-0058-3 · Cited by 293
The IκB kinase complex: master regulator of NF-κB signaling
Solt, L. A., & May, M. J. (2008) · Immunologic Research · doi:10.1007/s12026-008-8025-1 · Cited by 292
From inflammation to cancer
Korniluk, A., Koper, O., Kemona, H., & Dymicka-Piekarska, V. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-016-1464-0 · Cited by 282
NF-κB signaling, liver disease and hepatoprotective agents
Sun, B., & Karin, M. (2008) · Oncogene · doi:10.1038/onc.2008.300 · Cited by 307
Self-citation
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Bose, P., Dai, Y., & Grant, S. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.04.004 · Cited by 287

Authors: Karin, M.
Affiliations: University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Karin, Michael
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-05
Volume: 441
Issue: 7092
Pages: 431-436
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04870
OpenAlex: W2315613727
Cited by: 3,519
References: 71
Citations by year: 2026: 60 · 2025: 97 · 2024: 111 · 2023: 118 · 2022: 118 · 2021: 159 · 2020: 162 · 2019: 133 · 2018: 168 · 2017: 149 · 2016: 192 · 2015: 235 · 2014: 203 · 2013: 231 · 2012: 250
FWCI: 15.68
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: NF-κB, carcinogenesis, tumor progression, inflammation and cancer, apoptosis resistance, tumor surveillance, tumor angiogenesis, tumour invasiveness, chemoprevention, chemotherapeutic target, NF-κB signaling
MeSH terms: Animals, Humans, Inflammation, Liver Neoplasms, Neoplasms, Skin Neoplasms, NF-kappa B, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nuclear factor-κB in cancer development and progression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks