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A single type of progenitor cell maintains normal epidermis
Open accessAbstract
According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.
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“adult epidermal homeostasis seems to rely solely on active stem cells34”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [34]
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317
Capturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998
Conboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905
Lajtha, L. G. (1979) · Differentiation · doi:10.1111/j.1432-0436.1979.tb01007.x · Cited by 562
Stem cells of the skin epithelium
Alonso, L. C., & Fuchs, E. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734203100 · Cited by 531
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong, W., Feder, J. N., Jiang, M., Jan, L. Y., & Jan, Y. N. (1996) · Neuron · doi:10.1016/s0896-6273(00)80279-2 · Cited by 478
Temple, S., & RAFF, M. C. (1986) · Cell · doi:10.1016/0092-8674(86)90843-3 · Cited by 455
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Nicholson, A. M., Graham, T. A., Simpson, A. I., Humphries, A., Burch, N., Rodriguez‐Justo, M., Novelli, M. R., Harrison, R. F., Wright, N. A., McDonald, S. A. C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301174 · Cited by 85
Building Epithelial Tissues from Skin Stem CellsPreprint
Fuchs, E. V., & Nowak, J. A. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.032 · Cited by 89
Teunissen, M. B. M., Haniffa, M. A., & Collin, M. P. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_169 · Cited by 89
Epidermal Stem Cells in Skin Wound Healing
Li, Y., Zhang, J., Yue, J., Gou, X., & Wu, X. (2017) · Advances in Wound Care · doi:10.1089/wound.2017.0728 · Cited by 83
Unraveling intestinal stem cell behavior with models of crypt dynamics
Carulli, A. J., Samuelson, L. C., & Schnell, S. D. (2014) · Integrative Biology · doi:10.1039/c3ib40163d · Cited by 82
Switching roles: the functional plasticity of adult tissue stem cells
Wabik, A., & Jones, P. H. (2015) · The EMBO Journal · doi:10.15252/embj.201490386 · Cited by 84
Self-citationA Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues
Fellous, T. G., McDonald, S. A. C., Burkert, J., Humphries, A., Islam, S., De-Alwis, N. M. W., Gutiérrez-González, L., Tadrous, P. J., Elia, G., Kocher, H. M., et al. (2009) · Stem Cells · doi:10.1002/stem.67 · Cited by 80
Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium
Mort, R. L., Ramaesh, T., Kleinjan, D. A., Morley, S. D., & West, J. D. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-4 · Cited by 78
Heterogeneous Stem Cells in Skin Homeostatis and Wound Repair
Meilana, A., Dewi, N. M., & Wijaya, A. (2015) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v7i2.74 · Cited by 78
Jarid2 regulates mouse epidermal stem cell activation and differentiation
Mejetta, S., Morey, L., Pascual, G., Kuebler, B., Mysliwiec, M. R., Lee, Y., Shiekhattar, R., Croce, L. D., & Benitah, S. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.265 · Cited by 77
Was skin cancer a selective force for black pigmentation in early hominin evolution?
Greaves, M. F. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.2955 · Cited by 77
aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation
Niessen, M. T., Scott, J. A., Zielinski, J. G., Vorhagen, S., Sotiropoulou, P. A., Blanpain, C., Leitges, M., & Niessen, C. M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201307001 · Cited by 76
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Santoro, A., Vlachou, T., Carminati, M., Pelicci, P. G., & Mapelli, M. (2016) · EMBO Reports · doi:10.15252/embr.201643021 · Cited by 81
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Ema, H., & Suda, T. (2012) · Blood · doi:10.1182/blood-2012-04-424507 · Cited by 78
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Frede, J., Greulich, P., Nagy, T., Simons, B. D., & Jones, P. H. (2016) · Nature Cell Biology · doi:10.1038/ncb3400 · Cited by 75
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Maddox, J., Shakya, A., South, S., Shelton, D. N., Andersen, J. N., Chidester, S., Kang, J., Gligorich, K. M., Jones, D. A., Spangrude, G. J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003048 · Cited by 77
Dermal Contributions to Human Interfollicular Epidermal Architecture and Self-Renewal
Lawlor, K. T., & Kaur, P. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226078 · Cited by 80
Jones, K. B., Furukawa, S., Marangoni, P., Ma, H., Pinkard, H., D’Urso, R. S., Žilionis, R., Klein, A. M., & Klein, O. D. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.015 · Cited by 75
Self-citationMechanisms regulating epidermal stem cells
Beck, B., & Blanpain, C. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.67 · Cited by 75
Kinetics of cell division in epidermal maintenance
Klein, A. M., Doupé, D. P., Jones, P. H., & Simons, B. D. (2007) · Physical Review E · doi:10.1103/physreve.76.021910 · Cited by 76
