Cited by 853Hair Growth and DisordersSkin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

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A single type of progenitor cell maintains normal epidermis

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Clayton, Elizabeth, Doupé, David P., Klein, Allon M., Winton, Douglas J., Simons, Benjamin D., Jones, Philip H.·2007·Nature

DOI 10.1038/nature05574

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Abstract

According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division. By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.

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Authors: Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H.
Affiliations: MRC Cancer Unit (GB)
University of Cambridge (GB)
Cancer Research UK (GB)
Corresponding author: Jones, Philip H.
ORCID: Doupé, David P.
Klein, Allon M.
Winton, Douglas J.
Simons, Benjamin D.
Jones, Philip H.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-02-28
Volume: 446
Issue: 7132
Pages: 185-189
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05574
OpenAlex: W1979812265
Cited by: 853
References: 29
Citations by year: 2026: 22 · 2025: 22 · 2024: 38 · 2023: 22 · 2022: 32 · 2021: 36 · 2020: 41 · 2019: 44 · 2018: 47 · 2017: 51 · 2016: 49 · 2015: 46 · 2014: 59 · 2013: 61 · 2012: 79
FWCI: 61.13
Type: journal article
Language: en
Open access: green
durham-repository.worktribe.com
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Durham Research Online (Durham University) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: epidermal homeostasis, skin stem cells, progenitor cells, asymmetric cell division, symmetric cell division, transit amplifying cells, clone size distribution, tissue maintenance
MeSH terms: Epidermal Cells, Animals, Cell Differentiation, Cell Division, Clone Cells, Homeostasis, Models, Biological, Stem Cells, Cell Lineage, Mice

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A single type of progenitor cell maintains normal epidermis

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