The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.
Abstract
Precise patterning of dendritic fields is essential for neuronal circuit formation and function, but how neurons establish and maintain their dendritic fields during development is poorly understood. In Drosophila class IV dendritic arborization neurons, dendritic tiling, which allows for the complete but non-overlapping coverage of the dendritic fields, is established through a 'like-repels-like' behaviour of dendrites mediated by Tricornered (Trc), one of two NDR (nuclear Dbf2-related) family kinases in Drosophila. Here we report that the other NDR family kinase, the tumour suppressor Warts/Lats (Wts), regulates the maintenance of dendrites; in wts mutants, dendrites initially tile the body wall normally, but progressively lose branches at later larval stages, whereas the axon shows no obvious defects. We further provide biochemical and genetic evidence for the tumour suppressor kinase Hippo (Hpo) as an upstream regulator of Wts and Trc for dendrite maintenance and tiling, respectively, thereby revealing important functions of tumour suppressor genes of the Hpo signalling pathway in dendrite morphogenesis.
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Drosophila and C. elegans Ndr homologs Tricornered and SAX-1 are involved in patterning dendrites.
“The Drosophila and Caenorhabditis elegans Ndr homologs Tricornered and SAX-1 are involved in patterning dendrites (Emoto et al., 2004; Emoto et al., 2006; Gallegos and Bargmann, 2004; He et al., 2005).”
From Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation (2014) · cites this paper as Emoto et al., 2006
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Dendritic arbor development and synaptogenesis
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Dendritic atrophy in children with down’s syndrome.
Becker, L. E., Armstrong, D. L., & Chan, F. (1986) · Annals of Neurology · doi:10.1002/ana.410200413 · Cited by 279 · see citing works
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The Hippo Signaling Pathway in Development and Disease
Zheng, Y., & Pan, D. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.003 · Cited by 867 · see citing works
Branching out: mechanisms of dendritic arborization
Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693 · see citing works
Self-citationWu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · see citing works
The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
Harvey, K., & Tapon, N. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2070 · Cited by 628 · see citing works
Wang, K., Degerny, C., Xu, M., & Yang, X.-J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-114 · Cited by 180 · see citing works
Lin, Z., & Pu, W. T. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.04.010 · Cited by 52 · see citing works
Yang, R., Kong, E., Jin, J., Hergovich, A., & Püschel, A. W. (2014) · Journal of Cell Science · doi:10.1242/jcs.146696 · Cited by 25 · see citing works
- Authors
- Emoto, K., Parrish, J. Z., Jan, L. Y., & Jan, Y.-N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Nature
- Published
- 2006-08-13
- Volume
- 443
- Issue
- 7108
- Pages
- 210-213
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2035358499
- Cited by
- 194
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 11 · 2012: 20
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of Mental Health (F32MH071101)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Hippo signaling pathway, Warts kinase, NDR kinase, dendrite morphogenesis, tumor suppressor, Drosophila
- MeSH terms
- Hippo Kinases, Animals, Cell Count, Dendrites, Drosophila melanogaster, Larva, Morphogenesis, Mutation, Phosphorylation, Phosphothreonine, Protein Binding, Protein Kinases, Threonine, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Tumor Suppressor Proteins, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Cell Shape
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