Self-citationLee, J., Basak, J. M., Demehri, S., & Kopan, R. (2007) · Development · doi:10.1242/dev.02868 · Cited by 72
Modelling epidermis homoeostasis and psoriasis pathogenesis
Zhang, H., Hou, W., Henrot, L., Schnebert, S., Dumas, M., Heusèle, C., & Yang, J. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.1071 · Cited by 72
The keratinocyte in epidermal renewal and defence
Suter, M. M., Schulze, K., Bergman, W., Welle, M. M., Roosje, P. J., & Müller, E. J. (2009) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2009.00819.x · Cited by 71
Exact solution of a two-type branching process: models of tumor progression
Tibor Antal, A., & Krapivsky, P. L. (2011) · Journal of Statistical Mechanics Theory and Experiment · doi:10.1088/1742-5468/2011/08/p08018 · Cited by 74
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D’Arcangelo, D., Tinaburri, L., & Dellambra, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071591 · Cited by 77
N6‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness
Lee, J., Wu, Y., Harada, B. T., Li, Y., Zhao, J. C., He, C., Ma, Y., & Wu, X. (2021) · The EMBO Journal · doi:10.15252/embj.2020106276 · Cited by 71
Schlüter, H., Paquet‐Fifield, S., Gangatirkar, P., Li, J., & Kaur, P. (2011) · Stem Cells · doi:10.1002/stem.675 · Cited by 77
Harfouche, G., & Martin, M. T. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.007 · Cited by 75
Stachelscheid, H., Ibrahim, H., Koch, L., Schmitz, A., Tscharntke, M., Wunderlich, F. T., Scott, J. A., Michels, C., Wickenhauser, C., Haase, I., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.141 · Cited by 70
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Keymeulen, A. V., & Blanpain, C. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201201041 · Cited by 74
Farrelly, O. M., Suzuki-Horiuchi, Y., Brewster, M., Kuri, P., Huang, S., Rice, G., Bae, H., Xu, J., Dentchev, T., Lee, V., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.022 · Cited by 69
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Su, X., Cho, M. S., Gi, Y. J., Ayanga, B. A., Sherr, C. J., & Flores, E. R. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.151 · Cited by 71
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Gaisa, N. T., Graham, T. A., McDonald, S. A. C., Cañadillas, S., Poulsom, R., Heidenreich, A., Jakse, G., Tadrous, P. J., Knuechel, R., & Wright, N. A. (2011) · The Journal of Pathology · doi:10.1002/path.2945 · Cited by 68
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Tajbakhsh, S., Rocheteau, P., & Roux, I. L. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175415 · Cited by 74
Wang, Y., Christley, S., Mjolsness, E., & Xie, X. S. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-99 · Cited by 68
Towards a statistical mechanics of cell fate decisions
García‐Ojalvo, J., & Arias, A. M. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.10.004 · Cited by 67
Enzo, E., Secone Seconetti, A., Forcato, M., Tenedini, E., Polito, M. P., Sala, I., Carulli, S., Contin, R., Peano, C., Tagliafico, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22779-9 · Cited by 66
Spindle orientation and epidermal morphogenesis
Kulukian, A., & Fuchs, E. V. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0016 · Cited by 66
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West, J. D. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i2.281 · Cited by 67
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Self-citationEpidermal stem cells: location, potential and contribution to cancer
Ambler, C. A., & Määttå, A. (2008) · The Journal of Pathology · doi:10.1002/path.2468 · Cited by 63
25 Years of Epidermal Stem Cell Research
Ghadially, R. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.434 · Cited by 66
Pereira, D., & Sequeira, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.682143 · Cited by 65
Dynamic heterogeneity as a strategy of stem cell self-renewal
Greulich, P., & Simons, B. D. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602779113 · Cited by 62
Self-citationStem cells, niches and scaffolds: Applications to burns and wound care
Watt, S. M., & Pleat, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.012 · Cited by 63
Vagnozzi, A. N., Reiter, J. F., & Wong, S. Y. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1090062 · Cited by 61
Byrd, K. M., Piehl, N., Patel, J. H., Huh, W. J., Sequeira, I., Lough, K. J., Wagner, B. L., Marangoni, P., Watt, F. M., Klein, O. D., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.11.005 · Cited by 61
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Yan, X., & Owens, D. M. (2008) · Stem Cell Reviews and Reports · doi:10.1007/s12015-008-9022-4 · Cited by 63
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Youssefpour, H., Li, X., Lander, A. D., & Lowengrub, J. S. (2012) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.02.030 · Cited by 61
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Yoshida, S. (2018) · Development Growth & Differentiation · doi:10.1111/dgd.12574 · Cited by 60
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Spradling, A. C., Nystul, T. G., Lighthouse, D. V., Morris, L. X., Fox, D. T., Cox, R. T., Tootle, T. L., Frederick, R., & Skora, A. D. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.023 · Cited by 58
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Rawlins, E. L., Okubo, T., Que, J., Xue, Y., Clark, C. P., Luo, X., & Hogan, B. L. M. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.037 · Cited by 59
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Jones, P. H., & Simons, B. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2292 · Cited by 57
Self-citationMorgun, E. I., & Vorotelyak, E. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.581697 · Cited by 56
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Wells, J., Lee, B., Cai, A. Q., Karapetyan, A., Lee, W.-J., Rugg, E. L., Sinha, S., Nie, Q. H., & Dai, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008847 · Cited by 56
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Gaisa, N. T., Graham, T. A., McDonald, S. A. C., Poulsom, R., Heidenreich, A., Jakse, G., Knuechel, R., & Wright, N. A. (2011) · The Journal of Pathology · doi:10.1002/path.2959 · Cited by 55
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O’Brien, L. E., & Bilder, D. H. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122319 · Cited by 60
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Nagosa, S., Leesch, F., Putin, D., Bhattacharya, S., Altshuler, A., Serror, L., Amitai-Lange, A., Nasser, W., Aberdam, É., Rouleau, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.030 · Cited by 55
Box, K., Joyce, B. W., & Devenport, D. (2019) · eLife · doi:10.7554/elife.47102 · Cited by 55
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Demetriou, S. K., Ona-Vu, K., Teichert, A. E., Cleaver, J. E., Bikle, D. D., & Oh, D. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.107 · Cited by 50
Li, N., Sarojini, H., An, J., & Wang, E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06565.x · Cited by 50
Doma, E., Rupp, C., & Baccarini, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141019361 · Cited by 52
Roy, E., Neufeld, Z., Cerone, L., Wong, H. Y., Hodgson, S., Livet, J., & Khosrotehrani, K. (2016) · The EMBO Journal · doi:10.15252/embj.201693806 · Cited by 50
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Andersen, M. S., Hannezo, É., Ulyanchenko, S., Estrach, S., Antoku, Y., Pisano, S., Boonekamp, K. E., Sendrup, S., Maimets, M., Pedersen, M. T., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0362-x · Cited by 49
Self-citationWalker, G. J., Soyer, H. P., Terzian, T., & Box, N. F. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00923.x · Cited by 49
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Ryser, M. D., Myers, E. R., & Durrett, R. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004113 · Cited by 51
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Brafman, D. A. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00099.2013 · Cited by 48
Turner, C., & Kohandel, M. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.05.024 · Cited by 47
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Asselin-Labat, M.-L., & Filby, C. E. (2012) · Open Biology · doi:10.1098/rsob.120094 · Cited by 47
Cell motion predicts human epidermal stemness
Nanba, D., Toki, F., Tate, S., Imai, M., Matsushita, N., Shiraishi, K., Sayama, K., Toki, H., Higashiyama, S., & Barrandon, Y. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409024 · Cited by 47
Foijer, F., DiTommaso, T., Donati, G., Hautaviita, K., Xie, S. Z.-J., Heath, E., Smyth, I., Watt, F. M., Sorger, P. K., & Bradley, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217388110 · Cited by 48
Kranjec, C., Holleywood, C., Libert, D. M., Griffin, H. M., Mahmood, R., Isaacson, E. R., & Doorbar, J. (2017) · The Journal of Pathology · doi:10.1002/path.4917 · Cited by 48
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Metadata
- Authors
- Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H.
- Affiliations
- MRC Cancer Unit (GB)
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Corresponding author
- Jones, Philip H.
- Venue
- Nature
- Published
- 2007-02-28
- Volume
- 446
- Issue
- 7132
- Pages
- 185-189
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1979812265
- Cited by
- 853
- References
- 29
- Citations by year
- 2026: 22 · 2025: 22 · 2024: 38 · 2023: 22 · 2022: 32 · 2021: 36 · 2020: 41 · 2019: 44 · 2018: 47 · 2017: 51 · 2016: 49 · 2015: 46 · 2014: 59 · 2013: 61 · 2012: 79
- FWCI
- 61.13
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- epidermal homeostasis, skin stem cells, progenitor cells, asymmetric cell division, symmetric cell division, transit amplifying cells, clone size distribution, tissue maintenance
- MeSH terms
- Epidermal Cells, Animals, Cell Differentiation, Cell Division, Clone Cells, Homeostasis, Models, Biological, Stem Cells, Cell Lineage, Mice
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